JP2018537966A5 - - Google Patents
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- JP2018537966A5 JP2018537966A5 JP2018521308A JP2018521308A JP2018537966A5 JP 2018537966 A5 JP2018537966 A5 JP 2018537966A5 JP 2018521308 A JP2018521308 A JP 2018521308A JP 2018521308 A JP2018521308 A JP 2018521308A JP 2018537966 A5 JP2018537966 A5 JP 2018537966A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- polypeptide chain
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 644
- 229920001184 polypeptide Polymers 0.000 claims 248
- 102000004196 processed proteins & peptides Human genes 0.000 claims 248
- 108090000765 processed proteins & peptides Proteins 0.000 claims 248
- 102000023732 binding proteins Human genes 0.000 claims 39
- 108091008324 binding proteins Proteins 0.000 claims 39
- 102000004169 proteins and genes Human genes 0.000 claims 20
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 239000013598 vector Substances 0.000 claims 13
- 238000006467 substitution reaction Methods 0.000 claims 10
- 108060003951 Immunoglobulin Proteins 0.000 claims 8
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 8
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 8
- 102000018358 immunoglobulin Human genes 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 6
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 108090000288 Glycoproteins Proteins 0.000 claims 4
- 102000003886 Glycoproteins Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 238000011225 antiretroviral therapy Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021016190A JP7328267B2 (ja) | 2015-10-25 | 2021-02-04 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| JP2023061823A JP7724814B2 (ja) | 2015-10-25 | 2023-04-06 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246113P | 2015-10-25 | 2015-10-25 | |
| US62/246,113 | 2015-10-25 | ||
| EP16305211.1 | 2016-02-24 | ||
| EP16305211 | 2016-02-24 | ||
| US201662322029P | 2016-04-13 | 2016-04-13 | |
| US62/322,029 | 2016-04-13 | ||
| US201662331169P | 2016-05-03 | 2016-05-03 | |
| US62/331,169 | 2016-05-03 | ||
| PCT/US2016/058540 WO2017074878A1 (en) | 2015-10-25 | 2016-10-24 | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021016190A Division JP7328267B2 (ja) | 2015-10-25 | 2021-02-04 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537966A JP2018537966A (ja) | 2018-12-27 |
| JP2018537966A5 true JP2018537966A5 (enExample) | 2019-11-21 |
| JP7169190B2 JP7169190B2 (ja) | 2022-11-10 |
Family
ID=55588187
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521308A Active JP7169190B2 (ja) | 2015-10-25 | 2016-10-24 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| JP2021016190A Active JP7328267B2 (ja) | 2015-10-25 | 2021-02-04 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| JP2023061823A Active JP7724814B2 (ja) | 2015-10-25 | 2023-04-06 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021016190A Active JP7328267B2 (ja) | 2015-10-25 | 2021-02-04 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| JP2023061823A Active JP7724814B2 (ja) | 2015-10-25 | 2023-04-06 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US20190054182A1 (enExample) |
| EP (2) | EP3819310A1 (enExample) |
| JP (3) | JP7169190B2 (enExample) |
| KR (1) | KR102687212B1 (enExample) |
| CN (4) | CN116789841A (enExample) |
| AR (1) | AR106466A1 (enExample) |
| AU (2) | AU2016347058B2 (enExample) |
| BR (1) | BR112018008011A2 (enExample) |
| CA (1) | CA3002664A1 (enExample) |
| CL (1) | CL2018001065A1 (enExample) |
| CO (1) | CO2018005337A2 (enExample) |
| CR (1) | CR20180288A (enExample) |
| DO (1) | DOP2018000102A (enExample) |
| EA (1) | EA201891028A1 (enExample) |
| ES (1) | ES2894304T3 (enExample) |
| HR (1) | HRP20211528T1 (enExample) |
