JP2020074776A5 - - Google Patents
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- JP2020074776A5 JP2020074776A5 JP2019237695A JP2019237695A JP2020074776A5 JP 2020074776 A5 JP2020074776 A5 JP 2020074776A5 JP 2019237695 A JP2019237695 A JP 2019237695A JP 2019237695 A JP2019237695 A JP 2019237695A JP 2020074776 A5 JP2020074776 A5 JP 2020074776A5
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- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- cell
- seq
- car
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 49
- 210000004027 cell Anatomy 0.000 claims 34
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 18
- 101001014668 Homo sapiens Glypican-3 Proteins 0.000 claims 9
- 102100032530 Glypican-3 Human genes 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 230000001472 cytotoxic effect Effects 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102100037850 Interferon gamma Human genes 0.000 claims 5
- 108010074328 Interferon-gamma Proteins 0.000 claims 5
- 238000002619 cancer immunotherapy Methods 0.000 claims 5
- 101150058049 car gene Proteins 0.000 claims 4
- 102000048373 human GPC3 Human genes 0.000 claims 3
- 102000000704 Interleukin-7 Human genes 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 229940100994 interleukin-7 Drugs 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 102000010956 Glypican Human genes 0.000 claims 1
- 108050001154 Glypican Proteins 0.000 claims 1
- 108050007237 Glypican-3 Proteins 0.000 claims 1
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims 1
- 230000020411 cell activation Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022159364A JP7389424B2 (ja) | 2017-01-10 | 2022-10-03 | 抗ｇｐｃ３抗体 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017001732 | 2017-01-10 | ||
| JP2017001732 | 2017-01-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019151869A Division JP6647675B2 (ja) | 2017-01-10 | 2019-08-22 | 抗ｇｐｃ３抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022159364A Division JP7389424B2 (ja) | 2017-01-10 | 2022-10-03 | 抗ｇｐｃ３抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020074776A JP2020074776A (ja) | 2020-05-21 |
| JP2020074776A5 true JP2020074776A5 (enExample) | 2021-03-25 |
Family
ID=62839598
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561377A Active JP6579640B2 (ja) | 2017-01-10 | 2018-01-10 | 抗ｇｐｃ３抗体 |
| JP2019151869A Active JP6647675B2 (ja) | 2017-01-10 | 2019-08-22 | 抗ｇｐｃ３抗体 |
| JP2019237695A Pending JP2020074776A (ja) | 2017-01-10 | 2019-12-27 | 抗ｇｐｃ３抗体 |
| JP2022159364A Active JP7389424B2 (ja) | 2017-01-10 | 2022-10-03 | 抗ｇｐｃ３抗体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561377A Active JP6579640B2 (ja) | 2017-01-10 | 2018-01-10 | 抗ｇｐｃ３抗体 |
| JP2019151869A Active JP6647675B2 (ja) | 2017-01-10 | 2019-08-22 | 抗ｇｐｃ３抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022159364A Active JP7389424B2 (ja) | 2017-01-10 | 2022-10-03 | 抗ｇｐｃ３抗体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11718663B2 (enExample) |
| EP (1) | EP3569709A4 (enExample) |
| JP (4) | JP6579640B2 (enExample) |
| KR (1) | KR102564097B1 (enExample) |
| CN (2) | CN116102651A (enExample) |
| AU (1) | AU2018208191B2 (enExample) |
| BR (1) | BR112019013947A2 (enExample) |
| CA (1) | CA3049189A1 (enExample) |
| EA (1) | EA201991385A1 (enExample) |
| IL (2) | IL300270A (enExample) |
| MA (1) | MA47268A (enExample) |
| MX (1) | MX2019008221A (enExample) |
| TW (2) | TWI780102B (enExample) |
| WO (1) | WO2018131586A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102564097B1 (ko) * | 2017-01-10 | 2023-08-04 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 항 gpc3 항체 |
| TWI809130B (zh) | 2018-06-22 | 2023-07-21 | 美商凱特製藥公司 | 嵌合跨膜蛋白及其用途 |
| CN112469829B (zh) * | 2018-07-17 | 2023-07-07 | 诺伊尔免疫生物科技株式会社 | 包含抗gpc3单链抗体的car |
