JP2015530983A5 - - Google Patents
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- JP2015530983A5 JP2015530983A5 JP2015525845A JP2015525845A JP2015530983A5 JP 2015530983 A5 JP2015530983 A5 JP 2015530983A5 JP 2015525845 A JP2015525845 A JP 2015525845A JP 2015525845 A JP2015525845 A JP 2015525845A JP 2015530983 A5 JP2015530983 A5 JP 2015530983A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fusion protein
- igg class
- heavy chain
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020001507 fusion proteins Proteins 0.000 claims 18
- 102000037865 fusion proteins Human genes 0.000 claims 18
- 102000003814 Interleukin-10 Human genes 0.000 claims 11
- 108090000174 Interleukin-10 Proteins 0.000 claims 11
- 239000000178 monomer Substances 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 108010087819 Fc receptors Proteins 0.000 claims 6
- 102000009109 Fc receptors Human genes 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108010073807 IgG Receptors Proteins 0.000 claims 2
- 102000009490 IgG Receptors Human genes 0.000 claims 2
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims 1
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims 1
- 101001033233 Homo sapiens Interleukin-10 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 1
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 102000052620 human IL10 Human genes 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018190250A JP6985232B2 (ja) | 2012-08-08 | 2018-10-05 | インターロイキン−１０融合タンパク質及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179709.6 | 2012-08-08 | ||
| EP12179709 | 2012-08-08 | ||
| PCT/EP2013/066342 WO2014023673A1 (en) | 2012-08-08 | 2013-08-05 | Interleukin-10 fusion proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018190250A Division JP6985232B2 (ja) | 2012-08-08 | 2018-10-05 | インターロイキン−１０融合タンパク質及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015530983A JP2015530983A (ja) | 2015-10-29 |
| JP2015530983A5 true JP2015530983A5 (enExample) | 2016-09-29 |
Family
ID=48917543
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525845A Pending JP2015530983A (ja) | 2012-08-08 | 2013-08-05 | インターロイキン−１０融合タンパク質及びその使用 |
| JP2018190250A Expired - Fee Related JP6985232B2 (ja) | 2012-08-08 | 2018-10-05 | インターロイキン−１０融合タンパク質及びその使用 |
| JP2021009946A Withdrawn JP2021087426A (ja) | 2012-08-08 | 2021-01-26 | インターロイキン−１０融合タンパク質及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018190250A Expired - Fee Related JP6985232B2 (ja) | 2012-08-08 | 2018-10-05 | インターロイキン−１０融合タンパク質及びその使用 |
| JP2021009946A Withdrawn JP2021087426A (ja) | 2012-08-08 | 2021-01-26 | インターロイキン−１０融合タンパク質及びその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9346872B2 (enExample) |
| EP (1) | EP2882774B1 (enExample) |
| JP (3) | JP2015530983A (enExample) |
| KR (1) | KR20150038012A (enExample) |
| CN (1) | CN104540848B (enExample) |
| AR (1) | AR092050A1 (enExample) |
| AU (1) | AU2013301656A1 (enExample) |
| BR (1) | BR112015002085A2 (enExample) |
| CA (1) | CA2876285A1 (enExample) |
| CL (1) | CL2014003605A1 (enExample) |
| CO (1) | CO7151522A2 (enExample) |
| CR (1) | CR20140565A (enExample) |
| EA (1) | EA201500208A1 (enExample) |
| IL (1) | IL236809A0 (enExample) |
| MA (1) | MA20150232A1 (enExample) |
| MX (1) | MX2015001675A (enExample) |
| PE (1) | PE20150645A1 (enExample) |
| PH (1) | PH12015500284A1 (enExample) |
| SG (1) | SG11201408526SA (enExample) |
| TW (1) | TW201418283A (enExample) |
