MX2021007934A - Dispositivo integrado para el depósito temporal de fotones recibidos. - Google Patents

Dispositivo integrado para el depósito temporal de fotones recibidos.

Info

Publication number
MX2021007934A
MX2021007934A MX2021007934A MX2021007934A MX2021007934A MX 2021007934 A MX2021007934 A MX 2021007934A MX 2021007934 A MX2021007934 A MX 2021007934A MX 2021007934 A MX2021007934 A MX 2021007934A MX 2021007934 A MX2021007934 A MX 2021007934A
Authority
MX
Mexico
Prior art keywords
integrated device
charge carriers
integrated circuit
received photons
charge
Prior art date
Application number
MX2021007934A
Other languages
English (en)
Inventor
Jonathan M Rothberg
Keith G Fife
David Boisvert
Original Assignee
Quantum Si Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Si Inc filed Critical Quantum Si Inc
Publication of MX2021007934A publication Critical patent/MX2021007934A/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • H01L27/14601—Structural or functional details thereof
    • H01L27/14603—Special geometry or disposition of pixel-elements, address-lines or gate-electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
    • G01S7/483—Details of pulse systems
    • G01S7/486—Receivers
    • G01S7/4865—Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • H01L27/14683—Processes or apparatus peculiar to the manufacture or treatment of these devices or parts thereof
    • H01L27/14687—Wafer level processing
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • H01L27/148—Charge coupled imagers
    • H01L27/14806—Structural or functional details thereof
    • H01L27/14812—Special geometry or disposition of pixel-elements, address lines or gate-electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/069—Supply of sources
    • G01N2201/0696—Pulsed
    • G01N2201/0697—Pulsed lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S17/00—Systems using the reflection or reradiation of electromagnetic waves other than radio waves, e.g. lidar systems
    • G01S17/88—Lidar systems specially adapted for specific applications
    • G01S17/89—Lidar systems specially adapted for specific applications for mapping or imaging
    • G01S17/894—3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
    • G01S7/483—Details of pulse systems
    • G01S7/486—Receivers
    • G01S7/4861—Circuits for detection, sampling, integration or read-out
    • G01S7/4863—Detector arrays, e.g. charge-transfer gates

Abstract

Un circuito integrado incluye una región de fotodetección configurada para recibir fotones incidentes; la región de fotodetección se configura para producir una pluralidad de portadores de carga en respuesta a los fotones incidentes; el circuito integrado también incluye al menos una región de almacenamiento de portador de carga; el circuito integrado también incluye una estructura de segregación de portador de carga configurada para dirigir selectivamente los portadores de carga de la pluralidad de portadores de carga en la al menos una región de almacenamiento de portador de carga con base en los tiempos en los que se producen los portadores de carga.
MX2021007934A 2014-08-08 2015-08-07 Dispositivo integrado para el depósito temporal de fotones recibidos. MX2021007934A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462035377P 2014-08-08 2014-08-08
US201562164506P 2015-05-20 2015-05-20
PCT/US2015/044360 WO2016022998A2 (en) 2014-08-08 2015-08-07 Integrated device for temporal binning of received photons

Publications (1)

Publication Number Publication Date
MX2021007934A true MX2021007934A (es) 2023-01-17

Family

ID=54064569

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017001806A MX2017001806A (es) 2014-08-08 2015-08-07 Dispositivo integrado para el depósito temporal de fotones recibidos.
MX2021007934A MX2021007934A (es) 2014-08-08 2015-08-07 Dispositivo integrado para el depósito temporal de fotones recibidos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017001806A MX2017001806A (es) 2014-08-08 2015-08-07 Dispositivo integrado para el depósito temporal de fotones recibidos.

