JP2021520829A5 - - Google Patents

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Publication number
JP2021520829A5
JP2021520829A5 JP2020556782A JP2020556782A JP2021520829A5 JP 2021520829 A5 JP2021520829 A5 JP 2021520829A5 JP 2020556782 A JP2020556782 A JP 2020556782A JP 2020556782 A JP2020556782 A JP 2020556782A JP 2021520829 A5 JP2021520829 A5 JP 2021520829A5
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JP
Japan
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seq
nos
fusion protein
variant
domain
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JP2020556782A
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English (en)
Japanese (ja)
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JP2021520829A (ja
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Priority claimed from PCT/US2019/028192 external-priority patent/WO2019204655A1/en
Publication of JP2021520829A publication Critical patent/JP2021520829A/ja
Publication of JP2021520829A5 publication Critical patent/JP2021520829A5/ja
Pending legal-status Critical Current

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JP2020556782A 2018-04-18 2019-04-18 IL−15/IL−15RA Fc融合タンパク質およびTIM−3抗原結合ドメインを含む、TIM−3標的化ヘテロ二量体融合タンパク質 Pending JP2021520829A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862659626P 2018-04-18 2018-04-18
US62/659,626 2018-04-18
US201862783110P 2018-12-20 2018-12-20
US62/783,110 2018-12-20
PCT/US2019/028192 WO2019204655A1 (en) 2018-04-18 2019-04-18 Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains

Publications (2)

Publication Number Publication Date
JP2021520829A JP2021520829A (ja) 2021-08-26
JP2021520829A5 true JP2021520829A5 (enExample) 2022-04-25

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Application Number Title Priority Date Filing Date
JP2020556782A Pending JP2021520829A (ja) 2018-04-18 2019-04-18 IL−15/IL−15RA Fc融合タンパク質およびTIM−3抗原結合ドメインを含む、TIM−3標的化ヘテロ二量体融合タンパク質

Country Status (9)

Country Link
US (2) US11505595B2 (enExample)
EP (1) EP3781598A1 (enExample)
JP (1) JP2021520829A (enExample)
KR (1) KR20210003814A (enExample)
CN (1) CN112437777A (enExample)
AU (1) AU2019256529A1 (enExample)
CA (1) CA3097741A1 (enExample)
IL (1) IL278089A (enExample)
WO (1) WO2019204655A1 (enExample)

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CN113321736B (zh) * 2020-12-30 2024-01-09 苏州复融生物技术有限公司 一种长效化白介素15融合蛋白及其制备方法和应用
CN112979809B (zh) * 2021-02-24 2021-11-09 北京昭衍生物技术有限公司 一种与抗原tim-3结合的靶向分子
CN112961239B (zh) * 2021-02-24 2021-09-10 北京昭衍生物技术有限公司 Tim抑制剂及其应用
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MX2023011964A (es) * 2021-04-09 2024-01-08 Ose Immunotherapeutics Nuevo andamio para moléculas bifuncionales con propiedades mejoradas.
EP4376869A1 (en) * 2021-07-28 2024-06-05 Genentech, Inc. Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of blood cancers
US20240025968A1 (en) * 2022-04-07 2024-01-25 Xencor, Inc. LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS
CN116217735A (zh) * 2022-08-03 2023-06-06 深圳市先康达生命科学有限公司 一种自分泌IL-15与anti-TIM3结合的融合蛋白及其应用
CN115807020A (zh) * 2022-09-23 2023-03-17 卡瑞济(北京)生命科技有限公司 白介素15受体α装甲CAR-T细胞在降低白介素15诱导的细胞毒性中的用途
CN121949562A (zh) * 2024-10-30 2026-05-01 钱杭江医药科技(嘉兴)有限公司 一种新型蛋白复合物的二聚体化合物及其制备方法和制药用途
CN120289652B (zh) * 2025-04-16 2026-02-13 广东拓普灵生物医药科技有限公司 一种nk细胞的制备方法及其在肿瘤免疫治疗中的应用
CN122011187A (zh) * 2025-08-21 2026-05-12 合肥综合性国家科学中心大健康研究院 抗猪b细胞表面cd19的抗体或其抗原结合片段及其组合物和应用

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