| WO (1) | WO2014023673A1 (enExample) |
| ZA (1) | ZA201409304B (enExample) |
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| JP6254146B2 (ja) | 2012-03-27 | 2017-12-27 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 代謝障害を治療するための組成物および方法 |
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| JP2009536170A (ja) | 2006-05-08 | 2009-10-08 | フィロジェン・エッセペア | 治療用の抗体標的指向サイトカイン |
| EP2209805B1 (en) * | 2007-10-30 | 2017-09-06 | Philogen S.p.A. | An antigen associated with rheumatoid arthritis |
| WO2010005389A1 (en) * | 2008-07-11 | 2010-01-14 | Forskarpatent I Syd Ab | Oxidized ldl specific antibody-fusion and conjugated proteins |
| RU2583876C2 (ru) | 2009-08-17 | 2016-05-10 | Роше Гликарт Аг | Иммуноконъюгаты направленного действия |
| PE20171512A1 (es) | 2010-08-13 | 2017-10-20 | Roche Glycart Ag | Anticuerpos anti-fap |
| LT2691417T (lt) | 2011-03-29 | 2018-10-25 | Roche Glycart Ag | Antikūno fc variantai |
| EA201892619A1 (ru) * | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| BR112016016658A2 (pt) | 2014-02-06 | 2018-01-23 | F. Hoffmann-La Roche Ag | proteína de fusão de um anticorpo, polinucleotídeo, vetor, célula hospedeira, composição farmacêutica, métodos para produzir uma proteína de fusão e de tratamento de uma doença em um indivíduo e uso da proteína de fusão |
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2013
- 2013-08-05 US US13/959,051 patent/US9346872B2/en not_active Expired - Fee Related
- 2013-08-05 SG SG11201408526SA patent/SG11201408526SA/en unknown
- 2013-08-05 KR KR1020157003225A patent/KR20150038012A/ko not_active Withdrawn
- 2013-08-05 EA EA201500208A patent/EA201500208A1/ru unknown
- 2013-08-05 MA MA37793A patent/MA20150232A1/fr unknown
- 2013-08-05 AU AU2013301656A patent/AU2013301656A1/en not_active Abandoned
- 2013-08-05 WO PCT/EP2013/066342 patent/WO2014023673A1/en not_active Ceased
- 2013-08-05 EP EP13745407.0A patent/EP2882774B1/en active Active
- 2013-08-05 MX MX2015001675A patent/MX2015001675A/es unknown
- 2013-08-05 BR BR112015002085A patent/BR112015002085A2/pt not_active Application Discontinuation
- 2013-08-05 JP JP2015525845A patent/JP2015530983A/ja active Pending
- 2013-08-05 PE PE2015000169A patent/PE20150645A1/es not_active Application Discontinuation
- 2013-08-05 CN CN201380041222.1A patent/CN104540848B/zh not_active Expired - Fee Related
- 2013-08-05 CA CA2876285A patent/CA2876285A1/en not_active Abandoned
- 2013-08-06 AR ARP130102781A patent/AR092050A1/es unknown
- 2013-08-07 TW TW102128385A patent/TW201418283A/zh unknown
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2014
- 2014-12-05 CR CR20140565A patent/CR20140565A/es unknown
- 2014-12-12 CO CO14273530A patent/CO7151522A2/es unknown
- 2014-12-17 ZA ZA2014/09304A patent/ZA201409304B/en unknown
- 2014-12-31 CL CL2014003605A patent/CL2014003605A1/es unknown
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2015
- 2015-01-19 IL IL236809A patent/IL236809A0/en unknown
- 2015-02-09 PH PH12015500284A patent/PH12015500284A1/en unknown
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2016
- 2016-04-27 US US15/140,414 patent/US10040843B2/en active Active
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2018
- 2018-10-05 JP JP2018190250A patent/JP6985232B2/ja not_active Expired - Fee Related
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2021
- 2021-01-26 JP JP2021009946A patent/JP2021087426A/ja not_active Withdrawn
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