MX2022007659A - Compuestos de isoindolinona e indazol para la degradacion del receptor del factor de crecimiento epidermico (egfr). - Google Patents

Compuestos de isoindolinona e indazol para la degradacion del receptor del factor de crecimiento epidermico (egfr).

Info

Publication number
MX2022007659A
MX2022007659A MX2022007659A MX2022007659A MX2022007659A MX 2022007659 A MX2022007659 A MX 2022007659A MX 2022007659 A MX2022007659 A MX 2022007659A MX 2022007659 A MX2022007659 A MX 2022007659A MX 2022007659 A MX2022007659 A MX 2022007659A
Authority
MX
Mexico
Prior art keywords
egfr
degradation
isoindolinone
indazole compounds
compounds
Prior art date
Application number
MX2022007659A
Other languages
English (en)
Inventor
Martin Duplessis
Annick Goergler
Christopher G Nasveschuk
Jae Young Ahn
Yanke Liang
Kiel Lazarski
Georg Jaeschke
Antonio Ricci
Alexander W Hird
Ryan E Michael
Daniel Rueher
Original Assignee
C4 Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C4 Therapeutics Inc filed Critical C4 Therapeutics Inc
Publication of MX2022007659A publication Critical patent/MX2022007659A/es

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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract

La invención proporciona compuestos que degradan el receptor del factor de crecimiento epidérmico (EGFR), incluyendo formas mutantes a través de la ubiquitinación de la proteína EGFR y la subsiguiente degradación proteasómica; los compuestos son útiles para el tratamiento de varios tipos de cáncer.
MX2022007659A 2019-12-20 2020-12-18 Compuestos de isoindolinona e indazol para la degradacion del receptor del factor de crecimiento epidermico (egfr). MX2022007659A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962951467P 2019-12-20 2019-12-20
US201962951464P 2019-12-20 2019-12-20
PCT/US2020/066211 WO2021127561A1 (en) 2019-12-20 2020-12-18 Isoindolinone and indazole compounds for the degradation of egfr

Publications (1)

Publication Number Publication Date
MX2022007659A true MX2022007659A (es) 2022-07-19

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MX2022007659A MX2022007659A (es) 2019-12-20 2020-12-18 Compuestos de isoindolinona e indazol para la degradacion del receptor del factor de crecimiento epidermico (egfr).

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Country Link
US (2) US11673902B2 (es)
EP (1) EP4076450A4 (es)
JP (1) JP2023509375A (es)
KR (1) KR20220119415A (es)
AU (1) AU2020405237A1 (es)
BR (1) BR112022011827A2 (es)
CA (1) CA3154073A1 (es)
CL (1) CL2022001641A1 (es)
CO (1) CO2022008604A2 (es)
IL (1) IL293999A (es)
MX (1) MX2022007659A (es)
PE (1) PE20221724A1 (es)
TW (1) TW202136265A (es)
WO (1) WO2021127561A1 (es)

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