MX388419B - Fotodetector integrado con agrupamiento de pixeles directo - Google Patents
Fotodetector integrado con agrupamiento de pixeles directoInfo
- Publication number
- MX388419B MX388419B MX2019007530A MX2019007530A MX388419B MX 388419 B MX388419 B MX 388419B MX 2019007530 A MX2019007530 A MX 2019007530A MX 2019007530 A MX2019007530 A MX 2019007530A MX 388419 B MX388419 B MX 388419B
- Authority
- MX
- Mexico
- Prior art keywords
- integrated
- photodector
- charge carriers
- integrated circuit
- charge
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/80—Constructional details of image sensors
- H10F39/802—Geometry or disposition of elements in pixels, e.g. address-lines or gate electrodes
- H10F39/8023—Disposition of the elements in pixels, e.g. smaller elements in the centre of the imager compared to larger elements at the periphery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
- G01J1/44—Electric circuits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
- G01S7/483—Details of pulse systems
- G01S7/486—Receivers
- G01S7/4861—Circuits for detection, sampling, integration or read-out
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
- G01S7/483—Details of pulse systems
- G01S7/486—Receivers
- G01S7/4865—Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
- H04N25/70—SSIS architectures; Circuits associated therewith
- H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
- H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/011—Manufacture or treatment of image sensors covered by group H10F39/12
- H10F39/014—Manufacture or treatment of image sensors covered by group H10F39/12 of CMOS image sensors
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/011—Manufacture or treatment of image sensors covered by group H10F39/12
- H10F39/026—Wafer-level processing
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/10—Integrated devices
- H10F39/12—Image sensors
- H10F39/15—Charge-coupled device [CCD] image sensors
- H10F39/151—Geometry or disposition of pixel elements, address lines or gate electrodes
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/10—Integrated devices
- H10F39/12—Image sensors
- H10F39/15—Charge-coupled device [CCD] image sensors
- H10F39/156—CCD or CID colour image sensors
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/10—Integrated devices
- H10F39/12—Image sensors
- H10F39/18—Complementary metal-oxide-semiconductor [CMOS] image sensors; Photodiode array image sensors
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/80—Constructional details of image sensors
- H10F39/802—Geometry or disposition of elements in pixels, e.g. address-lines or gate electrodes
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/80—Constructional details of image sensors
- H10F39/803—Pixels having integrated switching, control, storage or amplification elements
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
- H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
- H10F39/80—Constructional details of image sensors
- H10F39/803—Pixels having integrated switching, control, storage or amplification elements
- H10F39/8037—Pixels having integrated switching, control, storage or amplification elements the integrated elements comprising a transistor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Computer Networks & Wireless Communication (AREA)
- Radar, Positioning & Navigation (AREA)
- Remote Sensing (AREA)
- Multimedia (AREA)
- Signal Processing (AREA)
- Genetics & Genomics (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Solid State Image Pick-Up Elements (AREA)
- Transforming Light Signals Into Electric Signals (AREA)
- Light Receiving Elements (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438051P | 2016-12-22 | 2016-12-22 | |
| PCT/US2017/068089 WO2018119347A1 (en) | 2016-12-22 | 2017-12-22 | Integrated photodetector with direct binning pixel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019007530A MX2019007530A (es) | 2019-08-16 |
| MX388419B true MX388419B (es) | 2025-03-19 |
Family
ID=61018002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019007530A MX388419B (es) | 2016-12-22 | 2017-12-22 | Fotodetector integrado con agrupamiento de pixeles directo |
| MX2021014745A MX2021014745A (es) | 2016-12-22 | 2019-06-21 | Fotodetector integrado con agrupamiento de pixeles directo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021014745A MX2021014745A (es) | 2016-12-22 | 2019-06-21 | Fotodetector integrado con agrupamiento de pixeles directo. |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10845308B2 (enExample) |
| EP (2) | EP4224530A1 (enExample) |
| JP (2) | JP7149275B2 (enExample) |
| KR (1) | KR102560427B1 (enExample) |
