JP2019535831A5 - - Google Patents
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- JP2019535831A5 JP2019535831A5 JP2019547600A JP2019547600A JP2019535831A5 JP 2019535831 A5 JP2019535831 A5 JP 2019535831A5 JP 2019547600 A JP2019547600 A JP 2019547600A JP 2019547600 A JP2019547600 A JP 2019547600A JP 2019535831 A5 JP2019535831 A5 JP 2019535831A5
- Authority
- JP
- Japan
- Prior art keywords
- phosphorus
- nitrogen
- sulfur
- oxygen
- silicon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 COP(**)N(*)* Chemical compound COP(**)N(*)* 0.000 description 4
- USASGRZAGIBLKB-UHFFFAOYSA-N CC(C)(C)[n]1c(N=C(N)NC2=O)c2nc1 Chemical compound CC(C)(C)[n]1c(N=C(N)NC2=O)c2nc1 USASGRZAGIBLKB-UHFFFAOYSA-N 0.000 description 1
- OEHLXFHBMYNPOZ-IMSGDLLMSA-N C[C@@]1(c2ccccc2)OP(C)N2[C@@H]1CCC2 Chemical compound C[C@@]1(c2ccccc2)OP(C)N2[C@@H]1CCC2 OEHLXFHBMYNPOZ-IMSGDLLMSA-N 0.000 description 1
- REHLFRCNMJTHIZ-QXNREYOVSA-N C[C@]([C@H]1N2CCC1)(c1ccccc1)OP2I Chemical compound C[C@]([C@H]1N2CCC1)(c1ccccc1)OP2I REHLFRCNMJTHIZ-QXNREYOVSA-N 0.000 description 1
- KHZYHKBQROIRKP-BEWYTNLXSA-N C[Si+](C[C@@H]([C@@H]1N2CCC1)OP2I)(c1ccccc1)c1ccccc1 Chemical compound C[Si+](C[C@@H]([C@@H]1N2CCC1)OP2I)(c1ccccc1)c1ccccc1 KHZYHKBQROIRKP-BEWYTNLXSA-N 0.000 description 1
- KHZYHKBQROIRKP-HXIJRHRVSA-N C[Si+](C[C@H]([C@H]1N2CCC1)OP2I)(c1ccccc1)c1ccccc1 Chemical compound C[Si+](C[C@H]([C@H]1N2CCC1)OP2I)(c1ccccc1)c1ccccc1 KHZYHKBQROIRKP-HXIJRHRVSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023026999A JP2023062180A (ja) | 2016-11-23 | 2023-02-24 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662426079P | 2016-11-23 | 2016-11-23 | |
| US62/426,079 | 2016-11-23 | ||
| PCT/US2017/062996 WO2018098264A1 (en) | 2016-11-23 | 2017-11-22 | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023026999A Division JP2023062180A (ja) | 2016-11-23 | 2023-02-24 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535831A JP2019535831A (ja) | 2019-12-12 |
| JP2019535831A5 true JP2019535831A5 (https=) | 2021-01-07 |
| JP7296882B2 JP7296882B2 (ja) | 2023-06-23 |
Family
ID=62195630
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547600A Active JP7296882B2 (ja) | 2016-11-23 | 2017-11-22 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
| JP2023026999A Pending JP2023062180A (ja) | 2016-11-23 | 2023-02-24 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023026999A Pending JP2023062180A (ja) | 2016-11-23 | 2023-02-24 | ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11873316B2 (https=) |
| EP (1) | EP3544987A4 (https=) |
| JP (2) | JP7296882B2 (https=) |
| CN (1) | CN110088113A (https=) |
| MA (1) | MA46905A (https=) |
| WO (1) | WO2018098264A1 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
| IL320434A (en) | 2015-07-22 | 2025-06-01 | Wave Life Sciences Ltd | Oligonucleotide preparations and methods |
| IL295755A (en) | 2015-10-09 | 2022-10-01 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof |
| CN108779132B (zh) | 2016-03-13 | 2022-04-15 | 波涛生命科学有限公司 | 用于亚磷酰胺和寡核苷酸合成的组合物和方法 |
| EP3452596A4 (en) | 2016-05-04 | 2020-03-18 | Wave Life Sciences Ltd. | OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS |
| JP2019520339A (ja) | 2016-06-03 | 2019-07-18 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド、その組成物および方法 |
| WO2017220751A1 (en) | 2016-06-22 | 2017-12-28 | Proqr Therapeutics Ii B.V. | Single-stranded rna-editing oligonucleotides |
| CN110352244B (zh) | 2016-09-01 | 2023-03-21 | ProQR治疗上市公司Ⅱ | 化学修饰的编辑rna的单链寡核苷酸 |
| US11873316B2 (en) | 2016-11-23 | 2024-01-16 | Wave Life Sciences Ltd. | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
| CA3065523A1 (en) | 2017-06-02 | 2018-12-06 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| JP2020522510A (ja) | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド組成物及びその使用方法 |
| US11718638B2 (en) | 2017-06-21 | 2023-08-08 | Wave Life Sciences Ltd. | Compounds, compositions and methods for synthesis |
| EP3664816A4 (en) | 2017-08-08 | 2021-05-19 | Wave Life Sciences Ltd. | OLIGONUCLEOTIDE COMPOSITIONS AND RELATED PROCESSES |
| CA3072110A1 (en) | 2017-09-18 | 2019-03-21 | Wave Life Sciences Ltd. | Technologies for oligonucleotide preparation |
| EP3694530A4 (en) | 2017-10-12 | 2021-06-30 | Wave Life Sciences Ltd. | COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES |
| SG11202009877XA (en) | 2018-04-12 | 2020-11-27 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods of use thereof |
