JP2018518974A5 - - Google Patents
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- JP2018518974A5 JP2018518974A5 JP2017567178A JP2017567178A JP2018518974A5 JP 2018518974 A5 JP2018518974 A5 JP 2018518974A5 JP 2017567178 A JP2017567178 A JP 2017567178A JP 2017567178 A JP2017567178 A JP 2017567178A JP 2018518974 A5 JP2018518974 A5 JP 2018518974A5
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- 239000000427 antigen Substances 0.000 claims 32
- 102000036639 antigens Human genes 0.000 claims 32
- 108091007433 antigens Proteins 0.000 claims 32
- 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 19
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims 17
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims 17
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 14
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 13
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 13
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 13
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 13
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 12
- 102000010956 Glypican Human genes 0.000 claims 12
- 108050001154 Glypican Proteins 0.000 claims 12
- 108050007237 Glypican-3 Proteins 0.000 claims 12
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 12
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 12
- -1 LeY Proteins 0.000 claims 12
- 102100035721 Syndecan-1 Human genes 0.000 claims 12
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 12
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 12
- 230000000139 costimulatory effect Effects 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 11
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 11
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 11
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 11
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 claims 10
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 claims 10
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 10
- 102100028801 Calsyntenin-1 Human genes 0.000 claims 10
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 10
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 10
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 10
- 101000668858 Spinacia oleracea 30S ribosomal protein S1, chloroplastic Proteins 0.000 claims 10
- 101000898746 Streptomyces clavuligerus Clavaminate synthase 1 Proteins 0.000 claims 10
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 10
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 7
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 7
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 6
- 102100022749 Aminopeptidase N Human genes 0.000 claims 6
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 6
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 6
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 6
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 6
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 6
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 6
- 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 claims 6
- 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 claims 6
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 claims 6
- 101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 claims 6
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 6
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 6
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 6
- 102100032999 Integrin beta-3 Human genes 0.000 claims 6
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 6
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 6
- 102100025136 Macrosialin Human genes 0.000 claims 6
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 6
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 6
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 6
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 6
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 5
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 3
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 3
- 108010065524 CD52 Antigen Proteins 0.000 claims 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 3
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 3
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 3
- 108010065805 Interleukin-12 Proteins 0.000 claims 3
- 108090000172 Interleukin-15 Proteins 0.000 claims 3
- 102100020789 Interleukin-15 receptor subunit alpha Human genes 0.000 claims 3
- 101710107699 Interleukin-15 receptor subunit alpha Proteins 0.000 claims 3
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 108010002586 Interleukin-7 Proteins 0.000 claims 3
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 3
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 108010074108 interleukin-21 Proteins 0.000 claims 3
- 108010083359 Antigen Receptors Proteins 0.000 claims 2
- 102000006306 Antigen Receptors Human genes 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000000581 natural killer T-cell Anatomy 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 206010020631 Hypergammaglobulinaemia benign monoclonal Diseases 0.000 claims 1
- 208000001715 Osteoblastoma Diseases 0.000 claims 1
- 208000002774 Paraproteinemias Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 208000025750 heavy chain disease Diseases 0.000 claims 1
- 201000005328 monoclonal gammopathy of uncertain significance Diseases 0.000 claims 1
- 208000031223 plasma cell leukemia Diseases 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021167360A JP7254870B2 (ja) | 2015-06-25 | 2021-10-12 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP2023053851A JP7502515B2 (ja) | 2015-06-25 | 2023-03-29 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP2024092213A JP2024116259A (ja) | 2015-06-25 | 2024-06-06 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562184321P | 2015-06-25 | 2015-06-25 | |
| US62/184,321 | 2015-06-25 | ||
| US201562235840P | 2015-10-01 | 2015-10-01 | |
| US62/235,840 | 2015-10-01 | ||
| US201562244435P | 2015-10-21 | 2015-10-21 | |
| US62/244,435 | 2015-10-21 | ||
| PCT/US2016/039306 WO2016210293A1 (en) | 2015-06-25 | 2016-06-24 | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021167360A Division JP7254870B2 (ja) | 2015-06-25 | 2021-10-12 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518974A JP2018518974A (ja) | 2018-07-19 |
| JP2018518974A5 true JP2018518974A5 (enExample) | 2019-07-18 |
| JP6961497B2 JP6961497B2 (ja) | 2021-11-05 |
Family
ID=57586695
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567178A Active JP6961497B2 (ja) | 2015-06-25 | 2016-06-24 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP2021167360A Active JP7254870B2 (ja) | 2015-06-25 | 2021-10-12 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP2023053851A Active JP7502515B2 (ja) | 2015-06-25 | 2023-03-29 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP2024092213A Pending JP2024116259A (ja) | 2015-06-25 | 2024-06-06 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021167360A Active JP7254870B2 (ja) | 2015-06-25 | 2021-10-12 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP2023053851A Active JP7502515B2 (ja) | 2015-06-25 | 2023-03-29 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP2024092213A Pending JP2024116259A (ja) | 2015-06-25 | 2024-06-06 | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11655452B2 (enExample) |
| EP (1) | EP3313872A4 (enExample) |
| JP (4) | JP6961497B2 (enExample) |
| KR (1) | KR20180021137A (enExample) |
| CN (2) | CN115058395B (enExample) |
| AU (3) | AU2016283102B2 (enExample) |
| CA (1) | CA2990177A1 (enExample) |
| IL (2) | IL287718B2 (enExample) |
| SG (1) | SG10201913682QA (enExample) |
| TW (2) | TWI833684B (enExample) |
| WO (1) | WO2016210293A1 (enExample) |
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| SG11201609118RA (en) | 2014-05-15 | 2016-11-29 | Univ Singapore | Modified natural killer cells and uses thereof |
| KR102376242B1 (ko) | 2014-12-24 | 2022-03-21 | 오토러스 리미티드 | 세포 |
| HUE059218T2 (hu) | 2015-04-08 | 2022-11-28 | Novartis Ag | CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel |
| SG10201913682QA (en) * | 2015-06-25 | 2020-03-30 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF |
| US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| JP7010487B2 (ja) | 2015-08-17 | 2022-03-03 | ソウル大学校産学協力団 | 抗コチニン抗体が連結したキメラ抗原受容体およびその使用 |
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| RU2717984C2 (ru) | 2013-11-21 | 2020-03-27 | ЮСиЭл БИЗНЕС ЛТД | Клетка |
| EP4303229A3 (en) | 2014-01-21 | 2024-04-17 | Novartis AG | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| EP3102236A4 (en) | 2014-02-05 | 2017-08-30 | The University of Chicago | Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants |
| PT3105317T (pt) | 2014-02-14 | 2019-02-27 | Cellectis | Células para imunoterapia manipuladas para atuar sobre antigénios presentes tanto em células imunitárias como em células patológicas |
| RU2016143389A (ru) | 2014-04-10 | 2018-05-15 | Сиэтл Чилдрен'С Хоспитал (Дба Сиэтл Чилдрен'С Ресёрч Инститьют) | Получение генно-инженерных т-клеток посредством транспозона "спящая красавица" в сочетании с отбором метотрексатом |
| US10301370B2 (en) | 2014-05-02 | 2019-05-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor T cells |
| DE112014006656B4 (de) | 2014-05-14 | 2018-05-17 | Carsgen Therapeutics Limited | Nukleinsäure zur Kodierung eines chimären Antigen-Rezeptor-Proteins und T-Lymphozyt zur Expression eines chimären Antigen-Rezeptor-Proteins |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| MY189028A (en) * | 2014-08-19 | 2022-01-20 | Novartis Ag | Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment |
| DK4074735T3 (da) | 2014-08-28 | 2025-07-14 | Bioatla Inc | Betinget aktive kimæriske antigenreceptorer til modificerede t-celler |
| EP3204491A1 (en) * | 2014-10-07 | 2017-08-16 | Cellectis | Method for modulating car-induced immune cells activity |
| KR102376242B1 (ko) | 2014-12-24 | 2022-03-21 | 오토러스 리미티드 | 세포 |
| CA2977106A1 (en) * | 2015-02-27 | 2016-09-01 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof |
| HUE059218T2 (hu) * | 2015-04-08 | 2022-11-28 | Novartis Ag | CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel |
| US20190135894A1 (en) * | 2015-06-25 | 2019-05-09 | iCell Gene Therapeuticics LLC | COMPOUND CHIMERIC ANTIGEN RECEPTOR (cCAR) TARGETING MULTIPLE ANTIGENS, COMPOSITIONS AND METHODS OF USE THEREOF |
| US20220241327A1 (en) * | 2015-06-25 | 2022-08-04 | Icell Gene Therapeutics Llc | Chimeric Antigen Receptor (CAR) Targeting Multiple Antigens, Compositions and Methods of Use Thereof |
| SG10201913682QA (en) * | 2015-06-25 | 2020-03-30 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF |
| US11173179B2 (en) * | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| CN105384825B (zh) * | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| CN105087495B (zh) * | 2015-08-21 | 2016-04-27 | 深圳市茵冠生物科技有限公司 | 双嵌合抗原受体修饰的t淋巴细胞及其制备方法 |
| GB201518817D0 (en) | 2015-10-23 | 2015-12-09 | Autolus Ltd | Cell |
| US20180371052A1 (en) * | 2015-12-22 | 2018-12-27 | Icell Gene Therapeutics Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
| EP4353750A3 (en) * | 2016-06-24 | 2024-07-24 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars), compositions and methods thereof |
| JP2020524512A (ja) * | 2017-06-21 | 2020-08-20 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体（ＣＡＲｓ）の組成物およびその使用方法 |
| SG11202003258QA (en) * | 2017-10-12 | 2020-05-28 | Icell Gene Therapeutics Llc | Compound chimeric antigen receptor (ccar) targeting multiple antigens, compositions and methods of use thereof |
| BR112020010579A2 (pt) * | 2017-11-30 | 2020-11-10 | Novartis Ag | receptor de antígeno quimérico de alvejamento de bcma e usos do mesmo |
-
2016
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- 2016-06-24 WO PCT/US2016/039306 patent/WO2016210293A1/en not_active Ceased
- 2016-06-24 CA CA2990177A patent/CA2990177A1/en active Pending
- 2016-06-24 KR KR1020187002389A patent/KR20180021137A/ko active Pending
- 2016-06-24 CN CN202210523997.3A patent/CN115058395B/zh active Active
- 2016-06-24 US US15/739,596 patent/US11655452B2/en active Active
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- 2016-06-24 CN CN201680036459.4A patent/CN107849112B/zh active Active
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