| MX2021003744A (es) * | 2018-10-01 | 2021-06-23 | Adicet Bio Inc | Composiciones y métodos relacionados con linfocitos t gamma delta modificados y no modificados para el tratamiento de tumores sólidos. |
| CN111040036B (zh) * | 2018-10-12 | 2023-10-20 | 上海卡智生物技术有限公司 | 抗gpc3单克隆抗体、由其修饰的免疫效应细胞及其应用 |
| CN109504660B (zh) * | 2018-11-02 | 2021-08-06 | 温州启星生物技术有限公司 | 一种第四代car-t细胞及其构建方法和应用 |
| US12109235B2 (en) | 2019-06-21 | 2024-10-08 | Kite Pharma, Inc. | TGF-beta receptors and methods of use |
| CN112574297B (zh) * | 2019-09-27 | 2022-06-24 | 上海生物制品研究所有限责任公司 | 抗神经氨酸酶的单克隆抗体及其应用 |
| CN113227148B (zh) * | 2019-12-05 | 2022-11-01 | 上海翰森生物医药科技有限公司 | 抗gpc3抗体、其抗原结合片段及其医药用途 |
| CN115960207A (zh) * | 2019-12-13 | 2023-04-14 | 南京大户生物科技有限公司 | 原发性肝癌相关抗原的胸腺依赖性淋巴细胞抗原表位肽及其应用 |
| EP4106880A4 (en) * | 2020-02-17 | 2024-07-03 | Board of Regents, The University of Texas System | HUMAN 4-1BB AGONIST ANTIBODIES AND METHODS OF USE THEREOF |
| EP4110912A4 (en) * | 2020-02-27 | 2024-07-10 | Legend Biotech Ireland Limited | ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS TARGETING GLYPICAN-3 (GPC3) AND METHODS OF USE THEREOF |
| WO2021186397A1 (en) * | 2020-03-18 | 2021-09-23 | Eutilex Co., Ltd. | Gpc3 car-t cell compositions and methods of making and using the same |
| CN115461449A (zh) * | 2020-03-18 | 2022-12-09 | 优特力克斯有限公司 | 分泌il-18的gpc3 car-t细胞及其制备和使用方法 |
| EP4247426A4 (en) * | 2020-11-18 | 2024-10-23 | Memorial Sloan Kettering Cancer Center | MULTISPECIFIC ANTI-GPA33 ANTIBODIES AND THEIR USES |
| CN114573702A (zh) * | 2020-12-02 | 2022-06-03 | 康诺亚生物医药科技（成都）有限公司 | 一种新型肿瘤衔接器治疗药物的开发和应用 |
| KR20220080381A (ko) * | 2020-12-07 | 2022-06-14 | (주)이노베이션바이오 | Gpc3에 특이적인 항체 및 이의 용도 |
| CN113072643B (zh) * | 2021-03-22 | 2021-10-15 | 南京医科大学 | 抗Glypican-3耐酸性全人源抗体、其免疫毒素、其嵌合抗原受体细胞及应用 |
| JP2024511906A (ja) * | 2021-03-28 | 2024-03-15 | イムノーム、インコーポレイテッド | Ｉｌ－３８特異的抗体 |
| CN116761826B (zh) * | 2021-05-31 | 2026-04-14 | 上海以岭药业有限公司 | 针对CLDN18.2的单克隆抗体及其Fc工程化形式 |
| CN117730100A (zh) * | 2021-06-08 | 2024-03-19 | 凯德药业股份有限公司 | Gpc3结合分子 |
| WO2022268196A1 (zh) * | 2021-06-25 | 2022-12-29 | 天辰生物医药(苏州)有限公司 | 靶向gpc3的抗原结合蛋白 |
| CN113527500B (zh) * | 2021-07-16 | 2022-09-20 | 蒋小滔 | 一种磷脂酰肌醇蛋白聚糖3的全人源单克隆抗体、其嵌合抗原受体及应用 |
| US20250332195A1 (en) * | 2021-07-16 | 2025-10-30 | Noile-Immune Biotech Inc. | Chimeric antigen receptor, cell expressing said receptor, pharmaceutical composition including said cell, method for producing said cell, and polynucleotide or vector including nucleotide sequence encoding said chimeric antigen receptor |
| WO2023023354A2 (en) * | 2021-08-19 | 2023-02-23 | Adicet Therapeutics, Inc. | Methods for detection of membrane bound glypican-3 |
| CN116063527A (zh) * | 2021-09-30 | 2023-05-05 | 南京北恒生物科技有限公司 | 靶向间皮素的抗体及其用途 |
| CN116004639A (zh) * | 2022-08-18 | 2023-04-25 | 武汉生之源生物科技股份有限公司 | 一种磷脂酰肌醇蛋白聚糖3的n末端片段、编码基因、多克隆抗体及其制备方法和应用 |
| JP7295324B1 (ja) | 2022-11-30 | 2023-06-20 | 株式会社合同資源 | フッ化物イオンとリン酸イオンの選択除去性を持つ無機系凝集剤によるヨウ素成分含有水溶液の製造方法 |
| WO2024118866A1 (en) * | 2022-12-01 | 2024-06-06 | Modernatx, Inc. | Gpc3-specific antibodies, binding domains, and related proteins and uses thereof |
| WO2024177972A2 (en) * | 2023-02-20 | 2024-08-29 | The Wistar Institute Of Anatomy And Biology | Antibody-cytokine chimeras |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| CN118063612B (zh) * | 2024-04-18 | 2024-07-26 | 上海宏成药业有限公司 | 抗ror1抗体或其抗原结合片段及其用途 |
| CN119978147B (zh) * | 2025-02-26 | 2025-11-11 | 中山大学 | 一种用于富集酪氨酸n-乙酰半乳糖胺修饰位点的磁珠及其制备方法和应用 |
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| ATE255162T1 (de) | 1983-01-13 | 2003-12-15 | Max Planck Gesellschaft | Transgene dicotyledone pflanzenzellen und pflanzen |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| ATE204017T1 (de) | 1984-05-11 | 2001-08-15 | Syngenta Participations Ag | Transformation von pflanzenerbgut |
