BR112019013947A2 - Anticorpo, receptor de antígeno quimérico, célula imunocompetente, gene de anticorpo, vetor, célula hospedeira, método para detectar gpc3, e, kit para a detecção de gpc3. - Google Patents

Anticorpo, receptor de antígeno quimérico, célula imunocompetente, gene de anticorpo, vetor, célula hospedeira, método para detectar gpc3, e, kit para a detecção de gpc3. Download PDF

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BR112019013947A2
BR112019013947A2 BR112019013947-8A BR112019013947A BR112019013947A2 BR 112019013947 A2 BR112019013947 A2 BR 112019013947A2 BR 112019013947 A BR112019013947 A BR 112019013947A BR 112019013947 A2 BR112019013947 A2 BR 112019013947A2
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Prior art keywords
amino acid
acid sequence
seq
sequence represented
chain
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BR112019013947-8A
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English (en)
Portuguese (pt)
Inventor
Tamada Koji
Sakoda Yukimi
Nakatsura Tetsuya
Saito Keigo
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Yamaguchi University
National Cancer Center
Noile-Immune Biotech, Inc.
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Application filed by Yamaguchi University, National Cancer Center, Noile-Immune Biotech, Inc. filed Critical Yamaguchi University
Publication of BR112019013947A2 publication Critical patent/BR112019013947A2/pt

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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001174Proteoglycans, e.g. glypican, brevican or CSPG4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
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    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2319/00Fusion polypeptide
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BR112019013947-8A 2017-01-10 2018-01-10 Anticorpo, receptor de antígeno quimérico, célula imunocompetente, gene de anticorpo, vetor, célula hospedeira, método para detectar gpc3, e, kit para a detecção de gpc3. BR112019013947A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017-001732 2017-01-10
JP2017001732 2017-01-10
PCT/JP2018/000257 WO2018131586A1 (ja) 2017-01-10 2018-01-10 抗gpc3抗体

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BR112019013947A2 true BR112019013947A2 (pt) 2020-02-11

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US (3) US11718663B2 (enExample)
EP (1) EP3569709A4 (enExample)
JP (4) JP6579640B2 (enExample)
KR (1) KR102564097B1 (enExample)
CN (2) CN116102651A (enExample)
AU (1) AU2018208191B2 (enExample)
BR (1) BR112019013947A2 (enExample)
CA (1) CA3049189A1 (enExample)
EA (1) EA201991385A1 (enExample)
IL (2) IL300270A (enExample)
MA (1) MA47268A (enExample)
MX (1) MX2019008221A (enExample)
TW (2) TWI780102B (enExample)
WO (1) WO2018131586A1 (enExample)

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CN111040036B (zh) * 2018-10-12 2023-10-20 上海卡智生物技术有限公司 抗gpc3单克隆抗体、由其修饰的免疫效应细胞及其应用
CN109504660B (zh) * 2018-11-02 2021-08-06 温州启星生物技术有限公司 一种第四代car-t细胞及其构建方法和应用
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CN112574297B (zh) * 2019-09-27 2022-06-24 上海生物制品研究所有限责任公司 抗神经氨酸酶的单克隆抗体及其应用
TW202134286A (zh) * 2019-12-05 2021-09-16 大陸商上海翰森生物醫藥科技有限公司 抗gpc3抗體、其抗原結合片段及其醫藥用途
CN115960205A (zh) * 2019-12-13 2023-04-14 南京大户生物科技有限公司 原发性肝癌相关抗原的胸腺依赖性淋巴细胞抗原表位肽及其应用
US20230092390A1 (en) * 2020-02-17 2023-03-23 Board Of Regents, The University Of Texas System Human 4-1bb agonist antibodies and methods of use thereof
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CN115461449A (zh) * 2020-03-18 2022-12-09 优特力克斯有限公司 分泌il-18的gpc3 car-t细胞及其制备和使用方法
US20240026037A1 (en) * 2020-11-18 2024-01-25 Memorial Sloan Kettering Cancer Center Anti-gpa33 multi-specific antibodies and uses thereof
CN114573702A (zh) * 2020-12-02 2022-06-03 康诺亚生物医药科技(成都)有限公司 一种新型肿瘤衔接器治疗药物的开发和应用
KR20220080381A (ko) * 2020-12-07 2022-06-14 (주)이노베이션바이오 Gpc3에 특이적인 항체 및 이의 용도
CN113072643B (zh) * 2021-03-22 2021-10-15 南京医科大学 抗Glypican-3耐酸性全人源抗体、其免疫毒素、其嵌合抗原受体细胞及应用
KR20240004375A (ko) * 2021-03-28 2024-01-11 이뮤놈 인코포레이티드 Il-38-특이적 항체
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KR20240035506A (ko) * 2021-07-16 2024-03-15 노일 이뮨 바이오테크 가부시키가이샤 키메라 항원 수용체, 상기 수용체를 발현하는 세포, 상기 세포를 포함하는 의약 조성물, 상기 세포의 제조 방법, 및 상기 키메라 항원 수용체를 코딩하는 염기서열을 포함하는 폴리뉴클레오티드 또는 벡터
CN113527500B (zh) * 2021-07-16 2022-09-20 蒋小滔 一种磷脂酰肌醇蛋白聚糖3的全人源单克隆抗体、其嵌合抗原受体及应用
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