| HU (1) | HUE056608T2 (enExample) |
| IL (2) | IL301140A (enExample) |
| MA (1) | MA42641A1 (enExample) |
| MX (2) | MX2018005048A (enExample) |
| MY (1) | MY192278A (enExample) |
| PE (1) | PE20181167A1 (enExample) |
| PH (1) | PH12018500873A1 (enExample) |
| PL (1) | PL3365366T3 (enExample) |
| RS (1) | RS62437B1 (enExample) |
| SG (1) | SG11201803324VA (enExample) |
| SI (1) | SI3365366T1 (enExample) |
| TW (3) | TW202442675A (enExample) |
| UY (1) | UY36965A (enExample) |
| WO (1) | WO2017074878A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10376583B2 (en) | 2013-09-30 | 2019-08-13 | Beth Israel Deaconess Medical Center, Inc. | Human immunodeficiency virus therapies utilizing N332-glycan-dependent antibodies and a reservoir activator |
| US10308707B2 (en) | 2013-12-02 | 2019-06-04 | Aaron Diamond Aids Research Center | Bispecific HIV-1-neutralizing antibodies |
| CN106459186B (zh) * | 2014-02-28 | 2021-02-02 | 美国卫生和人力服务部 | 针对hiv-1 v1v2 env区域的广谱中和性单克隆抗体 |
| MX2018005048A (es) | 2015-10-25 | 2018-09-06 | Sanofi Sa | Proteinas de union triespecificas y/o trivalantes para la prevencion o el tratamiento de la infeccion por vih. |
| AU2016349392B2 (en) * | 2015-11-03 | 2023-07-13 | The Trustees Of Columbia University In The City Of New York | Neutralizing antibodies to HIV-1 gp41 and their use |
| BR112018070998A2 (pt) * | 2016-04-13 | 2019-02-26 | Sanofi | proteínas de ligação triespecíficas e/ou trivalentes |
| SI3443006T1 (sl) * | 2016-04-13 | 2024-01-31 | Sanofi | Trispecifični in/ali trivalentni vezni proteini |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| CA3053774A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| US10626169B2 (en) | 2017-02-17 | 2020-04-21 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| WO2018183294A1 (en) * | 2017-03-27 | 2018-10-04 | David Weiner | Dna antibody constructs for use against hiv |
| US10882907B2 (en) | 2017-06-21 | 2021-01-05 | Gilead Sciences, Inc. | Multispecific antibodies that target HIV GP120 and CD3 |
| CN120058938A (zh) | 2017-10-10 | 2025-05-30 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
| WO2019123262A1 (en) * | 2017-12-18 | 2019-06-27 | VIIV Healthcare UK (No.5) Limited | Antigen binding polypeptides |
| TWI745643B (zh) * | 2017-12-21 | 2021-11-11 | 紐約市哥倫比亞大學理事會 | 雙專一性hiv-1-中和性抗體 |
| WO2019140320A1 (en) | 2018-01-12 | 2019-07-18 | Genzyme Corporation | Methods for the quantitation of polypeptides |
| US11845788B2 (en) | 2018-05-22 | 2023-12-19 | Beth Israel Deaconess Medical Center, Inc. | Antibody therapies for human immunodeficiency virus (HIV) |
| MX2021004147A (es) * | 2018-10-09 | 2021-09-08 | Sanofi Sa | Proteínas de unión triespecíficas anti-cd38, anti-cd28 y anti-cd3 y métodos de uso para tratar una infección viral. |
| US12459989B2 (en) * | 2018-11-21 | 2025-11-04 | Beth Israel Deaconess Medical Center, Inc. | Antibody therapies for human immunodeficiency virus (HIV) |
| CN113950484B (zh) * | 2019-04-09 | 2025-07-29 | 赛诺菲 | 三特异性结合蛋白、其方法和用途 |
| TW202104274A (zh) * | 2019-04-09 | 2021-02-01 | 法商賽諾菲公司 | 用於治療ｈｉｖ感染之三特異性及／或三價結合蛋白 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| EP4048690A1 (en) | 2019-10-25 | 2022-08-31 | Sanofi | Methods for analyzing chain mispairing in multispecific binding proteins |
| WO2021203103A2 (en) * | 2020-04-03 | 2021-10-07 | Somasekar Seshagiri | Ace2 receptor polymorphisms and varying susceptibility to sars-cov-2, methods for diagnosis and treatment |
| MX2023002194A (es) * | 2020-08-25 | 2023-03-03 | Gilead Sciences Inc | Moleculas multiespecificas de union a antigenos dirigidas al vih y metodos de uso. |
| US20230235092A1 (en) * | 2021-09-29 | 2023-07-27 | Modex Therapeutics | Antigen binding polypeptides, antigen binding polypeptide complexes and methods of use thereof |