Country Status (10)

Country Link
US (8) US9759658B2 (es)
EP (2) EP3471402B1 (es)
JP (2) JP6707520B2 (es)
KR (3) KR102384909B1 (es)
CN (2) CN107112333B (es)
AU (2) AU2015300766B2 (es)
BR (1) BR112017002485B1 (es)
CA (1) CA2957540A1 (es)
MX (2) MX2017001806A (es)
WO (1) WO2016022998A2 (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016011084B8 (pt) 2013-11-17 2021-11-09 Quantum Si Incorporated Dispositivo integrado para analisar uma pluralidade de amostras em paralelo, métodos de análise desta pluralidade de amostras, para a fabricação de uma cavidade de amostra e estrutura ótica alinhada à referida cavidade, de sequenciamento de uma molécula de ácido nucleico e de formação de uma fonte de excitação de escala nano alinhada, e instrumento portátil
JP6707520B2 (ja) 2014-08-08 2020-06-10 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 受け取られた光子の時間ビニングのための集積デバイス
US9885657B2 (en) 2014-08-08 2018-02-06 Quantum-Si Incorporated Integrated device with external light source for probing detecting and analyzing molecules
KR20220165282A (ko) 2014-08-08 2022-12-14 퀀텀-에스아이 인코포레이티드 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩
KR101725099B1 (ko) * 2014-12-05 2017-04-26 삼성전자주식회사 컴퓨터 단층 촬영장치 및 그 제어방법
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
AU2015203591A1 (en) * 2015-06-26 2017-01-19 Canon Kabushiki Kaisha System and method for object matching
JP2017098809A (ja) * 2015-11-26 2017-06-01 キヤノン株式会社 光電変換装置、および、撮像システム
US10441174B2 (en) * 2016-02-17 2019-10-15 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
TWI755400B (zh) * 2016-06-01 2022-02-21 美商寬騰矽公司 脈衝命名器及基質命名器、識別核苷酸之方法、校準定序儀器之方法、識別發生核苷酸併入事件之時間的方法、非暫時性電腦可讀儲存媒體、及定序儀器
WO2017214391A1 (en) * 2016-06-08 2017-12-14 Invisage Technologies, Inc. Image sensors with electronic shutter
JP6908819B2 (ja) * 2016-09-29 2021-07-28 ミツミ電機株式会社 近接センサ
EP3305170B1 (en) * 2016-10-04 2020-12-02 ams AG Fluorescence lifetime sensor module and method of determining a fluorescence lifetime using a sensor module
JP6808463B2 (ja) * 2016-11-30 2021-01-06 キヤノン株式会社 光電変換装置および光電変換システム
MX2019007247A (es) 2016-12-19 2019-08-16 Quantum Si Inc Carga de moleculas en pocillos para muestra para su analisis.
WO2018119347A1 (en) 2016-12-22 2018-06-28 Quantum-Si Incorporated Integrated photodetector with direct binning pixel
GB201622429D0 (en) * 2016-12-30 2017-02-15 Univ Court Of The Univ Of Edinburgh The Photon sensor apparatus
US11224878B2 (en) 2017-05-05 2022-01-18 Quantum-Si Incorporated Substrates having modified surface reactivity and antifouling properties in biological reactions
CA3069974A1 (en) * 2017-07-24 2019-01-31 Quantum-Si Incorporated Optical rejection photonic structures
CN111357118A (zh) * 2017-10-29 2020-06-30 鲁克·克里斯托弗·J 一种电子传递门电路及其制造、操作和使用方法
US10817780B2 (en) 2017-10-29 2020-10-27 Christopher J. Rourk Electron transport gate circuits and methods of manufacture, operation and use
DE112018005712T5 (de) 2017-10-30 2020-07-23 Sony Semiconductor Solutions Corporation Solid-state bildaufnahmeelement
AU2019211435A1 (en) * 2018-01-26 2020-07-30 Quantum-Si Incorporated Machine learning enabled pulse and base calling for sequencing devices
KR20210021018A (ko) * 2018-06-15 2021-02-24 퀀텀-에스아이 인코포레이티드 펄스형 광학 소스들을 갖는 고급 분석 기기들을 위한 데이터 취득 제어
US11391626B2 (en) 2018-06-22 2022-07-19 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
JP7419336B2 (ja) 2018-07-16 2024-01-22 ギガジョット テクノロジー，インコーポレイテッド 非アバランシェ光検出器を有する高感度深度センサ
CN108760641B (zh) * 2018-08-17 2023-05-16 龙岩学院 基于单光子探测的熔焊过程监测装置及监测方法
MX2021002414A (es) * 2018-08-29 2021-04-28 Quantum Si Inc Sistema y metodos para la deteccion de vida util usando fotodetectores de conteo de fotones.