| US12391942B2 (en) | 2018-05-11 | 2025-08-19 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| JP2022525541A (ja) | 2019-03-20 | 2022-05-17 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド調製に有用な技術 |
| MX2022014606A (es) | 2020-05-22 | 2023-03-08 | Wave Life Sciences Ltd | Composiciones de oligonucleótidos bicatenarios y métodos relacionados con las mismas. |
| EP4479535A1 (en) | 2022-02-14 | 2024-12-25 | ProQR Therapeutics II B.V. | Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia |
| US20260027237A1 (en) | 2022-07-15 | 2026-01-29 | Proqr Therapeutics Ii B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
| JP2025524566A (ja) | 2022-07-15 | 2025-07-30 | プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ | Ａｄａｒ媒介ｒｎａ編集のためのオリゴヌクレオチドおよびその使用 |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
| WO2024110565A1 (en) | 2022-11-24 | 2024-05-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of hereditary hfe-hemochromatosis |
| GB202218090D0 (en) | 2022-12-01 | 2023-01-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency |
| AU2023390632A1 (en) | 2022-12-09 | 2025-07-10 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of cardiovascular disease |
| GB202300865D0 (en) | 2023-01-20 | 2023-03-08 | Proqr Therapeutics Ii Bv | Delivery of oligonucleotides |
| WO2024175550A1 (en) | 2023-02-20 | 2024-08-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease |
| GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
| EP4689110A1 (en) | 2023-03-24 | 2026-02-11 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| EP4688143A1 (en) | 2023-03-27 | 2026-02-11 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for the treatment of liver disease |
| TW202516003A (zh) | 2023-06-16 | 2025-04-16 | 荷蘭商Ｐｒｏｑｒ治療上市公司Ｉｉ | 用於治療神經退化性疾病之反義寡核苷酸 |
| WO2025015335A1 (en) | 2023-07-13 | 2025-01-16 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| WO2025051946A1 (en) | 2023-09-07 | 2025-03-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2025096809A1 (en) | 2023-10-31 | 2025-05-08 | Korro Bio, Inc. | Oligonucleotides comprising phosphoramidate internucleotide linkages |
| WO2025104239A1 (en) | 2023-11-16 | 2025-05-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of classic galactosemia |
| WO2025128799A1 (en) | 2023-12-12 | 2025-06-19 | Korro Bio, Inc. | Double-stranded rna-editing oligonucleotides and uses thereof |
| WO2025132708A1 (en) | 2023-12-20 | 2025-06-26 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of huntington's disease |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| WO2025224230A1 (en) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of fatty liver disease |
| GB202410081D0 (en) | 2024-07-11 | 2024-08-28 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of cardiovascular disease |
| WO2026022136A1 (en) | 2024-07-23 | 2026-01-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2026050243A1 (en) | 2024-08-26 | 2026-03-05 | Korro Bio, Inc. | Galnac conjugated oligonucleotides for rna editing |
| WO2026060374A2 (en) | 2024-09-16 | 2026-03-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| WO2026068781A1 (en) | 2024-09-30 | 2026-04-02 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
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| AU2023227808A1 (en) | 2022-03-02 | 2024-09-19 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof for exon skipping |
| EP4507700A2 (en) | 2022-04-15 | 2025-02-19 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods relating thereto |
| US20250302995A1 (en) | 2022-05-12 | 2025-10-02 | Chikdu Shakti Shivalila | Oligonucleotide compositions and methods thereof |
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| WO2025030155A1 (en) | 2023-08-03 | 2025-02-06 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
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2017
- 2017-11-22 US US16/463,328 patent/US11873316B2/en active Active
- 2017-11-22 CN CN201780072663.6A patent/CN110088113A/zh active Pending
- 2017-11-22 JP JP2019547600A patent/JP7296882B2/ja active Active
- 2017-11-22 WO PCT/US2017/062996 patent/WO2018098264A1/en not_active Ceased
- 2017-11-22 EP EP17874211.0A patent/EP3544987A4/en active Pending
- 2017-11-22 MA MA046905A patent/MA46905A/fr unknown
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2023
- 2023-02-24 JP JP2023026999A patent/JP2023062180A/ja active Pending
- 2023-11-28 US US18/522,146 patent/US12473321B2/en active Active
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