JP5779592B2 - ラコサミドの合成のための方法 - Google Patents

ラコサミドの合成のための方法 Download PDF

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JP5779592B2
JP5779592B2 JP2012550525A JP2012550525A JP5779592B2 JP 5779592 B2 JP5779592 B2 JP 5779592B2 JP 2012550525 A JP2012550525 A JP 2012550525A JP 2012550525 A JP2012550525 A JP 2012550525A JP 5779592 B2 JP5779592 B2 JP 5779592B2
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carried out
compound
solvent
formula
organic solvent
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Japanese (ja)
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JP2013518092A (ja
JP2013518092A5 (enExample
Inventor
ボローニャ アルベルト
ボローニャ アルベルト
カストルディ パトリジア
カストルディ パトリジア
ベルガーニ ドメニコ
ベルガーニ ドメニコ
ベルトリーニ ジョルジオ
ベルトリーニ ジョルジオ
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ユーティカルズ ソシエタ ペル アチオニ
ユーティカルズ ソシエタ ペル アチオニ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
JP2012550525A 2010-01-29 2010-12-22 ラコサミドの合成のための方法 Expired - Fee Related JP5779592B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2010A000127A IT1398044B1 (it) 2010-01-29 2010-01-29 Processo per la preparazione della lacosamide
ITMI2010A000127 2010-01-29
PCT/IB2010/056014 WO2011092559A1 (en) 2010-01-29 2010-12-22 Process for the synthesis of lacosamide

Publications (3)

Publication Number Publication Date
JP2013518092A JP2013518092A (ja) 2013-05-20
JP2013518092A5 JP2013518092A5 (enExample) 2013-12-05
JP5779592B2 true JP5779592B2 (ja) 2015-09-16

Family

ID=42174220

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012550525A Expired - Fee Related JP5779592B2 (ja) 2010-01-29 2010-12-22 ラコサミドの合成のための方法

Country Status (12)

Country Link
US (1) US8796488B2 (enExample)
EP (1) EP2528892B1 (enExample)
JP (1) JP5779592B2 (enExample)
KR (1) KR101766506B1 (enExample)
CN (1) CN102822140B (enExample)
BR (1) BR112012018625A2 (enExample)
CL (1) CL2012002082A1 (enExample)
ES (1) ES2495815T3 (enExample)
IL (1) IL220936A (enExample)
IT (1) IT1398044B1 (enExample)
RU (1) RU2585762C2 (enExample)
WO (1) WO2011092559A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013030654A1 (en) 2011-08-29 2013-03-07 Signa S.A. De C.V. Processes for the preparation of (r)-2-acetamido-n-benzyl-3-methoxypropionamide and intermediates thereof
CN102424655B (zh) * 2011-10-28 2014-04-16 杭州迪克化工技术有限公司 一种r-(-)-2-乙酰胺基-3-甲氧基-n-苄基丙酰胺的制备方法
CN102516114B (zh) * 2011-10-28 2014-04-16 杭州迪克化工技术有限公司 一种r-(-)-2-氨基-3-甲氧基-n-苄基丙酰胺-d-酒石酸盐及其制备方法
GB201219627D0 (en) 2012-11-01 2012-12-12 Cambrex Karlskoga Ab New process
WO2016021711A1 (ja) * 2014-08-07 2016-02-11 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法
WO2016039393A1 (ja) * 2014-09-10 2016-03-17 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法
CN106699595B (zh) * 2015-07-21 2019-04-12 上海医药集团股份有限公司 一种拉科酰胺制备方法
CN106699605B (zh) * 2015-07-21 2019-08-20 上海医药集团股份有限公司 一种拉科酰胺中间体的甲基化方法
IN2015CH05001A (enExample) * 2015-09-18 2015-10-16 Divis Lab Ltd
WO2017082396A1 (ja) 2015-11-13 2017-05-18 株式会社エーピーアイ コーポレーション ラコサミド及びその中間体の製造方法
CN107641087A (zh) * 2017-06-01 2018-01-30 合肥远志医药科技开发有限公司 一种工业化拉科酰胺的制备方法
JP2022072636A (ja) * 2020-10-30 2022-05-17 住友化学株式会社 アミド化合物の製造方法
CN112574058B (zh) * 2020-12-31 2023-04-28 珠海润都制药股份有限公司 一种拉考沙胺的合成路线

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773475A (en) 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
ATE268169T1 (de) * 1996-03-15 2004-06-15 Res Corp Technologies Inc Antikonvulsive enantiomerische aminosäurederivate
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
CN100584821C (zh) * 2007-07-31 2010-01-27 浙江九洲药业股份有限公司 一种制备光学纯度叔亮氨酸的方法
US8093426B2 (en) 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
CN101333175A (zh) * 2008-07-29 2008-12-31 东南大学 制备d-天冬酰胺及d-高丝氨酸的方法
WO2010052011A1 (en) * 2008-11-07 2010-05-14 Ucb Pharma, S.A. Novel process for the preparation of amino acid derivatives

Also Published As

Publication number Publication date
CL2012002082A1 (es) 2013-07-26
IL220936A (en) 2014-11-30
RU2012131215A (ru) 2014-03-10
IT1398044B1 (it) 2013-02-07
JP2013518092A (ja) 2013-05-20
KR20130006438A (ko) 2013-01-16
ES2495815T3 (es) 2014-09-17
EP2528892A1 (en) 2012-12-05
ITMI20100127A1 (it) 2011-07-30
US8796488B2 (en) 2014-08-05
EP2528892B1 (en) 2014-06-04
KR101766506B1 (ko) 2017-08-08
RU2585762C2 (ru) 2016-06-10
WO2011092559A1 (en) 2011-08-04
IL220936A0 (en) 2012-09-24
US20130030216A1 (en) 2013-01-31
BR112012018625A2 (pt) 2016-04-05
CN102822140A (zh) 2012-12-12
CN102822140B (zh) 2014-10-22

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