CN1059445C - 红霉素的新型衍生物,其制备方法及作为药物的应用 - Google Patents

红霉素的新型衍生物,其制备方法及作为药物的应用 Download PDF

Info

Publication number
CN1059445C
CN1059445C CN95190283A CN95190283A CN1059445C CN 1059445 C CN1059445 C CN 1059445C CN 95190283 A CN95190283 A CN 95190283A CN 95190283 A CN95190283 A CN 95190283A CN 1059445 C CN1059445 C CN 1059445C
Authority
CN
China
Prior art keywords
formula
compound
methyl
oxygen
dideoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN95190283A
Other languages
English (en)
Chinese (zh)
Other versions
CN1126997A (zh
Inventor
C·阿古里达斯
Ｙ·本尼迪蒂
J·F·尚托特
A·丹尼斯
O·勒马特雷特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of CN1126997A publication Critical patent/CN1126997A/zh
Application granted granted Critical
Publication of CN1059445C publication Critical patent/CN1059445C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN95190283A 1994-04-08 1995-04-06 红霉素的新型衍生物,其制备方法及作为药物的应用 Expired - Lifetime CN1059445C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR94/04154 1994-04-08
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (2)

Publication Number Publication Date
CN1126997A CN1126997A (zh) 1996-07-17
CN1059445C true CN1059445C (zh) 2000-12-13

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95190283A Expired - Lifetime CN1059445C (zh) 1994-04-08 1995-04-06 红霉素的新型衍生物,其制备方法及作为药物的应用

Country Status (49)

