JP2019535831A5 - - Google Patents

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JP2019535831A5
JP2019535831A5 JP2019547600A JP2019547600A JP2019535831A5 JP 2019535831 A5 JP2019535831 A5 JP 2019535831A5 JP 2019547600 A JP2019547600 A JP 2019547600A JP 2019547600 A JP2019547600 A JP 2019547600A JP 2019535831 A5 JP2019535831 A5 JP 2019535831A5
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phosphorus
nitrogen
sulfur
oxygen
silicon
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JP2019547600A
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JP2019535831A (ja
JP7296882B2 (ja
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Priority claimed from PCT/US2017/062996 external-priority patent/WO2018098264A1/en
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Priority to JP2023026999A priority Critical patent/JP2023062180A/ja
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JP2019547600A 2016-11-23 2017-11-22 ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法 Active JP7296882B2 (ja)

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JP2023026999A JP2023062180A (ja) 2016-11-23 2023-02-24 ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法

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US201662426079P 2016-11-23 2016-11-23
US62/426,079 2016-11-23
PCT/US2017/062996 WO2018098264A1 (en) 2016-11-23 2017-11-22 Compositions and methods for phosphoramidite and oligonucleotide synthesis

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JP2023026999A Division JP2023062180A (ja) 2016-11-23 2023-02-24 ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法

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JP2019535831A JP2019535831A (ja) 2019-12-12
JP2019535831A5 true JP2019535831A5 (OSRAM) 2021-01-07
JP7296882B2 JP7296882B2 (ja) 2023-06-23

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JP2019547600A Active JP7296882B2 (ja) 2016-11-23 2017-11-22 ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法
JP2023026999A Pending JP2023062180A (ja) 2016-11-23 2023-02-24 ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法

