JP3000023B2 - 新規なエリスロマイシン誘導体、それらの製造法及び薬剤としての使用 - Google Patents

新規なエリスロマイシン誘導体、それらの製造法及び薬剤としての使用

Info

Publication number
JP3000023B2
JP3000023B2 JP7103170A JP10317095A JP3000023B2 JP 3000023 B2 JP3000023 B2 JP 3000023B2 JP 7103170 A JP7103170 A JP 7103170A JP 10317095 A JP10317095 A JP 10317095A JP 3000023 B2 JP3000023 B2 JP 3000023B2
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JP
Japan
Prior art keywords
compound
group
general formula
hydrogen atom
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP7103170A
Other languages
English (en)
Japanese (ja)
Other versions
JPH07278177A (ja
Inventor
コンスタンタン・アグーリダ
ヤニク・ベネデッティ
ジャンフランソワ・シャント
アレクシ・ドニ
オディル・ル・マルトレ
Original Assignee
ヘキスト・マリオン・ルセル
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Application filed by ヘキスト・マリオン・ルセル filed Critical ヘキスト・マリオン・ルセル
Publication of JPH07278177A publication Critical patent/JPH07278177A/ja
Application granted granted Critical
Publication of JP3000023B2 publication Critical patent/JP3000023B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP7103170A 1994-04-08 1995-04-05 新規なエリスロマイシン誘導体、それらの製造法及び薬剤としての使用 Expired - Lifetime JP3000023B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR94-04154 1994-04-08

Publications (2)

Publication Number Publication Date
JPH07278177A JPH07278177A (ja) 1995-10-24
JP3000023B2 true JP3000023B2 (ja) 2000-01-17

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7103170A Expired - Lifetime JP3000023B2 (ja) 1994-04-08 1995-04-05 新規なエリスロマイシン誘導体、それらの製造法及び薬剤としての使用

Country Status (49)

Country Link
US (2) US5656607A (enExample)
EP (1) EP0676409B1 (enExample)
JP (1) JP3000023B2 (enExample)
KR (1) KR100317148B1 (enExample)
CN (1) CN1059445C (enExample)
AP (1) AP587A (enExample)
AT (1) ATE234853T1 (enExample)
AU (1) AU684939B2 (enExample)
BG (1) BG61916B1 (enExample)
BR (1) BR9506147A (enExample)
CA (1) CA2164638C (enExample)
CO (1) CO4370097A1 (enExample)
CZ (1) CZ296005B6 (enExample)
DE (1) DE69529934T2 (enExample)
DK (1) DK0676409T3 (enExample)
DZ (1) DZ1869A1 (enExample)
EE (1) EE04498B1 (enExample)
ES (1) ES2189820T3 (enExample)
FI (1) FI111264B (enExample)
FR (1) FR2718450B1 (enExample)
GB (1) GB2288174A (enExample)
GE (1) GEP19991836B (enExample)
HR (1) HRP950217B1 (enExample)
HU (1) HU215396B (enExample)
IL (1) IL112954A (enExample)
IS (1) IS1865B (enExample)
JO (1) JO1850B1 (enExample)
LV (1) LV11182B (enExample)
MA (1) MA23501A1 (enExample)
MD (1) MD663G2 (enExample)
MY (1) MY114672A (enExample)
NO (1) NO308361B1 (enExample)
NZ (1) NZ284498A (enExample)
OA (1) OA10200A (enExample)
PE (1) PE2896A1 (enExample)
PL (1) PL180837B1 (enExample)
PT (1) PT676409E (enExample)
RO (1) RO115634B1 (enExample)
RU (1) RU2141965C1 (enExample)
SA (1) SA97170757A (enExample)
SI (1) SI0676409T1 (enExample)
SK (1) SK284079B6 (enExample)
SV (1) SV1995000018A (enExample)
TN (1) TNSN95026A1 (enExample)
TW (1) TW316908B (enExample)
UA (1) UA44705C2 (enExample)
WO (1) WO1995027720A1 (enExample)
YU (1) YU49221B (enExample)
ZA (1) ZA952059B (enExample)

