JP2019503686A5 - - Google Patents

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Publication number

JP2019503686A5

JP2019503686A5 JP2018535399A JP2018535399A JP2019503686A5 JP 2019503686 A5 JP2019503686 A5 JP 2019503686A5 JP 2018535399 A JP2018535399 A JP 2018535399A JP 2018535399 A JP2018535399 A JP 2018535399A JP 2019503686 A5 JP2019503686 A5 JP 2019503686A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

sequence

cdr

Prior art date

2017-01-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 102000040430 polynucleotide Human genes 0.000 claims description 27
• 108091033319 polynucleotide Proteins 0.000 claims description 27
• 239000002157 polynucleotide Substances 0.000 claims description 27
• 238000000034 method Methods 0.000 claims description 16
• 210000004369 blood Anatomy 0.000 claims description 13
• 239000008280 blood Substances 0.000 claims description 13
• 108010054395 P-selectin ligand protein Proteins 0.000 claims description 12
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 12
• 239000000539 dimer Substances 0.000 claims description 12
• 208000027866 inflammatory disease Diseases 0.000 claims description 12
• 230000001404 mediated effect Effects 0.000 claims description 12
• 239000000178 monomer Substances 0.000 claims description 12
• 229920001184 polypeptide Polymers 0.000 claims description 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
• 201000004681 Psoriasis Diseases 0.000 claims description 11
• 238000002054 transplantation Methods 0.000 claims description 10
• 238000006467 substitution reaction Methods 0.000 claims description 7
• 210000004027 cell Anatomy 0.000 claims description 6
• 238000004519 manufacturing process Methods 0.000 claims description 5
• 208000009329 Graft vs Host Disease Diseases 0.000 claims description 4
• 210000004899 c-terminal region Anatomy 0.000 claims description 4
• 239000003937 drug carrier Substances 0.000 claims description 4
• 208000024908 graft versus host disease Diseases 0.000 claims description 4
• 210000001519 tissue Anatomy 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 2
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• 208000011231 Crohn disease Diseases 0.000 claims description 2
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 2
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• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
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• 125000003607 serino group Chemical class [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims description 2
• 210000003491 skin Anatomy 0.000 claims description 2
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• 201000006704 Ulcerative Colitis Diseases 0.000 description 1