BR112022002138A2 - Moduladores do receptor de estrogênio para tratamento de mutantes - Google Patents
Moduladores do receptor de estrogênio para tratamento de mutantesInfo
- Publication number
- BR112022002138A2 BR112022002138A2 BR112022002138A BR112022002138A BR112022002138A2 BR 112022002138 A2 BR112022002138 A2 BR 112022002138A2 BR 112022002138 A BR112022002138 A BR 112022002138A BR 112022002138 A BR112022002138 A BR 112022002138A BR 112022002138 A2 BR112022002138 A2 BR 112022002138A2
- Authority
- BR
- Brazil
- Prior art keywords
- estrogen receptor
- mutants
- treatment
- receptor modulators
- breast cancer
- Prior art date
Links
- 239000002834 estrogen receptor modulator Substances 0.000 title abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 abstract 2
- 108010007005 Estrogen Receptor alpha Proteins 0.000 abstract 2
- 102100038595 Estrogen receptor Human genes 0.000 abstract 2
- 101150064205 ESR1 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
moduladores do receptor de estrogênio para tratamento de mutantes. a presente invenção se refere a usos e métodos que incluem uma quantidade eficaz de composto a (isto é, ácido (e)-3-(4-((1r, 3r)-2-(biciclo[1.1.1]pen-tan-1-il)-3-metil-2,3,4,9-tetra-hidro-1h-pirido[3,4-b]indol-1-il)-3,5-difluorofenil) acrílico), ou um sal farmaceuticamente aceitável do mesmo, que são aqui descritos para tratar câncer de mama em um indivíduo que esteja precisando do mesmo, sendo que o câncer de mama tem ao menos uma mutação pontual dentro do receptor de estrogênio 1 (esr1) que codifica o receptor de estrogênio alfa (rea), como y537s ou l536p.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962883395P | 2019-08-06 | 2019-08-06 | |
US202063009746P | 2020-04-14 | 2020-04-14 | |
PCT/US2020/044884 WO2021026153A1 (en) | 2019-08-06 | 2020-08-04 | Estrogen receptor modulators for treating mutants |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022002138A2 true BR112022002138A2 (pt) | 2022-04-19 |
Family
ID=74499460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022002138A BR112022002138A2 (pt) | 2019-08-06 | 2020-08-04 | Moduladores do receptor de estrogênio para tratamento de mutantes |
Country Status (12)
Country | Link |
---|---|
US (2) | US11278532B2 (pt) |
EP (1) | EP3993787A4 (pt) |
JP (1) | JP2022543832A (pt) |
KR (1) | KR20220044528A (pt) |
CN (1) | CN114269342A (pt) |
AU (1) | AU2020326691A1 (pt) |
BR (1) | BR112022002138A2 (pt) |
CA (1) | CA3148221A1 (pt) |
IL (1) | IL290280A (pt) |
MX (1) | MX2022001149A (pt) |
TW (1) | TW202120084A (pt) |
WO (1) | WO2021026153A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2024502270A (ja) | 2020-12-23 | 2024-01-18 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | エストロゲン受容体調節薬 |
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CZ264996A3 (cs) | 1994-03-11 | 1998-01-14 | Eli Lilly And Company | Použití sloučenin, které jsou aktivní na 5HT2B receptor |
GB9604996D0 (en) | 1996-03-08 | 1996-05-08 | Black James Foundation | Benzodiazonine derivatives |
EP1113007A1 (en) | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
DE60216952T2 (de) | 2001-10-19 | 2007-07-05 | Transtech Pharma Inc. | Beta-carbolin-derivate als ptp-inhibitoren |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US20080103164A1 (en) | 2004-08-02 | 2008-05-01 | Kristjan Gudmundsson | Useful compounds for hpv infection |
WO2007002051A1 (en) | 2005-06-22 | 2007-01-04 | Smithkline Beecham Corporation | Carboline derivatives and their use as inhibitors of flaviviridae infections |
EP2037905B1 (en) | 2006-06-23 | 2013-05-01 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
CA2683444A1 (en) | 2007-04-13 | 2008-10-23 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
DE102007028515A1 (de) | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
TW201028414A (en) | 2009-01-16 | 2010-08-01 | Merck Sharp & Dohme | Oxadiazole beta carboline derivatives as antidiabetic compounds |