| CN (2) | CN110168732B (enExample) |
| AU (2) | AU2017382316B2 (enExample) |
| BR (1) | BR112019012540A2 (enExample) |
| CA (1) | CA3047826A1 (enExample) |
| MX (2) | MX388419B (enExample) |
| TW (2) | TWI796311B (enExample) |
| WO (1) | WO2018119347A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111710687B (zh) | 2014-08-08 | 2023-11-14 | 宽腾矽公司 | 基于入射光子到达时间的识别、成像、测序法及存储介质 |
| US10418407B2 (en) | 2015-11-06 | 2019-09-17 | Artilux, Inc. | High-speed light sensing apparatus III |
| US10254389B2 (en) | 2015-11-06 | 2019-04-09 | Artilux Corporation | High-speed light sensing apparatus |
| US10886309B2 (en) | 2015-11-06 | 2021-01-05 | Artilux, Inc. | High-speed light sensing apparatus II |
| TW202139919A (zh) | 2016-02-17 | 2021-11-01 | 美商太斯萊特健康股份有限公司 | 用於生命期成像及偵測應用之感測器及裝置 |
| CN110168732B (zh) | 2016-12-22 | 2024-03-08 | 宽腾矽公司 | 具有直接合并像素的整合式光电侦测器 |
| WO2019036055A2 (en) | 2017-08-18 | 2019-02-21 | Ignite Biosciences, Inc. | METHODS OF SELECTING BINDING REAGENTS |
| US11105928B2 (en) | 2018-02-23 | 2021-08-31 | Artilux, Inc. | Light-sensing apparatus and light-sensing method thereof |
| TWI780007B (zh) | 2018-04-08 | 2022-10-01 | 美商光程研創股份有限公司 | 光偵測裝置及其系統 |
| WO2019222684A1 (en) * | 2018-05-18 | 2019-11-21 | The Charles Stark Draper Laboratory, Inc. | Convolved augmented range lidar nominal area |
| MX2020013788A (es) | 2018-06-22 | 2021-03-02 | Quantum Si Inc | Fotodetector integrado con deposito de almacenamiento de carga con tiempo de deteccion variado. |
| JP7070199B2 (ja) * | 2018-07-25 | 2022-05-18 | 株式会社デンソー | 光検出素子およびライダー装置 |
| WO2020022313A1 (ja) * | 2018-07-25 | 2020-01-30 | 株式会社デンソー | 光検出素子およびライダー装置 |
| JP7056439B2 (ja) * | 2018-07-25 | 2022-04-19 | 株式会社デンソー | 光検出素子およびライダー装置 |
| US11018168B2 (en) * | 2018-09-20 | 2021-05-25 | Taiwan Semiconductor Manufacturing Co., Ltd. | Image sensor with improved timing resolution and photon detection probability |
| TWI863941B (zh) | 2018-11-15 | 2024-12-01 | 美商寬騰矽公司 | 用於蛋白質定序之方法及組合物 |
| JP2022513092A (ja) | 2018-11-20 | 2022-02-07 | ノーティラス・バイオテクノロジー・インコーポレイテッド | 親和性試薬の設計および選択 |
| CN111385495B (zh) * | 2018-12-29 | 2022-02-11 | 天津大学青岛海洋技术研究院 | 一种用于补偿tof传感器中电荷转移不完全的方法 |
| EP3937780A4 (en) * | 2019-03-14 | 2022-12-07 | InSilixa, Inc. | METHODS AND SYSTEMS FOR TIMED FLUORESCENCE-BASED DETECTION |
| AU2020266136B2 (en) | 2019-04-29 | 2026-04-02 | Nautilus Subsidiary, Inc. | Methods and systems for integrated on-chip single-molecule detection |
| WO2020223589A1 (en) * | 2019-05-01 | 2020-11-05 | Sense Photonics, Inc. | Event driven shared memory pixel |
| EP3973272A1 (en) | 2019-06-28 | 2022-03-30 | Quantum-Si Incorporated | Optical and electrical secondary path rejection |
| US11652184B2 (en) | 2019-08-28 | 2023-05-16 | Artilux, Inc. | Photo-detecting apparatus with low dark current |
| US12477856B2 (en) | 2019-08-28 | 2025-11-18 | Artilux, Inc. | Photo-detecting apparatus with low dark current |
| US12278252B2 (en) | 2019-08-28 | 2025-04-15 | Artilux, Inc. | Photo-detecting apparatus with low dark current |
| US20210116377A1 (en) * | 2019-10-17 | 2021-04-22 | C2Sense, Inc. | White light emissive species and related methods |
| KR20220098147A (ko) | 2019-10-17 | 2022-07-11 | 씨2센스, 인크. | 감지 및/또는 인증을 위한 발광 이미징 |
| EP4051903A1 (en) | 2019-10-29 | 2022-09-07 | Quantum-Si Incorporated | Peristaltic pumping of fluids and associated methods, systems, and devices |
| TW202137577A (zh) * | 2019-10-31 | 2021-10-01 | 美商寬騰矽公司 | 具有增強汲極之像素 |
| KR102718982B1 (ko) * | 2019-12-05 | 2024-10-18 | 삼성전자주식회사 | 이미지 센서 |
| AU2021208557A1 (en) * | 2020-01-14 | 2022-09-01 | Quantum-Si Incorporated | Sensor for lifetime plus spectral characterization |
| CA3168138A1 (en) * | 2020-01-14 | 2021-07-22 | Quantum-Si Incorporated | Integrated sensor for lifetime characterization |
| TW202147591A (zh) | 2020-03-02 | 2021-12-16 | 美商寬騰矽公司 | 用於多維信號分析之整合感應器 |
| KR20220165754A (ko) | 2020-04-08 | 2022-12-15 | 퀀텀-에스아이 인코포레이티드 | 스큐가 감소된 통합 센서 |
| AU2021276522A1 (en) | 2020-05-20 | 2023-01-05 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
| US12356088B2 (en) * | 2020-06-18 | 2025-07-08 | Meta Platforms Technologies, Llc | Multimode detector for different time-of-flight based depth sensing modalities |
| JP2023547110A (ja) * | 2020-10-22 | 2023-11-09 | クアンタム-エスアイ インコーポレイテッド | 順次結合電荷蓄積部を備える集積回路および関連技術 |
| IL303570A (en) * | 2020-12-11 | 2023-08-01 | Quantum Si Inc | An integrated circuit with improved charge transfer efficiency and related methods |
| AU2021401791A1 (en) | 2020-12-15 | 2023-07-06 | Quantum-Si Incorporated | Molecular barcode analysis by single-molecule kinetics |
