SG11201805557SA - Tetravalent anti-psgl-1 antibodies and uses thereof - Google Patents

Tetravalent anti-psgl-1 antibodies and uses thereof

Info

Publication number
SG11201805557SA
SG11201805557SA SG11201805557SA SG11201805557SA SG11201805557SA SG 11201805557S A SG11201805557S A SG 11201805557SA SG 11201805557S A SG11201805557S A SG 11201805557SA SG 11201805557S A SG11201805557S A SG 11201805557SA SG 11201805557S A SG11201805557S A SG 11201805557SA
Authority
SG
Singapore
Prior art keywords
antibodies
international
psgl
tetravalent
scfv
Prior art date
Application number
SG11201805557SA
Inventor
Rong-Hwa Lin
Shih-Yao Lin
Yu-Ying Tsai
Original Assignee
Bioalliance Cv
Abgenomics Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioalliance Cv, Abgenomics Int Inc filed Critical Bioalliance Cv
Publication of SG11201805557SA publication Critical patent/SG11201805557SA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111010111111011111111111101111011111 International Bureau 0.. .... .. ..... ..or::,,, (10) International Publication Number (43) International Publication Date WO 2017/120534 Al 13 July 2017 (13.07.2017) WI P0 I P CT (51) International Patent C07K 16/18 (2006.01) (21) International Application (22) International Filing (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/276,806 8 (71) Applicants: BIOALLIANCE weg 103, 1043 GP TERNATIONAL Highway, Dover, DE (72) Inventors: LIN, Rong-Hwa; Palo Alto, CA 94306 Lane 105, Lishan Street, Neihu District, Taipei, 114 (TW). — TSAI, Yu-Ying; 3f., No. 7 Alley 15, Lane 121, Jinghua Classification: (81) Designated States (unless otherwise indicated, for every A61K 39/395 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/US2017/012621 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 6 January 2017 (06.01.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. January 2016 (08.01.2016) US (84) Designated States (unless otherwise indicated, for every C.V. [NL/NL]; Kingsford- kind of regional protection available): ARIPO (BW, GH, Amsterdam (NL). ABGENOMICS IN- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, INC. [US/US]; 3500 South Dupont TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 19901 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 4201 Juniper Lane Unit G, DK, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (US). LIN, Shih-Yao; 7f., No. 1, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CL CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Taipei City, 116 (TW). Published: et al.; Morrison & Foerster LLP, — with international search report (Art. 21(3)) San Francisco, CA 94105-2482 (US). with sequence listing part of description (Rule 5.2(a)) — Street, Wenshan District, _ (74) Agents: JONES, Kevin = 425 Market Street, (54) Title: TETRAVALENT ANTI-PSGL-1 .....___ _ _ _ _ _...._ (1) 01, 2 -Fc = ANTIBODIES AND USES ....... (2) tafv z - Fc THEREOF (3) scFv-IgG antibodies, these (VL) domains and tetravalent antibodies can be used in diseases, trans - = — ' 3 Gs) , .6GSAAA CAp Fc to F c igGGGGS),AGGGGS),Gif (GGGGSOG herein are tetravalent antibodies that specifically bind to human PSGL-1. Unlike bivalent a dimer of two monomers, with each monomer comprising two light chain variable (VH) domains. This enhanced efficacy as compared to bivalent PSGL-1 antibodies. These tetravalent antibodies therapeutic methods, V2 - iG664), ASTGS C WS c 1/2-wl-?4pFc V4 .. GGGGS), ASTS5 V2 . SAM Gapic V4-V2-g4pFc FIG. including without , .. AiSAAA 1 _GGS), format allows for cross-linker/FcR-expressing cell-independent GGSGS NC x 3 a ,-,SGA 0 yy I 36GGS) 5 . scFv 2 -LC-IgG4p LC - sOY2 -1 11 64 P V2 i ;GGGSj s scFv 4 - 4p 1A limitation treating T-cell mediated inflammatory = — = = = = = _ 11 71' M ir) 0 ei 11 L ------ (57) : Provided ::::) tetravalent antibodies contain N two heavy chain variable O against PSGL-1 that show a variety of diagnostic and plantations, and transfusions.
SG11201805557SA 2016-01-08 2017-01-06 Tetravalent anti-psgl-1 antibodies and uses thereof SG11201805557SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662276806P 2016-01-08 2016-01-08
PCT/US2017/012621 WO2017120534A1 (en) 2016-01-08 2017-01-06 Tetravalent anti-psgl-1 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
SG11201805557SA true SG11201805557SA (en) 2018-07-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201805557SA SG11201805557SA (en) 2016-01-08 2017-01-06 Tetravalent anti-psgl-1 antibodies and uses thereof

Country Status (17)

Country Link
US (4) US10472422B2 (en)
EP (1) EP3400239B1 (en)
JP (1) JP7078536B2 (en)
KR (1) KR20180117102A (en)
CN (1) CN108713026B (en)
AU (1) AU2017206074B2 (en)
BR (1) BR112018013912A2 (en)
CA (1) CA3010601A1 (en)
ES (1) ES2880731T3 (en)
IL (1) IL260289B (en)
MX (1) MX2018008144A (en)
NZ (1) NZ743815A (en)
RU (1) RU2766000C2 (en)
SG (1) SG11201805557SA (en)
TW (1) TWI753875B (en)
WO (1) WO2017120534A1 (en)
ZA (1) ZA201804328B (en)

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US10472422B2 (en) 2016-01-08 2019-11-12 Abgenomics International Inc. Tetravalent anti-PSGL-1 antibodies and uses thereof
KR20230132603A (en) 2017-01-11 2023-09-15 브리스톨-마이어스 스큅 컴퍼니 Psgl-1 antagonists and uses thereof
EP3595720A4 (en) 2017-03-14 2021-05-26 Five Prime Therapeutics, Inc. Antibodies binding to vista at acidic ph
EP3938400A4 (en) * 2019-03-11 2022-11-23 Memorial Sloan Kettering Cancer Center Cd22 antibodies and methods of using the same
CN113968910A (en) * 2019-07-11 2022-01-25 武汉友芝友生物制药有限公司 Tetravalent symmetric bispecific antibodies
CN114786720A (en) * 2019-12-05 2022-07-22 艾贝乐医药科技有限公司 Compositions of TriAx antibodies and methods of making and using the same
US20230149544A1 (en) * 2021-11-17 2023-05-18 Altrubio Inc. Methods of using anti-psgl-1 antibodies in combination with jak inhibitors to treat t-cell mediated inflammatory diseases or cancers

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