JP4386967B2 - プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物 - Google Patents

プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物 Download PDF

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Publication number
JP4386967B2
JP4386967B2 JP50559698A JP50559698A JP4386967B2 JP 4386967 B2 JP4386967 B2 JP 4386967B2 JP 50559698 A JP50559698 A JP 50559698A JP 50559698 A JP50559698 A JP 50559698A JP 4386967 B2 JP4386967 B2 JP 4386967B2
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Japan
Prior art keywords
quinazolin
methyl
benzyloxy
amine
phenyl
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Expired - Lifetime
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JP50559698A
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English (en)
Japanese (ja)
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JP2000514806A (ja
JP2000514806A5 (cg-RX-API-DMAC10.html
Inventor
ジョージ、スチュアート、コッカリル
マルコム、クリーブ、カーター
スティーブン、バリー、ガントリップ
キャスリン、ジェーン、スミス
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Glaxo Group Ltd
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Glaxo Group Ltd
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Priority claimed from GBGB9614755.8A external-priority patent/GB9614755D0/en
Priority claimed from GBGB9625458.6A external-priority patent/GB9625458D0/en
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Publication of JP2000514806A publication Critical patent/JP2000514806A/ja
Publication of JP2000514806A5 publication Critical patent/JP2000514806A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP50559698A 1996-07-13 1997-07-11 プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物 Expired - Lifetime JP4386967B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9614755.8A GB9614755D0 (en) 1996-07-13 1996-07-13 Heterocyclic compounds
GB9614755.8 1996-07-13
GB9625458.6 1996-12-07
GBGB9625458.6A GB9625458D0 (en) 1996-12-07 1996-12-07 Heterocyclic compounds
PCT/EP1997/003672 WO1998002434A1 (en) 1996-07-13 1997-07-11 Fused heterocyclic compounds as protein tyrosine kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2000514806A JP2000514806A (ja) 2000-11-07
JP2000514806A5 JP2000514806A5 (cg-RX-API-DMAC10.html) 2005-03-10
JP4386967B2 true JP4386967B2 (ja) 2009-12-16

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JP50559698A Expired - Lifetime JP4386967B2 (ja) 1996-07-13 1997-07-11 プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物

Country Status (13)

Country Link
US (2) US6391874B1 (cg-RX-API-DMAC10.html)
EP (1) EP0912559B1 (cg-RX-API-DMAC10.html)
JP (1) JP4386967B2 (cg-RX-API-DMAC10.html)
AR (1) AR007857A1 (cg-RX-API-DMAC10.html)
AT (1) ATE227283T1 (cg-RX-API-DMAC10.html)
AU (1) AU3766897A (cg-RX-API-DMAC10.html)
CY (1) CY2451B1 (cg-RX-API-DMAC10.html)
DE (1) DE69716916T2 (cg-RX-API-DMAC10.html)
DK (1) DK0912559T3 (cg-RX-API-DMAC10.html)
ES (1) ES2186908T3 (cg-RX-API-DMAC10.html)
ID (1) ID19609A (cg-RX-API-DMAC10.html)
PT (1) PT912559E (cg-RX-API-DMAC10.html)
WO (1) WO1998002434A1 (cg-RX-API-DMAC10.html)

Families Citing this family (515)

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