JP2020072317A (ja) * 2018-10-30 2020-05-07 ソニーセミコンダクタソリューションズ株式会社 センサ及び制御方法
WO2020102741A1 (en) 2018-11-15 2020-05-22 Quantum-Si Incorporated Methods and compositions for protein sequencing
US11607119B2 (en) * 2018-12-17 2023-03-21 Qatar University Fluorescence lifetime spectroscopy based capsule endoscopy
DE102018222118A1 (de) * 2018-12-18 2020-06-18 Robert Bosch Gmbh CCD-Photodetektor und zugehöriges Verfahren zum Betrieb
US11423306B2 (en) * 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
CN114174858A (zh) * 2019-07-12 2022-03-11 索尼半导体解决方案公司 半导体装置
AU2020364058A1 (en) 2019-10-11 2022-05-26 Quantum-Si Incorporated Surface modification in the vapor phase
CN110579460B (zh) * 2019-10-14 2023-04-18 深圳大学 一种寻址扫描快速荧光寿命显微成像系统及方法
CA3167740A1 (en) * 2020-01-14 2021-07-22 Quantum-Si Incorporated Amplitude-modulated laser
CA3167863A1 (en) 2020-01-14 2021-07-22 Quantum-Si Incorporated Sensor for lifetime plus spectral characterization
CA3168138A1 (en) 2020-01-14 2021-07-22 Quantum-Si Incorporated Integrated sensor for lifetime characterization
US11719639B2 (en) 2020-03-02 2023-08-08 Quantum-Si Incorporated Integrated sensor for multi-dimensional signal analysis
KR20220165754A (ko) 2020-04-08 2022-12-15 퀀텀-에스아이 인코포레이티드 스큐가 감소된 통합 센서
US11532150B1 (en) * 2020-06-02 2022-12-20 Honeywell Federal Manufacturing & Technologies, Llc Method for determining a histogram of variable sample rate waveforms
WO2021252800A1 (en) 2020-06-11 2021-12-16 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
CN116670494A (zh) * 2020-10-22 2023-08-29 宽腾矽公司 具有按序耦合电荷存储的集成电路及相关技术
US20220128566A1 (en) * 2020-10-27 2022-04-28 Quantum-Si Incorporated Calibration of single-molecule detection system
US20220186305A1 (en) * 2020-12-11 2022-06-16 Quantum-Si Incorporated Integrated circuit with improved charge transfer efficiency and associated techniques
US20220227890A1 (en) 2021-01-21 2022-07-21 Nautilus Biotechnology, Inc. Systems and methods for biomolecule preparation
CA3209038A1 (en) 2021-03-11 2022-09-15 Tural AKSEL Systems and methods for biomolecule retention
CN113268142B (zh) * 2021-06-09 2024-04-02 江苏集萃脑机融合智能技术研究所有限公司 基于直接测量飞行时间技术的脑机接口系统、脑机接口穿戴设备及其控制方法
WO2023038859A1 (en) 2021-09-09 2023-03-16 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
AU2022352593A1 (en) 2021-09-22 2024-02-15 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US20230314324A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
WO2024019988A1 (en) * 2022-07-18 2024-01-25 Cellsbin, Inc. Devices for biological analysis
WO2024039853A1 (en) * 2022-08-19 2024-02-22 Quantum-Si Incorporated Backside illuminated structures with parallel charge transfer
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes

Family Cites Families (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5355165A (en) 1992-08-06 1994-10-11 Princeton Scientific Instruments, Inc. Very high frame rate CCD imager
JPH08506664A (ja) 1993-02-01 1996-07-16 セック，リミテッド Ｄｎａ配列決定の方法および装置
US6456326B2 (en) 1994-01-28 2002-09-24 California Institute Of Technology Single chip camera device having double sampling operation
US5471515A (en) 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
ATE216491T1 (de) 1994-05-27 2002-05-15 Novartis Ag Verfahren zum nachweis abklingend angeregter lumineszenz
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5990506A (en) 1996-03-20 1999-11-23 California Institute Of Technology Active pixel sensors with substantially planarized color filtering elements
WO1998022799A2 (de) 1996-11-18 1998-05-28 Novartis Ag Messvorrichtung und deren verwendung
CA2281205A1 (en) 1997-02-12 1998-08-13 Eugene Y. Chan Methods and products for analyzing polymers
IT1290553B1 (it) 1997-02-27 1998-12-10 Ist Nazionale Fisica Nucleare Rivelatore dell'energia e della posizione di incidenza di radiazioni elettromagnetiche o di particelle ionizzanti a deriva controllata
EP2202312B1 (en) 1997-03-12 2016-01-06 Applied Biosystems, LLC DNA polymerases having improved labelled nucleotide incorporation properties
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
EP0921196A1 (en) 1997-12-02 1999-06-09 Roche Diagnostics GmbH Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
US6232103B1 (en) 1998-03-23 2001-05-15 Invitrogen Corporation Methods useful for nucleic acid sequencing using modified nucleotides comprising phenylboronic acid
JP3813818B2 (ja) 1998-05-01 2006-08-23 アリゾナ ボード オブ リージェンツ オリゴヌクレオチドおよびｄｎａ分子のヌクレオチド配列の決定方法
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6280939B1 (en) 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
JP4326050B2 (ja) 1998-09-22 2009-09-02 ハイスペック合資会社 高速撮像素子
CA2355816C (en) 1998-12-14 2007-10-30 Li-Cor, Inc. A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
US6445491B2 (en) 1999-01-29 2002-09-03 Irma America, Inc. Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification
AU3174600A (en) 1999-03-10 2000-09-28 Asm Scientific, Inc. A method for direct nucleic acid sequencing
EP1681357A3 (en) 1999-05-19 2006-07-26 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6137117A (en) 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
CN2433618Y (zh) * 1999-10-29 2001-06-06 中国科学院上海原子核研究所 基因芯片检测装置
US6399335B1 (en) 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
JP4433347B2 (ja) * 2000-01-17 2010-03-17 富士フイルム株式会社 蛍光撮像装置
EP1285290A1 (en) 2000-04-28 2003-02-26 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
CA2412567A1 (en) 2000-06-07 2001-12-13 Li-Cor, Inc. Charge-switch nucleotides
US6975898B2 (en) 2000-06-19 2005-12-13 University Of Washington Medical imaging, diagnosis, and therapy using a scanning single optical fiber system
EP1311824A4 (en) 2000-06-25 2010-12-08 Affymetrix Inc OPTICALLY ACTIVE SUBSTRATES
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
US7153672B1 (en) 2000-08-30 2006-12-26 University Of Rochester Method of performing reverse transcription reaction using reverse transcriptase encoded by non-LTR retrotransposable element
US20020031836A1 (en) 2000-09-11 2002-03-14 Feldstein Mark J. Fluidics system
EP1207387A1 (en) 2000-11-20 2002-05-22 Institut Curie Multi-photon imaging installation.