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US (2) US11873316B2 (OSRAM)
EP (1) EP3544987A4 (OSRAM)
JP (2) JP7296882B2 (OSRAM)
CN (1) CN110088113A (OSRAM)
MA (1) MA46905A (OSRAM)
WO (1) WO2018098264A1 (OSRAM)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2012DN00720A (OSRAM) 2009-07-06 2015-06-19 Ontorii Inc
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
MX347361B (es) 2011-07-19 2017-04-12 Wave Life Sciences Ltd Metodos para la sintesis de acidos nucleicos funcionalizados.
EP2872485B1 (en) 2012-07-13 2020-12-16 Wave Life Sciences Ltd. Asymmetric auxiliary group
EP2872147B1 (en) 2012-07-13 2022-12-21 Wave Life Sciences Ltd. Method for making chiral oligonucleotides
CN106068325B (zh) 2014-01-16 2021-07-09 波涛生命科学有限公司 手性设计
MA43072A (fr) 2015-07-22 2018-05-30 Wave Life Sciences Ltd Compositions d'oligonucléotides et procédés associés
JP7511326B2 (ja) 2015-10-09 2024-07-05 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物およびその方法
MA43822A (fr) 2016-03-13 2018-11-28 Wave Life Sciences Ltd Compositions et procédés de synthèse de phosphoramidite et d'oligonucléotides
MA45270A (fr) 2016-05-04 2017-11-09 Wave Life Sciences Ltd Compositions d'oligonucléotides et procédés associés
JP2019520339A (ja) 2016-06-03 2019-07-18 ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. オリゴヌクレオチド、その組成物および方法
CN109477103A (zh) 2016-06-22 2019-03-15 ProQR治疗上市公司Ⅱ 单链rna-编辑寡核苷酸
NZ751483A (en) 2016-09-01 2022-07-01 Proqr Therapeutics Ii Bv Chemically modified single-stranded rna-editing oligonucleotides
US11873316B2 (en) 2016-11-23 2024-01-16 Wave Life Sciences Ltd. Compositions and methods for phosphoramidite and oligonucleotide synthesis
US11603532B2 (en) 2017-06-02 2023-03-14 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
TW201904587A (zh) 2017-06-02 2019-02-01 新加坡商波濤生命科學有限公司 寡核苷酸組合物及其使用方法
CN111051281A (zh) * 2017-06-21 2020-04-21 波涛生命科学有限公司 用于合成的化合物、组合物和方法
JP2020534253A (ja) 2017-08-08 2020-11-26 ウェーブ ライフ サイエンシーズ リミテッド オリゴヌクレオチド組成物及びその方法
KR20200052369A (ko) 2017-09-18 2020-05-14 웨이브 라이프 사이언시스 리미티드 올리고뉴클레오티드 제조 기술
US11596646B2 (en) 2017-10-12 2023-03-07 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
AU2019265904A1 (en) 2018-05-11 2020-11-12 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
GB201808146D0 (en) 2018-05-18 2018-07-11 Proqr Therapeutics Ii Bv Stereospecific Linkages in RNA Editing Oligonucleotides
EP4153747A2 (en) 2020-05-22 2023-03-29 Wave Life Sciences Ltd. Double stranded oligonucleotide compositions and methods relating thereto
EP4479535A1 (en) 2022-02-14 2024-12-25 ProQR Therapeutics II B.V. Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia
EP4555085A1 (en) 2022-07-15 2025-05-21 ProQR Therapeutics II B.V. Chemically modified oligonucleotides for adar-mediated rna editing
JP2025524566A (ja) 2022-07-15 2025-07-30 プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ Adar媒介rna編集のためのオリゴヌクレオチドおよびその使用
GB202215614D0 (en) 2022-10-21 2022-12-07 Proqr Therapeutics Ii Bv Heteroduplex rna editing oligonucleotide complexes
KR20250113455A (ko) 2022-11-24 2025-07-25 프로큐알 테라퓨틱스 Ⅱ 비.브이. 유전성 hfe-혈색소침착증의 치료를 위한 안티센스 올리고뉴클레오티드
GB202218090D0 (en) 2022-12-01 2023-01-18 Proqr Therapeutics Ii Bv Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency
KR20250115388A (ko) 2022-12-09 2025-07-30 프로큐알 테라퓨틱스 Ⅱ 비.브이. 심혈관 질환 치료용 안티센스 올리고뉴클레오타이드
GB202300865D0 (en) 2023-01-20 2023-03-08 Proqr Therapeutics Ii Bv Delivery of oligonucleotides
EP4669753A1 (en) 2023-02-20 2025-12-31 ProQR Therapeutics II B.V. Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease
GB202304363D0 (en) 2023-03-24 2023-05-10 Proqr Therapeutics Ii Bv Chemically modified antisense oligonucleotides for use in RNA editing
WO2024206175A1 (en) 2023-03-24 2024-10-03 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of neurological disorders
WO2024200472A1 (en) 2023-03-27 2024-10-03 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of liver disease
TW202516003A (zh) 2023-06-16 2025-04-16 荷蘭商Proqr治療上市公司Ii 用於治療神經退化性疾病之反義寡核苷酸
WO2025015335A1 (en) 2023-07-13 2025-01-16 Korro Bio, Inc. Rna-editing oligonucleotides and uses thereof
WO2025051946A1 (en) 2023-09-07 2025-03-13 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of metabolic disorders
WO2025096809A1 (en) 2023-10-31 2025-05-08 Korro Bio, Inc. Oligonucleotides comprising phosphoramidate internucleotide linkages
WO2025104239A1 (en) 2023-11-16 2025-05-22 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of classic galactosemia
WO2025128799A1 (en) 2023-12-12 2025-06-19 Korro Bio, Inc. Double-stranded rna-editing oligonucleotides and uses thereof
WO2025132708A1 (en) 2023-12-20 2025-06-26 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of huntington's disease
GB202404661D0 (en) 2024-04-02 2024-05-15 Proqr Therapeutics Ii Bv Antisense oligoncleotides for the treatment of liver disease
WO2025224230A1 (en) 2024-04-25 2025-10-30 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of fatty liver disease

