AU2002330656B9 - Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same - Google Patents

Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same Download PDF

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Publication number
AU2002330656B9
AU2002330656B9 AU2002330656A AU2002330656A AU2002330656B9 AU 2002330656 B9 AU2002330656 B9 AU 2002330656B9 AU 2002330656 A AU2002330656 A AU 2002330656A AU 2002330656 A AU2002330656 A AU 2002330656A AU 2002330656 B9 AU2002330656 B9 AU 2002330656B9
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AU
Australia
Prior art keywords
general formula
hydrogen
compound
acid addition
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002330656A
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English (en)
Other versions
AU2002330656B2 (en
AU2002330656A1 (en
AU2002330656A2 (en
Inventor
Jozsef Barkoczy
Andras Egyed
Istvan Gacsalyi
Laszlo Gabor Harsing
Hajnalka Kompagne
Peter Kotay Nagy
Gyorgy Levay
Csilla Leveleki
Bernadett Martonne Marko
Aniko Miklosne Kovacs
Eva Schmidt
Gyula Simig
Gabor Szenasi
Janos Wellmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of AU2002330656A2 publication Critical patent/AU2002330656A2/en
Publication of AU2002330656A1 publication Critical patent/AU2002330656A1/en
Publication of AU2002330656B2 publication Critical patent/AU2002330656B2/en
Application granted granted Critical
Publication of AU2002330656B9 publication Critical patent/AU2002330656B9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2002330656A 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same Ceased AU2002330656B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
HUP0103912 2001-09-27
PCT/HU2002/000097 WO2003027078A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Publications (4)

Publication Number Publication Date
AU2002330656A2 AU2002330656A2 (en) 2003-04-07
AU2002330656A1 AU2002330656A1 (en) 2003-06-26
AU2002330656B2 AU2002330656B2 (en) 2009-04-09
AU2002330656B9 true AU2002330656B9 (en) 2009-09-03

Family

ID=89979721

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002330656A Ceased AU2002330656B9 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
AU2002328166A Ceased AU2002328166B2 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2002328166A Ceased AU2002328166B2 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Country Status (25)

Country Link
US (2) US20050043314A1 (enExample)
EP (2) EP1430034B1 (enExample)
JP (2) JP2005508914A (enExample)
KR (2) KR100890667B1 (enExample)
CN (3) CN1325489C (enExample)
AT (2) ATE288910T1 (enExample)
AU (2) AU2002330656B9 (enExample)
BR (2) BR0212932A (enExample)
CA (2) CA2461510C (enExample)
CZ (2) CZ2004532A3 (enExample)
DE (2) DE60202970T2 (enExample)
DK (2) DK1430034T3 (enExample)
EA (2) EA006942B1 (enExample)
ES (2) ES2237696T3 (enExample)
HU (1) HU227237B1 (enExample)
MA (2) MA27068A1 (enExample)
MX (2) MXPA04002838A (enExample)
NO (2) NO326370B1 (enExample)
NZ (2) NZ532103A (enExample)
PL (2) PL369107A1 (enExample)
PT (2) PT1430047E (enExample)
SI (2) SI1430047T1 (enExample)
SK (2) SK1902004A3 (enExample)
WO (2) WO2003027078A1 (enExample)
ZA (2) ZA200402545B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
CL2008000725A1 (es) * 2007-03-15 2008-11-14 Schering Corp Compuestos derivados de heterociclos aromaticos; composicion farmaceutica; kit farmceuticos; uso de la composicion y de los compuestos como inhibidores de glucano sintasa para el tratamiento o prevencion del crecimiento de patogenos fungicos en planta y para tratar o prevenir infecciones producidas por hongos.
SI3788040T1 (sl) * 2018-04-30 2023-07-31 Ribon Therapeutics Inc. Piridazinoni kot zaviralci parp7
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
US12371421B2 (en) 2019-04-29 2025-07-29 Ribon Therapeutics, Inc. Solid forms of a PARP7 inhibitor
MX2022005216A (es) 2019-10-30 2022-06-02 Ribon Therapeutics Inc Piridazinonas como inhibidores de poli(adp-ribosa) polimerasa 7 (parp7).
WO2022188889A1 (zh) * 2021-03-12 2022-09-15 杭州英创医药科技有限公司 作为parp7抑制剂的化合物
CN115490671B (zh) * 2022-10-21 2024-05-14 水木未来(北京)科技有限公司 Parp7抑制剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034391A (en) * 1988-12-06 1991-07-23 Cl Pharma Aktiengesellschaft Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
PL164079B1 (pl) * 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu) * 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
JP2004500314A (ja) * 1998-06-05 2004-01-08 エギシュ　ヂョヂセルヂャール　エルテー ３（２ｈ）−ピリダジノン−４−置換アミノ−５−クロロ−誘導体の製法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034391A (en) * 1988-12-06 1991-07-23 Cl Pharma Aktiengesellschaft Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure

Also Published As

Publication number Publication date
BR0212839A (pt) 2004-10-13
DK1430034T3 (da) 2005-05-30
ATE288910T1 (de) 2005-02-15
MA27068A1 (fr) 2004-12-20
HUP0103912A2 (hu) 2003-07-28
PT1430047E (pt) 2005-06-30
HUP0103912A3 (en) 2004-03-01
MXPA04002838A (es) 2004-07-05
EP1430047B1 (en) 2005-02-09
SI1430034T1 (en) 2005-08-31
ZA200402545B (en) 2005-04-26
EP1430047A1 (en) 2004-06-23
ES2237690T3 (es) 2005-08-01
CN101099740B (zh) 2010-09-08
CA2461510A1 (en) 2003-04-03
NO20041704L (no) 2004-04-26
DE60202969T2 (de) 2006-01-19
WO2003027097A1 (en) 2003-04-03
KR100911069B1 (ko) 2009-08-06
AU2002328166B2 (en) 2008-04-17
AU2002330656B2 (en) 2009-04-09
KR20040039445A (ko) 2004-05-10
PT1430034E (pt) 2005-06-30
JP2005508914A (ja) 2005-04-07
CN1571783A (zh) 2005-01-26
SI1430047T1 (en) 2005-08-31
HU0103912D0 (en) 2001-12-28
JP4472337B2 (ja) 2010-06-02
CA2461510C (en) 2009-07-07
CN100368404C (zh) 2008-02-13
PL369107A1 (en) 2005-04-18
AU2002328166A2 (en) 2003-04-07
CN1558904A (zh) 2004-12-29
HK1069816A1 (en) 2005-06-03
NO326370B1 (no) 2008-11-17
CN101099740A (zh) 2008-01-09
DE60202970T2 (de) 2006-02-16
ES2237696T3 (es) 2005-08-01
ATE288899T1 (de) 2005-02-15
NZ532103A (en) 2005-08-26
KR20040039446A (ko) 2004-05-10
US6930110B2 (en) 2005-08-16
DE60202969D1 (de) 2005-03-17
NO20041551L (no) 2004-06-10
PL369256A1 (en) 2005-04-18
JP2005503437A (ja) 2005-02-03
EP1430034A1 (en) 2004-06-23
CZ2004532A3 (cs) 2004-08-18
CN1325489C (zh) 2007-07-11
HU227237B1 (en) 2010-12-28
DE60202970D1 (de) 2005-03-17
CA2461467A1 (en) 2003-04-03
EA200400469A1 (ru) 2004-08-26
MXPA04002836A (es) 2004-07-05
MA27137A1 (fr) 2005-01-03
DK1430047T3 (da) 2005-06-06
NO325080B1 (no) 2008-01-28
HK1115728A1 (en) 2008-12-05
ZA200402544B (en) 2005-04-26
EA006392B1 (ru) 2005-12-29
EP1430034B1 (en) 2005-02-09
NZ532104A (en) 2005-10-28
AU2002330656A2 (en) 2003-04-07
HK1069817A1 (en) 2005-06-03
US20040242873A1 (en) 2004-12-02
BR0212932A (pt) 2004-10-13
SK1902004A3 (en) 2004-10-05
EA006942B1 (ru) 2006-06-30
WO2003027078A1 (en) 2003-04-03
KR100890667B1 (ko) 2009-03-26
SK1892004A3 (en) 2004-10-05
CZ2004528A3 (cs) 2004-08-18
EA200400470A1 (ru) 2004-08-26
US20050043314A1 (en) 2005-02-24

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 30 NOV 2004

FGA Letters patent sealed or granted (standard patent)
SREP Specification republished
MK14 Patent ceased section 143(a) (annual fees not paid) or expired