DE60202969D1 - Substituierte alkylaminopyridazinonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen - Google Patents
Substituierte alkylaminopyridazinonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungenInfo
- Publication number
- DE60202969D1 DE60202969D1 DE60202969T DE60202969T DE60202969D1 DE 60202969 D1 DE60202969 D1 DE 60202969D1 DE 60202969 T DE60202969 T DE 60202969T DE 60202969 T DE60202969 T DE 60202969T DE 60202969 D1 DE60202969 D1 DE 60202969D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- hydrogen
- stands
- alkyl
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0103912A HU227237B1 (en) | 2001-09-27 | 2001-09-27 | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
| HU0103912 | 2001-09-27 | ||
| PCT/HU2002/000097 WO2003027078A1 (en) | 2001-09-27 | 2002-09-26 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60202969D1 true DE60202969D1 (de) | 2005-03-17 |
| DE60202969T2 DE60202969T2 (de) | 2006-01-19 |
Family
ID=89979721
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60202969T Expired - Lifetime DE60202969T2 (de) | 2001-09-27 | 2002-09-26 | Substituierte alkylaminopyridazinonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| DE60202970T Expired - Lifetime DE60202970T2 (de) | 2001-09-27 | 2002-09-26 | Substituierte alkylaminopyridazinonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60202970T Expired - Lifetime DE60202970T2 (de) | 2001-09-27 | 2002-09-26 | Substituierte alkylaminopyridazinonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6930110B2 (de) |
| EP (2) | EP1430034B1 (de) |
| JP (2) | JP2005508914A (de) |
| KR (2) | KR100911069B1 (de) |
| CN (3) | CN1325489C (de) |
| AT (2) | ATE288899T1 (de) |
| AU (2) | AU2002330656B9 (de) |
| BR (2) | BR0212932A (de) |
| CA (2) | CA2461510C (de) |
| CZ (2) | CZ2004528A3 (de) |
| DE (2) | DE60202969T2 (de) |
| DK (2) | DK1430034T3 (de) |
| EA (2) | EA006392B1 (de) |
| ES (2) | ES2237696T3 (de) |
| HK (3) | HK1069816A1 (de) |
| HU (1) | HU227237B1 (de) |
| MA (2) | MA27068A1 (de) |
| MX (2) | MXPA04002838A (de) |
| NO (2) | NO326370B1 (de) |
| NZ (2) | NZ532103A (de) |
| PL (2) | PL369107A1 (de) |
| PT (2) | PT1430047E (de) |
| SI (2) | SI1430047T1 (de) |
| SK (2) | SK1902004A3 (de) |
| WO (2) | WO2003027097A1 (de) |
| ZA (2) | ZA200402544B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7504395B2 (en) * | 2001-07-20 | 2009-03-17 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| HU227592B1 (en) * | 2002-11-13 | 2011-09-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions |
| JP5147866B2 (ja) * | 2007-03-15 | 2013-02-20 | メルク・シャープ・アンド・ドーム・コーポレーション | グルカン合成酵素阻害剤として有用であるピリダジノン誘導体 |
| CA3098585A1 (en) * | 2018-04-30 | 2019-11-07 | Ribon Therapeutics Inc. | Pyridazinones as parp7 inhibitors |
| CN109053693B (zh) | 2018-09-20 | 2021-02-05 | 顺毅股份有限公司 | 哒嗪胺类化合物的制备及其应用 |
| CN117425648A (zh) * | 2021-03-12 | 2024-01-19 | 杭州英创医药科技有限公司 | 作为parp7抑制剂的化合物 |
| CN115490671B (zh) * | 2022-10-21 | 2024-05-14 | 水木未来(北京)科技有限公司 | Parp7抑制剂及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH557819A (de) * | 1970-11-12 | 1975-01-15 | Sandoz Ag | Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin(2h)-3-onen. |
| IE62890B1 (en) * | 1988-12-06 | 1995-03-08 | Hafslund Nycomed Pharma | New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure |
| PL164079B1 (pl) * | 1990-06-15 | 1994-06-30 | Akad Medyczna | posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu |
| HU209388B (en) * | 1990-12-27 | 1994-05-30 | Richter Gedeon Vegyeszet | Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same |
| HU214320B (hu) * | 1991-12-20 | 1998-03-02 | EGIS Gyógyszergyár Rt. | Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| HU224067B1 (hu) | 1995-05-29 | 2005-05-30 | Gyógyszerkutató Intézet Kft. | 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények |
| ATE304535T1 (de) * | 1998-06-05 | 2005-09-15 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zu herstellung von 3(2h)pyridazinon-4- substituierte amino-5-chloro derivate |
-
2001
- 2001-09-27 HU HU0103912A patent/HU227237B1/hu not_active IP Right Cessation
-
2002
- 2002-09-26 BR BR0212932-9A patent/BR0212932A/pt not_active IP Right Cessation
- 2002-09-26 AU AU2002330656A patent/AU2002330656B9/en not_active Ceased
- 2002-09-26 CN CNB028204425A patent/CN1325489C/zh not_active Expired - Fee Related
- 2002-09-26 EP EP02767729A patent/EP1430034B1/de not_active Expired - Lifetime
- 2002-09-26 AT AT02767729T patent/ATE288899T1/de not_active IP Right Cessation
- 2002-09-26 PL PL02369107A patent/PL369107A1/xx not_active IP Right Cessation
- 2002-09-26 AT AT02762620T patent/ATE288910T1/de not_active IP Right Cessation
- 2002-09-26 SK SK1902004A patent/SK1902004A3/sk unknown
- 2002-09-26 EA EA200400469A patent/EA006392B1/ru not_active IP Right Cessation
