JP2019532089A - ピラゾロ［１，５−ａ］ピリミジン類およびその塩の調製方法 - Google Patents

ピラゾロ［１，５−ａ］ピリミジン類およびその塩の調製方法 Download PDF

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Publication number
JP2019532089A
JP2019532089A JP2019522507A JP2019522507A JP2019532089A JP 2019532089 A JP2019532089 A JP 2019532089A JP 2019522507 A JP2019522507 A JP 2019522507A JP 2019522507 A JP2019522507 A JP 2019522507A JP 2019532089 A JP2019532089 A JP 2019532089A
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Prior art keywords
compound
formula
salt
cancer
alkyl
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Pending
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JP2019522507A
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English (en)
Japanese (ja)
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JP2019532089A5 (https=
Inventor
ツァオ，キアン
スペンサー，ステイシー
ジャン，ユートン
ハース，ジュリア
トッド アーリー，チャールズ
トッド アーリー，チャールズ
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Loxo Oncology Inc
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Loxo Oncology Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62023982&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2019532089(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2016/058951 external-priority patent/WO2017075107A1/en
Application filed by Loxo Oncology Inc filed Critical Loxo Oncology Inc
Publication of JP2019532089A publication Critical patent/JP2019532089A/ja
Publication of JP2019532089A5 publication Critical patent/JP2019532089A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019522507A 2016-10-26 2017-10-26 ピラゾロ［１，５−ａ］ピリミジン類およびその塩の調製方法 Pending JP2019532089A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2016/058951 WO2017075107A1 (en) 2015-10-26 2016-10-26 Point mutations in trk inhibitor-resistant cancer and methods relating to the same
USPCT/US2016/058951 2016-10-26
US201762524801P 2017-06-26 2017-06-26
US62/524,801 2017-06-26
PCT/US2017/058518 WO2018081417A2 (en) 2016-10-26 2017-10-26 PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF

Publications (2)

Publication Number Publication Date
JP2019532089A true JP2019532089A (ja) 2019-11-07
JP2019532089A5 JP2019532089A5 (https=) 2020-12-03

Family

ID=62023982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019522507A Pending JP2019532089A (ja) 2016-10-26 2017-10-26 ピラゾロ［１，５−ａ］ピリミジン類およびその塩の調製方法

Country Status (28)

Country Link
US (1) US11091486B2 (https=)
EP (1) EP3532475A2 (https=)
JP (1) JP2019532089A (https=)
KR (1) KR20190082808A (https=)
CN (1) CN110267958A (https=)
AR (1) AR112207A1 (https=)
AU (1) AU2017348259B2 (https=)
BR (1) BR112019008341A2 (https=)
CA (1) CA3041316A1 (https=)
CL (2) CL2019001094A1 (https=)
CO (1) CO2019004123A2 (https=)
CR (1) CR20190255A (https=)
DO (1) DOP2019000109A (https=)
EA (1) EA201991055A1 (https=)
EC (1) ECSP19036765A (https=)
IL (1) IL266170A (https=)
JO (1) JOP20190092A1 (https=)
MA (2) MA46054A (https=)
MX (1) MX387902B (https=)
NI (1) NI201900037A (https=)
PE (1) PE20191543A1 (https=)
PH (1) PH12019500930A1 (https=)
SG (1) SG11201903487SA (https=)
TN (2) TN2020000195A1 (https=)
TW (1) TW201906840A (https=)
UA (1) UA124271C2 (https=)
UY (1) UY37781A (https=)
WO (2) WO2018081417A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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JP2021527623A (ja) * 2018-06-08 2021-10-14 江蘇威凱爾医薬科技有限公司 トロポミオシン受容体キナーゼインヒビター及びその調製方法と適用
JP2023525997A (ja) * 2020-05-08 2023-06-20 シャンドン シュエンヂュ ファーマ カンパニー リミテッド 大環類チロシンキナーゼ阻害剤の結晶形及びその製造方法

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ME03376B (me) 2010-05-20 2020-01-20 Array Biopharma Inc Makrociklička jedinjenja kао inhibiтori trk kinaze
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EP3368039A1 (en) 2015-10-26 2018-09-05 The Regents of The University of Colorado, A Body Corporate Point mutations in trk inhibitor-resistant cancer and methods relating to the same
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
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EP3458456B1 (en) 2016-05-18 2020-11-25 Loxo Oncology Inc. Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
JOP20190092A1 (ar) * 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
WO2019084285A1 (en) * 2017-10-26 2019-05-02 Qian Zhao FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR
AU2018364938B2 (en) * 2017-11-10 2021-11-11 Angex Pharmaceutical, Inc. Macrocyclic compounds as TRK kinase inhibitors and uses thereof
WO2019233461A1 (zh) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 原肌球蛋白受体激酶抑制剂及其制备方法和应用
EP3858834A4 (en) * 2018-09-29 2022-06-22 Shandong Luye Pharmaceutical Co., Ltd. PYRAZOLOPYRIMIDE DERIVATIVES AS SELECTIVE TRK INHIBITORS
JP7631193B2 (ja) 2018-10-22 2025-02-18 アルミス インコーポレイテッド Ｔｙｋ２阻害剤およびその使用
WO2020094112A1 (zh) * 2018-11-09 2020-05-14 山东轩竹医药科技有限公司 大环类酪氨酸激酶抑制剂及其用途
CN111253402B (zh) * 2018-11-30 2021-08-03 广州白云山医药集团股份有限公司白云山制药总厂 一种trk激酶抑制剂化合物的中间体化合物及制备方法
CA3132632A1 (en) * 2019-03-11 2020-09-17 Esker Therapeutics, Inc. Tyk2 inhibitors and uses thereof
AR119140A1 (es) 2019-06-13 2021-11-24 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
CN113135938B (zh) * 2020-01-19 2022-06-14 山东轩竹医药科技有限公司 取代的大环类酪氨酸激酶抑制剂及其用途
WO2022208370A1 (en) 2021-03-31 2022-10-06 Pi Industries Ltd. Fused heterocyclic compounds and their use as pest control agents
CN113444070A (zh) * 2021-07-28 2021-09-28 深圳市真味生物科技有限公司 一种由手性叔丁基亚磺酰胺合成手性尼古丁的制备方法
PY2513474A (es) 2024-02-23 2025-10-10 Pi Industries Ltd Compuestos heterocíclicos fusionados y usos de los mismos
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