JP4270742B2 (ja) 2000-11-30 2009-06-03 Ｎｅｃエレクトロニクス株式会社 固体撮像装置
AU2002258997A1 (en) 2001-04-24 2002-11-05 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymerases
US7668697B2 (en) 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
US7727722B2 (en) 2001-08-29 2010-06-01 General Electric Company Ligation amplification
ATE458067T1 (de) 2001-08-29 2010-03-15 Ge Healthcare Bio Sciences Markierte nukleosidpolyphosphate
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7256019B2 (en) 2001-08-29 2007-08-14 Ge Healthcare Bio-Sciences Corp. Terminal phosphate blocked nucleoside polyphosphates
US7052839B2 (en) 2001-08-29 2006-05-30 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides and methods of use
US7223541B2 (en) 2001-08-29 2007-05-29 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides and methods of use
EP1436385A4 (en) 2001-09-14 2005-12-14 Invitrogen Corp DNA POLYMERASES AND MUTANTS CORRESPONDING
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB2382648B (en) 2001-12-11 2003-11-12 Amersham Pharm Biotech Uk Ltd System and method for time correlated multi-photon counting measurements
CN1138862C (zh) * 2002-01-28 2004-02-18 国前 一种核酸分析用收集装置及其应用方法
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US6924887B2 (en) 2002-03-27 2005-08-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse
US8238993B2 (en) 2002-04-04 2012-08-07 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime
US20040144927A1 (en) * 2003-01-28 2004-07-29 Auner Gregory W. Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040106163A1 (en) 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
WO2004047353A2 (en) 2002-11-19 2004-06-03 Safetzone Technologies Corporation Guest communication system and method
WO2004072238A2 (en) 2003-02-05 2004-08-26 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides with new linkers
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US7078670B2 (en) * 2003-09-15 2006-07-18 Imagerlabs, Inc. Low noise charge gain circuit and CCD using same
WO2005073407A1 (en) 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
DE10348949A1 (de) * 2003-10-18 2005-05-19 Bayer Healthcare Ag Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer
SG147471A1 (en) 2003-10-18 2008-11-28 Bayer Healthcare Ag Direct observation of molecular modifications in biological test systems by measuring fluorescence lifetime
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20070281288A1 (en) 2004-01-27 2007-12-06 Shimshon Belkin Method and System for Detecting Analytes
WO2005080605A2 (en) 2004-02-19 2005-09-01 Helicos Biosciences Corporation Methods and kits for analyzing polynucleotide sequences
EP1583150A1 (en) 2004-03-31 2005-10-05 CSEM Centre Suisse d'Electronique et de Microtechnique SA Image sensor with large-area, high-sensitivity and high-speed pixels
US20060019265A1 (en) 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
EP1622200A1 (en) 2004-07-26 2006-02-01 CSEM Centre Suisse d'Electronique et de Microtechnique SA Solid-state photodetector pixel and photodetecting method
GB2423819B (en) 2004-09-17 2008-02-06 Pacific Biosciences California Apparatus and method for analysis of molecules
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7345764B2 (en) 2005-02-07 2008-03-18 Vladimir Bulovic Apparatus and method for a slim format spectrometer
US20060223067A1 (en) 2005-03-31 2006-10-05 Paolo Vatta Mutant DNA polymerases and methods of use
US7365299B2 (en) 2005-05-09 2008-04-29 Sensors Unlimited, Inc. Method and apparatus for providing flexible photodetector binning
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
JP2008546424A (ja) 2005-06-28 2008-12-25 アジェンコート パーソナル ジェノミクス コーポレイション 修飾ポリヌクレオチドを作製する方法および配列決定する方法
EP1907592B1 (en) 2005-07-01 2011-03-09 Dako Denmark A/S Monomeric and polymeric linkers useful for conjugating biological molecules and other substances
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US8344121B2 (en) 2005-12-12 2013-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nanoprobes for detection or modification of molecules
