BR0212839A - Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes e composição farmacêutica contendo os mesmos - Google Patents

Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes e composição farmacêutica contendo os mesmos

Info

Publication number
BR0212839A
BR0212839A BR0212839-0A BR0212839A BR0212839A BR 0212839 A BR0212839 A BR 0212839A BR 0212839 A BR0212839 A BR 0212839A BR 0212839 A BR0212839 A BR 0212839A
Authority
BR
Brazil
Prior art keywords
hydrogen
preparation
pharmaceutical composition
composition containing
carbon atoms
Prior art date
Application number
BR0212839-0A
Other languages
English (en)
Inventor
Jozsef Barkoczy
Gyula Simig
Peter Kotay Nagy
Gy Rgy Levay
Istvan Gacsalyi
Bernadett Marttonne Marko
Eva Schmidt
Andras Egyed
Hajnalka Kompagne
Csilla Leveleki
Aniko Miklosne Kovacs
Janos Wellmann
Garbor Szenasi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of BR0212839A publication Critical patent/BR0212839A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22Nitrogen and oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"DERIVADOS DE ALQUILAMINOPIRIDAZINONA SUBSTITUìDOS, PROCESSO PARA A PREPARAçãO DESTES E COMPOSIçãO FARMACêUTICA CONTENDO OS MESMOS". Novos derivados de alquilaminopiridazinona substituídos de Fórmula Geral I, onde R~ 1~ é hidrogênio ou alquil possuindo de 1 a 4 átomos de carbono; X é hidrogênio ou halogênio; R~ 2~ é hidrogênio ou alquil possuindo de 1 a 4 átomos de carbono; n é 1, 2 ou 3; Q e W independentemente um do outro representam, -N= ou -CH=; e R~ 4~ e R~ 5~ independentemente um do outro representam hidrogênio, halogênio, trifluorometil ou alcoxi possuindo de 1 a 4 átomos de carbono, e sais de adição ácida destes farmaceuticamente aceitáveis possuem propriedades ansiolíticas e de melhoramento da cognição úteis.
BR0212839-0A 2001-09-27 2002-09-26 Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes e composição farmacêutica contendo os mesmos BR0212839A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
PCT/HU2002/000097 WO2003027078A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Publications (1)

Publication Number Publication Date
BR0212839A true BR0212839A (pt) 2004-10-13

Family

ID=89979721

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0212932-9A BR0212932A (pt) 2001-09-27 2002-09-26 Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes, composição farmacêutica contendo os mesmos e seus usos
BR0212839-0A BR0212839A (pt) 2001-09-27 2002-09-26 Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes e composição farmacêutica contendo os mesmos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0212932-9A BR0212932A (pt) 2001-09-27 2002-09-26 Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes, composição farmacêutica contendo os mesmos e seus usos

Country Status (26)

Country Link
US (2) US20050043314A1 (pt)
EP (2) EP1430047B1 (pt)
JP (2) JP2005508914A (pt)
KR (2) KR100890667B1 (pt)
CN (3) CN100368404C (pt)
AT (2) ATE288899T1 (pt)
AU (2) AU2002328166B2 (pt)
BR (2) BR0212932A (pt)
CA (2) CA2461510C (pt)
CZ (2) CZ2004528A3 (pt)
DE (2) DE60202969T2 (pt)
DK (2) DK1430047T3 (pt)
EA (2) EA006392B1 (pt)
ES (2) ES2237696T3 (pt)
HK (3) HK1069816A1 (pt)
HU (1) HU227237B1 (pt)
MA (2) MA27137A1 (pt)
MX (2) MXPA04002838A (pt)
NO (2) NO326370B1 (pt)
NZ (2) NZ532103A (pt)
PL (2) PL369107A1 (pt)
PT (2) PT1430034E (pt)
SI (2) SI1430047T1 (pt)
SK (2) SK1902004A3 (pt)
WO (2) WO2003027097A1 (pt)
ZA (2) ZA200402545B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5080716B2 (ja) 2001-07-20 2012-11-21 サイコジェニックス・インコーポレーテッド 注意欠陥・多動性障害の治療
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
CL2008000725A1 (es) * 2007-03-15 2008-11-14 Schering Corp Compuestos derivados de heterociclos aromaticos; composicion farmaceutica; kit farmceuticos; uso de la composicion y de los compuestos como inhibidores de glucano sintasa para el tratamiento o prevencion del crecimiento de patogenos fungicos en planta y para tratar o prevenir infecciones producidas por hongos.
TW202344505A (zh) * 2018-04-30 2023-11-16 美商律幫治療股份有限公司 作為parp7抑制劑的嗒𠯤酮
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
CN117425648A (zh) * 2021-03-12 2024-01-19 杭州英创医药科技有限公司 作为parp7抑制剂的化合物
CN115490671B (zh) * 2022-10-21 2024-05-14 水木未来(北京)科技有限公司 Parp7抑制剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
PL164079B1 (pl) * 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu) 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
CA2334220A1 (en) * 1998-06-05 1999-12-16 Egis Gyogyszergyar Rt. Process for the preparation of a 3(2h)-pyridazinone- 4-substituted amino- 5-chloro- derivative