US20120135089A1 (en) | 2009-03-17 | 2012-05-31 | Stockwell Brent R | E3 ligase inhibitors |
CA2785790A1 (en) | 2010-01-15 | 2011-07-21 | Merck Sharp & Dohme Corp. | Oxadiazole beta carboline derivatives as antidiabetic compounds |
WO2011103487A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
EP2580210B1 (en) | 2010-06-10 | 2017-03-01 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
CN102432608B (zh) | 2011-11-01 | 2013-04-17 | 浙江大学 | 手性螺环磷酸催化合成光学活性四氢-β-咔啉衍生物的方法 |
US9187460B2 (en) | 2011-12-14 | 2015-11-17 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
DK2797921T3 (en) | 2011-12-31 | 2017-10-02 | Beigene Ltd | FUSED TETRA- OR PENTA-CYCLIC DIHYDRODIAZEPINOCARBAZOLONES AS PARB INHIBITORS |
WO2013142266A1 (en) | 2012-03-20 | 2013-09-26 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
AU2013203600C1 (en) | 2012-07-13 | 2016-11-24 | University Of Tennessee Research Foundation | A method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMS) |
AU2014219283C1 (en) | 2013-02-19 | 2016-10-27 | Novartis Ag | Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders |
JP2016517420A (ja) | 2013-03-14 | 2016-06-16 | セラゴン ファーマシューティカルズ, インク. | 多環式エストロゲン受容体モジュレーター及びその使用 |
PT3004090T (pt) | 2013-05-28 | 2017-12-22 | Astrazeneca Ab | Compostos químicos |
WO2015082990A1 (en) | 2013-12-06 | 2015-06-11 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer |
CN104693211A (zh) | 2013-12-10 | 2015-06-10 | 南京明德新药研发股份有限公司 | 作为抗病毒剂的咪唑衍生物及其制药用途 |
US9695166B2 (en) | 2014-05-05 | 2017-07-04 | Global Blood Therapeutics, Inc. | Pyrazolopyridine pyrazolopyrimidine and related compounds |
EP3143007B1 (en) | 2014-05-16 | 2018-07-11 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
CN106536520B (zh) | 2014-06-27 | 2020-08-14 | 诺格拉制药有限公司 | 芳基受体调制剂及其制备和使用方法 |
AU2015330490B2 (en) | 2014-10-09 | 2018-08-09 | Guangdong Raynovent Biotech Co., Ltd. | Hydroxyl purine compounds and applications thereof |
CN117865872A (zh) | 2014-12-18 | 2024-04-12 | 豪夫迈·罗氏有限公司 | 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途 |
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KR20180012853A (ko) | 2015-06-16 | 2018-02-06 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 피페리딘 유도체 및 이의 제조 방법 및 약학적 용도 |
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WO2018130124A1 (zh) | 2017-01-11 | 2018-07-19 | 南京圣和药业股份有限公司 | 作为选择性雌激素受体下调剂的三环类化合物及其应用 |
-
2020
- 2020-08-04 JP JP2022507525A patent/JP2022543832A/ja active Pending
- 2020-08-04 BR BR112022002138A patent/BR112022002138A2/pt not_active Application Discontinuation
- 2020-08-04 KR KR1020227006821A patent/KR20220044528A/ko unknown
- 2020-08-04 EP EP20849650.5A patent/EP3993787A4/en active Pending
- 2020-08-04 AU AU2020326691A patent/AU2020326691A1/en active Pending
- 2020-08-04 WO PCT/US2020/044884 patent/WO2021026153A1/en active Application Filing
- 2020-08-04 CA CA3148221A patent/CA3148221A1/en active Pending
- 2020-08-04 MX MX2022001149A patent/MX2022001149A/es unknown
- 2020-08-04 CN CN202080056054.3A patent/CN114269342A/zh active Pending
- 2020-08-04 US US16/985,004 patent/US11278532B2/en active Active
- 2020-08-05 TW TW109126553A patent/TW202120084A/zh unknown
-
2022
- 2022-01-05 US US17/647,153 patent/US20220125769A1/en not_active Abandoned
- 2022-02-01 IL IL290280A patent/IL290280A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20210038573A1 (en) | 2021-02-11 |
MX2022001149A (es) | 2022-04-06 |
KR20220044528A (ko) | 2022-04-08 |
IL290280A (en) | 2022-04-01 |
EP3993787A1 (en) | 2022-05-11 |
EP3993787A4 (en) | 2023-07-12 |
CN114269342A (zh) | 2022-04-01 |
US20220125769A1 (en) | 2022-04-28 |
US11278532B2 (en) | 2022-03-22 |
WO2021026153A1 (en) | 2021-02-11 |
JP2022543832A (ja) | 2022-10-14 |
AU2020326691A1 (en) | 2022-03-03 |
CA3148221A1 (en) | 2021-02-11 |
TW202120084A (zh) | 2021-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |