JP2020504507A5 - - Google Patents

Download PDF

Info

Publication number
JP2020504507A5
JP2020504507A5 JP2019534096A JP2019534096A JP2020504507A5 JP 2020504507 A5 JP2020504507 A5 JP 2020504507A5 JP 2019534096 A JP2019534096 A JP 2019534096A JP 2019534096 A JP2019534096 A JP 2019534096A JP 2020504507 A5 JP2020504507 A5 JP 2020504507A5
Authority
JP
Japan
Prior art keywords
region
charge carrier
charge
photodetection
charge carriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019534096A
Other languages
English (en)
Japanese (ja)
Other versions
JP7149275B2 (ja
JP2020504507A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/068089 external-priority patent/WO2018119347A1/en
Publication of JP2020504507A publication Critical patent/JP2020504507A/ja
Publication of JP2020504507A5 publication Critical patent/JP2020504507A5/ja
Priority to JP2022152536A priority Critical patent/JP7429744B2/ja
Application granted granted Critical
Publication of JP7149275B2 publication Critical patent/JP7149275B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019534096A 2016-12-22 2017-12-22 直接ビニングピクセルを備える集積光検出器 Active JP7149275B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022152536A JP7429744B2 (ja) 2016-12-22 2022-09-26 直接ビニングピクセルを備える集積光検出器

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662438051P 2016-12-22 2016-12-22
US62/438,051 2016-12-22
PCT/US2017/068089 WO2018119347A1 (en) 2016-12-22 2017-12-22 Integrated photodetector with direct binning pixel

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022152536A Division JP7429744B2 (ja) 2016-12-22 2022-09-26 直接ビニングピクセルを備える集積光検出器

Publications (3)

Publication Number Publication Date
JP2020504507A JP2020504507A (ja) 2020-02-06
JP2020504507A5 true JP2020504507A5 (enExample) 2021-02-04
JP7149275B2 JP7149275B2 (ja) 2022-10-06

Family

ID=61018002

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019534096A Active JP7149275B2 (ja) 2016-12-22 2017-12-22 直接ビニングピクセルを備える集積光検出器
JP2022152536A Active JP7429744B2 (ja) 2016-12-22 2022-09-26 直接ビニングピクセルを備える集積光検出器

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022152536A Active JP7429744B2 (ja) 2016-12-22 2022-09-26 直接ビニングピクセルを備える集積光検出器

Country Status (11)