Country Link
US (2) US5656607A (enExample)
EP (1) EP0676409B1 (enExample)
JP (1) JP3000023B2 (enExample)
KR (1) KR100317148B1 (enExample)
CN (1) CN1059445C (enExample)
AP (1) AP587A (enExample)
AT (1) ATE234853T1 (enExample)
AU (1) AU684939B2 (enExample)
BG (1) BG61916B1 (enExample)
BR (1) BR9506147A (enExample)
CA (1) CA2164638C (enExample)
CO (1) CO4370097A1 (enExample)
CZ (1) CZ296005B6 (enExample)
DE (1) DE69529934T2 (enExample)
DK (1) DK0676409T3 (enExample)
DZ (1) DZ1869A1 (enExample)
EE (1) EE04498B1 (enExample)
ES (1) ES2189820T3 (enExample)
FI (1) FI111264B (enExample)
FR (1) FR2718450B1 (enExample)
GB (1) GB2288174A (enExample)
GE (1) GEP19991836B (enExample)
HR (1) HRP950217B1 (enExample)
HU (1) HU215396B (enExample)
IL (1) IL112954A (enExample)
IS (1) IS1865B (enExample)
JO (1) JO1850B1 (enExample)
LV (1) LV11182B (enExample)
MA (1) MA23501A1 (enExample)
MD (1) MD663G2 (enExample)
MY (1) MY114672A (enExample)
NO (1) NO308361B1 (enExample)
NZ (1) NZ284498A (enExample)
OA (1) OA10200A (enExample)
PE (1) PE2896A1 (enExample)
PL (1) PL180837B1 (enExample)
PT (1) PT676409E (enExample)
RO (1) RO115634B1 (enExample)
RU (1) RU2141965C1 (enExample)
SA (1) SA97170757A (enExample)
SI (1) SI0676409T1 (enExample)
SK (1) SK284079B6 (enExample)
SV (1) SV1995000018A (enExample)
TN (1) TNSN95026A1 (enExample)
TW (1) TW316908B (enExample)
UA (1) UA44705C2 (enExample)
WO (1) WO1995027720A1 (enExample)
YU (1) YU49221B (enExample)
ZA (1) ZA952059B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
KR20000011071A (ko) * 1996-05-07 2000-02-25 스티븐 에프. 웨인스톡 3-데스클라디노스-2,3-안하이드로에리트로마이신 유도체
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DK1291353T3 (da) * 1996-09-04 2005-10-03 Abbott Lab 6-O-substituerede ketolider med antibakteriel aktivitet
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6421398A (en) * 1997-03-24 1998-10-20 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998051696A1 (en) * 1997-05-09 1998-11-19 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
PL337606A1 (en) * 1997-06-11 2000-08-28 Pfizer Prod Inc Derivatives of erythromycin 9-oxime
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
EP1115732B1 (en) * 1998-09-22 2005-06-29 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
AU6484199A (en) 1998-12-10 2000-06-26 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
BR0010680A (pt) * 1999-04-16 2002-02-19 Kosan Biosciences Inc Agentes antiinfecciosos de macrolìdeo
EP1171447A2 (en) 1999-04-16 2002-01-16 Ortho-McNeil Pharmaceutical, Inc. Ketolide antibacterials
CN1351608A (zh) * 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
KR101035043B1 (ko) 2002-07-01 2011-05-19 아르키온 라이프 사이언씨즈 엘엘씨 글루코사민 및 ｎ-아세틸글루코사민의 제조를 위한 물질및 공정
WO2004080391A2 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
PL2550286T3 (pl) 2010-03-22 2016-07-29 Cempra Pharmaceuticals Inc Krystaliczne postaci makrolidu i ich zastosowanie
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
WO2012034058A1 (en) 2010-09-10 2012-03-15 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
EP2830632A4 (en) 2012-03-27 2015-10-21 Cempra Pharmaceuticals Inc PARENTERAL FORMULATIONS FOR THE ADMINISTRATION OF MAKROLID ANTIBIOTICS
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
HK1220394A1 (zh) 2013-03-15 2017-05-05 Cempra Pharmaceuticals, Inc. 收敛了制备大环内酯类抗菌剂
BR112015025159A2 (pt) 2013-04-04 2017-07-18 Harvard College macrolídeos e métodos de sua preparação e uso
CN106998685A (zh) 2014-10-08 2017-08-01 哈佛大学的校长及成员们 14‑元酮内酯及其制备和使用方法
US10640528B2 (en) 2015-03-25 2020-05-05 President And Fellows Of Havard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692579A1 (fr) * 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692579A1 (fr) * 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
AU684939B2 (en) 1998-01-08
HU9503505D0 (en) 1996-02-28
FI111264B (fi) 2003-06-30
SA97170757A (ar) 2005-12-03
BG61916B1 (bg) 1998-09-30
AP9500743A0 (en) 1995-07-31
ES2189820T3 (es) 2003-07-16
CZ296005B6 (cs) 2005-12-14
EE04498B1 (et) 2005-06-15
FI955913A0 (fi) 1995-12-08
AP587A (en) 1997-04-29
MD663F1 (ro) 1997-01-31
CN1126997A (zh) 1996-07-17
GB9506856D0 (en) 1995-05-24
AU2310795A (en) 1995-10-30
LV11182A (lv) 1996-04-20
CA2164638A1 (fr) 1995-10-19
FI955913A7 (fi) 1995-12-08
DE69529934D1 (de) 2003-04-24
SI0676409T1 (en) 2003-06-30
ZA952059B (en) 1996-03-13
ATE234853T1 (de) 2003-04-15
PL180837B1 (pl) 2001-04-30
US5656607A (en) 1997-08-12
YU21695A (sh) 1997-12-05
HRP950217A2 (en) 1997-08-31
KR100317148B1 (ko) 2002-06-22
MD663G2 (ro) 1997-07-31
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
IL112954A0 (en) 1995-06-29
TNSN95026A1 (fr) 1996-02-06
IS1865B (is) 2003-05-02
WO1995027720A1 (fr) 1995-10-19
LV11182B (en) 1997-04-20
DZ1869A1 (fr) 2002-02-17
SK284079B6 (sk) 2004-09-08
GEP19991836B (en) 1999-11-05
CO4370097A1 (es) 1996-10-07
IS4309A (is) 1995-11-17
DK0676409T3 (da) 2003-06-23
FR2718450B1 (fr) 1997-01-10
IL112954A (en) 2000-07-16
OA10200A (fr) 1996-12-18
PE2896A1 (es) 1996-02-12
SV1995000018A (es) 1997-10-24
EE9500080A (et) 1996-12-16
DE69529934T2 (de) 2003-09-04
YU49221B (sh) 2004-11-25
BR9506147A (pt) 1996-04-16
HUT73772A (en) 1996-09-30
JP3000023B2 (ja) 2000-01-17
NZ284498A (en) 1997-07-27
MA23501A1 (fr) 1995-12-31
SK154695A3 (en) 1996-10-02
PL311871A1 (en) 1996-03-18
CZ322395A3 (en) 1996-08-14
MY114672A (en) 2002-12-31
GB2288174A (en) 1995-10-11
FR2718450A1 (fr) 1995-10-13
CA2164638C (fr) 2003-12-30
HRP950217B1 (en) 2004-06-30
PT676409E (pt) 2003-08-29
NO954942L (no) 1996-02-07
RU2141965C1 (ru) 1999-11-27
EP0676409A1 (fr) 1995-10-11
UA44705C2 (uk) 2002-03-15
JPH07278177A (ja) 1995-10-24
US5760233A (en) 1998-06-02
RO115634B1 (ro) 2000-04-28
NO308361B1 (no) 2000-09-04
NO954942D0 (no) 1995-12-06
BG100150A (bg) 1996-06-28
TW316908B (enExample) 1997-10-01
HU215396B (hu) 1998-12-28

