RU2141965C1 - Производные эритромицина, способы их получения и фармацевтическая композиция на их основе - Google Patents

Производные эритромицина, способы их получения и фармацевтическая композиция на их основе Download PDF

Info

Publication number
RU2141965C1
RU2141965C1 RU96101139A RU96101139A RU2141965C1 RU 2141965 C1 RU2141965 C1 RU 2141965C1 RU 96101139 A RU96101139 A RU 96101139A RU 96101139 A RU96101139 A RU 96101139A RU 2141965 C1 RU2141965 C1 RU 2141965C1
Authority
RU
Russia
Prior art keywords
methyl
formula
compound
dideoxy
erythromycin
Prior art date
Application number
RU96101139A
Other languages
English (en)
Russian (ru)
Other versions
RU96101139A (ru
Inventor
Агуридас Константин
Бенедетти Янник
Шанто Жан-Франсуа
Денис Алексис
Ле Мартре Одиль
Original Assignee
Руссель Юклаф
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Руссель Юклаф filed Critical Руссель Юклаф
Publication of RU96101139A publication Critical patent/RU96101139A/ru
Application granted granted Critical
Publication of RU2141965C1 publication Critical patent/RU2141965C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU96101139A 1994-04-08 1995-04-06 Производные эритромицина, способы их получения и фармацевтическая композиция на их основе RU2141965C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR94/04154 1994-04-08
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
RU96101139A RU96101139A (ru) 1998-03-27
RU2141965C1 true RU2141965C1 (ru) 1999-11-27

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96101139A RU2141965C1 (ru) 1994-04-08 1995-04-06 Производные эритромицина, способы их получения и фармацевтическая композиция на их основе

Country Status (49)

Country Link
US (2) US5656607A (enExample)
EP (1) EP0676409B1 (enExample)
JP (1) JP3000023B2 (enExample)
KR (1) KR100317148B1 (enExample)
CN (1) CN1059445C (enExample)
AP (1) AP587A (enExample)
AT (1) ATE234853T1 (enExample)
AU (1) AU684939B2 (enExample)
BG (1) BG61916B1 (enExample)
BR (1) BR9506147A (enExample)
CA (1) CA2164638C (enExample)
CO (1) CO4370097A1 (enExample)
CZ (1) CZ296005B6 (enExample)
DE (1) DE69529934T2 (enExample)
DK (1) DK0676409T3 (enExample)
DZ (1) DZ1869A1 (enExample)
EE (1) EE04498B1 (enExample)
ES (1) ES2189820T3 (enExample)
FI (1) FI111264B (enExample)
FR (1) FR2718450B1 (enExample)
GB (1) GB2288174A (enExample)
GE (1) GEP19991836B (enExample)
HR (1) HRP950217B1 (enExample)
HU (1) HU215396B (enExample)
IL (1) IL112954A (enExample)
IS (1) IS1865B (enExample)
JO (1) JO1850B1 (enExample)
LV (1) LV11182B (enExample)
MA (1) MA23501A1 (enExample)
MD (1) MD663G2 (enExample)
MY (1) MY114672A (enExample)
NO (1) NO308361B1 (enExample)
NZ (1) NZ284498A (enExample)
OA (1) OA10200A (enExample)
PE (1) PE2896A1 (enExample)
PL (1) PL180837B1 (enExample)
PT (1) PT676409E (enExample)
RO (1) RO115634B1 (enExample)
RU (1) RU2141965C1 (enExample)
SA (1) SA97170757A (enExample)
SI (1) SI0676409T1 (enExample)
SK (1) SK284079B6 (enExample)
SV (1) SV1995000018A (enExample)
TN (1) TNSN95026A1 (enExample)
TW (1) TW316908B (enExample)
UA (1) UA44705C2 (enExample)
WO (1) WO1995027720A1 (enExample)
YU (1) YU49221B (enExample)
ZA (1) ZA952059B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7332304B2 (en) 2002-07-01 2008-02-19 Arkion Life Sciences Llc Process and materials for production of glucosamine and N-acetylglucosamine

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
KR20000011071A (ko) * 1996-05-07 2000-02-25 스티븐 에프. 웨인스톡 3-데스클라디노스-2,3-안하이드로에리트로마이신 유도체
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DK1291353T3 (da) * 1996-09-04 2005-10-03 Abbott Lab 6-O-substituerede ketolider med antibakteriel aktivitet
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6421398A (en) * 1997-03-24 1998-10-20 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998051696A1 (en) * 1997-05-09 1998-11-19 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
PL337606A1 (en) * 1997-06-11 2000-08-28 Pfizer Prod Inc Derivatives of erythromycin 9-oxime
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
EP1115732B1 (en) * 1998-09-22 2005-06-29 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
AU6484199A (en) 1998-12-10 2000-06-26 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
BR0010680A (pt) * 1999-04-16 2002-02-19 Kosan Biosciences Inc Agentes antiinfecciosos de macrolìdeo
EP1171447A2 (en) 1999-04-16 2002-01-16 Ortho-McNeil Pharmaceutical, Inc. Ketolide antibacterials
CN1351608A (zh) * 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
WO2004080391A2 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
PL2550286T3 (pl) 2010-03-22 2016-07-29 Cempra Pharmaceuticals Inc Krystaliczne postaci makrolidu i ich zastosowanie
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
WO2012034058A1 (en) 2010-09-10 2012-03-15 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
EP2830632A4 (en) 2012-03-27 2015-10-21 Cempra Pharmaceuticals Inc PARENTERAL FORMULATIONS FOR THE ADMINISTRATION OF MAKROLID ANTIBIOTICS
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
HK1220394A1 (zh) 2013-03-15 2017-05-05 Cempra Pharmaceuticals, Inc. 收敛了制备大环内酯类抗菌剂
BR112015025159A2 (pt) 2013-04-04 2017-07-18 Harvard College macrolídeos e métodos de sua preparação e uso
CN106998685A (zh) 2014-10-08 2017-08-01 哈佛大学的校长及成员们 14‑元酮内酯及其制备和使用方法
US10640528B2 (en) 2015-03-25 2020-05-05 President And Fellows Of Havard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU682134A3 (ru) * 1975-04-07 1979-08-25 Д-Р Карл Томэ Гмбх (Фирма) Способ получени производных эритромицина или их солей
EP0596802B1 (fr) * 1992-11-05 1996-03-20 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU682134A3 (ru) * 1975-04-07 1979-08-25 Д-Р Карл Томэ Гмбх (Фирма) Способ получени производных эритромицина или их солей
EP0596802B1 (fr) * 1992-11-05 1996-03-20 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EP, A, 0487411, 1992. FR A, 2692579, 1993. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7332304B2 (en) 2002-07-01 2008-02-19 Arkion Life Sciences Llc Process and materials for production of glucosamine and N-acetylglucosamine
US8124381B2 (en) 2002-07-01 2012-02-28 Arkion Life Sciences Process and materials for production of glucosamine and N-acetylglucosamine