| US20220227890A1 (en) | 2021-01-21 | 2022-07-21 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| KR102432200B1 (ko) * | 2021-03-25 | 2022-08-12 | 재단법인 오송첨단의료산업진흥재단 | 형광정보 및 산성도 정보를 이용한 진단시스템 및 이를 이용한 진단방법 |
| US20220328541A1 (en) | 2021-04-08 | 2022-10-13 | Quantum-Si Incorporated | Integrated circuit having mirrored pixel configuration |
| TW202312508A (zh) * | 2021-09-01 | 2023-03-16 | 美商伊路米納有限公司 | 半導體光接收 |
| EP4399528A1 (en) | 2021-09-09 | 2024-07-17 | Nautilus Subsidiary, Inc. | Characterization and localization of protein modifications |
| EP4405683A1 (en) | 2021-09-22 | 2024-07-31 | Nautilus Subsidiary, Inc. | Methods and systems for determining polypeptide interactions |
| WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| WO2023137051A2 (en) | 2022-01-12 | 2023-07-20 | Quantum-Si Incorporated | Integrated sensor |
| US12328519B2 (en) * | 2022-02-15 | 2025-06-10 | Novatek Microelectronics Corp. | Image sensor |
| CA3245990A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES |
| WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| WO2024039853A1 (en) * | 2022-08-19 | 2024-02-22 | Quantum-Si Incorporated | Backside illuminated structures with parallel charge transfer |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| US20240192202A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | Fluidic media for single-analtye arrays |
| EP4634285A1 (en) | 2022-12-15 | 2025-10-22 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| EP4689173A1 (en) | 2023-03-24 | 2026-02-11 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| US20240394902A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| US20250066841A1 (en) | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| US20250189519A1 (en) | 2023-12-11 | 2025-06-12 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| US20250205706A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| US20250298016A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
Family Cites Families (206)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3890500A (en) * | 1974-02-11 | 1975-06-17 | Gen Electric | Apparatus for sensing radiation and providing electrical readout |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| US5355165A (en) | 1992-08-06 | 1994-10-11 | Princeton Scientific Instruments, Inc. | Very high frame rate CCD imager |
| CA2155186A1 (en) | 1993-02-01 | 1994-08-18 | Kevin M. Ulmer | Methods and apparatus for dna sequencing |
| US5471515A (en) | 1994-01-28 | 1995-11-28 | California Institute Of Technology | Active pixel sensor with intra-pixel charge transfer |
| MXPA96005828A (es) | 1994-05-27 | 2005-07-15 | Novartis Ag Tambien Denominada | Proceso para detectar luminescencia excitada evanescentemente. |
| US5912155A (en) | 1994-09-30 | 1999-06-15 | Life Technologies, Inc. | Cloned DNA polymerases from Thermotoga neapolitana |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| US6261797B1 (en) | 1996-01-29 | 2001-07-17 | Stratagene | Primer-mediated polynucleotide synthesis and manipulation techniques |
| JP3748571B2 (ja) | 1996-11-18 | 2006-02-22 | ノバルティス アクチエンゲゼルシャフト | 測定装置及びその使用方法 |
| IL156002A0 (en) | 1997-02-12 | 2003-12-23 | Eugene Y Chan | Methods and products for analyzing polymers |
| IT1290553B1 (it) * | 1997-02-27 | 1998-12-10 | Ist Nazionale Fisica Nucleare | Rivelatore dell'energia e della posizione di incidenza di radiazioni elettromagnetiche o di particelle ionizzanti a deriva controllata |
| JP3435416B2 (ja) | 1997-03-12 | 2003-08-11 | ピーイー コーポレイション(エヌワイ) | 改善された標識ヌクレオチド取込み特性を有するdnaポリメラーゼ |
| US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
| US6825921B1 (en) | 1999-11-10 | 2004-11-30 | Molecular Devices Corporation | Multi-mode light detection system |
| DE19748211A1 (de) | 1997-10-31 | 1999-05-06 | Zeiss Carl Fa | Optisches Array-System und Reader für Mikrotiterplatten |
| EP0921196A1 (en) | 1997-12-02 | 1999-06-09 | Roche Diagnostics GmbH | Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction |
| DE19810879A1 (de) | 1998-03-13 | 1999-09-16 | Roche Diagnostics Gmbh | Polymerasenchimären |
| US6232103B1 (en) | 1998-03-23 | 2001-05-15 | Invitrogen Corporation | Methods useful for nucleic acid sequencing using modified nucleotides comprising phenylboronic acid |
| US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| GB9810350D0 (en) | 1998-05-14 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US6716394B2 (en) | 1998-08-11 | 2004-04-06 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
| US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
| US6280939B1 (en) | 1998-09-01 | 2001-08-28 | Veeco Instruments, Inc. | Method and apparatus for DNA sequencing using a local sensitive force detector |
| JP4326050B2 (ja) | 1998-09-22 | 2009-09-02 | ハイスペック合資会社 | 高速撮像素子 |