Country Link
US (4) US10845308B2 (enExample)
EP (2) EP4224530A1 (enExample)
JP (2) JP7149275B2 (enExample)
KR (1) KR102560427B1 (enExample)
CN (2) CN110168732B (enExample)
AU (2) AU2017382316B2 (enExample)
BR (1) BR112019012540A2 (enExample)
CA (1) CA3047826A1 (enExample)
MX (2) MX388419B (enExample)
TW (2) TWI836905B (enExample)
WO (1) WO2018119347A1 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3194935B1 (en) 2014-08-08 2018-10-31 Quantum-si Incorporated Integrated device for temporal binning of received photons
US10886309B2 (en) 2015-11-06 2021-01-05 Artilux, Inc. High-speed light sensing apparatus II
US10418407B2 (en) 2015-11-06 2019-09-17 Artilux, Inc. High-speed light sensing apparatus III
US10254389B2 (en) 2015-11-06 2019-04-09 Artilux Corporation High-speed light sensing apparatus
KR20180111999A (ko) 2016-02-17 2018-10-11 테서렉트 헬스, 인코포레이티드 수명 촬상 및 검출 응용을 위한 센서 및 디바이스
CN110168732B (zh) 2016-12-22 2024-03-08 宽腾矽公司 具有直接合并像素的整合式光电侦测器
EP3669018A4 (en) 2017-08-18 2021-05-26 Nautilus Biotechnology, Inc. Binding reagent selection methods
US11105928B2 (en) 2018-02-23 2021-08-31 Artilux, Inc. Light-sensing apparatus and light-sensing method thereof
TWI758599B (zh) 2018-04-08 2022-03-21 美商光程研創股份有限公司 光偵測裝置
US11921238B2 (en) * 2018-05-18 2024-03-05 The Charles Stark Draper Laboratory, Inc. Convolved augmented range LIDAR nominal area
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
JP7070199B2 (ja) * 2018-07-25 2022-05-18 株式会社デンソー 光検出素子およびライダー装置
JP7056439B2 (ja) * 2018-07-25 2022-04-19 株式会社デンソー 光検出素子およびライダー装置
WO2020022313A1 (ja) * 2018-07-25 2020-01-30 株式会社デンソー 光検出素子およびライダー装置
US11018168B2 (en) * 2018-09-20 2021-05-25 Taiwan Semiconductor Manufacturing Co., Ltd. Image sensor with improved timing resolution and photon detection probability
MX2021005757A (es) 2018-11-15 2021-08-11 Quantum Si Inc Metodos y composiciones para la secuenciacion de proteinas.
EP3884048A4 (en) 2018-11-20 2022-08-17 Nautilus Biotechnology, Inc. DESIGN AND SELECTION OF AFFINITY REAGENTS
CN111385495B (zh) * 2018-12-29 2022-02-11 天津大学青岛海洋技术研究院 一种用于补偿tof传感器中电荷转移不完全的方法
WO2020186252A1 (en) 2019-03-14 2020-09-17 Insilixa, Inc. Methods and systems for time-gated fluorescent-based detection
CN119510370A (zh) * 2019-03-14 2025-02-25 因斯利克萨公司 基于时间门控的荧光检测的方法和系统
EP3963091A4 (en) 2019-04-29 2023-07-19 Nautilus Biotechnology, Inc. METHODS AND SYSTEMS FOR ON-CHIP INTEGRATED SINGLE MOLECULE DETECTION
US12481065B2 (en) 2019-05-01 2025-11-25 Sense Photonics, Inc. Event driven shared memory pixel
KR20220025853A (ko) 2019-06-28 2022-03-03 퀀텀-에스아이 인코포레이티드 광학적 및 전기적 2차 경로 제거
US11652184B2 (en) 2019-08-28 2023-05-16 Artilux, Inc. Photo-detecting apparatus with low dark current
US12477856B2 (en) 2019-08-28 2025-11-18 Artilux, Inc. Photo-detecting apparatus with low dark current
US12278252B2 (en) 2019-08-28 2025-04-15 Artilux, Inc. Photo-detecting apparatus with low dark current
US20210123921A1 (en) * 2019-10-17 2021-04-29 C2Sense, Inc. Diagnostic assays and related methods
US11726037B2 (en) * 2019-10-17 2023-08-15 C2Sense, Inc. Luminescence imaging for sensing and/or authentication
AU2020372908A1 (en) 2019-10-29 2022-06-02 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices
KR20220091534A (ko) * 2019-10-31 2022-06-30 퀀텀-에스아이 인코포레이티드 강화된 드레인을 갖는 픽셀
KR102718982B1 (ko) * 2019-12-05 2024-10-18 삼성전자주식회사 이미지 센서
US11869917B2 (en) * 2020-01-14 2024-01-09 Quantum-Si Incorporated Integrated sensor for lifetime characterization
EP4088319A1 (en) 2020-01-14 2022-11-16 Quantum-si Incorporated Sensor for lifetime plus spectral characterization
US11719639B2 (en) 2020-03-02 2023-08-08 Quantum-Si Incorporated Integrated sensor for multi-dimensional signal analysis
WO2021207400A2 (en) 2020-04-08 2021-10-14 Quantum-Si Incorporated Integrated sensor with reduced skew
JP2023527764A (ja) 2020-05-20 2023-06-30 クアンタム-エスアイ インコーポレイテッド タンパク質シーケンスのための方法及び組成物
