BR112012018625A2 - archimica - Google Patents
archimicaInfo
- Publication number
- BR112012018625A2 BR112012018625A2 BR112012018625A BR112012018625A BR112012018625A2 BR 112012018625 A2 BR112012018625 A2 BR 112012018625A2 BR 112012018625 A BR112012018625 A BR 112012018625A BR 112012018625 A BR112012018625 A BR 112012018625A BR 112012018625 A2 BR112012018625 A2 BR 112012018625A2
- Authority
- BR
- Brazil
- Prior art keywords
- lacosamide
- enantiometer
- low cost
- racemic mixture
- mixture
- Prior art date
Links
- VPPJLAIAVCUEMN-GFCCVEGCSA-N lacosamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC=C1 VPPJLAIAVCUEMN-GFCCVEGCSA-N 0.000 abstract 3
- 229960002623 lacosamide Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000007031 hydroxymethylation reaction Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100001223 noncarcinogenic Toxicity 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N serine Chemical compound OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/20—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2010A000127A IT1398044B1 (it) | 2010-01-29 | 2010-01-29 | Processo per la preparazione della lacosamide |
| PCT/IB2010/056014 WO2011092559A1 (en) | 2010-01-29 | 2010-12-22 | Process for the synthesis of lacosamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012018625A2 true BR112012018625A2 (pt) | 2016-04-05 |
Family
ID=42174220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012018625A BR112012018625A2 (pt) | 2010-01-29 | 2010-12-22 | archimica |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8796488B2 (enExample) |
| EP (1) | EP2528892B1 (enExample) |
| JP (1) | JP5779592B2 (enExample) |
| KR (1) | KR101766506B1 (enExample) |
| CN (1) | CN102822140B (enExample) |
| BR (1) | BR112012018625A2 (enExample) |
| CL (1) | CL2012002082A1 (enExample) |
| ES (1) | ES2495815T3 (enExample) |
| IL (1) | IL220936A (enExample) |
| IT (1) | IT1398044B1 (enExample) |
| RU (1) | RU2585762C2 (enExample) |
| WO (1) | WO2011092559A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2847285C (en) | 2011-08-29 | 2019-10-01 | Signa S.A. De C.V. | Processes for the preparation of (r)-2-acetamido-n-benzyl-3-methoxypropionamide and intermediates thereof |
| CN102424655B (zh) * | 2011-10-28 | 2014-04-16 | 杭州迪克化工技术有限公司 | 一种r-(-)-2-乙酰胺基-3-甲氧基-n-苄基丙酰胺的制备方法 |
| CN102516114B (zh) * | 2011-10-28 | 2014-04-16 | 杭州迪克化工技术有限公司 | 一种r-(-)-2-氨基-3-甲氧基-n-苄基丙酰胺-d-酒石酸盐及其制备方法 |
| GB201219627D0 (en) | 2012-11-01 | 2012-12-12 | Cambrex Karlskoga Ab | New process |
| WO2016021711A1 (ja) * | 2014-08-07 | 2016-02-11 | 株式会社エーピーアイ コーポレーション | アミノ酸誘導体の製造方法 |
| WO2016039393A1 (ja) * | 2014-09-10 | 2016-03-17 | 株式会社エーピーアイ コーポレーション | アミノ酸誘導体の製造方法 |
| CN106699595B (zh) * | 2015-07-21 | 2019-04-12 | 上海医药集团股份有限公司 | 一种拉科酰胺制备方法 |
| CN106699605B (zh) * | 2015-07-21 | 2019-08-20 | 上海医药集团股份有限公司 | 一种拉科酰胺中间体的甲基化方法 |
| IN2015CH05001A (enExample) | 2015-09-18 | 2015-10-16 | Divis Lab Ltd | |
| EP3659997A1 (en) | 2015-11-13 | 2020-06-03 | API Corporation | Method for producing lacosamide and intermediate thereof |
| CN107641087A (zh) * | 2017-06-01 | 2018-01-30 | 合肥远志医药科技开发有限公司 | 一种工业化拉科酰胺的制备方法 |
