CN109362222B - 选择性雌激素受体降解物及其用途 - Google Patents
选择性雌激素受体降解物及其用途 Download PDFInfo
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- CN109362222B CN109362222B CN201780008535.5A CN201780008535A CN109362222B CN 109362222 B CN109362222 B CN 109362222B CN 201780008535 A CN201780008535 A CN 201780008535A CN 109362222 B CN109362222 B CN 109362222B
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- acceptable salt
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C—CHEMISTRY; METALLURGY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
Description
Claims (39)
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WO2017119917A1 (en) * | 2016-02-26 | 2017-07-13 | Triangle Research Labs, LLC | Method for pooling hepatocytes |
US10519148B2 (en) * | 2015-11-12 | 2019-12-31 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Acrylic acid derivative, preparation method and use in medicine thereof |
BR112018015419B1 (pt) * | 2016-02-05 | 2024-01-30 | Inventisbio Llc | Degradantes seletivos de receptor de estrogênio, seus usos, e composição farmacêutica |
KR102401841B1 (ko) * | 2016-04-01 | 2022-05-25 | 리커리엄 아이피 홀딩스, 엘엘씨 | 에스트로겐 수용체 조절제 |
JP7018026B2 (ja) * | 2016-06-16 | 2022-02-09 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | ヘテロアリールエストロゲン受容体モジュレーター及びその使用 |
CN107814798B (zh) * | 2016-09-14 | 2020-11-03 | 四川科伦博泰生物医药股份有限公司 | 3-取代丙烯酸类化合物及其制备方法和用途 |
WO2018130124A1 (zh) * | 2017-01-11 | 2018-07-19 | 南京圣和药业股份有限公司 | 作为选择性雌激素受体下调剂的三环类化合物及其应用 |
WO2019168999A1 (en) | 2018-02-28 | 2019-09-06 | Ferro Therapeutics, Inc. | Compounds with ferroptosis inducing activity and methods of their use |
CN110343101B (zh) * | 2018-04-04 | 2022-07-12 | 青岛福沃药业有限公司 | 用于治疗乳腺癌的雌激素受体降解剂 |
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AU2017213614B2 (en) | 2022-09-01 |
BR112018015419A2 (pt) | 2018-12-18 |
JP6905539B2 (ja) | 2021-07-21 |
KR102479822B1 (ko) | 2022-12-21 |
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JP2019504890A (ja) | 2019-02-21 |
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DK3411034T3 (da) | 2021-01-11 |
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