JP2022088416A5 - - Google Patents
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- JP2022088416A5 JP2022088416A5 JP2022034691A JP2022034691A JP2022088416A5 JP 2022088416 A5 JP2022088416 A5 JP 2022088416A5 JP 2022034691 A JP2022034691 A JP 2022034691A JP 2022034691 A JP2022034691 A JP 2022034691A JP 2022088416 A5 JP2022088416 A5 JP 2022088416A5
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- 150000001875 compounds Chemical class 0.000 claims 35
- 238000000034 method Methods 0.000 claims 27
- 230000002194 synthesizing effect Effects 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 7
- 229910052794 bromium Inorganic materials 0.000 claims 6
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 125000006763 (C3-C9) cycloalkyl group Chemical group 0.000 claims 2
- URBUZQPPQLQHBZ-UHFFFAOYSA-N 1-fluoro-3-iodopropane Chemical compound FCCCI URBUZQPPQLQHBZ-UHFFFAOYSA-N 0.000 claims 2
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims 2
- CZGVAISJIQNQEJ-UHFFFAOYSA-N 4-bromo-2,6-difluorobenzaldehyde Chemical compound FC1=CC(Br)=CC(F)=C1C=O CZGVAISJIQNQEJ-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- SEMQFCQRSCQTJK-NWKMIUOTSA-N (2r)-1-(1h-indol-3-yl)propan-2-amine Chemical compound C1=CC=C2C(C[C@H](N)C)=CNC2=C1.C1=CC=C2C(C[C@H](N)C)=CNC2=C1 SEMQFCQRSCQTJK-NWKMIUOTSA-N 0.000 claims 1
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
- NRORRPGWPOACKJ-UHFFFAOYSA-N FC(S(=O)(=O)OCC(CO[Si](C1=CC=CC=C1)(C1=CC=CC=C1)C(C)(C)C)(F)F)(F)F Chemical compound FC(S(=O)(=O)OCC(CO[Si](C1=CC=CC=C1)(C1=CC=CC=C1)C(C)(C)C)(F)F)(F)F NRORRPGWPOACKJ-UHFFFAOYSA-N 0.000 claims 1
- 150000001263 acyl chlorides Chemical class 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 claims 1
- WPGLRFGDZJSQGI-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC(N)C1 WPGLRFGDZJSQGI-UHFFFAOYSA-N 0.000 claims 1
- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023201538A JP2024028785A (ja) | 2014-12-18 | 2023-11-29 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093929P | 2014-12-18 | 2014-12-18 | |
| US62/093,929 | 2014-12-18 | ||
| US201562110998P | 2015-02-02 | 2015-02-02 | |
| US62/110,998 | 2015-02-02 | ||
| US201562142077P | 2015-04-02 | 2015-04-02 | |
| US62/142,077 | 2015-04-02 | ||
| JP2019223278A JP7128169B2 (ja) | 2014-12-18 | 2019-12-10 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019223278A Division JP7128169B2 (ja) | 2014-12-18 | 2019-12-10 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023201538A Division JP2024028785A (ja) | 2014-12-18 | 2023-11-29 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022088416A JP2022088416A (ja) | 2022-06-14 |
| JP2022088416A5 true JP2022088416A5 (enExample) | 2022-10-18 |
| JP7446348B2 JP7446348B2 (ja) | 2024-03-08 |
Family
ID=54850193
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532740A Active JP6679147B2 (ja) | 2014-12-18 | 2015-12-17 | テトラヒドロ−ピリド［３，４−ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
| JP2019223278A Active JP7128169B2 (ja) | 2014-12-18 | 2019-12-10 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
| JP2022034691A Active JP7446348B2 (ja) | 2014-12-18 | 2022-03-07 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
| JP2023201538A Pending JP2024028785A (ja) | 2014-12-18 | 2023-11-29 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532740A Active JP6679147B2 (ja) | 2014-12-18 | 2015-12-17 | テトラヒドロ−ピリド［３，４−ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
| JP2019223278A Active JP7128169B2 (ja) | 2014-12-18 | 2019-12-10 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023201538A Pending JP2024028785A (ja) | 2014-12-18 | 2023-11-29 | テトラヒドロ－ピリド［３，４－ｂ］インドールエストロゲン受容体モジュレーター及びその使用 |
Country Status (33)
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