| JP2022072636A (ja) * | 2020-10-30 | 2022-05-17 | 住友化学株式会社 | アミド化合物の製造方法 |
| CN112574058B (zh) * | 2020-12-31 | 2023-04-28 | 珠海润都制药股份有限公司 | 一种拉考沙胺的合成路线 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1038522E (pt) * | 1996-03-15 | 2004-10-29 | Res Corp Technologies Inc | Derivados enantiomericos anticonvulsivos de aminoacidos |
| US5773475A (en) * | 1997-03-17 | 1998-06-30 | Research Corporation Technologies, Inc. | Anticonvulsant enantiomeric amino acid derivatives |
| EP1642889A1 (en) | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| CN100584821C (zh) * | 2007-07-31 | 2010-01-27 | 浙江九洲药业股份有限公司 | 一种制备光学纯度叔亮氨酸的方法 |
| US8093426B2 (en) | 2007-12-04 | 2012-01-10 | Ranbaxy Laboratories Limited | Intermediate compounds and their use in preparation of lacosamide |
| CN101333175A (zh) * | 2008-07-29 | 2008-12-31 | 东南大学 | 制备d-天冬酰胺及d-高丝氨酸的方法 |
| KR101755548B1 (ko) * | 2008-11-07 | 2017-07-07 | 유씨비 파르마 게엠베하 | 아미노산 유도체의 제조 방법 |
-
2010
- 2010-01-29 IT ITMI2010A000127A patent/IT1398044B1/it active
- 2010-12-22 BR BR112012018625A patent/BR112012018625A2/pt not_active IP Right Cessation
- 2010-12-22 ES ES10814670.5T patent/ES2495815T3/es active Active
- 2010-12-22 US US13/575,152 patent/US8796488B2/en not_active Expired - Fee Related
- 2010-12-22 KR KR1020127022484A patent/KR101766506B1/ko not_active Expired - Fee Related
- 2010-12-22 RU RU2012131215/04A patent/RU2585762C2/ru not_active IP Right Cessation
- 2010-12-22 JP JP2012550525A patent/JP5779592B2/ja not_active Expired - Fee Related
- 2010-12-22 CN CN201080061927.6A patent/CN102822140B/zh not_active Expired - Fee Related
- 2010-12-22 EP EP10814670.5A patent/EP2528892B1/en not_active Not-in-force
- 2010-12-22 WO PCT/IB2010/056014 patent/WO2011092559A1/en not_active Ceased
-
2012
- 2012-07-12 IL IL220936A patent/IL220936A/en not_active IP Right Cessation
- 2012-07-26 CL CL2012002082A patent/CL2012002082A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102822140B (zh) | 2014-10-22 |
| US8796488B2 (en) | 2014-08-05 |
| CN102822140A (zh) | 2012-12-12 |
| KR20130006438A (ko) | 2013-01-16 |
| EP2528892A1 (en) | 2012-12-05 |
| IL220936A0 (en) | 2012-09-24 |
| EP2528892B1 (en) | 2014-06-04 |
| RU2012131215A (ru) | 2014-03-10 |
| JP2013518092A (ja) | 2013-05-20 |
| ITMI20100127A1 (it) | 2011-07-30 |
| IT1398044B1 (it) | 2013-02-07 |
| US20130030216A1 (en) | 2013-01-31 |
| CL2012002082A1 (es) | 2013-07-26 |
| IL220936A (en) | 2014-11-30 |
| ES2495815T3 (es) | 2014-09-17 |
| KR101766506B1 (ko) | 2017-08-08 |
| RU2585762C2 (ru) | 2016-06-10 |
| JP5779592B2 (ja) | 2015-09-16 |
| WO2011092559A1 (en) | 2011-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08E | Application fees: payment of additional fee required [chapter 8.5 patent gazette] |
Free format text: COMPLEMENTAR A RETRIBUICAO DA 8A ANUIDADE, DE ACORDO COM TABELA VIGENTE, REFERENTE A GUIA DE RECOLHIMENTO 29409161803259778. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 8A ANUIDADE (COMPLEMENTACAO). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2509 DE 05-02-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |