JP3262329B2 - 糖尿病治療に有用なglp―1アナログ - Google Patents
糖尿病治療に有用なglp―1アナログInfo
- Publication number
- JP3262329B2 JP3262329B2 JP50361891A JP50361891A JP3262329B2 JP 3262329 B2 JP3262329 B2 JP 3262329B2 JP 50361891 A JP50361891 A JP 50361891A JP 50361891 A JP50361891 A JP 50361891A JP 3262329 B2 JP3262329 B2 JP 3262329B2
- Authority
- JP
- Japan
- Prior art keywords
- glp
- analogs
- peptide
- amino acid
- analog
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46873690A | 1990-01-24 | 1990-01-24 | |
| US468,736 | 1990-01-24 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000311202A Division JP2001151798A (ja) | 1990-01-24 | 2000-10-11 | 糖尿病治療に有用なglp−1アナログ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05506427A JPH05506427A (ja) | 1993-09-22 |
| JP3262329B2 true JP3262329B2 (ja) | 2002-03-04 |
Family
ID=23861028
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50361891A Expired - Lifetime JP3262329B2 (ja) | 1990-01-24 | 1991-01-24 | 糖尿病治療に有用なglp―1アナログ |
| JP2000311202A Pending JP2001151798A (ja) | 1990-01-24 | 2000-10-11 | 糖尿病治療に有用なglp−1アナログ |
| JP2002315982A Pending JP2003192698A (ja) | 1990-01-24 | 2002-10-30 | 糖尿病治療に有用なglp−1アナログ |
| JP2004081117A Pending JP2004196825A (ja) | 1990-01-24 | 2004-03-19 | 糖尿病治療に有用なglp−1アナログ |
| JP2005022265A Pending JP2005132848A (ja) | 1990-01-24 | 2005-01-28 | 糖尿病治療に有用なglp−1アナログ |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000311202A Pending JP2001151798A (ja) | 1990-01-24 | 2000-10-11 | 糖尿病治療に有用なglp−1アナログ |
| JP2002315982A Pending JP2003192698A (ja) | 1990-01-24 | 2002-10-30 | 糖尿病治療に有用なglp−1アナログ |
| JP2004081117A Pending JP2004196825A (ja) | 1990-01-24 | 2004-03-19 | 糖尿病治療に有用なglp−1アナログ |
| JP2005022265A Pending JP2005132848A (ja) | 1990-01-24 | 2005-01-28 | 糖尿病治療に有用なglp−1アナログ |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0512042B1 (enExample) |
| JP (5) | JP3262329B2 (enExample) |
| AT (1) | ATE164852T1 (enExample) |
| CA (1) | CA2073856C (enExample) |
| DE (1) | DE69129226T2 (enExample) |
| DK (1) | DK0512042T3 (enExample) |
| ES (1) | ES2113879T3 (enExample) |
| WO (1) | WO1991011457A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6493794B1 (en) | 1998-05-18 | 2002-12-10 | Nec Corporation | Large scale FIFO circuit |
Families Citing this family (239)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6849708B1 (en) | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
| US5614492A (en) * | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US7138486B2 (en) | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| DK36392D0 (da) * | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
| DK36492D0 (da) * | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Praeparat |
| USRE37302E1 (en) * | 1992-03-19 | 2001-07-31 | Novo Nordisk A/S | Peptide |
| BR9306551A (pt) * | 1992-06-15 | 1998-09-15 | Pfizer | Derivados de peptídeo do tipo glucagona e de insulinotropina |
| NZ250844A (en) * | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
| US6284727B1 (en) * | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| EP0658568A1 (en) * | 1993-12-09 | 1995-06-21 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| DK144093D0 (enExample) * | 1993-12-23 | 1993-12-23 | Novo Nordisk As | |
| GB9409496D0 (en) | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
| US5574008A (en) | 1994-08-30 | 1996-11-12 | Eli Lilly And Company | Biologically active fragments of glucagon-like insulinotropic peptide |
| US5512549A (en) * | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| US5990077A (en) * | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| AU5685296A (en) * | 1995-05-17 | 1996-11-29 | Novo Nordisk A/S | Immunoassay for glucagon like protein 1 (glp-1) in plasma |
| US6852690B1 (en) | 1995-08-22 | 2005-02-08 | Amylin Pharmaceuticals, Inc. | Method and composition for enhanced parenteral nutrition |