US12356088B2 (en) * 2020-06-18 2025-07-08 Meta Platforms Technologies, Llc Multimode detector for different time-of-flight based depth sensing modalities
KR20230093003A (ko) 2020-10-22 2023-06-26 퀀텀-에스아이 인코포레이티드 순차적으로 결합된 전하 저장소를 갖는 집적 회로 및 연관된 기술들
JP2024500353A (ja) * 2020-12-11 2024-01-09 クアンタム-エスアイ インコーポレイテッド 電荷移動効率を向上した集積回路および関連技術
JP2023554368A (ja) 2020-12-15 2023-12-27 クアンタム-エスアイ インコーポレイテッド 単一分子速度論による分子バーコード分析
AU2022209365A1 (en) 2021-01-21 2023-07-20 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
KR102432200B1 (ko) * 2021-03-25 2022-08-12 재단법인 오송첨단의료산업진흥재단 형광정보 및 산성도 정보를 이용한 진단시스템 및 이를 이용한 진단방법
TW202249269A (zh) 2021-04-08 2022-12-16 美商寬騰矽公司 具有鏡像像素組態之積體電路
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
EP4405683A1 (en) 2021-09-22 2024-07-31 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US12328519B2 (en) 2022-02-15 2025-06-10 Novatek Microelectronics Corp. Image sensor
AU2023241893A1 (en) 2022-03-29 2024-09-26 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
US20250376716A1 (en) 2022-06-21 2025-12-11 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US12159887B2 (en) 2022-08-19 2024-12-03 Quantum-Si Incorporated Backside illuminated structures with parallel charge transfer
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
WO2024206122A1 (en) 2023-03-24 2024-10-03 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
WO2024243237A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
WO2025137166A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
WO2025199236A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Family Cites Families (206)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890500A (en) * 1974-02-11 1975-06-17 Gen Electric Apparatus for sensing radiation and providing electrical readout
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5355165A (en) 1992-08-06 1994-10-11 Princeton Scientific Instruments, Inc. Very high frame rate CCD imager
CA2155186A1 (en) 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
US5471515A (en) 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
PL317379A1 (en) 1994-05-27 1997-04-01 Ciba Geigy Ag Supercritically excited luminescence detecting process
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US6198869B1 (en) 1996-11-18 2001-03-06 Novartis Ag Measuring device and its use
ATE273381T1 (de) 1997-02-12 2004-08-15 Eugene Y Chan Verfahren zur analyse von polymeren
IT1290553B1 (it) * 1997-02-27 1998-12-10 Ist Nazionale Fisica Nucleare Rivelatore dell'energia e della posizione di incidenza di radiazioni elettromagnetiche o di particelle ionizzanti a deriva controllata
EP2208789B1 (en) 1997-03-12 2015-07-22 Applied Biosystems, LLC DNA polymerases having improved labeled nucleotide incorporation properties
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
EP0921196A1 (en) 1997-12-02 1999-06-09 Roche Diagnostics GmbH Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
WO1999049082A2 (en) 1998-03-23 1999-09-30 Invitrogen Corporation Modified nucleotides and methods useful for nucleic acid sequencing
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6280939B1 (en) 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
JP4326050B2 (ja) 1998-09-22 2009-09-02 ハイスペック合資会社 高速撮像素子
US6232075B1 (en) 1998-12-14 2001-05-15 Li-Cor, Inc. Heterogeneous assay for pyrophosphate detection
US6445491B2 (en) 1999-01-29 2002-09-03 Irma America, Inc. Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification
AU3174600A (en) 1999-03-10 2000-09-28 Asm Scientific, Inc. A method for direct nucleic acid sequencing
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
EP1681356B1 (en) 1999-05-19 2011-10-19 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6137117A (en) 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
CN2433618Y (zh) 1999-10-29 2001-06-06 中国科学院上海原子核研究所 基因芯片检测装置