| WO2000036152A1 (en) | 1998-12-14 | 2000-06-22 | Li-Cor, Inc. | A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis |
| US6445491B2 (en) | 1999-01-29 | 2002-09-03 | Irma America, Inc. | Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification |
| AU3174600A (en) | 1999-03-10 | 2000-09-28 | Asm Scientific, Inc. | A method for direct nucleic acid sequencing |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| EP1681356B1 (en) | 1999-05-19 | 2011-10-19 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| US6137117A (en) | 1999-06-21 | 2000-10-24 | The United States Of America As Represented By The Secretary Of The Navy | Integrating multi-waveguide sensor |
| CN2433618Y (zh) | 1999-10-29 | 2001-06-06 | 中国科学院上海原子核研究所 | 基因芯片检测装置 |
| US6399335B1 (en) | 1999-11-16 | 2002-06-04 | Advanced Research And Technology Institute, Inc. | γ-phosphoester nucleoside triphosphates |
| JP4433347B2 (ja) | 2000-01-17 | 2010-03-17 | 富士フイルム株式会社 | 蛍光撮像装置 |
| US20020090650A1 (en) * | 2000-04-06 | 2002-07-11 | Quantum Dot Corporation | Two-dimensional spectral imaging system |
| WO2001084197A1 (en) | 2000-04-28 | 2001-11-08 | Edgelight Biosciences, Inc. | Micro-array evanescent wave fluorescence detection device |
| US6917726B2 (en) | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
| US6936702B2 (en) | 2000-06-07 | 2005-08-30 | Li-Cor, Inc. | Charge-switch nucleotides |
| US6975898B2 (en) | 2000-06-19 | 2005-12-13 | University Of Washington | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
| WO2002001194A1 (en) | 2000-06-25 | 2002-01-03 | Affymetrix, Inc. | Optically active substrates |
| FR2813121A1 (fr) | 2000-08-21 | 2002-02-22 | Claude Weisbuch | Dispositif perfectionne de support d'elements chromophores |
| AU2001286963A1 (en) | 2000-08-30 | 2002-03-13 | University Of Rochester | Method of performing reverse transcription reaction using reverse transcriptase encoded by non-ltr retrotransposable element |
| AU2001284681A1 (en) | 2000-09-11 | 2002-03-26 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Fluidics system |
| EP1207387A1 (en) | 2000-11-20 | 2002-05-22 | Institut Curie | Multi-photon imaging installation. |
| JP4270742B2 (ja) | 2000-11-30 | 2009-06-03 | Necエレクトロニクス株式会社 | 固体撮像装置 |
| US7668697B2 (en) | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
| US7033762B2 (en) | 2001-08-29 | 2006-04-25 | Amersham Biosciences Corp | Single nucleotide amplification and detection by polymerase |
| WO2003025132A2 (en) | 2001-09-14 | 2003-03-27 | Invitrogen Corporation | Dna polymerases and mutants thereof |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| GB2382648B (en) * | 2001-12-11 | 2003-11-12 | Amersham Pharm Biotech Uk Ltd | System and method for time correlated multi-photon counting measurements |
| CN1138862C (zh) | 2002-01-28 | 2004-02-18 | 国前 | 一种核酸分析用收集装置及其应用方法 |
| US7179654B2 (en) | 2002-03-18 | 2007-02-20 | Agilent Technologies, Inc. | Biochemical assay with programmable array detection |
| US6924887B2 (en) | 2002-03-27 | 2005-08-02 | Sarnoff Corporation | Method and apparatus for generating charge from a light pulse |
| US8238993B2 (en) | 2002-04-04 | 2012-08-07 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime |
| US20040144927A1 (en) | 2003-01-28 | 2004-07-29 | Auner Gregory W. | Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays |
| US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
| US20040106163A1 (en) | 2002-11-12 | 2004-06-03 | Workman Jerome James | Non-invasive measurement of analytes |
| AU2003294365A1 (en) | 2002-11-19 | 2004-06-15 | Safetzone Technologies Corporation | Guest communication system and method |
| WO2004072238A2 (en) | 2003-02-05 | 2004-08-26 | Amersham Biosciences Corp | Terminal-phosphate-labeled nucleotides with new linkers |
| US7745116B2 (en) | 2003-04-08 | 2010-06-29 | Pacific Biosciences Of California, Inc. | Composition and method for nucleic acid sequencing |
| FR2857158B1 (fr) * | 2003-07-01 | 2006-04-28 | St Microelectronics Sa | Procede de commande d'un photocopieur de type mos |
| US7078670B2 (en) | 2003-09-15 | 2006-07-18 | Imagerlabs, Inc. | Low noise charge gain circuit and CCD using same |
| WO2005073407A1 (en) | 2003-10-07 | 2005-08-11 | Ut-Battelle, Llc | Advanced integrated circuit biochip |
| JP2007509317A (ja) | 2003-10-18 | 2007-04-12 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 生物学的試験システムにおける、蛍光寿命の測定による分子修飾の直接的観察 |
| DE10348949A1 (de) | 2003-10-18 | 2005-05-19 | Bayer Healthcare Ag | Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer |
| US20070281288A1 (en) | 2004-01-27 | 2007-12-06 | Shimshon Belkin | Method and System for Detecting Analytes |