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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
DE69723848T2 (de) * 1996-05-07 2004-07-01 Abbott Laboratories, Abbott Park 3-descladinose-2,3-anhydroerythromycin-derivate
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
IL128681A0 (en) * 1996-09-04 2000-01-31 Abbott Lab 6-O substituted ketolides having antibacterial activity
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (fr) * 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
BR9810021A (pt) * 1997-06-11 2000-09-19 Pfizer Prod Inc Derivados 9-oxima-eritromicina
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
ES2243066T3 (es) 1998-09-22 2005-11-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TR200102129T2 (tr) 1998-12-10 2002-01-21 Pfizer Products Inc. Karbamat ve karbazat ketolid antibiyotikleri.
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
WO2000063224A2 (en) * 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Macrolide antiinfective agents
WO2000062783A2 (en) 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
EP1180110A1 (en) * 1999-05-24 2002-02-20 Pfizer Products Inc. 13-methyl-erythromycin derivatives
CA2451391A1 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
MXPA04012978A (es) 2002-07-01 2005-09-12 Arkion Life Sciences Llc D B A Proceso y material para la produccion de glucosamina y n-acetilglucosamina.
EP2772254A3 (en) 2003-03-10 2015-03-11 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
US7332476B2 (en) * 2003-04-25 2008-02-19 Novartis Ag Pyridyl substituted ketolide antibiotics
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
CA2703475A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
AU2009308182B2 (en) 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
WO2011119604A1 (en) 2010-03-22 2011-09-29 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
DK2571506T3 (en) 2010-05-20 2017-08-28 Cempra Pharmaceuticals Inc PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
US10188674B2 (en) 2012-03-27 2019-01-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
KR20160020403A (ko) 2013-03-15 2016-02-23 셈프라 파마슈티컬스, 인크. 매크로라이드 항세균제들을 제조하기 위한 수렴 프로세스들
WO2014165792A2 (en) 2013-04-04 2014-10-09 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
HK1242920A1 (zh) 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-元酮内酯及其制备和使用方法
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692579A1 (fr) 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

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US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
FR2692579A1 (fr) 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
IS1865B (is) 2003-05-02
LV11182A (lv) 1996-04-20
AU684939B2 (en) 1998-01-08
KR100317148B1 (ko) 2002-06-22
US5760233A (en) 1998-06-02
TW316908B (enExample) 1997-10-01
HRP950217A2 (en) 1997-08-31
LV11182B (en) 1997-04-20
EE04498B1 (et) 2005-06-15
EP0676409A1 (fr) 1995-10-11
HRP950217B1 (en) 2004-06-30
IS4309A (is) 1995-11-17
ZA952059B (en) 1996-03-13
MD663G2 (ro) 1997-07-31
GB9506856D0 (en) 1995-05-24
FI955913A7 (fi) 1995-12-08
AP9500743A0 (en) 1995-07-31
SV1995000018A (es) 1997-10-24
DE69529934T2 (de) 2003-09-04
NO308361B1 (no) 2000-09-04
HU9503505D0 (en) 1996-02-28
PE2896A1 (es) 1996-02-12
US5656607A (en) 1997-08-12
GEP19991836B (en) 1999-11-05
PT676409E (pt) 2003-08-29
NO954942L (no) 1996-02-07
CN1059445C (zh) 2000-12-13
HU215396B (hu) 1998-12-28
BR9506147A (pt) 1996-04-16
CZ296005B6 (cs) 2005-12-14
FR2718450B1 (fr) 1997-01-10
AU2310795A (en) 1995-10-30
SK284079B6 (sk) 2004-09-08
OA10200A (fr) 1996-12-18
PL311871A1 (en) 1996-03-18
BG61916B1 (bg) 1998-09-30
SK154695A3 (en) 1996-10-02
CA2164638A1 (fr) 1995-10-19
SI0676409T1 (en) 2003-06-30
CZ322395A3 (en) 1996-08-14
NO954942D0 (no) 1995-12-06
MA23501A1 (fr) 1995-12-31
MD663F1 (ro) 1997-01-31
DZ1869A1 (fr) 2002-02-17
DE69529934D1 (de) 2003-04-24
UA44705C2 (uk) 2002-03-15
DK0676409T3 (da) 2003-06-23
FI955913A0 (fi) 1995-12-08
RO115634B1 (ro) 2000-04-28
IL112954A0 (en) 1995-06-29
HUT73772A (en) 1996-09-30
ES2189820T3 (es) 2003-07-16
FI111264B (fi) 2003-06-30
CN1126997A (zh) 1996-07-17
SA97170757A (ar) 2005-12-03
WO1995027720A1 (fr) 1995-10-19
IL112954A (en) 2000-07-16
NZ284498A (en) 1997-07-27
GB2288174A (en) 1995-10-11
YU21695A (sh) 1997-12-05
RU2141965C1 (ru) 1999-11-27
MY114672A (en) 2002-12-31
CA2164638C (fr) 2003-12-30
BG100150A (bg) 1996-06-28
TNSN95026A1 (fr) 1996-02-06
CO4370097A1 (es) 1996-10-07
PL180837B1 (pl) 2001-04-30
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
JPH07278177A (ja) 1995-10-24
AP587A (en) 1997-04-29
ATE234853T1 (de) 2003-04-15
FR2718450A1 (fr) 1995-10-13
EE9500080A (et) 1996-12-16
YU49221B (sh) 2004-11-25

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