| TW202325744A (zh) * | 2021-09-29 | 2023-07-01 | 美商莫德斯醫療公司 | 用於ｈｉｖ之抗原結合多肽、抗原結合多肽複合物及其使用方法 |
| CN118591388A (zh) * | 2021-09-29 | 2024-09-03 | 摩德斯医疗股份有限公司 | 抗原结合多肽、抗原结合多肽复合物及其使用方法 |
| WO2025109206A1 (en) | 2023-11-22 | 2025-05-30 | Mabylon Ag | Multispecific anti-allergen antibodies and uses thereof |
| WO2025108551A1 (en) | 2023-11-23 | 2025-05-30 | Mabylon Ag | Multispecific anti-allergen antibodies and uses thereof |
| WO2025238419A1 (en) | 2024-05-17 | 2025-11-20 | Sanofi | Methods of treating cancer using trispecific binding proteins targeting her2-expressing tumors |
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| ES2058199T3 (es) | 1987-09-23 | 1994-11-01 | Bristol Myers Squibb Co | Heteroconjugados de anticuerpos para la eliminacion de celulas infectadas por el vih. |
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| CN1294148C (zh) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | 环状单链三特异抗体 |
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| WO2017053556A1 (en) | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
| MX2018005048A (es) | 2015-10-25 | 2018-09-06 | Sanofi Sa | Proteinas de union triespecificas y/o trivalantes para la prevencion o el tratamiento de la infeccion por vih. |
| CN105837688B (zh) | 2015-11-20 | 2019-02-26 | 北京大学深圳研究生院 | 单域抗体及其编码基因，免疫毒素及其编码基因、制备方法、表达载体、应用，及宿主细胞 |
| MA44077A (fr) | 2015-12-15 | 2021-05-05 | Gilead Sciences Inc | Anticorps neutralisants le virus de l'immunodéficience humaine |
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| SI3443006T1 (sl) | 2016-04-13 | 2024-01-31 | Sanofi | Trispecifični in/ali trivalentni vezni proteini |
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| CA3053774A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| US10626169B2 (en) | 2017-02-17 | 2020-04-21 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| WO2018183294A1 (en) | 2017-03-27 | 2018-10-04 | David Weiner | Dna antibody constructs for use against hiv |
| CN120058938A (zh) | 2017-10-10 | 2025-05-30 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
| MX2021004147A (es) | 2018-10-09 | 2021-09-08 | Sanofi Sa | Proteínas de unión triespecíficas anti-cd38, anti-cd28 y anti-cd3 y métodos de uso para tratar una infección viral. |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
-
2016
- 2016-10-24 MX MX2018005048A patent/MX2018005048A/es unknown
- 2016-10-24 WO PCT/US2016/058540 patent/WO2017074878A1/en not_active Ceased
- 2016-10-24 SI SI201631358T patent/SI3365366T1/sl unknown
- 2016-10-24 JP JP2018521308A patent/JP7169190B2/ja active Active
- 2016-10-24 IL IL301140A patent/IL301140A/en unknown
- 2016-10-24 EP EP20197556.2A patent/EP3819310A1/en active Pending
- 2016-10-24 HR HRP20211528TT patent/HRP20211528T1/hr unknown
- 2016-10-24 CR CR20180288A patent/CR20180288A/es unknown
- 2016-10-24 EA EA201891028A patent/EA201891028A1/ru unknown
- 2016-10-24 PE PE2018000603A patent/PE20181167A1/es unknown
- 2016-10-24 PL PL16794472T patent/PL3365366T3/pl unknown
- 2016-10-24 ES ES16794472T patent/ES2894304T3/es active Active
- 2016-10-24 SG SG11201803324VA patent/SG11201803324VA/en unknown
- 2016-10-24 US US15/770,471 patent/US20190054182A1/en not_active Abandoned
- 2016-10-24 CN CN202310186776.6A patent/CN116789841A/zh active Pending
- 2016-10-24 AU AU2016347058A patent/AU2016347058B2/en active Active
- 2016-10-24 CA CA3002664A patent/CA3002664A1/en active Pending
- 2016-10-24 CN CN202310185803.8A patent/CN117069855A/zh active Pending
- 2016-10-24 MA MA42641A patent/MA42641A1/fr unknown
- 2016-10-24 RS RS20211266A patent/RS62437B1/sr unknown
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