| ATE463584T1 (de) | 2004-02-19 | 2010-04-15 | Helicos Biosciences Corp | Verfahren zur analyse von polynukleotidsequenzen |
| EP1583150A1 (en) * | 2004-03-31 | 2005-10-05 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Image sensor with large-area, high-sensitivity and high-speed pixels |
| US20060019265A1 (en) | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
| US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
| EP1622200A1 (en) | 2004-07-26 | 2006-02-01 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Solid-state photodetector pixel and photodetecting method |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| US7345764B2 (en) | 2005-02-07 | 2008-03-18 | Vladimir Bulovic | Apparatus and method for a slim format spectrometer |
| US20060223067A1 (en) | 2005-03-31 | 2006-10-05 | Paolo Vatta | Mutant DNA polymerases and methods of use |
| US7738086B2 (en) | 2005-05-09 | 2010-06-15 | The Trustees Of Columbia University In The City Of New York | Active CMOS biosensor chip for fluorescent-based detection |
| US7365299B2 (en) | 2005-05-09 | 2008-04-29 | Sensors Unlimited, Inc. | Method and apparatus for providing flexible photodetector binning |
| WO2007002890A2 (en) | 2005-06-28 | 2007-01-04 | Agencourt Personal Genomics Corporation | Methods of producing and sequencing modified polynucleotides |
| EP1920072A2 (en) | 2005-07-01 | 2008-05-14 | Dako Denmark A/S | In situ hybridization detection method |
| US7426322B2 (en) | 2005-07-20 | 2008-09-16 | Searete Llc. | Plasmon photocatalysis |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| US7501631B2 (en) * | 2005-10-07 | 2009-03-10 | Schick Technologies, Inc. | Shielding an imaging array from X-ray noise |
| JP2009519041A (ja) | 2005-12-12 | 2009-05-14 | アメリカ合衆国 | 核酸配列決定のためのプローブおよび使用方法 |
| AU2006331512B2 (en) | 2005-12-22 | 2012-02-23 | Pacific Biosciences Of California, Inc. | Active surface coupled polymerases |
| JP2009521227A (ja) | 2005-12-22 | 2009-06-04 | パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド | ヌクレオチドアナログ組込み用ポリメラーゼ |
| US7995202B2 (en) | 2006-02-13 | 2011-08-09 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| US7715001B2 (en) | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| US20080050747A1 (en) | 2006-03-30 | 2008-02-28 | Pacific Biosciences Of California, Inc. | Articles having localized molecules disposed thereon and methods of producing and using same |
| WO2007119626A1 (ja) * | 2006-03-31 | 2007-10-25 | National University Corporation Shizuoka University | 半導体測距素子及び固体撮像装置 |
| DE102006030541B4 (de) | 2006-06-23 | 2010-05-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Optische Anordnung |
| US8471230B2 (en) | 2006-09-01 | 2013-06-25 | Pacific Biosciences Of California, Inc. | Waveguide substrates and optical systems and methods of use thereof |
| AU2007289057C1 (en) | 2006-09-01 | 2014-01-16 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
| US8207509B2 (en) | 2006-09-01 | 2012-06-26 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
| JP4710017B2 (ja) | 2006-10-20 | 2011-06-29 | 国立大学法人静岡大学 | Cmosイメージセンサ |
| EP2089517A4 (en) | 2006-10-23 | 2010-10-20 | Pacific Biosciences California | POLYMERASEENZYME AND REAGENTS FOR ADVANCED NUCKIC ACID SEQUENCING |
| FR2908888B1 (fr) | 2006-11-21 | 2012-08-03 | Centre Nat Rech Scient | Dispositif pour la detection exaltee de l'emission d'une particule cible |
| WO2008069141A1 (ja) | 2006-11-30 | 2008-06-12 | National University Corporation Shizuoka University | 半導体測距素子及び固体撮像装置 |
| JP5270835B2 (ja) | 2006-12-29 | 2013-08-21 | パナソニック株式会社 | 光検出素子、空間情報の検出装置 |
| JP2010524012A (ja) | 2007-03-22 | 2010-07-15 | ユニベルシテ・ドウ・ストラスブール | 電磁エネルギーを選別して集めるデバイス、及び、そのようなデバイスを少なくとも1つ備える装置 |
| US20080241866A1 (en) | 2007-03-30 | 2008-10-02 | Pacific Biosciences Of California, Inc. | Systems and methods for enhancing fluorescent signals |
| US7873085B2 (en) | 2007-10-23 | 2011-01-18 | Andrei Babushkin | Method and device for controlling optical output of laser diode |
| WO2009082706A1 (en) | 2007-12-21 | 2009-07-02 | The Trustees Of Columbia University In The City Of New York | Active cmos sensor array for electrochemical biomolecular detection |
| WO2009091847A2 (en) | 2008-01-14 | 2009-07-23 | Life Technologies Corporation | Compositions, methods and systems for single molecule sequencing |
| EP2252625B1 (en) | 2008-02-07 | 2017-12-20 | Pacific Biosciences of California, Inc. | Cis reactive oxygen quenchers integrated into linkers |
| US7968702B2 (en) | 2008-03-13 | 2011-06-28 | Pacific Biosciences Of California, Inc. | Labeled reactants and their uses |
| US7973146B2 (en) | 2008-03-26 | 2011-07-05 | Pacific Biosciences Of California, Inc. | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing |
| JP2011515102A (ja) | 2008-03-28 | 2011-05-19 | パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド | 核酸シーケンシング用組成物及び方法 |
| US8906831B2 (en) | 2008-03-31 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Single molecule loading methods and compositions |
| US9127259B2 (en) | 2008-03-31 | 2015-09-08 | Pacific Biosciences Of California, Inc. | Enzymes resistant to photodamage |
| US8133672B2 (en) | 2008-03-31 | 2012-03-13 | Pacific Biosciences Of California, Inc. | Two slow-step polymerase enzyme systems and methods |
| JP5283216B2 (ja) * | 2008-07-31 | 2013-09-04 | 国立大学法人静岡大学 | 高速電荷転送フォトダイオード、ロックインピクセル及び固体撮像装置 |
| WO2010025331A1 (en) | 2008-08-28 | 2010-03-04 | Mesa Imaging Ag | Demodulation pixel with daisy chain charge storage sites and method of operation therefor |
| US20100148221A1 (en) * | 2008-11-13 | 2010-06-17 | Zena Technologies, Inc. | Vertical photogate (vpg) pixel structure with nanowires |
| US8481264B2 (en) | 2008-09-19 | 2013-07-09 | Pacific Biosciences Of California, Inc. | Immobilized nucleic acid complexes for sequence analysis |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US8247216B2 (en) | 2008-09-30 | 2012-08-21 | Pacific Biosciences Of California, Inc. | Ultra-high multiplex analytical systems and methods |
| EP2182523B1 (en) | 2008-10-31 | 2013-01-09 | CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement | Charge sampling device and method based on a MOS-transmission line |
| WO2010057185A1 (en) | 2008-11-17 | 2010-05-20 | Pacific Biosciences Of California, Inc. | Phospholink nucleotides for sequencing applications |
| US8519340B2 (en) | 2008-12-22 | 2013-08-27 | Koninklijke Philips N.V. | High dynamic range light sensor |
| JP5688756B2 (ja) | 2008-12-25 | 2015-03-25 | 国立大学法人静岡大学 | 半導体素子及び固体撮像装置 |
| CN102482330A (zh) | 2009-01-30 | 2012-05-30 | 牛津纳米孔技术有限公司 | 酶突变体 |
| EP2416697A1 (en) | 2009-03-12 | 2012-02-15 | RSP Systems A/S | Optical probe for measuring light signals in vivo |
| WO2010111674A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Methods and apparatus for single molecule sequencing using energy transfer detection |
| WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
| JP5415805B2 (ja) | 2009-03-31 | 2014-02-12 | オリンパスメディカルシステムズ株式会社 | 診断支援装置 |
| CN102395874B (zh) | 2009-04-15 | 2014-10-15 | 皇家飞利浦电子股份有限公司 | 时间控制荧光检测装置 |
| JP4798254B2 (ja) * | 2009-05-13 | 2011-10-19 | 株式会社デンソー | 受光デバイス及びその制御方法 |
| WO2010148252A1 (en) * | 2009-06-17 | 2010-12-23 | Jody Vykoukal | Method and apparatus for quantitative microimaging |
| US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
| EP2459053A2 (en) | 2009-07-28 | 2012-06-06 | F. Hoffmann-La Roche AG | Non-invasive in vivo optical imaging method |
| DE102009037596B4 (de) * | 2009-08-14 | 2014-07-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Pixelstruktur, System und Verfahren zur optischen Abstandsmessung sowie Steuerschaltung für die Pixelstruktur |
| JP5648922B2 (ja) | 2009-10-05 | 2015-01-07 | 国立大学法人静岡大学 | 半導体素子及び固体撮像装置 |
| US8278728B2 (en) | 2009-10-17 | 2012-10-02 | Florida Institute Of Technology | Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels |
| WO2011068569A1 (en) | 2009-12-04 | 2011-06-09 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
| JP6017107B2 (ja) | 2009-12-28 | 2016-10-26 | ソニー株式会社 | イメージセンサ及びその製造方法、並びにセンサデバイス |
| US20110236983A1 (en) | 2009-12-29 | 2011-09-29 | Joseph Beechem | Single molecule detection and sequencing using fluorescence lifetime imaging |
| EP2362207A1 (de) | 2010-01-28 | 2011-08-31 | F. Hoffmann-La Roche AG | Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung |
| US20130072768A1 (en) | 2010-02-19 | 2013-03-21 | Barry Colin Crane | Intravascular glucose sensor |
| EP2933629B1 (en) | 2010-02-19 | 2019-04-10 | Pacific Biosciences Of California, Inc. | System for measuring analytical reactions comprising a socket for an optode array chip |
| JP2013534614A (ja) | 2010-03-25 | 2013-09-05 | モコン・インコーポレーテッド | 発光寿命に基づく分析物検出装置及び校正技術 |
| US20130149734A1 (en) | 2010-05-28 | 2013-06-13 | The Regents Of The University Of Colorado, A Body Corporate | Multi-photon Tissue Imaging |
| US8865077B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| US8865078B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| JP2012132741A (ja) | 2010-12-21 | 2012-07-12 | Fujifilm Corp | 時間分解蛍光測定装置、及び方法 |
| JP2012134827A (ja) * | 2010-12-22 | 2012-07-12 | Toshiba Corp | 放射線画像検出器 |
| US8946845B1 (en) * | 2011-02-02 | 2015-02-03 | Aptina Imaging Corporation | Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors |
| TWI553887B (zh) * | 2011-02-21 | 2016-10-11 | 美國密西根州立大學 | 嵌入電子傳導激子阻隔層的有機光伏打電池 |
| CN103404124A (zh) * | 2011-03-01 | 2013-11-20 | 松下电器产业株式会社 | 固体摄像装置 |