Also Published As

Publication number Publication date
AU684939B2 (en) 1998-01-08
HU9503505D0 (en) 1996-02-28
FI111264B (fi) 2003-06-30
SA97170757A (ar) 2005-12-03
BG61916B1 (bg) 1998-09-30
AP9500743A0 (en) 1995-07-31
ES2189820T3 (es) 2003-07-16
CZ296005B6 (cs) 2005-12-14
EE04498B1 (et) 2005-06-15
FI955913A0 (fi) 1995-12-08
AP587A (en) 1997-04-29
MD663F1 (ro) 1997-01-31
CN1126997A (zh) 1996-07-17
GB9506856D0 (en) 1995-05-24
AU2310795A (en) 1995-10-30
LV11182A (lv) 1996-04-20
CA2164638A1 (fr) 1995-10-19
FI955913A7 (fi) 1995-12-08
DE69529934D1 (de) 2003-04-24
SI0676409T1 (en) 2003-06-30
ZA952059B (en) 1996-03-13
ATE234853T1 (de) 2003-04-15
PL180837B1 (pl) 2001-04-30
US5656607A (en) 1997-08-12
YU21695A (sh) 1997-12-05
HRP950217A2 (en) 1997-08-31
KR100317148B1 (ko) 2002-06-22
MD663G2 (ro) 1997-07-31
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
IL112954A0 (en) 1995-06-29
TNSN95026A1 (fr) 1996-02-06
IS1865B (is) 2003-05-02
WO1995027720A1 (fr) 1995-10-19
LV11182B (en) 1997-04-20
DZ1869A1 (fr) 2002-02-17
SK284079B6 (sk) 2004-09-08
GEP19991836B (en) 1999-11-05
CO4370097A1 (es) 1996-10-07
IS4309A (is) 1995-11-17
DK0676409T3 (da) 2003-06-23
FR2718450B1 (fr) 1997-01-10
IL112954A (en) 2000-07-16
OA10200A (fr) 1996-12-18
PE2896A1 (es) 1996-02-12
SV1995000018A (es) 1997-10-24
EE9500080A (et) 1996-12-16
DE69529934T2 (de) 2003-09-04
YU49221B (sh) 2004-11-25
BR9506147A (pt) 1996-04-16
HUT73772A (en) 1996-09-30
JP3000023B2 (ja) 2000-01-17
NZ284498A (en) 1997-07-27
MA23501A1 (fr) 1995-12-31
SK154695A3 (en) 1996-10-02
PL311871A1 (en) 1996-03-18
CZ322395A3 (en) 1996-08-14
MY114672A (en) 2002-12-31
GB2288174A (en) 1995-10-11
FR2718450A1 (fr) 1995-10-13
CN1059445C (zh) 2000-12-13
CA2164638C (fr) 2003-12-30
HRP950217B1 (en) 2004-06-30
PT676409E (pt) 2003-08-29
NO954942L (no) 1996-02-07
EP0676409A1 (fr) 1995-10-11
UA44705C2 (uk) 2002-03-15
JPH07278177A (ja) 1995-10-24
US5760233A (en) 1998-06-02
RO115634B1 (ro) 2000-04-28
NO308361B1 (no) 2000-09-04
NO954942D0 (no) 1995-12-06
BG100150A (bg) 1996-06-28
TW316908B (enExample) 1997-10-01
HU215396B (hu) 1998-12-28

Similar Documents

Publication Publication Date Title
RU2141965C1 (ru) Производные эритромицина, способы их получения и фармацевтическая композиция на их основе
US6028181A (en) 6-0-Substituted antibacterial erythromycin ketolides and methods of making
US5866549A (en) 6-O-substituted ketolides having antibacterial activity
JP4750755B2 (ja) 新規なエリスロマイシン誘導体、それらの製造法及び薬剤としての使用
JP4102440B2 (ja) 新規なエリスロマイシン誘導体、それらの調製方法及びそれらの医薬品としての使用
JP5188520B2 (ja) 新規なエリスロマイシン誘導体、製造方法及び医薬としての利用
US6162793A (en) Erythromycin derivatives, method for preparing same and use thereof as drugs
AP997A (en) Novel erythromycin derivatives, method for preparing them and their use as medicine.
MXPA99005226A (en) Novel erythromycin derivatives, method for preparing them and their use as medicine
JP2003534231A (ja) 新規の６−デオキシエリスロマイシン誘導体、それらの製造方法及びそれらの薬剤としての使用