| JPS62275650A (ja) | 1986-05-23 | 1987-11-30 | Hatsuho Seika Kk | 膨張菓子の製造方法 |
| IL84459A (en) | 1986-12-05 | 1993-07-08 | Agracetus | Apparatus and method for the injection of carrier particles carrying genetic material into living cells |
| JP2928287B2 (ja) | 1988-09-29 | 1999-08-03 | 協和醗酵工業株式会社 | 新規ポリペプチド |
| JPH0322979A (ja) | 1989-06-19 | 1991-01-31 | Kyowa Hakko Kogyo Co Ltd | 新規プラスミノーゲン活性化因子 |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| WO2004022597A1 (ja) | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | Gpc3の血中可溶化ｎ端ﾍﾟﾌﾟﾁﾄﾞに対する抗体 |
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| WO2012145469A1 (en) | 2011-04-19 | 2012-10-26 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
| US20140322216A1 (en) * | 2011-11-08 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
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| SG11201408037SA (en) * | 2012-06-08 | 2015-01-29 | Glenmark Pharmaceuticals Sa | Humanized anti-trka antibodies with amino acid substitutions |
| WO2014078373A1 (en) * | 2012-11-13 | 2014-05-22 | Iogenetics, Llc | Antimicrobial compositions |
| TWI693073B (zh) | 2012-12-21 | 2020-05-11 | 日商中外製藥股份有限公司 | 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑 |
| CN107460201A (zh) | 2013-05-08 | 2017-12-12 | 科济生物医药（上海）有限公司 | 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞 |
| CN105849562B (zh) | 2013-12-24 | 2019-08-16 | 中外制药株式会社 | 可溶性gpc3蛋白质的测定方法 |
| EP3145952A2 (en) * | 2014-05-22 | 2017-03-29 | Genentech, Inc. | Anti-gpc3 antibodies and immunoconjugates |
| US10093746B2 (en) * | 2014-09-04 | 2018-10-09 | The Trustees Of The University Of Pennsylvania | Glypican-3 antibody and uses thereof |
| EP3858991A1 (en) * | 2014-09-26 | 2021-08-04 | Baylor College of Medicine | Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy |
| DK3597742T3 (da) | 2014-10-09 | 2022-10-03 | Univ Yamaguchi | Car-udtrykkende vektor og car-udtrykkende t-celler |
| JP6558091B2 (ja) | 2015-06-15 | 2019-08-14 | 大日本印刷株式会社 | 注出口組合体、注出口組合体付容器、及び充填体 |
| KR102564097B1 (ko) * | 2017-01-10 | 2023-08-04 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 항 gpc3 항체 |
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2018
- 2018-01-10 KR KR1020197019505A patent/KR102564097B1/ko active Active
- 2018-01-10 WO PCT/JP2018/000257 patent/WO2018131586A1/ja not_active Ceased
- 2018-01-10 CA CA3049189A patent/CA3049189A1/en active Pending
- 2018-01-10 TW TW107100996A patent/TWI780102B/zh active
- 2018-01-10 CN CN202310167019.4A patent/CN116102651A/zh active Pending
- 2018-01-10 TW TW111134012A patent/TWI831365B/zh active
- 2018-01-10 US US16/472,356 patent/US11718663B2/en active Active
- 2018-01-10 EP EP18738824.4A patent/EP3569709A4/en active Pending
- 2018-01-10 CN CN201880006069.1A patent/CN110177876B/zh active Active
- 2018-01-10 IL IL300270A patent/IL300270A/en unknown
- 2018-01-10 JP JP2018561377A patent/JP6579640B2/ja active Active
- 2018-01-10 MA MA047268A patent/MA47268A/fr unknown
- 2018-01-10 MX MX2019008221A patent/MX2019008221A/es unknown
- 2018-01-10 AU AU2018208191A patent/AU2018208191B2/en active Active
- 2018-01-10 BR BR112019013947-8A patent/BR112019013947A2/pt unknown
- 2018-01-10 EA EA201991385A patent/EA201991385A1/ru unknown
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2019
- 2019-07-02 IL IL267797A patent/IL267797B2/en unknown
- 2019-08-21 US US16/546,787 patent/US10781249B2/en active Active
- 2019-08-22 JP JP2019151869A patent/JP6647675B2/ja active Active
- 2019-12-27 JP JP2019237695A patent/JP2020074776A/ja active Pending
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2022
- 2022-10-03 JP JP2022159364A patent/JP7389424B2/ja active Active
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2023
- 2023-06-15 US US18/335,477 patent/US12129291B2/en active Active