JP2010534463A5 - - Google Patents
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- JP2010534463A5 JP2010534463A5 JP2010517325A JP2010517325A JP2010534463A5 JP 2010534463 A5 JP2010534463 A5 JP 2010534463A5 JP 2010517325 A JP2010517325 A JP 2010517325A JP 2010517325 A JP2010517325 A JP 2010517325A JP 2010534463 A5 JP2010534463 A5 JP 2010534463A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- antigen
- seq
- expression vector
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 14
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 230000009260 cross reactivity Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07014797 | 2007-07-27 | ||
| EP07014797.0 | 2007-07-27 | ||
| US95316107P | 2007-07-31 | 2007-07-31 | |
| US60/953,161 | 2007-07-31 | ||
| PCT/EP2008/006153 WO2009015842A2 (en) | 2007-07-27 | 2008-07-25 | Novel immunogenic epitopes for immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014010161A Division JP5818920B2 (ja) | 2007-07-27 | 2014-01-23 | 免疫療法用の新規免疫原性エピトープ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010534463A JP2010534463A (ja) | 2010-11-11 |
| JP2010534463A5 true JP2010534463A5 (enExample) | 2011-11-17 |
| JP5484326B2 JP5484326B2 (ja) | 2014-05-07 |
Family
ID=39766525
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517325A Expired - Fee Related JP5484326B2 (ja) | 2007-07-27 | 2008-07-25 | 免疫療法用の新規免疫原性エピトープ |
| JP2014010161A Expired - Fee Related JP5818920B2 (ja) | 2007-07-27 | 2014-01-23 | 免疫療法用の新規免疫原性エピトープ |
| JP2015179979A Pending JP2016040257A (ja) | 2007-07-27 | 2015-09-11 | 免疫療法用の新規免疫原性エピトープ |
| JP2015225284A Expired - Fee Related JP6130469B2 (ja) | 2007-07-27 | 2015-11-18 | 免疫療法用の新規免疫原性エピトープ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014010161A Expired - Fee Related JP5818920B2 (ja) | 2007-07-27 | 2014-01-23 | 免疫療法用の新規免疫原性エピトープ |
| JP2015179979A Pending JP2016040257A (ja) | 2007-07-27 | 2015-09-11 | 免疫療法用の新規免疫原性エピトープ |
| JP2015225284A Expired - Fee Related JP6130469B2 (ja) | 2007-07-27 | 2015-11-18 | 免疫療法用の新規免疫原性エピトープ |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US8080634B2 (enExample) |
| EP (7) | EP3042914B1 (enExample) |
| JP (4) | JP5484326B2 (enExample) |
| KR (3) | KR101351195B1 (enExample) |
| CN (3) | CN103864893B (enExample) |
| AU (1) | AU2008281014B2 (enExample) |
| BR (1) | BRPI0813626A2 (enExample) |
| CA (1) | CA2694805C (enExample) |
| EA (1) | EA018456B1 (enExample) |
| ES (7) | ES2689851T3 (enExample) |
| HK (1) | HK1223381A1 (enExample) |
| HU (5) | HUE026776T2 (enExample) |
| MX (1) | MX2010001090A (enExample) |
| NZ (1) | NZ582822A (enExample) |
| PL (7) | PL2562184T3 (enExample) |
| UA (2) | UA101810C2 (enExample) |
| WO (1) | WO2009015842A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1918293A (zh) * | 2004-02-20 | 2007-02-21 | 莫洛根股份公司 | 用于对人及高等动物进行治疗性和预防性免疫刺激的取代的非编码核酸分子 |
| US9732131B2 (en) | 2006-02-27 | 2017-08-15 | Calviri, Inc. | Identification and use of novopeptides for the treatment of cancer |
| US20090004213A1 (en) * | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| GB201004575D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
| GB201019331D0 (en) * | 2010-03-19 | 2010-12-29 | Immatics Biotechnologies Gmbh | Methods for the diagnosis and treatment of cancer based on AVL9 |
| CN102183640A (zh) * | 2011-01-31 | 2011-09-14 | 浙江大学 | 筛选和鉴定乙肝病毒特异性细胞毒性t淋巴细胞表位方法 |
| CN102168066A (zh) * | 2011-01-31 | 2011-08-31 | 浙江大学 | 体外诱导乙型肝炎病毒特异性细胞毒性t淋巴细胞的方法 |
| WO2013054320A1 (en) * | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| US20130302366A1 (en) * | 2012-05-09 | 2013-11-14 | Christopher Marshall | Conformationally Specific Viral Immunogens |
| SI3456339T1 (sl) | 2013-08-05 | 2022-01-31 | Immatics Biotechnologies Gmbh | Nova imunoterapija proti več tumorjem, kot je pljučni rak, vključno z nedrobnoceličnim pljučnim rakom |
| MX2019013161A (es) * | 2013-11-04 | 2020-02-03 | Immatics Biotechnologies Gmbh | Inmunoterapia personalizada contra diversos tumores cerebrales y neuronales. |
| GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
| EP3122375B1 (en) | 2014-03-28 | 2021-03-03 | University of Washington through its Center for Commercialization | Breast and ovarian cancer vaccines |
| AP2016009504A0 (en) | 2014-04-27 | 2016-10-31 | Ccam Biotherapeutics Ltd | Humanized antibodies against ceacam1 |
| US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
| GB201408255D0 (en) | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
| HRP20191671T1 (hr) | 2014-05-09 | 2019-12-13 | Immatics Biotechnologies Gmbh | Nova imunoterapija za liječenje nekoliko tumora krvi, kao što je akutna mijeloidna leukemija (aml) |
| TWI755157B (zh) | 2015-03-17 | 2022-02-11 | 德商英麥提克生物技術股份有限公司 | 用於抗胰臟癌與其他癌症的免疫治療的新穎胜肽及胜肽的組合 |
| GB201504502D0 (en) * | 2015-03-17 | 2015-04-29 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| DK3388075T5 (da) | 2015-03-27 | 2024-09-23 | Immatics Biotechnologies Gmbh | Hidtil ukendte peptider og kombination af peptider til anvendelse ved immunterapi mod forskellige tumorer |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
| GB201507719D0 (en) * | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
| PH12021550910A1 (en) * | 2015-05-06 | 2022-03-07 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (crc) and other cancers |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| JP2018518956A (ja) * | 2015-06-19 | 2018-07-19 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 免疫療法で使用するための新規ペプチドおよびペプチド組み合わせおよび膵臓がんおよびその他のがんに対して使用するためにスキャフォールドを作製する方法 |
| GB201510771D0 (en) | 2015-06-19 | 2015-08-05 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer |
| GB201511191D0 (en) * | 2015-06-25 | 2015-08-12 | Immatics Biotechnologies Gmbh | T-cell epitopes for the immunotherapy of myeloma |
| HRP20202019T1 (hr) | 2015-07-01 | 2021-04-30 | Immatics Biotechnologies Gmbh | Novi peptidi i kombinacija peptida za uporabu u imunoterapiji protiv raka jajnika i drugih malignih tumora |
| GB201511546D0 (en) * | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
| MA51531A (fr) | 2015-07-06 | 2020-11-11 | Immatics Biotechnologies Gmbh | Nouveaux peptides et nouvelle combinaison de peptides à utiliser dans l'immunothérapie du cancer de l' oesophage et d'autres cancers |
| MY189596A (en) * | 2015-07-15 | 2022-02-18 | Immatics Biotechnologies Gmbh | A novel peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
| GB201515321D0 (en) | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| TWI796642B (zh) | 2015-08-28 | 2023-03-21 | 德商英麥提克生物技術股份有限公司 | 用於多種癌症之免疫治療的新穎胜肽、胜肽的組合物及支架 |
| US20170136108A1 (en) | 2015-08-28 | 2017-05-18 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| GB201521894D0 (en) * | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
| HK1255541A1 (zh) * | 2015-12-11 | 2019-08-23 | Immatics Biotechnologies Gmbh | 用於多种癌症免疫治疗的新型肽和肽组合物 |
| US20170199961A1 (en) | 2015-12-16 | 2017-07-13 | Gritstone Oncology, Inc. | Neoantigen Identification, Manufacture, and Use |
| GB201603987D0 (en) | 2016-03-08 | 2016-04-20 | Immatics Biotechnologies Gmbh | Uterine cancer treatments |
| GB201604458D0 (en) * | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| JP7075125B2 (ja) | 2016-05-25 | 2022-05-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ |
| GB201609193D0 (en) | 2016-05-25 | 2016-07-06 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
| TW202304970A (zh) * | 2016-08-26 | 2023-02-01 | 德商英麥提克生物技術股份有限公司 | 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架 |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| KR102379955B1 (ko) | 2016-12-08 | 2022-03-29 | 이매틱스 바이오테크놀로지스 게엠베하 | 짝짓기가 향상된 t 세포 수용체 |
| WO2018138257A1 (en) * | 2017-01-27 | 2018-08-02 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
| EA201991444A1 (ru) | 2017-01-27 | 2019-12-30 | Имматикс Байотекнолоджиз Гмбх | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака яичника и других видов рака |
| ES2946584T3 (es) | 2017-01-27 | 2023-07-21 | Immatics Biotechnologies Gmbh | Nuevos péptidos y nuevas combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncer |
| CN110996970A (zh) | 2017-06-02 | 2020-04-10 | 亚利桑那州立大学董事会 | 创建个性化癌症疫苗的方法 |
| WO2019055618A1 (en) | 2017-09-15 | 2019-03-21 | Arizona Board Of Regents On Behalf Of Arizona State University | METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY |
| ES3029080T3 (en) | 2017-10-10 | 2025-06-23 | Seattle Project Corp | Neoantigen identification using hotspots |
| US11885815B2 (en) | 2017-11-22 | 2024-01-30 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
| TWI727232B (zh) * | 2017-12-01 | 2021-05-11 | 大陸商上海桀蒙生物技術有限公司 | 個人化癌症疫苗的製備方法 |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
| CN109045290B (zh) * | 2018-11-02 | 2021-08-31 | 遵义医学院附属医院 | 基于内皮细胞特异分子-1的双靶标肿瘤疫苗及其制备方法 |
| WO2021067550A1 (en) | 2019-10-02 | 2021-04-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions for identifying neoantigens for use in treating and preventing cancer |
| WO2021116470A2 (en) * | 2019-12-11 | 2021-06-17 | Molecular Partners Ag | Recombinant peptide-mhc complex binding proteins and their generation and use |
| CN114929730A (zh) | 2019-12-11 | 2022-08-19 | 分子合作伙伴股份公司 | 重组肽-mhc复合物结合蛋白及其生成和用途 |
| CN113881707B (zh) * | 2021-10-25 | 2023-07-14 | 中国人民解放军军事科学院军事医学研究院 | 调控脐带间充质干细胞免疫抑制作用的产品、方法及用途 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| IE53176B1 (en) | 1978-12-22 | 1988-08-17 | Biogen Nv | Recombinant dna molecules and their method of production |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
| US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| JPS6081130A (ja) * | 1983-10-07 | 1985-05-09 | Fujisawa Pharmaceut Co Ltd | 抗ｈｌａ−ａ２抗体およびそれを産生するハイブリド−マ |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
| JP3055687B2 (ja) | 1987-08-10 | 2000-06-26 | ザ ユニバーシティー オブ メルボルン | Ｖｐ７をコードするヒトロタウイルス血清型４遺伝子９の分子クローニング、糖タンパク質特異的主要外部カプシド中和及びワクチンに使用するためのｖｐ７及びそのフラグメントの発現 |
| US5651972A (en) | 1989-04-21 | 1997-07-29 | University Of Florida Research Foundation, Inc. | Use of recombinant swine poxvirus as a live vaccine vector |
| US5119700A (en) | 1991-03-01 | 1992-06-09 | Titan Tool Company | Automatic stud driving tool having collarless retention mechanism for driven head |
| US20020168374A1 (en) * | 1992-08-07 | 2002-11-14 | Ralph T. Kubo | Hla binding peptides and their uses |
| AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
| WO1996031604A1 (en) * | 1995-04-07 | 1996-10-10 | The Regents Of The University Of California | Antibodies for the detection of hla-g |
| ES2203782T3 (es) | 1996-01-17 | 2004-04-16 | Imperial College Innovations Limited | Inmunoterapia que utiliza linfocitos t citotoxicos (ctl). |
| US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
| BR9708220A (pt) * | 1996-03-21 | 2000-01-04 | Epimmune Inc | Peptìdios de ligação hla-a2.1 e seus usos |
| JP4063359B2 (ja) * | 1997-01-23 | 2008-03-19 | タカラバイオ株式会社 | 硫酸基転移酵素遺伝子 |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| DE69841994D1 (de) * | 1997-05-30 | 2010-12-23 | Human Genome Sciences Inc | 32 Humane sekretierte Proteine |
| DE19739089A1 (de) | 1997-09-06 | 1999-03-11 | Hella Kg Hueck & Co | Scheinwerfer für Fahrzeuge |
| EP1015616A2 (en) * | 1997-09-19 | 2000-07-05 | Dana Farber Cancer Institute, Inc. | Intrabody-mediated control of immune reactions |
| US6747137B1 (en) | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| CA2375145A1 (en) | 1999-06-03 | 2000-12-14 | Cold Spring Harbor Laboratory | Substrate trapping protein tyrosine phosphatases |
| AU7721500A (en) * | 1999-09-29 | 2001-04-30 | Human Genome Sciences, Inc. | Colon and colon cancer associated polynucleotides and polypeptides |
| WO2001055309A2 (en) * | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| US20020048763A1 (en) * | 2000-02-04 | 2002-04-25 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis |
| WO2001072331A1 (en) * | 2000-03-31 | 2001-10-04 | Vaccine Chip Technology Aps | Immunostimulating properties of a fragment of tgf-beta |
| GB0011220D0 (en) | 2000-05-10 | 2000-06-28 | Blockfoil Group Limited | Foil embossing |
