BR0011127A - Derivados de 4-fenil-pirimidina - Google Patents
Derivados de 4-fenil-pirimidinaInfo
- Publication number
- BR0011127A BR0011127A BR0011127-9A BR0011127A BR0011127A BR 0011127 A BR0011127 A BR 0011127A BR 0011127 A BR0011127 A BR 0011127A BR 0011127 A BR0011127 A BR 0011127A
- Authority
- BR
- Brazil
- Prior art keywords
- lower alkyl
- hydrogen
- phenyl
- halogen
- pyrimidine derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: "DERIVADOS DE 4-FENIL-PIRIMIDINA". A invenção refere-se a compostos de fórmula (I) onde R^ 1^ é hidrogênio ou halogênio; R^ 2^ é hidrogênio, halogênio, alquila inferior ou alcóxi inferior; R^ 1^ e R^ 2^ podem ser juntos com os dois átomos de carbono -CH=CH-CH=CH-; R^ 3^ é halogênio, trifluorometila, alquila inferior ou alcóxi inferior; R^ 4^ R^ 4^' são independentemente um do outro hidrogênio ou alquila inferior; R^ 5^ é alquila inferior, alcóxi inferior, amino, fenila, alquila inferior de hidróxi, alquila inferior de ciano, alquila inferior de carbamoíla, piridila, pirimidila, -(CH~ 2~)~ n~-Piperazinila, que é opcionalmente substituída por um ou dois grupos de alquila inferior ou por alquila inferior de hidróxi, -(CH~ 2~),-morfolinila, -(CH~ 2~)~ n~-Piperidinila, -(CH~ 2~)~ n+1~-imidazolila, sulfanila de alquila inferior, sulfonila de alquila inferior, benzilamino, -NH-(CH~ 2~)~ n+1~R(R^ 4^")~ 2~, -(CH~ 2~)~ n+1~N(R^ 4^")~ 2~, -O(CH~ 2~)~ n+1~-morfolinila, -O-(CH~ 2~)~ n+1~"-piperidinila ou -O-(CH~ 2~)~ n+1~N(R^ 4^")~ 2~, onde R^ 4^" é hidrogênio ou alquila inferior; e n é 0 a 2; X é -C(O)N(R^ 4^")- ou -N(R^ 4^)C(O)-; e a sais de adição de ácido farmaceuticamente aceitáveis destes. Foi demonstrado que os compostos têm uma boa afinidade ao receptor de NK-1 e pode portanto ser empregado para o tratamento de doenças relacionadas a este receptor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99110483 | 1999-05-31 | ||
PCT/EP2000/004701 WO2000073279A1 (en) | 1999-05-31 | 2000-05-24 | 4-phenyl-pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011127A true BR0011127A (pt) | 2002-02-19 |
Family
ID=8238271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011127-9A BR0011127A (pt) | 1999-05-31 | 2000-05-24 | Derivados de 4-fenil-pirimidina |
Country Status (36)
Country | Link |
---|---|
US (1) | US6274588B1 (pt) |
EP (1) | EP1187815B1 (pt) |
JP (1) | JP3590592B2 (pt) |
KR (1) | KR100440106B1 (pt) |
CN (1) | CN1166643C (pt) |
AR (1) | AR024146A1 (pt) |
AT (1) | ATE317389T1 (pt) |
AU (1) | AU770786B2 (pt) |
BR (1) | BR0011127A (pt) |
CA (1) | CA2375671C (pt) |
CO (1) | CO5170520A1 (pt) |
CZ (1) | CZ20014271A3 (pt) |
DE (1) | DE60025918T2 (pt) |
DK (1) | DK1187815T3 (pt) |
ES (1) | ES2257294T3 (pt) |
GC (1) | GC0000191A (pt) |
HK (1) | HK1046528B (pt) |
HR (1) | HRP20010871A2 (pt) |
HU (1) | HUP0201315A3 (pt) |
IL (2) | IL146460A0 (pt) |
JO (1) | JO2261B1 (pt) |
MA (1) | MA26793A1 (pt) |
MX (1) | MXPA01012089A (pt) |
MY (1) | MY122731A (pt) |
NO (1) | NO321354B1 (pt) |
NZ (1) | NZ515407A (pt) |
PE (1) | PE20010153A1 (pt) |
PL (1) | PL353441A1 (pt) |
PT (1) | PT1187815E (pt) |
RU (1) | RU2243221C2 (pt) |
SI (1) | SI1187815T1 (pt) |
TR (1) | TR200103457T2 (pt) |
TW (1) | TW550258B (pt) |
WO (1) | WO2000073279A1 (pt) |
YU (1) | YU84901A (pt) |
ZA (1) | ZA200109163B (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPQ514600A0 (en) | 2000-01-18 | 2000-02-10 | James Cook University | Brain injury treatment |
WO2002022588A1 (fr) * | 2000-09-14 | 2002-03-21 | Ajinomoto Co.,Inc. | Nouveau derive de pyrimidine et nouveau derive de pyridine |
HUP0303841A2 (hu) * | 2001-02-20 | 2004-03-01 | Bristol-Myers Squibb Company | 2,4-Diszubsztituált-5-pirimidinkarboxamid-származékok mint KCNQ káliumcsatorna modulátorok és ezeket tartalmazó gyógyszerkészítmények és előállításuk |
US20070099938A1 (en) * | 2003-10-24 | 2007-05-03 | Ono Pharmaceutical Co., Ltd. | Antistress drug and medical use thereof |
HUP0400405A3 (en) * | 2004-02-10 | 2009-03-30 | Sanofi Synthelabo | Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
WO2006050476A2 (en) | 2004-11-03 | 2006-05-11 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives as ion channel modulators and methods of use |
US7176205B2 (en) * | 2005-02-22 | 2007-02-13 | Hoffmann-La Roche Inc. | Bi-pyridinyl derivatives as NK-1 antagonists |