| DE122010000020I1 (de) * | 1996-04-25 | 2010-07-08 | Prosidion Ltd | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| IL128332A0 (en) * | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| EP1566180A3 (en) * | 1996-08-30 | 2007-08-08 | Eli Lilly & Company | Use of GLP-1 or Analogs in Treatment of Myocardial Infarction |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6277819B1 (en) * | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| AU4112497A (en) * | 1996-08-30 | 1998-03-19 | Novo Nordisk A/S | Glp-2 derivatives |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6006753A (en) * | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| JP4798814B2 (ja) | 1997-01-07 | 2011-10-19 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 食物摂取低減用のエキセンジンおよびそのアゴニストの使用 |
| CA2283834A1 (en) * | 1997-03-31 | 1998-10-08 | James Arthur Hoffmann | Glucagon-like peptide-1 analogs |
| US7157555B1 (en) | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| ES2222613T3 (es) * | 1997-09-12 | 2005-02-01 | Pharis Biotec Gmbh | Composicion para la terapia de diabetes mellitus y de la obesidad. |
| US7223725B1 (en) | 1997-11-14 | 2007-05-29 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| WO1999025727A2 (en) | 1997-11-14 | 1999-05-27 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| AU1617399A (en) * | 1997-12-05 | 1999-06-28 | Eli Lilly And Company | Glp-1 formulations |
| EP1520582A3 (en) | 1998-02-02 | 2009-07-01 | Trustees Of Tufts College | Use of dipeptidylpetidase inhibitors to regulate glucose metabolism |
| AU3247799A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| EP1061946B1 (en) * | 1998-02-27 | 2004-04-28 | Novo Nordisk A/S | Glp-1 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates |
| JP2002506792A (ja) | 1998-02-27 | 2002-03-05 | ノボ ノルディスク アクティーゼルスカブ | N末端修飾glp−1誘導体 |
| FR2777283B1 (fr) * | 1998-04-10 | 2000-11-24 | Adir | Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
| EP1100530B1 (en) | 1998-07-31 | 2003-10-08 | Novo Nordisk A/S | In-vitro stimulation of beta cell proliferation |
| EP1666054A1 (en) | 1998-08-28 | 2006-06-07 | Eli Lilly & Company | Method for administering insulinotropic peptides |
| JP2002524514A (ja) | 1998-09-17 | 2002-08-06 | イーライ・リリー・アンド・カンパニー | タンパク質製剤 |
| US6461834B1 (en) | 1998-11-06 | 2002-10-08 | Bionebraska, Inc. | Clostripain catalyzed amidation of peptides |
| PL205713B1 (pl) * | 1998-12-07 | 2010-05-31 | Sod Conseils Rech Applic | Związki stanowiące analogi GLP-1, kompozycje farmaceutyczne zawierające takie związki oraz zastosowanie tych związków |
| CN1495198A (zh) * | 1998-12-07 | 2004-05-12 | �о���Ӧ�ÿ�ѧЭ��ɷ�����˾ | 胰高血糖素样肽-1的类似物 |
| AR021576A1 (es) * | 1998-12-07 | 2002-07-24 | Ipsen Pharma Sas | Analogos del peptido 1-similar al glucagon, uso de los mismos para la manufactura de un medicamento y composiciones farmaceuticas que los contienen. |
| US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
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| US6451987B1 (en) | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
| ATE509028T1 (de) | 1999-03-15 | 2011-05-15 | Novo Nordisk As | Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden |
| US6444788B1 (en) | 1999-03-15 | 2002-09-03 | Novo Nordisk A/S | Ion exchange chromatography of GLP-1, analogs and derivatives thereof |
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| DK3300721T4 (da) | 2003-11-20 | 2025-03-03 | Novo Nordisk As | Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger |
| EP1694356B1 (en) | 2003-12-09 | 2011-02-16 | Novo Nordisk A/S | Regulation of food preference using glp-1 agonists |
| CA2551039C (en) | 2003-12-16 | 2013-01-29 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Analogues of glp-1 |
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| EP0512042B1 (en) | 1998-04-08 |
| JP2001151798A (ja) | 2001-06-05 |
| DE69129226T2 (de) | 1998-07-30 |
| JP2003192698A (ja) | 2003-07-09 |
| DE69129226D1 (de) | 1998-05-14 |
| CA2073856A1 (en) | 1991-07-25 |
| EP0512042A4 (en) | 1993-02-17 |
| DK0512042T3 (da) | 1998-05-11 |
| ES2113879T3 (es) | 1998-05-16 |
| WO1991011457A1 (en) | 1991-08-08 |
| ATE164852T1 (de) | 1998-04-15 |
| CA2073856C (en) | 2002-12-03 |
| JPH05506427A (ja) | 1993-09-22 |
| JP2005132848A (ja) | 2005-05-26 |
| EP0512042A1 (en) | 1992-11-11 |
| JP2004196825A (ja) | 2004-07-15 |
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