| WO2001096390A2 (en) * | 2000-06-09 | 2001-12-20 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| US20030017167A1 (en) * | 2000-06-09 | 2003-01-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| WO2002006515A2 (en) * | 2000-07-17 | 2002-01-24 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating colon cancer |
| JP2004520810A (ja) * | 2000-08-24 | 2004-07-15 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| JP2002173450A (ja) * | 2000-12-07 | 2002-06-21 | Hokkaido Technology Licence Office Co Ltd | 糖脂質特異的硫酸転移酵素遺伝子を含む医薬組成物 |
| WO2002059609A2 (en) * | 2000-12-08 | 2002-08-01 | Eos Biotechnology, Inc. | Methods of diagnosing colorectal cancer and/or breast cancer, compositions, and methods of screening for colorectal cancer and/or breast cancer modulators |
| US6455026B1 (en) | 2001-03-23 | 2002-09-24 | Agy Therapeutics, Inc. | Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors |
| US20030118585A1 (en) | 2001-10-17 | 2003-06-26 | Agy Therapeutics | Use of protein biomolecular targets in the treatment and visualization of brain tumors |
| JP2003012544A (ja) * | 2001-03-27 | 2003-01-15 | Kouji Egawa | 癌予防・治療剤 |
| WO2002078524A2 (en) * | 2001-03-28 | 2002-10-10 | Zycos Inc. | Translational profiling |
| EP1992643A3 (en) * | 2001-06-20 | 2008-12-10 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| WO2003042661A2 (en) | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| DE10225144A1 (de) * | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| JP2005185101A (ja) * | 2002-05-30 | 2005-07-14 | National Institute Of Agrobiological Sciences | 植物の全長ｃＤＮＡおよびその利用 |
| AU2003242163A1 (en) * | 2002-06-06 | 2003-12-22 | Yamanouchi Pharmaceutical Co., Ltd. | Novel oxidase |
| EP1594447A2 (en) * | 2002-10-02 | 2005-11-16 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US20060188889A1 (en) | 2003-11-04 | 2006-08-24 | Christopher Burgess | Use of differentially expressed nucleic acid sequences as biomarkers for cancer |
| KR100494979B1 (ko) | 2003-07-14 | 2005-06-14 | 주식회사 정우인터내셔날 | 조직 절편 보호 및 해상력 증진용 액상 커버 슬립, 그제조용 조성물, 그로부터 제조된 커버슬립을 구비한슬라이드 구조체 및 그 제조방법 |
| WO2005021739A1 (ja) * | 2003-09-01 | 2005-03-10 | Kureha Corporation | Nox1ポリペプチドに対する抗体、Nox1遺伝子を利用したガン診断方法、及びガン増殖抑制物質のスクリーニング方法 |
| EP1716227A4 (en) | 2004-01-27 | 2010-01-06 | Compugen Ltd | METHOD OF IDENTIFYING PUTATIVE GENE PRODUCTS USING THE INTERSPEZIES SEQUENCE COMPARISON AND BIOMOLECULAR SEQUENCES DISCOVERED THEREFOR |
| DE102004026135A1 (de) * | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| US8668905B2 (en) * | 2005-05-12 | 2014-03-11 | University Of South Florida | P53 vaccines for the treatment of cancers |
| EP1748067A1 (en) * | 2005-07-29 | 2007-01-31 | Institut Pasteur | Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes |
| US8030443B2 (en) * | 2005-08-09 | 2011-10-04 | Kurume University | Squamous cell carcinoma antigen-derived peptide binding to HLA-A24 molecule |
| EP1760089B1 (en) * | 2005-09-05 | 2009-08-19 | Immatics Biotechnologies GmbH | Tumor-associated peptides binding to human leukocyte antigen (HLA) class I or II molecules and related anti-cancer vaccine |
| ATE461215T1 (de) * | 2005-09-05 | 2010-04-15 | Immatics Biotechnologies Gmbh | Tumor-assoziierte peptide, welche an unterschiedliche menschliche leukozytenantigene der klasse ii binden |
| CA2638912A1 (en) * | 2006-02-20 | 2007-08-30 | Phylogica Limited | Method of constructing and screening libraries of peptide structures |
| JPWO2007119515A1 (ja) * | 2006-03-28 | 2009-08-27 | 昇志 佐藤 | 新規腫瘍抗原ペプチド |
| WO2008108257A1 (ja) * | 2007-03-05 | 2008-09-12 | International Institute Of Cancer Immunology, Inc. | 癌抗原特異的ｔ細胞のレセプター遺伝子およびそれによりコードされるペプチドならびにそれらの使用 |
| US20090004213A1 (en) * | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| SI2113253T1 (sl) | 2008-04-30 | 2010-06-30 | Immatics Biotechnologies Gmbh | Nove formulacije s tumorjem povezanih peptidov ki se vežejo na molekule humanega levkocitnega antigena HLA razreda I ali II za cepiva |
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