US6399335B1 (en) 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
JP4433347B2 (ja) 2000-01-17 2010-03-17 富士フイルム株式会社 蛍光撮像装置
US20020090650A1 (en) * 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US7175811B2 (en) 2000-04-28 2007-02-13 Edgelight Biosciences Micro-array evanescent wave fluorescence detection device
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
US6975898B2 (en) 2000-06-19 2005-12-13 University Of Washington Medical imaging, diagnosis, and therapy using a scanning single optical fiber system
US7158224B2 (en) 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
EP1320596A4 (en) 2000-08-30 2005-01-12 Univ Rochester REVERSE TRANSCRIPTION REACTION METHOD USING REVERSE TRANSCRIPTASE CODED BY RETROTRANSPOSON NON-LTR
WO2002023167A1 (en) 2000-09-11 2002-03-21 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
EP1207387A1 (en) 2000-11-20 2002-05-22 Institut Curie Multi-photon imaging installation.
JP4270742B2 (ja) 2000-11-30 2009-06-03 Necエレクトロニクス株式会社 固体撮像装置
US7668697B2 (en) 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
JP2005508630A (ja) 2001-09-14 2005-04-07 インヴィトロジェン コーポレーション Dnaポリメラーゼとその変異体
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB2382648B (en) * 2001-12-11 2003-11-12 Amersham Pharm Biotech Uk Ltd System and method for time correlated multi-photon counting measurements
CN1138862C (zh) 2002-01-28 2004-02-18 国前 一种核酸分析用收集装置及其应用方法
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US6924887B2 (en) 2002-03-27 2005-08-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse
US8238993B2 (en) 2002-04-04 2012-08-07 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime
US20040144927A1 (en) 2003-01-28 2004-07-29 Auner Gregory W. Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040106163A1 (en) 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
WO2004047353A2 (en) 2002-11-19 2004-06-03 Safetzone Technologies Corporation Guest communication system and method
JP4896708B2 (ja) 2003-02-05 2012-03-14 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 新規リンカー類を有する末端リン酸標識ヌクレオチド類
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
FR2857158B1 (fr) * 2003-07-01 2006-04-28 St Microelectronics Sa Procede de commande d'un photocopieur de type mos
US7078670B2 (en) 2003-09-15 2006-07-18 Imagerlabs, Inc. Low noise charge gain circuit and CCD using same
WO2005073407A1 (en) 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
DE10348949A1 (de) 2003-10-18 2005-05-19 Bayer Healthcare Ag Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer
CA2542774A1 (en) 2003-10-18 2005-05-12 Bayer Healthcare Ag Direct observation of molecular modifications in biological test systems by measuring fluorescence lifetime
WO2005069737A2 (en) 2004-01-27 2005-08-04 Ramot At Tel Aviv University Ltd. Method and system for detecting analytes
DE602005020421D1 (de) 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
EP1583150A1 (en) * 2004-03-31 2005-10-05 CSEM Centre Suisse d'Electronique et de Microtechnique SA Image sensor with large-area, high-sensitivity and high-speed pixels
US20060019265A1 (en) 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
EP1622200A1 (en) 2004-07-26 2006-02-01 CSEM Centre Suisse d'Electronique et de Microtechnique SA Solid-state photodetector pixel and photodetecting method
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7345764B2 (en) 2005-02-07 2008-03-18 Vladimir Bulovic Apparatus and method for a slim format spectrometer
US20060223067A1 (en) 2005-03-31 2006-10-05 Paolo Vatta Mutant DNA polymerases and methods of use
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US7365299B2 (en) 2005-05-09 2008-04-29 Sensors Unlimited, Inc. Method and apparatus for providing flexible photodetector binning
EP1907584A2 (en) 2005-06-28 2008-04-09 Agencourt Personal Genomics Corporation Methods of producing and sequencing modified polynucleotides
WO2007045998A2 (en) 2005-07-01 2007-04-26 Dako Denmark A/S New nucleic acid base pairs
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US7501631B2 (en) * 2005-10-07 2009-03-10 Schick Technologies, Inc. Shielding an imaging array from X-ray noise
DE602006016984D1 (de) 2005-12-12 2010-10-28 Us Gov Health & Human Serv Sonde zum sequenzieren von nukleinsäure und verwendungsverfahren
CA2633524A1 (en) 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
AU2006331512B2 (en) 2005-12-22 2012-02-23 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
WO2007119626A1 (ja) 2006-03-31 2007-10-25 National University Corporation Shizuoka University 半導体測距素子及び固体撮像装置
DE102006030541B4 (de) 2006-06-23 2010-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
CA2662521C (en) 2006-09-01 2016-08-09 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
JP4710017B2 (ja) 2006-10-20 2011-06-29 国立大学法人静岡大学 Cmosイメージセンサ
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
KR101030263B1 (ko) 2006-11-30 2011-04-22 고쿠리츠 다이가꾸 호우진 시즈오까 다이가꾸 반도체 거리 측정 소자 및 고체 촬상 장치
JP5270835B2 (ja) 2006-12-29 2013-08-21 パナソニック株式会社 光検出素子、空間情報の検出装置
ATE509265T1 (de) 2007-03-22 2011-05-15 Univ Strasbourg Etablissement Public A Caractere Scient Culturel Et Professionel Gerät zur sortierung und konzentration elektromagnetischer energie und vorrichtung mit mindestens einem derartigen gerät
EP2134871B1 (en) 2007-03-30 2012-03-07 Pacific Biosciences of California, Inc. Systems and methods for enhancing fluorescent signals
US7873085B2 (en) 2007-10-23 2011-01-18 Andrei Babushkin Method and device for controlling optical output of laser diode
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
WO2009091847A2 (en) 2008-01-14 2009-07-23 Life Technologies Corporation Compositions, methods and systems for single molecule sequencing
AU2009212165A1 (en) 2008-02-07 2009-08-13 Pacific Biosciences Of California, Inc. CIS reactive oxygen quenchers integrated into linkers
US7968702B2 (en) 2008-03-13 2011-06-28 Pacific Biosciences Of California, Inc. Labeled reactants and their uses
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
CN102084001B (zh) 2008-03-28 2015-03-18 加利福尼亚太平洋生物科学股份有限公司 用于核酸测序的组合物和方法
WO2009145828A2 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
WO2009145818A1 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc Single molecule loading methods and compositions
JP5283216B2 (ja) * 2008-07-31 2013-09-04 国立大学法人静岡大学 高速電荷転送フォトダイオード、ロックインピクセル及び固体撮像装置
EP2316221A1 (en) 2008-08-28 2011-05-04 MESA Imaging AG Demodulation pixel with daisy chain charge storage sites and method of operation therefor
US20100148221A1 (en) * 2008-11-13 2010-06-17 Zena Technologies, Inc. Vertical photogate (vpg) pixel structure with nanowires
CA2974241C (en) 2008-09-16 2020-01-07 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8247216B2 (en) 2008-09-30 2012-08-21 Pacific Biosciences Of California, Inc. Ultra-high multiplex analytical systems and methods
EP2182523B1 (en) 2008-10-31 2013-01-09 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line
WO2010057185A1 (en) 2008-11-17 2010-05-20 Pacific Biosciences Of California, Inc. Phospholink nucleotides for sequencing applications
US8519340B2 (en) 2008-12-22 2013-08-27 Koninklijke Philips N.V. High dynamic range light sensor
US8338248B2 (en) 2008-12-25 2012-12-25 National University Corporation Shizuoka University Semiconductor element and solid-state imaging device
CA2750874A1 (en) 2009-01-30 2010-08-05 Oxford Nanopore Technologies Limited Hybridization linkers
WO2010102621A1 (en) 2009-03-12 2010-09-16 Rsp Systems A/S Optical probe for measuring light signals in vivo
US20100261185A1 (en) 2009-03-27 2010-10-14 Life Technologies Corporation Labeled enzyme compositions, methods and systems
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP5415805B2 (ja) 2009-03-31 2014-02-12 オリンパスメディカルシステムズ株式会社 診断支援装置