| EP2689028B1 (en) | 2011-03-23 | 2017-08-30 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
| WO2013040058A1 (en) | 2011-09-12 | 2013-03-21 | Jian Guo | Imaging fluorescence or luminescence lifetime |
| US20130090537A1 (en) | 2011-10-07 | 2013-04-11 | 2M Engineering Limited | Blood glucose sensor |
| CA2856163C (en) | 2011-10-28 | 2019-05-07 | Illumina, Inc. | Microarray fabrication system and method |
| WO2013066959A1 (en) | 2011-10-31 | 2013-05-10 | The Trustees Of Columbia University In The City Of New York | Systems and methods for imaging using single photon avalanche diodes |
| US8804021B2 (en) * | 2011-11-03 | 2014-08-12 | Omnivision Technologies, Inc. | Method, apparatus and system for providing improved full well capacity in an image sensor pixel |
| US9606060B2 (en) | 2012-01-13 | 2017-03-28 | California Institute Of Technology | Filterless time-domain detection of one or more fluorophores |
| US8906660B2 (en) | 2012-02-01 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Recombinant polymerases with increased phototolerance |
| EP3222627B1 (en) | 2012-02-15 | 2019-08-07 | Pacific Biosciences of California, Inc. | Polymerase enzyme substrates with protein shield |
| DE102012206089B4 (de) * | 2012-03-15 | 2017-02-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren |
| US20130256822A1 (en) * | 2012-03-28 | 2013-10-03 | Omnivision Technologies, Inc. | Method and device with enhanced ion doping |
| CN102914525B (zh) | 2012-04-10 | 2016-06-01 | 广东工业大学 | 基于光学加法外差调制的新型荧光寿命显微成像装置及方法 |
| WO2013171197A1 (en) | 2012-05-15 | 2013-11-21 | Ait Austrian Institute Of Technology Gmbh | Compact plasmon-enhanced fluorescence biosensor |
| US9372308B1 (en) | 2012-06-17 | 2016-06-21 | Pacific Biosciences Of California, Inc. | Arrays of integrated analytical devices and methods for production |
| EP2885626B1 (en) | 2012-08-20 | 2020-03-04 | Illumina, Inc. | An integrated detection, flow cell and photonics (dfp) device |
| JP6281771B2 (ja) * | 2012-10-30 | 2018-02-21 | パナソニックIpマネジメント株式会社 | 蛍光検出装置 |
| NL2011568A (en) | 2012-10-31 | 2014-05-06 | Asml Netherlands Bv | Sensor and lithographic apparatus. |
| EP2936222B1 (en) | 2012-12-18 | 2019-07-03 | Pacific Biosciences Of California, Inc. | An optical analytical device |
| KR102495290B1 (ko) * | 2012-12-28 | 2023-02-06 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치 |
| GB201302664D0 (en) | 2013-02-15 | 2013-04-03 | Cmosis Nv | A pixel structure |
| WO2014134501A2 (en) * | 2013-02-28 | 2014-09-04 | Olive Medical Corporation | Videostroboscopy of vocal chords with cmos sensors |
| US9741754B2 (en) * | 2013-03-06 | 2017-08-22 | Apple Inc. | Charge transfer circuit with storage nodes in image sensors |
| KR102007277B1 (ko) * | 2013-03-11 | 2019-08-05 | 삼성전자주식회사 | 3차원 이미지 센서의 거리 픽셀 및 이를 포함하는 3차원 이미지 센서 |
| US9260251B2 (en) | 2013-07-09 | 2016-02-16 | Nd Industries, Inc. | Multi-row magnetic dial for the conveyance of workpieces and related method |
| US20150042954A1 (en) | 2013-08-08 | 2015-02-12 | University Of Rochester | System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics |
| EP3709003A1 (en) | 2013-11-17 | 2020-09-16 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| JP2016001712A (ja) * | 2013-11-29 | 2016-01-07 | 株式会社半導体エネルギー研究所 | 半導体装置の作製方法 |
| WO2015084991A1 (en) * | 2013-12-04 | 2015-06-11 | Rambus Inc. | High dynamic-range image sensor |
| CN103728446B (zh) | 2013-12-11 | 2016-02-24 | 天津大学 | 光子计数型多通道时间分辨荧光免疫分析系统及计数方法 |
| US9736388B2 (en) | 2013-12-13 | 2017-08-15 | Bio-Rad Laboratories, Inc. | Non-destructive read operations with dynamically growing images |
| DK3099232T3 (da) | 2014-01-31 | 2021-11-22 | Massachusetts Gen Hospital | System og fremgangsmåde til fotoluminescensdetektion |
| TWI665778B (zh) * | 2014-02-05 | 2019-07-11 | 日商半導體能源研究所股份有限公司 | 半導體裝置、模組及電子裝置 |
| US9765395B2 (en) | 2014-04-28 | 2017-09-19 | Nanomedical Diagnostics, Inc. | System and method for DNA sequencing and blood chemistry analysis |
| KR20150134543A (ko) * | 2014-05-22 | 2015-12-02 | 삼성전자주식회사 | 소자 제조용 기판 및 반도체 소자 |
| WO2016011534A1 (en) * | 2014-07-24 | 2016-01-28 | University Health Network | Collection and analysis of data for diagnostic purposes |
| WO2016016761A1 (en) * | 2014-07-31 | 2016-02-04 | Semiconductor Energy Laboratory Co., Ltd. | Method of manufacturing semiconductor device |
| US9885657B2 (en) * | 2014-08-08 | 2018-02-06 | Quantum-Si Incorporated | Integrated device with external light source for probing detecting and analyzing molecules |
| US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
| KR102738114B1 (ko) * | 2014-08-08 | 2024-12-06 | 퀀텀-에스아이 인코포레이티드 | 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩 |
| CN111710687B (zh) | 2014-08-08 | 2023-11-14 | 宽腾矽公司 | 基于入射光子到达时间的识别、成像、测序法及存储介质 |
| KR20170097748A (ko) * | 2014-12-19 | 2017-08-28 | 쥐-레이 스위츨란드 에스에이 | 모놀리식 cmos 통합된 픽셀 검출기와, 다양한 적용예를 포함하는 입자 검출 및 이미지화를 위한 시스템 및 방법 |
| US9871065B2 (en) | 2014-12-22 | 2018-01-16 | Google Inc. | RGBZ pixel unit cell with first and second Z transfer gates |
| US9666748B2 (en) | 2015-01-14 | 2017-05-30 | International Business Machines Corporation | Integrated on chip detector and zero waveguide module structure for use in DNA sequencing |
| JP6302146B1 (ja) * | 2015-02-09 | 2018-03-28 | エスプロス フォトニックス アーゲー | Tof距離センサ |
| CN113064236B (zh) | 2015-03-16 | 2022-11-01 | 加利福尼亚太平洋生物科学股份有限公司 | 用于自由空间光耦合的集成装置及系统 |
| TWI704229B (zh) | 2015-05-20 | 2020-09-11 | 美商寬騰矽公司 | 核酸定序方法 |
| US10976257B2 (en) | 2015-06-08 | 2021-04-13 | The Regents Of The University Of Michigan | Pixel circuit and method for optical sensing |
| CN105300949B (zh) | 2015-11-26 | 2019-06-11 | 浙江大学 | 一种荧光寿命测量方法及装置 |
| TW202139919A (zh) | 2016-02-17 | 2021-11-01 | 美商太斯萊特健康股份有限公司 | 用於生命期成像及偵測應用之感測器及裝置 |
| EP4009330A1 (en) | 2016-06-01 | 2022-06-08 | Quantum-si Incorporated | Pulse caller and base caller |
| US10249656B2 (en) * | 2016-06-07 | 2019-04-02 | Semiconductor Components Industries, Llc | Charge packet signal processing using pinned photodiode devices |
| EP4250361A3 (en) * | 2016-12-13 | 2024-04-17 | STMicroelectronics (Research & Development) Limited | A charge storage cell and method of manufacturing a charge storage cell |
| CN110168732B (zh) | 2016-12-22 | 2024-03-08 | 宽腾矽公司 | 具有直接合并像素的整合式光电侦测器 |
| MX2020013788A (es) | 2018-06-22 | 2021-03-02 | Quantum Si Inc | Fotodetector integrado con deposito de almacenamiento de carga con tiempo de deteccion variado. |
| EP3844486A1 (en) | 2018-08-29 | 2021-07-07 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
-
2017
- 2017-12-22 CN CN201780080076.1A patent/CN110168732B/zh active Active
- 2017-12-22 KR KR1020197020897A patent/KR102560427B1/ko active Active
- 2017-12-22 WO PCT/US2017/068089 patent/WO2018119347A1/en not_active Ceased
- 2017-12-22 AU AU2017382316A patent/AU2017382316B2/en active Active
- 2017-12-22 CA CA3047826A patent/CA3047826A1/en active Pending
- 2017-12-22 TW TW106145437A patent/TWI796311B/zh active
- 2017-12-22 EP EP23162952.8A patent/EP4224530A1/en not_active Withdrawn
- 2017-12-22 CN CN202410185098.6A patent/CN118099177A/zh active Pending
- 2017-12-22 US US15/852,571 patent/US10845308B2/en active Active
- 2017-12-22 BR BR112019012540-0A patent/BR112019012540A2/pt not_active Application Discontinuation
- 2017-12-22 EP EP17832851.4A patent/EP3559995B1/en active Active
- 2017-12-22 MX MX2019007530A patent/MX388419B/es unknown
- 2017-12-22 TW TW112105642A patent/TWI836905B/zh active
- 2017-12-22 JP JP2019534096A patent/JP7149275B2/ja active Active
-
2019
- 2019-06-21 MX MX2021014745A patent/MX2021014745A/es unknown
-
2020
- 2020-10-15 US US17/071,833 patent/US11112361B2/en active Active
-
2021
- 2021-08-02 US US17/391,473 patent/US11719635B2/en active Active
-
2022
- 2022-09-26 JP JP2022152536A patent/JP7429744B2/ja active Active
-
2023
- 2023-05-05 AU AU2023202821A patent/AU2023202821B2/en active Active
- 2023-06-06 US US18/330,295 patent/US12111261B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2021007934A (es) | Dispositivo integrado para el depósito temporal de fotones recibidos. | |
| MX2021014745A (es) | Fotodetector integrado con agrupamiento de pixeles directo. | |
| MX2020013788A (es) | Fotodetector integrado con deposito de almacenamiento de carga con tiempo de deteccion variado. | |
| EP3944359A4 (en) | BATTERY MODULE | |
| EP3731282A4 (en) | SOLAR BATTERY MODULE | |
| EP3531500A4 (en) | BATTERY MODULE | |
| EP3654445A4 (en) | BATTERY MODULE | |
| EP3764454A4 (en) | BATTERY MODULE | |
| WO2015016776A3 (en) | Optoelectronic modules that have shielding to reduce light leakage or stray light, and fabrication methods for such modules | |
| EP3926732A4 (en) | BATTERY MODULE | |
| EP2743732A3 (en) | Photon-counting detector and readout circuit | |
| GB2548445A (en) | RGBZ pixel cell unit for an RGBZ image sensor | |
| JP2013042481A5 (ja) | 半導体装置 | |
| EP3686954A4 (en) | BATTERY MODULE | |
| EP3982464A4 (en) | BATTERY MODULE | |
| EP3780153A4 (en) | BATTERY MODULE | |
| JP2015162646A5 (enExample) | ||
| EP3547401A4 (en) | BATTERY MODULE | |
| EP3561906A4 (en) | BATTERY MODULE | |
| EP3790097A4 (en) | BATTERY MODULE | |
| EP3840085A4 (en) | BATTERY MODULE | |
| EP3944358A4 (en) | BATTERY MODULE | |
| EP3800701A4 (en) | BATTERY MODULE | |
| EP3780154A4 (en) | BATTERY MODULE | |
| EP3483980A4 (en) | BATTERY MODULE WITH SIMPLE SENSOR STRUCTURE |