ATE518010T1 (de) 2005-12-22 2011-08-15 Pacific Biosciences California Aktive oberflächengekoppelte polymerasen
CA2633524A1 (en) 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
WO2007119626A1 (ja) 2006-03-31 2007-10-25 National University Corporation Shizuoka University 半導体測距素子及び固体撮像装置
DE102006030541B4 (de) 2006-06-23 2010-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung
EP3936857B1 (en) 2006-09-01 2023-06-21 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8343746B2 (en) 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
JP5270835B2 (ja) 2006-12-29 2013-08-21 パナソニック株式会社 光検出素子、空間情報の検出装置
ATE509265T1 (de) 2007-03-22 2011-05-15 Univ Strasbourg Etablissement Public A Caractere Scient Culturel Et Professionel Gerät zur sortierung und konzentration elektromagnetischer energie und vorrichtung mit mindestens einem derartigen gerät
EP2134871B1 (en) 2007-03-30 2012-03-07 Pacific Biosciences of California, Inc. Systems and methods for enhancing fluorescent signals
US7873085B2 (en) 2007-10-23 2011-01-18 Andrei Babushkin Method and device for controlling optical output of laser diode
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
WO2009091847A2 (en) 2008-01-14 2009-07-23 Life Technologies Corporation Compositions, methods and systems for single molecule sequencing
WO2009100382A1 (en) 2008-02-07 2009-08-13 Pacific Biosciences Of California, Inc. Cis reactive oxygen quenchers integrated into linkers
EP2255014A4 (en) 2008-02-12 2011-05-18 Pacific Biosciences California COMPOSITIONS AND METHODS FOR USE IN ANALYTICAL REACTIONS
US8530164B2 (en) 2008-09-05 2013-09-10 Pacific Biosciences Of California, Inc. Method for sequencing using branching fraction of incorporatable nucleotides
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
CA2718404C (en) 2008-03-13 2018-04-10 Pacific Biosciences Of California, Inc. Labeled reactants and their uses
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
BRPI0909212A2 (pt) 2008-03-28 2015-08-18 Pacific Biosciences California Composições e método para sequeciamento de ácido nucléico
WO2009120374A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
US8420366B2 (en) 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
WO2009145818A1 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc Single molecule loading methods and compositions
WO2009145828A2 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
US8257954B2 (en) 2008-03-31 2012-09-04 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
WO2010044932A2 (en) * 2008-07-11 2010-04-22 Cornell University Nanofluidic channels with integrated charge sensors and methods based thereon
JP5283216B2 (ja) * 2008-07-31 2013-09-04 国立大学法人静岡大学 高速電荷転送フォトダイオード、ロックインピクセル及び固体撮像装置
JP2012501608A (ja) * 2008-08-28 2012-01-19 メサ・イメージング・アー・ゲー デイジーチェーン構成の電荷格納領域を有する復調ピクセルおよびそれを操作する方法
AU2009292629B2 (en) 2008-09-16 2014-03-20 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8921046B2 (en) 2008-09-19 2014-12-30 Pacific Biosciences Of California, Inc. Nucleic acid sequence analysis
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8383369B2 (en) 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
WO2010036287A1 (en) 2008-09-24 2010-04-01 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
EP2362947B1 (en) 2008-09-30 2017-05-10 Pacific Biosciences of California, Inc. Ultra-high multiplex analytical systems and methods
EP2182523B1 (en) * 2008-10-31 2013-01-09 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line
WO2010057185A1 (en) 2008-11-17 2010-05-20 Pacific Biosciences Of California, Inc. Phospholink nucleotides for sequencing applications
WO2010073136A2 (en) 2008-12-22 2010-07-01 Koninklijke Philips Electronics N.V. High dynamic range light sensor
US8338248B2 (en) * 2008-12-25 2012-12-25 National University Corporation Shizuoka University Semiconductor element and solid-state imaging device
BRPI1007215A2 (pt) 2009-01-30 2017-08-29 Oxford Nanopore Tech Ltd Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes.
US9658440B2 (en) 2009-03-12 2017-05-23 Rsp Systems A/S Optical probe for measuring light signals in vivo
WO2010111686A2 (en) 2009-03-27 2010-09-30 Life Technologies Corp Labeled enzyme compositions, methods & systems
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP5415805B2 (ja) 2009-03-31 2014-02-12 オリンパスメディカルシステムズ株式会社 診断支援装置
US10514337B2 (en) * 2009-04-15 2019-12-24 Koninklijke Philips N.V. Device for time controlled fluorescence detection
US20120224053A1 (en) 2009-06-17 2012-09-06 Board Of Regents, The University Of Texas System Method and apparatus for quantitative microimaging
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
US9698196B2 (en) * 2009-08-14 2017-07-04 Heptagon Micro Optics Pte. Ltd. Demodulation pixel incorporating majority carrier current, buried channel and high-low junction
WO2011040971A2 (en) 2009-09-30 2011-04-07 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US9231006B2 (en) 2009-10-05 2016-01-05 National University Corporation Shizuoka University Semiconductor element and solid-state imaging device
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
US9579402B2 (en) 2009-12-04 2017-02-28 Biotium, Inc. Heterocycle-substituted xanthene dyes
JP6017107B2 (ja) 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
WO2011090745A1 (en) 2009-12-29 2011-07-28 Life Technologies Corporation Single molecule detection and sequencing using fluorescence lifetime imaging
EP2362207A1 (de) 2010-01-28 2011-08-31 F. Hoffmann-La Roche AG Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung
AU2011217862B9 (en) 2010-02-19 2014-07-10 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
CN102933144B (zh) 2010-02-19 2015-08-12 格莱苏有限公司 血管内葡萄糖传感器
JP2013534614A (ja) 2010-03-25 2013-09-05 モコン・インコーポレーテッド 発光寿命に基づく分析物検出装置及び校正技術
WO2011150431A1 (en) 2010-05-28 2011-12-01 The Regents Of The University Of Colorado, A Body Corporate Multi-photon tissue imaging
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
JP2012132741A (ja) 2010-12-21 2012-07-12 Fujifilm Corp 時間分解蛍光測定装置、及び方法
US8946845B1 (en) 2011-02-02 2015-02-03 Aptina Imaging Corporation Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US9968258B2 (en) 2011-09-12 2018-05-15 Tufts University Imaging fluorescence or luminescence lifetime
US20130090537A1 (en) 2011-10-07 2013-04-11 2M Engineering Limited Blood glucose sensor
EP2771103B1 (en) 2011-10-28 2017-08-16 Illumina, Inc. Microarray fabrication system and method
WO2013066959A1 (en) 2011-10-31 2013-05-10 The Trustees Of Columbia University In The City Of New York Systems and methods for imaging using single photon avalanche diodes
US9606060B2 (en) * 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
EP3222627B1 (en) 2012-02-15 2019-08-07 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
DE102012206089B4 (de) 2012-03-15 2017-02-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren
CN102914525B (zh) 2012-04-10 2016-06-01 广东工业大学 基于光学加法外差调制的新型荧光寿命显微成像装置及方法
WO2013171197A1 (en) 2012-05-15 2013-11-21 Ait Austrian Institute Of Technology Gmbh Compact plasmon-enhanced fluorescence biosensor
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
US10895534B2 (en) * 2012-08-20 2021-01-19 Illumina, Inc. Method and system for fluorescence lifetime based sequencing
WO2014068951A1 (ja) 2012-10-30 2014-05-08 パナソニック株式会社 試料保持担体およびそれを用いた蛍光検出装置
NL2011568A (en) 2012-10-31 2014-05-06 Asml Netherlands Bv Sensor and lithographic apparatus.