BRPI1006740A2 (pt) 2009-04-15 2017-07-11 Koninklijke Philips Electronics Nv Dispositivo para detecção de fluorescência com tempo controlado para aplicações de sequenciamento de dna e estrutura de dados
JP4798254B2 (ja) * 2009-05-13 2011-10-19 株式会社デンソー 受光デバイス及びその制御方法
US20120224053A1 (en) * 2009-06-17 2012-09-06 Board Of Regents, The University Of Texas System Method and apparatus for quantitative microimaging
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
CA2768330A1 (en) 2009-07-28 2011-02-03 F. Hoffmann-La Roche Ag Non-invasive in vivo optical imaging method
DE102009037596B4 (de) * 2009-08-14 2014-07-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pixelstruktur, System und Verfahren zur optischen Abstandsmessung sowie Steuerschaltung für die Pixelstruktur
JP5648922B2 (ja) * 2009-10-05 2015-01-07 国立大学法人静岡大学 半導体素子及び固体撮像装置
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
US9579402B2 (en) 2009-12-04 2017-02-28 Biotium, Inc. Heterocycle-substituted xanthene dyes
JP6017107B2 (ja) 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
US20110236983A1 (en) 2009-12-29 2011-09-29 Joseph Beechem Single molecule detection and sequencing using fluorescence lifetime imaging
EP2362207A1 (de) 2010-01-28 2011-08-31 F. Hoffmann-La Roche AG Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung
EP2537053B1 (en) 2010-02-19 2016-11-02 Pacific Biosciences of California, Inc. An analytical device comprising an optode array chip
CA2789932A1 (en) 2010-02-19 2011-08-25 Glysure Ltd Intravascular glucose sensor
JP2013534614A (ja) 2010-03-25 2013-09-05 モコン・インコーポレーテッド 発光寿命に基づく分析物検出装置及び校正技術
WO2011150431A1 (en) 2010-05-28 2011-12-01 The Regents Of The University Of Colorado, A Body Corporate Multi-photon tissue imaging
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
JP2012132741A (ja) 2010-12-21 2012-07-12 Fujifilm Corp 時間分解蛍光測定装置、及び方法
JP2012134827A (ja) * 2010-12-22 2012-07-12 Toshiba Corp 放射線画像検出器
US8946845B1 (en) * 2011-02-02 2015-02-03 Aptina Imaging Corporation Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors
CN103650187B (zh) * 2011-02-21 2016-11-02 密歇根大学董事会 包含电子传导激子阻挡层的有机光伏电池
WO2012117670A1 (ja) * 2011-03-01 2012-09-07 パナソニック株式会社 固体撮像装置
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US9968258B2 (en) 2011-09-12 2018-05-15 Tufts University Imaging fluorescence or luminescence lifetime
US20130090537A1 (en) 2011-10-07 2013-04-11 2M Engineering Limited Blood glucose sensor
US8778849B2 (en) 2011-10-28 2014-07-15 Illumina, Inc. Microarray fabrication system and method
WO2013066959A1 (en) 2011-10-31 2013-05-10 The Trustees Of Columbia University In The City Of New York Systems and methods for imaging using single photon avalanche diodes
US8804021B2 (en) * 2011-11-03 2014-08-12 Omnivision Technologies, Inc. Method, apparatus and system for providing improved full well capacity in an image sensor pixel
US9606060B2 (en) 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
EP3222627B1 (en) 2012-02-15 2019-08-07 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
DE102012206089B4 (de) * 2012-03-15 2017-02-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren
US20130256822A1 (en) * 2012-03-28 2013-10-03 Omnivision Technologies, Inc. Method and device with enhanced ion doping
CN102914525B (zh) 2012-04-10 2016-06-01 广东工业大学 基于光学加法外差调制的新型荧光寿命显微成像装置及方法
WO2013171197A1 (en) 2012-05-15 2013-11-21 Ait Austrian Institute Of Technology Gmbh Compact plasmon-enhanced fluorescence biosensor
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
CA2881823C (en) 2012-08-20 2019-06-11 Illumina, Inc. Method and system for fluorescence lifetime based sequencing
WO2014068951A1 (ja) * 2012-10-30 2014-05-08 パナソニック株式会社 試料保持担体およびそれを用いた蛍光検出装置
NL2011568A (en) 2012-10-31 2014-05-06 Asml Netherlands Bv Sensor and lithographic apparatus.
EP3734255B1 (en) 2012-12-18 2022-10-19 Pacific Biosciences Of California, Inc. An optical analytical device