- 2002-09-26 ES ES02767729T patent/ES2237696T3/es not_active Expired - Lifetime
- 2002-09-26 KR KR1020047004607A patent/KR100911069B1/ko not_active IP Right Cessation
- 2002-09-26 SK SK1892004A patent/SK1892004A3/sk unknown
- 2002-09-26 KR KR1020047004606A patent/KR100890667B1/ko not_active IP Right Cessation
- 2002-09-26 PT PT02762620T patent/PT1430047E/pt unknown
- 2002-09-26 EP EP02762620A patent/EP1430047B1/de not_active Expired - Lifetime
- 2002-09-26 BR BR0212839-0A patent/BR0212839A/pt not_active IP Right Cessation
- 2002-09-26 US US10/491,151 patent/US6930110B2/en not_active Expired - Fee Related
- 2002-09-26 SI SI200230109T patent/SI1430047T1/xx unknown
- 2002-09-26 JP JP2003530669A patent/JP2005508914A/ja active Pending
- 2002-09-26 DE DE60202969T patent/DE60202969T2/de not_active Expired - Lifetime
- 2002-09-26 EA EA200400470A patent/EA006942B1/ru not_active IP Right Cessation
- 2002-09-26 NZ NZ532103A patent/NZ532103A/en unknown
- 2002-09-26 CN CN200710104934XA patent/CN101099740B/zh not_active Expired - Fee Related
- 2002-09-26 CA CA002461510A patent/CA2461510C/en not_active Expired - Fee Related
- 2002-09-26 CA CA002461467A patent/CA2461467A1/en not_active Abandoned
- 2002-09-26 PT PT02767729T patent/PT1430034E/pt unknown
- 2002-09-26 DK DK02767729T patent/DK1430034T3/da active
- 2002-09-26 WO PCT/HU2002/000096 patent/WO2003027097A1/en active IP Right Grant
- 2002-09-26 CN CNB028189752A patent/CN100368404C/zh not_active Expired - Fee Related
- 2002-09-26 AU AU2002328166A patent/AU2002328166B2/en not_active Ceased
- 2002-09-26 US US10/490,959 patent/US20050043314A1/en not_active Abandoned
- 2002-09-26 SI SI200230107T patent/SI1430034T1/xx unknown
- 2002-09-26 CZ CZ2004528A patent/CZ2004528A3/cs unknown
- 2002-09-26 JP JP2003530685A patent/JP4472337B2/ja not_active Expired - Lifetime
- 2002-09-26 MX MXPA04002838A patent/MXPA04002838A/es active IP Right Grant
- 2002-09-26 DE DE60202970T patent/DE60202970T2/de not_active Expired - Lifetime
- 2002-09-26 MX MXPA04002836A patent/MXPA04002836A/es active IP Right Grant
- 2002-09-26 NZ NZ532104A patent/NZ532104A/en unknown
- 2002-09-26 CZ CZ2004532A patent/CZ2004532A3/cs unknown
- 2002-09-26 WO PCT/HU2002/000097 patent/WO2003027078A1/en active IP Right Grant
- 2002-09-26 ES ES02762620T patent/ES2237690T3/es not_active Expired - Lifetime
- 2002-09-26 PL PL02369256A patent/PL369256A1/xx unknown
- 2002-09-26 DK DK02762620T patent/DK1430047T3/da active
-
2004
- 2004-03-24 MA MA27589A patent/MA27068A1/fr unknown
- 2004-03-24 MA MA27588A patent/MA27137A1/fr unknown
- 2004-03-31 ZA ZA200402544A patent/ZA200402544B/en unknown
- 2004-03-31 ZA ZA200402545A patent/ZA200402545B/en unknown
- 2004-04-16 NO NO20041551A patent/NO326370B1/no not_active IP Right Cessation
- 2004-04-26 NO NO20041704A patent/NO325080B1/no not_active IP Right Cessation
- 2004-12-23 HK HK04110210A patent/HK1069816A1/xx not_active IP Right Cessation
- 2004-12-23 HK HK04110211A patent/HK1069817A1/xx not_active IP Right Cessation
-
2008
- 2008-05-26 HK HK08105825.2A patent/HK1115728A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0100615A2 (hu) | Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére | |
| HUP0401339A2 (hu) | Új 4-anilino-3-kinolinkarboxamidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0203971A2 (hu) | Imidazoimidazolok és -triazolok mint gyulladásellenes szerek és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HK1115728A1 (en) | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | |
| MX9604687A (es) | Procedimiento para la preparacion de derivados de imidazo-benzodiacepina. | |
| HUP0204354A2 (hu) | Új heterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0003577A2 (hu) | Tetrahidro-gamma-karbolinok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
| ATE337827T1 (de) | N-aryl-4,5-diaminopyrazole und diese verbindungen enthaltende färbemittel | |
| HK1075656A1 (en) | New piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds | |
| DE60227506D1 (de) | DIHYDROIMIDAZOi5,1-A -BETA-CARBOLIN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE ANWENDUNG ALS ARZNEIMITTEL | |
| HUP0100751A2 (hu) | Új aril-vagy heteroaril-kinolinilfoszfonsav-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP0004061A2 (hu) | Eljárás piperidinil-amino-metil-trifluor-metil ciklusos étervegyületek előállítására és intermedierjeik | |
| HUP0302901A2 (hu) | Cianoaril-(vagy cianoheteroaril)-karbonil-piperazinil-pirimidinek új származékai, előállításuk, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| EA200100156A3 (ru) | Новые производные 6-сульфамоил-3-хинолилфосфоновой кислоты, способ их получения и содержащие их фармацевтические композиции |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: EGIS GYOGYSZERGYAR RT, BUDAPEST, HU |
|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESVE, HU |