Also Published As

Publication number Publication date
EA006942B1 (ru) 2006-06-30
AU2002328166A2 (en) 2003-04-07
HK1115728A1 (en) 2008-12-05
SI1430034T1 (en) 2005-08-31
MA27137A1 (fr) 2005-01-03
CN101099740B (zh) 2010-09-08
SI1430047T1 (en) 2005-08-31
EP1430034A1 (en) 2004-06-23
EP1430047B1 (en) 2005-02-09
HUP0103912A3 (en) 2004-03-01
HU0103912D0 (en) 2001-12-28
NZ532104A (en) 2005-10-28
HU227237B1 (en) 2010-12-28
CN1571783A (zh) 2005-01-26
ZA200402545B (en) 2005-04-26
KR20040039445A (ko) 2004-05-10
DK1430034T3 (da) 2005-05-30
PT1430034E (pt) 2005-06-30
EP1430034B1 (en) 2005-02-09
HK1069817A1 (en) 2005-06-03
US20050043314A1 (en) 2005-02-24
MXPA04002838A (es) 2004-07-05
KR20040039446A (ko) 2004-05-10
US6930110B2 (en) 2005-08-16
ES2237690T3 (es) 2005-08-01
NO326370B1 (no) 2008-11-17
EP1430047A1 (en) 2004-06-23
MXPA04002836A (es) 2004-07-05
ES2237696T3 (es) 2005-08-01
JP2005503437A (ja) 2005-02-03
ATE288899T1 (de) 2005-02-15
AU2002330656B2 (en) 2009-04-09
BR0212932A (pt) 2004-10-13
PL369256A1 (en) 2005-04-18
CZ2004528A3 (cs) 2004-08-18
AU2002330656A2 (en) 2003-04-07
EA006392B1 (ru) 2005-12-29
NO20041704L (no) 2004-04-26
CZ2004532A3 (cs) 2004-08-18
US20040242873A1 (en) 2004-12-02
AU2002330656B9 (en) 2009-09-03
PT1430047E (pt) 2005-06-30
DE60202969D1 (de) 2005-03-17
SK1892004A3 (en) 2004-10-05
ZA200402544B (en) 2005-04-26
NO325080B1 (no) 2008-01-28
NZ532103A (en) 2005-08-26
KR100890667B1 (ko) 2009-03-26
KR100911069B1 (ko) 2009-08-06
CN101099740A (zh) 2008-01-09
JP4472337B2 (ja) 2010-06-02
AU2002328166B2 (en) 2008-04-17
CN100368404C (zh) 2008-02-13
NO20041551L (no) 2004-06-10
DE60202970D1 (de) 2005-03-17
EA200400469A1 (ru) 2004-08-26
CA2461510C (en) 2009-07-07
CN1558904A (zh) 2004-12-29
DE60202969T2 (de) 2006-01-19
CA2461467A1 (en) 2003-04-03
CN1325489C (zh) 2007-07-11
ATE288910T1 (de) 2005-02-15
SK1902004A3 (en) 2004-10-05
DE60202970T2 (de) 2006-02-16
MA27068A1 (fr) 2004-12-20
EA200400470A1 (ru) 2004-08-26
WO2003027097A1 (en) 2003-04-03
HK1069816A1 (en) 2005-06-03
WO2003027078A1 (en) 2003-04-03
PL369107A1 (en) 2005-04-18
DK1430047T3 (da) 2005-06-06
HUP0103912A2 (hu) 2003-07-28
CA2461510A1 (en) 2003-04-03
JP2005508914A (ja) 2005-04-07

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.