KR102495290B1 (ko) * 2012-12-28 2023-02-06 가부시키가이샤 한도오따이 에네루기 켄큐쇼 반도체 장치
GB201302664D0 (en) 2013-02-15 2013-04-03 Cmosis Nv A pixel structure
US10206561B2 (en) * 2013-02-28 2019-02-19 DePuy Synthes Products, Inc. Videostroboscopy of vocal cords with CMOS sensors
US9741754B2 (en) * 2013-03-06 2017-08-22 Apple Inc. Charge transfer circuit with storage nodes in image sensors
KR102007277B1 (ko) * 2013-03-11 2019-08-05 삼성전자주식회사 3차원 이미지 센서의 거리 픽셀 및 이를 포함하는 3차원 이미지 센서
US9260251B2 (en) 2013-07-09 2016-02-16 Nd Industries, Inc. Multi-row magnetic dial for the conveyance of workpieces and related method
US20150042954A1 (en) 2013-08-08 2015-02-12 University Of Rochester System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics
MX392471B (es) 2013-11-17 2025-03-24 Quantum Si Inc Sistema optico y chip de ensayo para sondear, detectar y analizar moleculas
JP2016001712A (ja) * 2013-11-29 2016-01-07 株式会社半導体エネルギー研究所 半導体装置の作製方法
WO2015084991A1 (en) * 2013-12-04 2015-06-11 Rambus Inc. High dynamic-range image sensor
CN103728446B (zh) 2013-12-11 2016-02-24 天津大学 光子计数型多通道时间分辨荧光免疫分析系统及计数方法
US9736388B2 (en) 2013-12-13 2017-08-15 Bio-Rad Laboratories, Inc. Non-destructive read operations with dynamically growing images
WO2015163957A2 (en) 2014-01-31 2015-10-29 The General Hospital Corporation System and method for photoluminescence detection
TWI665778B (zh) * 2014-02-05 2019-07-11 日商半導體能源研究所股份有限公司 半導體裝置、模組及電子裝置
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
KR20150134543A (ko) * 2014-05-22 2015-12-02 삼성전자주식회사 소자 제조용 기판 및 반도체 소자
CN115989999A (zh) * 2014-07-24 2023-04-21 大学健康网络 用于诊断目的的数据的收集和分析
WO2016016761A1 (en) * 2014-07-31 2016-02-04 Semiconductor Energy Laboratory Co., Ltd. Method of manufacturing semiconductor device
EP3194935B1 (en) * 2014-08-08 2018-10-31 Quantum-si Incorporated Integrated device for temporal binning of received photons
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
BR112017002501B1 (pt) 2014-08-08 2022-06-07 Quantum-Si Incorporated Dispositivos integrados, sistemas, método de detecção de presença de molécula em amostra, método de formação de dispositivo integrado e método de análise de espécime
KR102472061B1 (ko) * 2014-08-08 2022-11-29 퀀텀-에스아이 인코포레이티드 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩
JP2018505565A (ja) * 2014-12-19 2018-02-22 ジーレイ スイッツァーランド エスアー モノリシックcmos集積ピクセル検出器ならびに様々な用途を含む粒子検出および撮像のためのシステムおよび方法
US9871065B2 (en) 2014-12-22 2018-01-16 Google Inc. RGBZ pixel unit cell with first and second Z transfer gates
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
CN107003410B (zh) 2015-02-09 2018-08-24 埃斯普罗光电股份公司 Tof距离传感器
EP4220256A1 (en) 2015-03-16 2023-08-02 Pacific Biosciences of California, Inc. Analytical system comprising integrated devices and systems for free-space optical coupling
EP3298389B1 (en) 2015-05-20 2021-09-29 Quantum-Si Incorporated Method of determining the sequence of a nucleic acid using time resolved luminescence
US10976257B2 (en) 2015-06-08 2021-04-13 The Regents Of The University Of Michigan Pixel circuit and method for optical sensing
CN105300949B (zh) 2015-11-26 2019-06-11 浙江大学 一种荧光寿命测量方法及装置
KR20180111999A (ko) 2016-02-17 2018-10-11 테서렉트 헬스, 인코포레이티드 수명 촬상 및 검출 응용을 위한 센서 및 디바이스
AU2017274412B2 (en) 2016-06-01 2022-07-21 Quantum-Si Incorporated Pulse caller and base caller
US10249656B2 (en) * 2016-06-07 2019-04-02 Semiconductor Components Industries, Llc Charge packet signal processing using pinned photodiode devices
EP4250361A3 (en) * 2016-12-13 2024-04-17 STMicroelectronics (Research & Development) Limited A charge storage cell and method of manufacturing a charge storage cell
CN110168732B (zh) 2016-12-22 2024-03-08 宽腾矽公司 具有直接合并像素的整合式光电侦测器
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
EP3844486A1 (en) 2018-08-29 2021-07-07 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors

Similar Documents

Publication Publication Date Title
JP2020504507A5 (enExample)
US12072448B2 (en) High-speed light sensing apparatus
JP2022183181A5 (enExample)
JP7114647B2 (ja) 光検出装置および光検出システム
JP6930805B2 (ja) 飛行時間型撮像素子
RU2666525C2 (ru) Устройство фотоэлектрического преобразования, аппарат измерения дальности и система обработки информации
KR102025522B1 (ko) 3차원 센서, 시스템, 및 관련 방법
CN108391450B (zh) 解调像素元件、像素元件阵列以及结合它们的光电元件
CN105810775B (zh) 一种基于cmos图像传感器工艺的np型单光子雪崩二极管
JP2021192452A (ja) 光検出器
JP2011009749A (ja) アバランシェフォトダイオード
JP2015188049A5 (enExample)
RU2012142682A (ru) Устройство фотоэлектрического преобразования и система формирования изображений
CN104779317A (zh) 背侧照明式单光子雪崩二极管及包括其的成像传感器系统
JPWO2016013170A1 (ja) フォトダイオード、フォトダイオードアレイ、及び固体撮像素子
JP2015005752A (ja) イメージセンサで使用される埋め込みフォトダイオードの改良
RU2012118396A (ru) Твердотельное устройство захвата изображения
WO2018029369A1 (en) A demodulator with a carrier generating pinned photodiode and a method for operating it
JP6985054B2 (ja) 撮像装置
JP2018019040A5 (enExample)
CN111279493A (zh) 电离辐射和电离粒子的集成传感器
CN103178134B (zh) 用于光信号的相位敏感检测的光电池器件
WO2019087596A1 (ja) 撮像装置及び撮像素子
US20150279895A1 (en) Image sensor
Turchetta Notes about the limits of ultra-high speed solid-state imagers