CN102822140B - 合成拉科酰胺的方法 - Google Patents

合成拉科酰胺的方法 Download PDF

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Publication number
CN102822140B
CN102822140B CN201080061927.6A CN201080061927A CN102822140B CN 102822140 B CN102822140 B CN 102822140B CN 201080061927 A CN201080061927 A CN 201080061927A CN 102822140 B CN102822140 B CN 102822140B
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China
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carried out
acid
compound
solvent
temperature
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Expired - Fee Related
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CN201080061927.6A
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English (en)
Chinese (zh)
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CN102822140A (zh
Inventor
A·博洛尼亚
P·卡斯托蒂
D·韦尔加尼
G·贝托里尼
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Poli Industria Chimica SpA
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Poli Industria Chimica SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201080061927.6A 2010-01-29 2010-12-22 合成拉科酰胺的方法 Expired - Fee Related CN102822140B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2010A000127 2010-01-29
ITMI2010A000127A IT1398044B1 (it) 2010-01-29 2010-01-29 Processo per la preparazione della lacosamide
PCT/IB2010/056014 WO2011092559A1 (en) 2010-01-29 2010-12-22 Process for the synthesis of lacosamide

Publications (2)

Publication Number Publication Date
CN102822140A CN102822140A (zh) 2012-12-12
CN102822140B true CN102822140B (zh) 2014-10-22

Family

ID=42174220

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CN201080061927.6A Expired - Fee Related CN102822140B (zh) 2010-01-29 2010-12-22 合成拉科酰胺的方法

Country Status (12)

Country Link
US (1) US8796488B2 (enExample)
EP (1) EP2528892B1 (enExample)
JP (1) JP5779592B2 (enExample)
KR (1) KR101766506B1 (enExample)
CN (1) CN102822140B (enExample)
BR (1) BR112012018625A2 (enExample)
CL (1) CL2012002082A1 (enExample)
ES (1) ES2495815T3 (enExample)
IL (1) IL220936A (enExample)
IT (1) IT1398044B1 (enExample)
RU (1) RU2585762C2 (enExample)
WO (1) WO2011092559A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX337610B (es) 2011-08-29 2016-03-10 Signa S A De C V Proceso para la preparacion de (r)-2-acetamido-n-bencil-3-metoxipr opionamida e intermediarios de la misma.
CN102424655B (zh) * 2011-10-28 2014-04-16 杭州迪克化工技术有限公司 一种r-(-)-2-乙酰胺基-3-甲氧基-n-苄基丙酰胺的制备方法
CN102516114B (zh) * 2011-10-28 2014-04-16 杭州迪克化工技术有限公司 一种r-(-)-2-氨基-3-甲氧基-n-苄基丙酰胺-d-酒石酸盐及其制备方法
GB201219627D0 (en) 2012-11-01 2012-12-12 Cambrex Karlskoga Ab New process
JPWO2016021711A1 (ja) * 2014-08-07 2017-06-01 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法
JPWO2016039393A1 (ja) * 2014-09-10 2017-06-22 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法
CN106699605B (zh) * 2015-07-21 2019-08-20 上海医药集团股份有限公司 一种拉科酰胺中间体的甲基化方法
CN106699595B (zh) * 2015-07-21 2019-04-12 上海医药集团股份有限公司 一种拉科酰胺制备方法
IN2015CH05001A (enExample) * 2015-09-18 2015-10-16 Divis Lab Ltd
EP3659997A1 (en) 2015-11-13 2020-06-03 API Corporation Method for producing lacosamide and intermediate thereof
CN107641087A (zh) * 2017-06-01 2018-01-30 合肥远志医药科技开发有限公司 一种工业化拉科酰胺的制备方法
JP2022072636A (ja) * 2020-10-30 2022-05-17 住友化学株式会社 アミド化合物の製造方法
CN112574058B (zh) * 2020-12-31 2023-04-28 珠海润都制药股份有限公司 一种拉考沙胺的合成路线

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773475A (en) * 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
CN101100436A (zh) * 2007-07-31 2008-01-09 浙江九洲药业股份有限公司 一种制备光学纯度叔亮氨酸的方法
CN101333175A (zh) * 2008-07-29 2008-12-31 东南大学 制备d-天冬酰胺及d-高丝氨酸的方法
CN102209707A (zh) * 2008-11-07 2011-10-05 优时比制药有限公司 制备氨基酸衍生物的新方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2248317C (en) * 1996-03-15 2003-12-02 Harold Kohn Anticonvulsant enantiomeric amino acid derivatives
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US8093426B2 (en) 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773475A (en) * 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
CN101100436A (zh) * 2007-07-31 2008-01-09 浙江九洲药业股份有限公司 一种制备光学纯度叔亮氨酸的方法
CN101333175A (zh) * 2008-07-29 2008-12-31 东南大学 制备d-天冬酰胺及d-高丝氨酸的方法
CN102209707A (zh) * 2008-11-07 2011-10-05 优时比制药有限公司 制备氨基酸衍生物的新方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Synthesis and anticonvulsant activities of (R)-(O)-methylserine derivatives;Shridhar V. Andurkar等;《Tetrahedron: Asymmetry》;19981106;第9卷(第21期);第3731-3918页 *
Synthesis and Anticonvulsant Activities of N-Benzyl-2-acetamidopropionamide Derivatives;Daeock Choi等;《J. Med. Chem.》;19960426;第39卷;第1907-1916页 *

Also Published As

Publication number Publication date
IL220936A (en) 2014-11-30
KR101766506B1 (ko) 2017-08-08
ITMI20100127A1 (it) 2011-07-30
US8796488B2 (en) 2014-08-05
RU2012131215A (ru) 2014-03-10
RU2585762C2 (ru) 2016-06-10
WO2011092559A1 (en) 2011-08-04
IT1398044B1 (it) 2013-02-07
ES2495815T3 (es) 2014-09-17
CL2012002082A1 (es) 2013-07-26
IL220936A0 (en) 2012-09-24
BR112012018625A2 (pt) 2016-04-05
CN102822140A (zh) 2012-12-12
EP2528892A1 (en) 2012-12-05
JP2013518092A (ja) 2013-05-20
JP5779592B2 (ja) 2015-09-16
KR20130006438A (ko) 2013-01-16
EP2528892B1 (en) 2014-06-04
US20130030216A1 (en) 2013-01-31

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