CN101128189A (zh) | 2005-02-25 | 2008-02-20 | 弗·哈夫曼-拉罗切有限公司 | 药物物质分散性改善的片剂 |
AU2006259525B2 (en) * | 2005-06-14 | 2012-05-24 | Gpcr Therapeutics, Inc | Pyrimidine compounds |
CA2720229C (en) | 2008-04-21 | 2015-02-17 | Taigen Biotechnology Co., Ltd. | Heterocyclic compounds |
US8580805B2 (en) * | 2010-08-31 | 2013-11-12 | Hubert Maehr | Pyrimidine carboxamide derivatives |
CR20170387A (es) * | 2015-01-30 | 2018-02-16 | Basf Se | Fenilpirimidinas herbicidas |
RU2756055C2 (ru) * | 2017-01-10 | 2021-09-24 | Нэшнл Хелт Рисерч Инститьютс | Гетероциклические соединения и их применение |
KR102006547B1 (ko) * | 2017-11-16 | 2019-08-01 | 서울대학교산학협력단 | 벤즈아미드 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 염증질환의 치료 또는 예방용 약학적 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4698340A (en) | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
DE3614060A1 (de) * | 1986-04-23 | 1987-10-29 | Schering Ag | Pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
US5516775A (en) * | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
DE69428913T2 (de) | 1993-12-29 | 2002-05-29 | Merck Sharp & Dohme | Substituierte morpholinderivate und ihre verwendung als arzneimittel |
AU726522B2 (en) | 1995-09-01 | 2000-11-09 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions |
US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
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2000
- 2000-05-22 TW TW089109829A patent/TW550258B/zh not_active IP Right Cessation
- 2000-05-22 US US09/575,382 patent/US6274588B1/en not_active Expired - Fee Related
- 2000-05-24 PL PL00353441A patent/PL353441A1/xx unknown
- 2000-05-24 IL IL14646000A patent/IL146460A0/xx active IP Right Grant
- 2000-05-24 KR KR10-2001-7015393A patent/KR100440106B1/ko not_active IP Right Cessation
- 2000-05-24 WO PCT/EP2000/004701 patent/WO2000073279A1/en active IP Right Grant
- 2000-05-24 NZ NZ515407A patent/NZ515407A/xx unknown
- 2000-05-24 RU RU2001133458/04A patent/RU2243221C2/ru not_active IP Right Cessation
- 2000-05-24 SI SI200030813T patent/SI1187815T1/sl unknown
- 2000-05-24 DK DK00927234T patent/DK1187815T3/da active
- 2000-05-24 HU HU0201315A patent/HUP0201315A3/hu unknown
- 2000-05-24 CA CA002375671A patent/CA2375671C/en not_active Expired - Fee Related
- 2000-05-24 DE DE60025918T patent/DE60025918T2/de not_active Expired - Fee Related
- 2000-05-24 CN CNB008082758A patent/CN1166643C/zh not_active Expired - Fee Related
- 2000-05-24 ES ES00927234T patent/ES2257294T3/es not_active Expired - Lifetime
- 2000-05-24 CZ CZ20014271A patent/CZ20014271A3/cs unknown
- 2000-05-24 JP JP2000621345A patent/JP3590592B2/ja not_active Expired - Fee Related
- 2000-05-24 AT AT00927234T patent/ATE317389T1/de not_active IP Right Cessation
- 2000-05-24 PT PT00927234T patent/PT1187815E/pt unknown
- 2000-05-24 BR BR0011127-9A patent/BR0011127A/pt not_active Application Discontinuation
- 2000-05-24 YU YU84901A patent/YU84901A/sh unknown
- 2000-05-24 EP EP00927234A patent/EP1187815B1/en not_active Expired - Lifetime
- 2000-05-24 MX MXPA01012089A patent/MXPA01012089A/es active IP Right Grant
- 2000-05-24 TR TR2001/03457T patent/TR200103457T2/xx unknown
- 2000-05-24 AU AU45677/00A patent/AU770786B2/en not_active Ceased
- 2000-05-26 PE PE2000000508A patent/PE20010153A1/es not_active Application Discontinuation
- 2000-05-28 JO JO200083A patent/JO2261B1/en active
- 2000-05-29 MY MYPI20002384A patent/MY122731A/en unknown
- 2000-05-29 CO CO00039590A patent/CO5170520A1/es not_active Application Discontinuation
- 2000-05-29 AR ARP000102643A patent/AR024146A1/es not_active Application Discontinuation
- 2000-05-30 GC GCP2000684 patent/GC0000191A/en active
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2001
- 2001-11-06 ZA ZA200109163A patent/ZA200109163B/en unknown
- 2001-11-12 IL IL146460A patent/IL146460A/en not_active IP Right Cessation
- 2001-11-22 HR HR20010871A patent/HRP20010871A2/hr not_active Application Discontinuation
- 2001-11-22 NO NO20015700A patent/NO321354B1/no unknown
- 2001-11-26 MA MA26424A patent/MA26793A1/fr unknown
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2002
- 2002-10-22 HK HK02107643.4A patent/HK1046528B/zh not_active IP Right Cessation
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