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
WO1989009780A1 (en) * 1988-04-15 1989-10-19 Chemical Industry Institute Of Toxicology Site-specific tritium-labeled oligodeoxynucleotides
US5646265A (en) 1990-01-11 1997-07-08 Isis Pharmceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
US7101993B1 (en) 1990-01-11 2006-09-05 Isis Pharmaceuticals, Inc. Oligonucleotides containing 2′-O-modified purines
EP0628394B1 (en) 1993-06-10 1998-08-26 Idemitsu Petrochemical Co. Ltd. Injection molding die
US6180766B1 (en) 1993-12-02 2001-01-30 Raymond F. Schinazi Nucleosides and oligonucleotides containing boron clusters
US5571937A (en) 1994-05-13 1996-11-05 Sloan-Kettering Institute For Cancer Research Complementary DNA and toxins
WO1997009443A1 (en) 1995-09-05 1997-03-13 Michigan State University PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
US5869696A (en) 1996-04-22 1999-02-09 Beckman Instruments, Inc. Universal solid supports and methods for their use
GB9621522D0 (en) * 1996-10-16 1996-12-04 Biocompatibles Ltd Synthesis of phosphorus compounds
US6867294B1 (en) 1998-07-14 2005-03-15 Isis Pharmaceuticals, Inc. Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
US20030017451A1 (en) * 2000-12-21 2003-01-23 Hui Wang Methods for detecting transcripts
US7153954B2 (en) * 2001-07-12 2006-12-26 Santaris Pharma A/S Method for preparation of LNA phosphoramidites
US20030232978A1 (en) 2001-08-24 2003-12-18 Seeberger Peter H. Reagents that facilitate the purification of compounds synthesized on a solid support
JP4348044B2 (ja) 2002-02-12 2009-10-21 株式会社キラルジェン 立体規則性の高いジヌクレオシドホスホロチオエートの製造法
US7057062B2 (en) 2002-04-11 2006-06-06 Isis Pharmaceuticals, Inc. Process for manufacturing purified phosphorodiamidite
US7030230B2 (en) 2002-10-25 2006-04-18 Isis Pharmaceuticals, Inc. Process of purifying phosphoramidites
GB0229423D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
JP2005089441A (ja) * 2003-08-08 2005-04-07 Toudai Tlo Ltd 立体規則性の高いリン原子修飾ヌクレオチド類縁体の製造法
WO2005023828A1 (ja) 2003-09-02 2005-03-17 Takeshi Wada リボヌクレオチド又はリボヌクレオチド誘導体の製造方法
JP4616175B2 (ja) 2003-09-02 2011-01-19 株式会社キラルジェン 5’−ホスフィチル化モノマーおよびh−ホスホネートオリゴヌクレオチド誘導体の製造方法
WO2005070859A1 (ja) 2004-01-27 2005-08-04 Takeshi Wada フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
WO2005085272A1 (ja) 2004-03-05 2005-09-15 Takeshi Wada ボラノホスフェートモノマーおよびそれを用いたオリゴヌクレオチド誘導体の製造方法
JP4865544B2 (ja) 2004-03-25 2012-02-01 株式会社キラルジェン 立体規則性の高いリボヌクレオチド類縁体及びデオキシリボヌクレオチド類縁体の製造法
WO2005097817A2 (en) 2004-04-05 2005-10-20 Alnylam Pharmaceuticals, Inc. Process and reagents for oligonucleotide synthesis and purification
JP2006292394A (ja) 2005-04-06 2006-10-26 Hiroyuki Yamane シリカゲルの再生方法
WO2006116476A1 (en) * 2005-04-27 2006-11-02 Sigma-Aldrich Co. Activators for oligonucleotide and phosphoramidite synthesis
US7700567B2 (en) * 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
JP4713514B2 (ja) * 2006-02-20 2011-06-29 エフ.ホフマン−ラ ロシュ アーゲー 改善された標識試薬
WO2009143369A2 (en) 2008-05-22 2009-11-26 Isis Pharmaceuticals, Inc. Method of preparing nucleosides and analogs thereof without using chromatography
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