Similar Documents

Publication Publication Date Title
CN1059445C (zh) 红霉素的新型衍生物,其制备方法及作为药物的应用
CN1052984C (zh) 新的红霉素衍生物、其制备方法及其作为药物的应用
CN1241931C (zh) 大环内酯抗感染药物
CN1033974C (zh) 新的红霉素衍生物的制备方法
CN1153771C (zh) 苯并呋喃并[3，4-f]喹啉衍生物、含有其的药物组合物及其应用
CN1009930B (zh) 含喹啉羧酸衍生物的药物组合物的制备方法
CN1269836C (zh) 用于改进抗炎治疗的细胞靶向的免疫细胞特异性大环内酯化合物与抗炎化合物的共轭物
CN1221417A (zh) 具有抗糖尿病、降低血脂、抗高血压性能的噻唑烷二酮化合物,其制备方法及其药物组合物
CN1116208A (zh) 9，11-脱氢甾类化合物及9-α-羟基-16，17-脱氢甾类化合物的制备方法
CN1075957A (zh) 萘衍生物、其制备方法及其合成中间体
CN1151165C (zh) 具有抗炎活性的大环内酯
CN1259135A (zh) 9－肟红霉素衍生物
CN1108657A (zh) 雪花胺衍生物、其制备方法及其作为药物的用途
CN1151165A (zh) 三萜衍生物及其药用组合物
CN1213055C (zh) 核糖取代的新芳族酰胺、其制备方法及其作为药剂的用途
CN1021967C (zh) 新的喹啉衍生物的制备方法
CN1040877C (zh) 红霉素的新衍生物、它们的制备方法和作为药物的应用
CN1050719A (zh) 表鬼臼毒素阿卓糖苷衍生物的制备方法
CN1121715A (zh) 4-芳基-4-羟基-四氢吡喃类化合物和3-芳基-3-羟基-四氢呋喃类化合物作为5-脂氧合酶抑制剂
CN1308342C (zh) 核糖取代的芳族化合物,其制备方法和作为药物的应用
CN1729200A (zh) 大环内酯类
CN1019578B (zh) 喹啉羧酸衍生物的制备方法
CN1267300A (zh) 用于抑制法呢基蛋白转移酶的苯并(5,6)芳庚并(1,2－b)吡啶衍生物
CN1820016A (zh) 新型14和15元环化合物
CN85105864A (zh) 制备普瑞素盐和它的组合物的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: HOECHST MARION ROUSSEL INC.

Free format text: FORMER NAME OR ADDRESS: LUSUO ROUSSEL UCLAF CO., LTD.

Owner name: VENTIS PHARMA S.A.

Free format text: FORMER NAME OR ADDRESS: HOECHST MARION ROUSSEL INC.

Owner name: LUSUO ROUSSEL UCLAF CO., LTD.

Free format text: FORMER NAME OR ADDRESS: ROUSSEL-UCLAF

CP03 Change of name, title or address

Address after: French Anthony

Patentee after: AVENTIS PHARMA S.A.

Address before: French AUX

Patentee before: Hoechst Marion Roussel

Address after: French Roman

Patentee after: Roussel-Uclaf

Address before: Paris France

Patentee before: ROUSSEL UCLAF

Address after: French AUX

Patentee after: Hoechst Marion Roussel

Address before: French Roman

Patentee before: Roussel-Uclaf

C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20150406

Granted publication date: 20001213