CL2022001641A1 - Compuestos de isoindolinona e indazol para degradación del receptor del factor de crecimiento epidérmico (egfr) - Google Patents

Compuestos de isoindolinona e indazol para degradación del receptor del factor de crecimiento epidérmico (egfr)

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Publication number
CL2022001641A1
CL2022001641A1 CL2022001641A CL2022001641A CL2022001641A1 CL 2022001641 A1 CL2022001641 A1 CL 2022001641A1 CL 2022001641 A CL2022001641 A CL 2022001641A CL 2022001641 A CL2022001641 A CL 2022001641A CL 2022001641 A1 CL2022001641 A1 CL 2022001641A1
Authority
CL
Chile
Prior art keywords
egfr
growth factor
factor receptor
epidermal growth
degradation
Prior art date
Application number
CL2022001641A
Other languages
English (en)
Inventor
G Nasveschuk Christopher
Duplessis Martin
Young Ahn Jae
W Hird Alexander
E Michael Ryan
LAZARSKI Kie
Yanke Liang
Jaeschke Georg
Ricci Antonio
Goergler Annick
Rueher Daniel
Original Assignee
C4 Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C4 Therapeutics Inc filed Critical C4 Therapeutics Inc
Publication of CL2022001641A1 publication Critical patent/CL2022001641A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invención proporciona compuestos que degradan el receptor del factor de crecimiento epidérmico (EGFR), incluyendo formas mutantes a través de la ubiquitinación de la proteína EGFR y la subsiguiente degradación proteasómica; los compuestos son útiles para el tratamiento de varios tipos de cáncer.
CL2022001641A 2019-12-20 2022-06-16 Compuestos de isoindolinona e indazol para degradación del receptor del factor de crecimiento epidérmico (egfr) CL2022001641A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962951467P 2019-12-20 2019-12-20
US201962951464P 2019-12-20 2019-12-20

Publications (1)

Publication Number Publication Date
CL2022001641A1 true CL2022001641A1 (es) 2023-03-17

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CL2022001641A CL2022001641A1 (es) 2019-12-20 2022-06-16 Compuestos de isoindolinona e indazol para degradación del receptor del factor de crecimiento epidérmico (egfr)

Country Status (15)

Country Link
US (2) US11673902B2 (es)
EP (1) EP4076450A4 (es)
JP (1) JP2023509375A (es)
KR (1) KR20220119415A (es)
CN (1) CN114901277B (es)
AU (1) AU2020405237A1 (es)
BR (1) BR112022011827A2 (es)
CA (1) CA3154073A1 (es)
CL (1) CL2022001641A1 (es)
CO (1) CO2022008604A2 (es)
IL (1) IL293999A (es)
MX (1) MX2022007659A (es)
PE (1) PE20221724A1 (es)
TW (1) TW202136265A (es)
WO (1) WO2021127561A1 (es)

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AU2020405237A1 (en) 2022-07-07
CO2022008604A2 (es) 2022-07-08
KR20220119415A (ko) 2022-08-29
BR112022011827A2 (pt) 2022-08-30
CN114901277B (zh) 2024-05-17
TW202136265A (zh) 2021-10-01
MX2022007659A (es) 2022-07-19
US20240076300A1 (en) 2024-03-07
US11673902B2 (en) 2023-06-13
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