EP4123294A1 (en) 2012-12-18 2023-01-25 Pacific Biosciences Of California, Inc. An optical analytical device
GB201302664D0 (en) 2013-02-15 2013-04-03 Cmosis Nv A pixel structure
AU2014223163A1 (en) 2013-02-28 2015-08-20 Olive Medical Corporation Videostroboscopy of vocal chords with CMOS sensors
US9741754B2 (en) 2013-03-06 2017-08-22 Apple Inc. Charge transfer circuit with storage nodes in image sensors
KR102007277B1 (ko) 2013-03-11 2019-08-05 삼성전자주식회사 3차원 이미지 센서의 거리 픽셀 및 이를 포함하는 3차원 이미지 센서
US9260251B2 (en) 2013-07-09 2016-02-16 Nd Industries, Inc. Multi-row magnetic dial for the conveyance of workpieces and related method
US20150042954A1 (en) 2013-08-08 2015-02-12 University Of Rochester System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics
BR112016011084B8 (pt) 2013-11-17 2021-11-09 Quantum Si Incorporated Dispositivo integrado para analisar uma pluralidade de amostras em paralelo, métodos de análise desta pluralidade de amostras, para a fabricação de uma cavidade de amostra e estrutura ótica alinhada à referida cavidade, de sequenciamento de uma molécula de ácido nucleico e de formação de uma fonte de excitação de escala nano alinhada, e instrumento portátil
CN103728446B (zh) * 2013-12-11 2016-02-24 天津大学 光子计数型多通道时间分辨荧光免疫分析系统及计数方法
US9736388B2 (en) 2013-12-13 2017-08-15 Bio-Rad Laboratories, Inc. Non-destructive read operations with dynamically growing images
DK3099232T3 (da) 2014-01-31 2021-11-22 Massachusetts Gen Hospital System og fremgangsmåde til fotoluminescensdetektion
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
KR20150134543A (ko) 2014-05-22 2015-12-02 삼성전자주식회사 소자 제조용 기판 및 반도체 소자
US10438356B2 (en) 2014-07-24 2019-10-08 University Health Network Collection and analysis of data for diagnostic purposes
KR20220165282A (ko) 2014-08-08 2022-12-14 퀀텀-에스아이 인코포레이티드 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩
JP6707520B2 (ja) 2014-08-08 2020-06-10 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 受け取られた光子の時間ビニングのための集積デバイス
US9885657B2 (en) 2014-08-08 2018-02-06 Quantum-Si Incorporated Integrated device with external light source for probing detecting and analyzing molecules
TWI621254B (zh) 2014-12-19 2018-04-11 Ｇ射線瑞士公司 單片ｃｍｏｓ積體像素偵測器、及包括各種應用之粒子偵測和成像的系統與方法
US9871065B2 (en) 2014-12-22 2018-01-16 Google Inc. RGBZ pixel unit cell with first and second Z transfer gates
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
EP3191870B1 (de) 2015-02-09 2018-04-18 Espros Photonics AG Tof entfernungssensor
EP3271762B1 (en) 2015-03-16 2023-01-04 Pacific Biosciences of California, Inc. Analytical system comprising integrated devices and systems for free-space optical coupling
TWI569008B (zh) 2015-04-27 2017-02-01 財團法人工業技術研究院 尿素濃度檢測元件以及尿素濃度檢測方法
MX2017014821A (es) 2015-05-20 2018-06-27 Quantum Si Inc Método para determinar la secuencia de un acido nucleico usando luminiscencia resuelta por tiempo.
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
US10976257B2 (en) 2015-06-08 2021-04-13 The Regents Of The University Of Michigan Pixel circuit and method for optical sensing
CN105300949B (zh) 2015-11-26 2019-06-11 浙江大学 一种荧光寿命测量方法及装置
US10441174B2 (en) 2016-02-17 2019-10-15 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
TWI755400B (zh) 2016-06-01 2022-02-21 美商寬騰矽公司 脈衝命名器及基質命名器、識別核苷酸之方法、校準定序儀器之方法、識別發生核苷酸併入事件之時間的方法、非暫時性電腦可讀儲存媒體、及定序儀器
US10249656B2 (en) 2016-06-07 2019-04-02 Semiconductor Components Industries, Llc Charge packet signal processing using pinned photodiode devices
WO2018119347A1 (en) 2016-12-22 2018-06-28 Quantum-Si Incorporated Integrated photodetector with direct binning pixel
US11391626B2 (en) 2018-06-22 2022-07-19 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
MX2021002414A (es) 2018-08-29 2021-04-28 Quantum Si Inc Sistema y metodos para la deteccion de vida util usando fotodetectores de conteo de fotones.

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