JP2019054802A5 - - Google Patents

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JP2019054802A5
JP2019054802A5 JP2018210798A JP2018210798A JP2019054802A5 JP 2019054802 A5 JP2019054802 A5 JP 2019054802A5 JP 2018210798 A JP2018210798 A JP 2018210798A JP 2018210798 A JP2018210798 A JP 2018210798A JP 2019054802 A5 JP2019054802 A5 JP 2019054802A5
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seq
amino acid
chain variable
mab
nos
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JP2018210798A
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JP2019054802A (ja
JP6590428B2 (ja
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Priority claimed from US09/920,137 external-priority patent/US7250165B2/en
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Claims (4)

  1. 配列番号:16, 17, 18のアミノ酸配列をそれぞれ有するmAb TNV148の重鎖相補性決定領域(CDR)1, 2, 3; および
    配列番号:22, 23, 24のアミノ酸配列をそれぞれ有するmAb TNV148の軽鎖CDR1, 2, 3を含み、
    ヒト可溶性TNFに0.1〜9.9×10 -11 MのK D で結合する、抗TNF抗体を含む、関節リウマチを治療するための医薬組成物。
  2. 配列番号:16, 17, 18のアミノ酸配列をそれぞれ有するmAb TNV148の重鎖相補性決定領域(CDR)1, 2, 3と配列番号：19, 20, 21のアミノ酸配列をそれぞれ有するmAb TNV148の重鎖可変フレイムワーク領域(FR)1, 2, 3;および
    配列番号:22, 23, 24のアミノ酸配列をそれぞれ有するmAb TNV148の軽鎖CDR1, 2, 3と配列番号:25, 26, 27のアミノ酸配列をそれぞれ有するmAb TNV148の軽鎖可変FR1, 2, 3
    を含み、mAb TNV148の重鎖可変FR3におけるプロリンからセリンへの特異的な置換をさらに含んでよい
    抗体を含む、関節リウマチを治療するための医薬組成物。
  3. 配列番号;28, 29のアミノ酸配列をそれぞれ有するmAb TNV148の重鎖可変領域および軽鎖可変領域、または配列番号:30, 31のアミノ酸配列をそれぞれ有するmAb TNV148Bの重鎖可変領域および軽鎖可変領域を含む抗体を含む、関節リウマチを治療するための医薬組成物。
  4. 抗体が抗原結合性断片である、請求項１〜３のいずれか１項に記載の医薬組成物。
JP2018210798A 2000-08-07 2018-11-08 抗−ｔｎｆ抗体、組成物、方法および使用 Expired - Lifetime JP6590428B2 (ja)

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US22336000P 2000-08-07 2000-08-07
US60/223,360 2000-08-07
US23682600P 2000-09-29 2000-09-29
US60/236,826 2000-09-29
US09/920,137 US7250165B2 (en) 2000-08-07 2001-08-01 Anti-TNF antibodies, compositions, methods and uses
US09/920,137 2001-08-01

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JP2011088687A Withdrawn JP2011188862A (ja) 2000-08-07 2011-04-12 抗−ｔｎｆ抗体、組成物、方法および使用
JP2015134150A Expired - Lifetime JP6449113B2 (ja) 2000-08-07 2015-07-03 抗−ｔｎｆ抗体、組成物、方法および使用
JP2017177751A Expired - Lifetime JP6564438B2 (ja) 2000-08-07 2017-09-15 抗−ｔｎｆ抗体、組成物、方法および使用
JP2018210798A Expired - Lifetime JP6590428B2 (ja) 2000-08-07 2018-11-08 抗−ｔｎｆ抗体、組成物、方法および使用
JP2019135600A Ceased JP2019216721A (ja) 2000-08-07 2019-07-23 抗−ｔｎｆ抗体、組成物、方法および使用
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JP2011088687A Withdrawn JP2011188862A (ja) 2000-08-07 2011-04-12 抗−ｔｎｆ抗体、組成物、方法および使用
JP2015134150A Expired - Lifetime JP6449113B2 (ja) 2000-08-07 2015-07-03 抗−ｔｎｆ抗体、組成物、方法および使用
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US (3) US7250165B2 (ja)
EP (4) EP3118318B1 (ja)
JP (7) JP4748920B2 (ja)
KR (1) KR100883078B1 (ja)
CN (2) CN101980017B (ja)
AT (1) ATE446367T1 (ja)
AU (2) AU2001279227B2 (ja)
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CY (7) CY1109618T1 (ja)
DE (2) DE60140259D1 (ja)
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EA (2) EA007005B1 (ja)
ES (4) ES2709335T3 (ja)
FR (1) FR10C0014I2 (ja)
HK (2) HK1052948B (ja)
HR (1) HRP20030089B1 (ja)
HU (2) HU229523B1 (ja)
IL (3) IL154327A0 (ja)
LT (5) LT3118318T (ja)
LU (3) LU91663I2 (ja)
ME (1) ME00314B (ja)
MX (1) MXPA03001231A (ja)
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NO (3) NO333378B1 (ja)
NZ (2) NZ562811A (ja)
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SI (4) SI3118318T1 (ja)
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