JP2013518092A5 - - Google Patents
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- Publication number
- JP2013518092A5 JP2013518092A5 JP2012550525A JP2012550525A JP2013518092A5 JP 2013518092 A5 JP2013518092 A5 JP 2013518092A5 JP 2012550525 A JP2012550525 A JP 2012550525A JP 2012550525 A JP2012550525 A JP 2012550525A JP 2013518092 A5 JP2013518092 A5 JP 2013518092A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- carried out
- compound
- solvent
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *=C([C@](c1ccccc1Cl)O)O Chemical compound *=C([C@](c1ccccc1Cl)O)O 0.000 description 1
- ONUNDAQVOOLWTH-UHFFFAOYSA-N CC(NC(CO)C(OC)=O)=O Chemical compound CC(NC(CO)C(OC)=O)=O ONUNDAQVOOLWTH-UHFFFAOYSA-N 0.000 description 1
- WPLANNRKFDHEKD-SNVBAGLBSA-N COC[C@H](C(NCc1ccccc1)=O)N Chemical compound COC[C@H](C(NCc1ccccc1)=O)N WPLANNRKFDHEKD-SNVBAGLBSA-N 0.000 description 1
- MYZCBJRJVXAQIV-UHFFFAOYSA-N NCC(NCc1ccccc1)=O Chemical compound NCC(NCc1ccccc1)=O MYZCBJRJVXAQIV-UHFFFAOYSA-N 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2010A000127A IT1398044B1 (it) | 2010-01-29 | 2010-01-29 | Processo per la preparazione della lacosamide |
| ITMI2010A000127 | 2010-01-29 | ||
| PCT/IB2010/056014 WO2011092559A1 (en) | 2010-01-29 | 2010-12-22 | Process for the synthesis of lacosamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518092A JP2013518092A (ja) | 2013-05-20 |
| JP2013518092A5 true JP2013518092A5 (enExample) | 2013-12-05 |
| JP5779592B2 JP5779592B2 (ja) | 2015-09-16 |
Family
ID=42174220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550525A Expired - Fee Related JP5779592B2 (ja) | 2010-01-29 | 2010-12-22 | ラコサミドの合成のための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8796488B2 (enExample) |
| EP (1) | EP2528892B1 (enExample) |
| JP (1) | JP5779592B2 (enExample) |
| KR (1) | KR101766506B1 (enExample) |
| CN (1) | CN102822140B (enExample) |
| BR (1) | BR112012018625A2 (enExample) |
| CL (1) | CL2012002082A1 (enExample) |
| ES (1) | ES2495815T3 (enExample) |
| IL (1) | IL220936A (enExample) |
| IT (1) | IT1398044B1 (enExample) |
| RU (1) | RU2585762C2 (enExample) |
| WO (1) | WO2011092559A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013030654A1 (en) | 2011-08-29 | 2013-03-07 | Signa S.A. De C.V. | Processes for the preparation of (r)-2-acetamido-n-benzyl-3-methoxypropionamide and intermediates thereof |
| CN102516114B (zh) * | 2011-10-28 | 2014-04-16 | 杭州迪克化工技术有限公司 | 一种r-(-)-2-氨基-3-甲氧基-n-苄基丙酰胺-d-酒石酸盐及其制备方法 |
| CN102424655B (zh) * | 2011-10-28 | 2014-04-16 | 杭州迪克化工技术有限公司 | 一种r-(-)-2-乙酰胺基-3-甲氧基-n-苄基丙酰胺的制备方法 |
| GB201219627D0 (en) | 2012-11-01 | 2012-12-12 | Cambrex Karlskoga Ab | New process |
| WO2016021711A1 (ja) * | 2014-08-07 | 2016-02-11 | 株式会社エーピーアイ コーポレーション | アミノ酸誘導体の製造方法 |
| JPWO2016039393A1 (ja) * | 2014-09-10 | 2017-06-22 | 株式会社エーピーアイ コーポレーション | アミノ酸誘導体の製造方法 |
| CN106699605B (zh) * | 2015-07-21 | 2019-08-20 | 上海医药集团股份有限公司 | 一种拉科酰胺中间体的甲基化方法 |
| CN106699595B (zh) * | 2015-07-21 | 2019-04-12 | 上海医药集团股份有限公司 | 一种拉科酰胺制备方法 |
| IN2015CH05001A (enExample) * | 2015-09-18 | 2015-10-16 | Divis Lab Ltd | |
| EP3659997A1 (en) | 2015-11-13 | 2020-06-03 | API Corporation | Method for producing lacosamide and intermediate thereof |
| CN107641087A (zh) * | 2017-06-01 | 2018-01-30 | 合肥远志医药科技开发有限公司 | 一种工业化拉科酰胺的制备方法 |
| JP2022072636A (ja) * | 2020-10-30 | 2022-05-17 | 住友化学株式会社 | アミド化合物の製造方法 |
| CN112574058B (zh) * | 2020-12-31 | 2023-04-28 | 珠海润都制药股份有限公司 | 一种拉考沙胺的合成路线 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5773475A (en) * | 1997-03-17 | 1998-06-30 | Research Corporation Technologies, Inc. | Anticonvulsant enantiomeric amino acid derivatives |
| AU718577B2 (en) * | 1996-03-15 | 2000-04-13 | Research Corporation Technologies, Inc. | Anticonvulsant enantiomeric amino acid derivatives |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| CN100584821C (zh) * | 2007-07-31 | 2010-01-27 | 浙江九洲药业股份有限公司 | 一种制备光学纯度叔亮氨酸的方法 |
| US8093426B2 (en) * | 2007-12-04 | 2012-01-10 | Ranbaxy Laboratories Limited | Intermediate compounds and their use in preparation of lacosamide |
| CN101333175A (zh) * | 2008-07-29 | 2008-12-31 | 东南大学 | 制备d-天冬酰胺及d-高丝氨酸的方法 |
| EP2352721B1 (en) * | 2008-11-07 | 2013-03-27 | UCB Pharma GmbH | Novel process for the preparation of amino acid derivatives |
-
2010
- 2010-01-29 IT ITMI2010A000127A patent/IT1398044B1/it active
- 2010-12-22 WO PCT/IB2010/056014 patent/WO2011092559A1/en not_active Ceased
- 2010-12-22 US US13/575,152 patent/US8796488B2/en not_active Expired - Fee Related
- 2010-12-22 JP JP2012550525A patent/JP5779592B2/ja not_active Expired - Fee Related
- 2010-12-22 RU RU2012131215/04A patent/RU2585762C2/ru not_active IP Right Cessation
- 2010-12-22 EP EP10814670.5A patent/EP2528892B1/en not_active Not-in-force
- 2010-12-22 ES ES10814670.5T patent/ES2495815T3/es active Active
- 2010-12-22 KR KR1020127022484A patent/KR101766506B1/ko not_active Expired - Fee Related
- 2010-12-22 BR BR112012018625A patent/BR112012018625A2/pt not_active IP Right Cessation
- 2010-12-22 CN CN201080061927.6A patent/CN102822140B/zh not_active Expired - Fee Related
-
2012
- 2012-07-12 IL IL220936A patent/IL220936A/en not_active IP Right Cessation
- 2012-07-26 CL CL2012002082A patent/CL2012002082A1/es unknown
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