IN2012DN00720A (OSRAM) 2009-07-06 2015-06-19 Ontorii Inc
WO2011034072A1 (ja) 2009-09-16 2011-03-24 株式会社キラルジェン Rna及びその誘導体合成のための新規保護基
JP2011121881A (ja) 2009-12-09 2011-06-23 Nippon Shinyaku Co Ltd ホスホロアミダイト化合物の製造法
JP2011184318A (ja) 2010-03-05 2011-09-22 Univ Of Tokyo リボヌクレシドh−ボラノホスホネート
WO2011108682A1 (ja) 2010-03-05 2011-09-09 国立大学法人 東京大学 リボヌクレオシドホスホロチオエートの製造方法
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
EP2647644B1 (en) 2010-11-30 2020-09-09 Wave Life Sciences Japan, Inc. 2'-o-modified rna
MX347361B (es) 2011-07-19 2017-04-12 Wave Life Sciences Ltd Metodos para la sintesis de acidos nucleicos funcionalizados.
CN102516337B (zh) 2011-11-02 2014-07-02 东南大学 3’硫代-2’脱氧核糖-3’硝基吡咯亚磷酰胺单体及其合成方法和应用
CN102675386B (zh) 2011-12-24 2014-07-02 河南科技大学 一种龙胆苦苷分离提纯方法
EP2872485B1 (en) * 2012-07-13 2020-12-16 Wave Life Sciences Ltd. Asymmetric auxiliary group
EP2872147B1 (en) 2012-07-13 2022-12-21 Wave Life Sciences Ltd. Method for making chiral oligonucleotides
AU2013287630B2 (en) 2012-07-13 2017-05-25 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
JP2015119116A (ja) * 2013-12-19 2015-06-25 株式会社東芝 半導体装置
EP3095460A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
CN106068325B (zh) 2014-01-16 2021-07-09 波涛生命科学有限公司 手性设计
CN103819501B (zh) 2014-03-19 2015-11-04 厦门大学 一种甲基丙烯基亚磷酰胺单体及其合成方法
JP6730932B2 (ja) 2014-04-30 2020-07-29 アジレント・テクノロジーズ・インクAgilent Technologies, Inc. リン保護基ならびにそれらの調製方法および使用
US20180112217A1 (en) 2014-11-19 2018-04-26 Roche Innovation Center Copenhagen A/S Stereospecific Phosphorothioate LNA
MA43072A (fr) 2015-07-22 2018-05-30 Wave Life Sciences Ltd Compositions d'oligonucléotides et procédés associés
JP7511326B2 (ja) 2015-10-09 2024-07-05 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物およびその方法
MA43822A (fr) 2016-03-13 2018-11-28 Wave Life Sciences Ltd Compositions et procédés de synthèse de phosphoramidite et d'oligonucléotides
KR102372122B1 (ko) 2016-03-18 2022-03-07 로슈 이노베이션 센터 코펜하겐 에이/에스 아실-보호된 l-lna-구아노신 단량체
MA45290A (fr) 2016-05-04 2019-03-13 Wave Life Sciences Ltd Procédés et compositions d'agents biologiquement actifs
MA45270A (fr) 2016-05-04 2017-11-09 Wave Life Sciences Ltd Compositions d'oligonucléotides et procédés associés
JP2019520339A (ja) 2016-06-03 2019-07-18 ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. オリゴヌクレオチド、その組成物および方法
WO2018022473A1 (en) 2016-07-25 2018-02-01 Wave Life Sciences Ltd. Phasing
US11873316B2 (en) 2016-11-23 2024-01-16 Wave Life Sciences Ltd. Compositions and methods for phosphoramidite and oligonucleotide synthesis
CN120330183A (zh) 2017-06-02 2025-07-18 波涛生命科学有限公司 寡核苷酸组合物及其使用方法
US11603532B2 (en) 2017-06-02 2023-03-14 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
TW201904587A (zh) 2017-06-02 2019-02-01 新加坡商波濤生命科學有限公司 寡核苷酸組合物及其使用方法
CN111051281A (zh) 2017-06-21 2020-04-21 波涛生命科学有限公司 用于合成的化合物、组合物和方法
EP3645544B1 (en) 2017-06-28 2023-05-10 Roche Innovation Center Copenhagen A/S Multiple coupling&oxidation method
JP2020534253A (ja) 2017-08-08 2020-11-26 ウェーブ ライフ サイエンシーズ リミテッド オリゴヌクレオチド組成物及びその方法
KR20200052369A (ko) 2017-09-18 2020-05-14 웨이브 라이프 사이언시스 리미티드 올리고뉴클레오티드 제조 기술
US11596646B2 (en) 2017-10-12 2023-03-07 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
