JP3687900B2 - チロシンキナーゼの不可逆的阻害剤であるｎ−［４−（３−クロロ−４−フルオロフェニルアミノ）−７−（３−モルホリン−４−イルプロポキシ）キナゾリン−６−イル］アクリルアミド - Google Patents

チロシンキナーゼの不可逆的阻害剤であるｎ−［４−（３−クロロ−４−フルオロフェニルアミノ）−７−（３−モルホリン−４−イルプロポキシ）キナゾリン−６−イル］アクリルアミド Download PDF

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Publication number
JP3687900B2
JP3687900B2 JP2000583876A JP2000583876A JP3687900B2 JP 3687900 B2 JP3687900 B2 JP 3687900B2 JP 2000583876 A JP2000583876 A JP 2000583876A JP 2000583876 A JP2000583876 A JP 2000583876A JP 3687900 B2 JP3687900 B2 JP 3687900B2
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Prior art keywords
cancer
compound
chloro
tyrosine kinase
quinazolin
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Expired - Fee Related
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JP2000583876A
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Japanese (ja)
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JP2002530386A (ja
JP2002530386A5 (https=
Inventor
アレグザンダー・ジェイムズ・ブリッジェズ
デニース・ドリスコール
ウェイン・ダニエル・クロース
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Warner Lambert Co LLC
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Warner Lambert Co LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000583876A 1998-11-19 1999-09-23 チロシンキナーゼの不可逆的阻害剤であるｎ−［４−（３−クロロ−４−フルオロフェニルアミノ）−７−（３−モルホリン−４−イルプロポキシ）キナゾリン−６−イル］アクリルアミド Expired - Fee Related JP3687900B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10906598P 1998-11-19 1998-11-19
US60/109,065 1998-11-19
PCT/US1999/022116 WO2000031048A1 (en) 1998-11-19 1999-09-23 N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases

Publications (3)

Publication Number Publication Date
JP2002530386A JP2002530386A (ja) 2002-09-17
JP3687900B2 true JP3687900B2 (ja) 2005-08-24
JP2002530386A5 JP2002530386A5 (https=) 2005-12-22

Family

ID=22325607

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000583876A Expired - Fee Related JP3687900B2 (ja) 1998-11-19 1999-09-23 チロシンキナーゼの不可逆的阻害剤であるｎ−［４−（３−クロロ−４−フルオロフェニルアミノ）−７−（３−モルホリン−４−イルプロポキシ）キナゾリン−６−イル］アクリルアミド

Country Status (30)

Country Link
US (1) US6344455B1 (https=)
EP (1) EP1131304B1 (https=)
JP (1) JP3687900B2 (https=)
KR (1) KR20010080491A (https=)
CN (1) CN1160338C (https=)
AR (1) AR023706A1 (https=)
AT (1) ATE229008T1 (https=)
AU (1) AU763626B2 (https=)
BG (1) BG105608A (https=)
BR (1) BR9915487A (https=)
CA (1) CA2349721A1 (https=)
CO (1) CO5150185A1 (https=)
CZ (1) CZ20011759A3 (https=)
DE (1) DE69904358T2 (https=)
DK (1) DK1131304T3 (https=)
EA (1) EA003786B1 (https=)
EE (1) EE200100271A (https=)
ES (1) ES2188254T3 (https=)
GE (1) GEP20032997B (https=)
HU (1) HUP0104211A3 (https=)
IL (1) IL143089A0 (https=)
NO (1) NO319357B1 (https=)
NZ (2) NZ527718A (https=)
PE (1) PE20001242A1 (https=)
PL (1) PL347717A1 (https=)
PT (1) PT1131304E (https=)
SK (1) SK283688B6 (https=)
UY (1) UY25809A1 (https=)
WO (1) WO2000031048A1 (https=)
ZA (1) ZA200103535B (https=)

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ES2188254T3 (es) 2003-06-16
HK1041695A1 (en) 2002-07-19
HUP0104211A2 (hu) 2002-05-29
EA200100546A1 (ru) 2001-10-22
NO319357B1 (no) 2005-07-18
IL143089A0 (en) 2002-04-21
PE20001242A1 (es) 2000-11-08
NO20012465D0 (no) 2001-05-18
CO5150185A1 (es) 2002-04-29
DE69904358T2 (de) 2003-04-17
UY25809A1 (es) 2001-03-16
EE200100271A (et) 2002-10-15
CZ20011759A3 (cs) 2002-01-16
CA2349721A1 (en) 2000-06-02
US6344455B1 (en) 2002-02-05
SK6572001A3 (en) 2002-02-05
NZ527718A (en) 2004-11-26
DK1131304T3 (da) 2003-03-24
NO20012465L (no) 2001-07-13
PT1131304E (pt) 2003-04-30
EP1131304A1 (en) 2001-09-12
ZA200103535B (en) 2002-08-02
NZ512189A (en) 2003-10-31
EP1131304B1 (en) 2002-12-04
AU6261299A (en) 2000-06-13
AR023706A1 (es) 2002-09-04
SK283688B6 (sk) 2003-12-02

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