EP3775203A4 (en) 2018-04-12 2022-03-30 Wave Life Sciences Ltd. OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF
AU2019265904A1 (en) 2018-05-11 2020-11-12 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
SG11202105626TA (en) 2018-12-06 2021-06-29 Wave Life Sciences Ltd Oligonucleotide compositions and methods thereof
CA3126845A1 (en) 2019-02-01 2020-08-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
US20230089442A1 (en) 2019-03-20 2023-03-23 Pachamuthu Kandasamy Technologies useful for oligonucleotide preparation
US20220307019A1 (en) 2019-03-25 2022-09-29 National University Corporation Tokyo Medical And Dental University Double-stranded nucleic acid complex and use thereof
US20250051778A1 (en) 2019-04-25 2025-02-13 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
US20230145795A1 (en) 2019-04-25 2023-05-11 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
CN114502177A (zh) 2019-05-09 2022-05-13 波涛生命科学有限公司 寡核苷酸组合物及其使用方法
US20240175016A1 (en) 2019-10-06 2024-05-30 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
JP7766589B2 (ja) 2019-10-06 2025-11-10 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物及びその使用方法
EP4114939A4 (en) 2020-03-01 2024-03-20 Wave Life Sciences Ltd. OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
EP4153747A2 (en) 2020-05-22 2023-03-29 Wave Life Sciences Ltd. Double stranded oligonucleotide compositions and methods relating thereto
WO2021237223A1 (en) 2020-05-22 2021-11-25 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
WO2022046667A1 (en) 2020-08-24 2022-03-03 Wave Life Sciences Ltd. Cells and non-human animals engineered to express adar1 and uses thereof
WO2022046723A1 (en) 2020-08-24 2022-03-03 Wave Life Sciences Ltd. Immunoassays for detecting wild type huntingtin protein and methods of treatment employing such immunoassays
EP4217363A4 (en) 2020-09-24 2024-09-25 Mayo Foundation for Medical Education and Research Screening platforms
KR20230118716A (ko) 2020-11-08 2023-08-11 웨이브 라이프 사이언시스 리미티드 올리고뉴클레오티드 조성물 및 이의 방법
CN116507724A (zh) 2020-11-08 2023-07-28 波涛生命科学有限公司 寡核苷酸组合物及其方法
IL311625A (en) 2021-09-26 2024-05-01 Wave Life Sciences Ltd Oligonucleotide compositions and methods thereof
EP4404942A2 (en) 2021-09-26 2024-07-31 Wave Life Sciences Ltd. Compositions for editing mecp2 transcripts and methods thereof
CA3236136A1 (en) 2021-10-27 2023-05-04 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
EP4422645A4 (en) 2021-10-27 2025-12-03 Wave Life Sciences Ltd OLIGONUCLEOTID COMPOSITIONS AND THEIR METHODS OF USE
WO2023154528A1 (en) 2022-02-11 2023-08-17 Wave Life Sciences Ltd. Stereoselective technologies for chiral compounds
CN119137134A (zh) 2022-03-02 2024-12-13 波涛生命科学有限公司 寡核苷酸组合物及其用于外显子跳跃的方法
US20250262235A1 (en) 2022-04-15 2025-08-21 Wave Life Sciences Ltd. Oligonucleotide compositions and methods relating thereto
US20250302995A1 (en) 2022-05-12 2025-10-02 Chikdu Shakti Shivalila Oligonucleotide compositions and methods thereof
CN120476205A (zh) 2022-08-11 2025-08-12 波涛生命科学有限公司 寡核苷酸组合物及其方法
WO2025030155A1 (en) 2023-08-03 2025-02-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof

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