JP2018509135A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018509135A5 JP2018509135A5 JP2017518096A JP2017518096A JP2018509135A5 JP 2018509135 A5 JP2018509135 A5 JP 2018509135A5 JP 2017518096 A JP2017518096 A JP 2017518096A JP 2017518096 A JP2017518096 A JP 2017518096A JP 2018509135 A5 JP2018509135 A5 JP 2018509135A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- cell
- mhc
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 57
- 206010028980 Neoplasm Diseases 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 14
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 13
- 239000013604 expression vector Substances 0.000 claims 11
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 238000000338 in vitro Methods 0.000 claims 6
- 230000005847 immunogenicity Effects 0.000 claims 5
- -1 COL18A80 Proteins 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 238000010195 expression analysis Methods 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000002659 cell therapy Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 238000012163 sequencing technique Methods 0.000 claims 3
- 239000003053 toxin Substances 0.000 claims 3
- 231100000765 toxin Toxicity 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- 102100033772 Complement C4-A Human genes 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 101000710884 Homo sapiens Complement C4-A Proteins 0.000 claims 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 108010028930 invariant chain Proteins 0.000 claims 2
- 239000012931 lyophilized formulation Substances 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 102100032282 26S proteasome non-ATPase regulatory subunit 14 Human genes 0.000 claims 1
- 102100033458 26S proteasome non-ATPase regulatory subunit 4 Human genes 0.000 claims 1
- 102100033311 APOBEC1 complementation factor Human genes 0.000 claims 1
- 102100025339 ATP-dependent DNA helicase DDX11 Human genes 0.000 claims 1
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 1
- 102100024092 Aldo-keto reductase family 1 member C4 Human genes 0.000 claims 1
- 102100040410 Alpha-methylacyl-CoA racemase Human genes 0.000 claims 1
- 108010044434 Alpha-methylacyl-CoA racemase Proteins 0.000 claims 1
- 102100027139 Ankyrin repeat and SAM domain-containing protein 1A Human genes 0.000 claims 1
- 102100040202 Apolipoprotein B-100 Human genes 0.000 claims 1
- 102100040539 BTB/POZ domain-containing protein KCTD1 Human genes 0.000 claims 1
- 102100040534 BTB/POZ domain-containing protein KCTD3 Human genes 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 102100038451 CDK5 regulatory subunit-associated protein 2 Human genes 0.000 claims 1
- 102100037720 Calcium load-activated calcium channel Human genes 0.000 claims 1
- 102100038641 Cleavage and polyadenylation specificity factor subunit 1 Human genes 0.000 claims 1
- 102100026529 Cleavage and polyadenylation specificity factor subunit 6 Human genes 0.000 claims 1
- 102100021216 Cleft lip and palate transmembrane protein 1 Human genes 0.000 claims 1
- 102100029269 Coatomer subunit alpha Human genes 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102100025890 Complement C1q tumor necrosis factor-related protein 3 Human genes 0.000 claims 1
- 241000761389 Copa Species 0.000 claims 1
- 102100031051 Cysteine and glycine-rich protein 1 Human genes 0.000 claims 1
- 108010001202 Cytochrome P-450 CYP2E1 Proteins 0.000 claims 1
- 102100024889 Cytochrome P450 2E1 Human genes 0.000 claims 1
- 102100024916 Cytochrome P450 4F11 Human genes 0.000 claims 1
- 102100024918 Cytochrome P450 4F12 Human genes 0.000 claims 1
- 102100024902 Cytochrome P450 4F2 Human genes 0.000 claims 1
- 102100024901 Cytochrome P450 4F3 Human genes 0.000 claims 1
- 102100024899 Cytochrome P450 4F8 Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102100039077 Cytosolic 10-formyltetrahydrofolate dehydrogenase Human genes 0.000 claims 1
- 102100024460 DDB1- and CUL4-associated factor 8 Human genes 0.000 claims 1
- 102100025405 DENN domain-containing protein 5B Human genes 0.000 claims 1
- 102100021242 Dymeclin Human genes 0.000 claims 1
- 102100032238 Dynein axonemal assembly factor 5 Human genes 0.000 claims 1
- 102100025014 E3 ubiquitin-protein ligase TRIM63 Human genes 0.000 claims 1
- 102100025537 ERI1 exoribonuclease 3 Human genes 0.000 claims 1
- 238000011510 Elispot assay Methods 0.000 claims 1
- 102100021805 Enhancer of mRNA-decapping protein 4 Human genes 0.000 claims 1
- 102100038031 F-box only protein 22 Human genes 0.000 claims 1
- 102100029347 Fanconi anemia core complex-associated protein 100 Human genes 0.000 claims 1
- 102100026542 Fibronectin type-III domain-containing protein 3A Human genes 0.000 claims 1
- 102100037777 Galactokinase Human genes 0.000 claims 1
- 101100447191 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) FSL4 gene Proteins 0.000 claims 1
- 102100039611 Glutamine synthetase Human genes 0.000 claims 1
- 102100024008 Glycerol-3-phosphate acyltransferase 1, mitochondrial Human genes 0.000 claims 1
- 102100025303 Glycogenin-2 Human genes 0.000 claims 1
- 102100027489 Helicase-like transcription factor Human genes 0.000 claims 1
- 102100022695 Histidine ammonia-lyase Human genes 0.000 claims 1
- 101000590281 Homo sapiens 26S proteasome non-ATPase regulatory subunit 14 Proteins 0.000 claims 1
- 101001135231 Homo sapiens 26S proteasome non-ATPase regulatory subunit 4 Proteins 0.000 claims 1
- 101000799953 Homo sapiens APOBEC1 complementation factor Proteins 0.000 claims 1
- 101000722210 Homo sapiens ATP-dependent DNA helicase DDX11 Proteins 0.000 claims 1
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 1
- 101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 1
- 101000694621 Homo sapiens Ankyrin repeat and SAM domain-containing protein 1A Proteins 0.000 claims 1
- 101000889953 Homo sapiens Apolipoprotein B-100 Proteins 0.000 claims 1
- 101000613885 Homo sapiens BTB/POZ domain-containing protein KCTD1 Proteins 0.000 claims 1
- 101000613894 Homo sapiens BTB/POZ domain-containing protein KCTD3 Proteins 0.000 claims 1
- 101000882873 Homo sapiens CDK5 regulatory subunit-associated protein 2 Proteins 0.000 claims 1
- 101000663041 Homo sapiens Calcium load-activated calcium channel Proteins 0.000 claims 1
- 101000957603 Homo sapiens Cleavage and polyadenylation specificity factor subunit 1 Proteins 0.000 claims 1
- 101000855366 Homo sapiens Cleavage and polyadenylation specificity factor subunit 6 Proteins 0.000 claims 1
- 101000750204 Homo sapiens Cleft lip and palate transmembrane protein 1 Proteins 0.000 claims 1
- 101000770458 Homo sapiens Coatomer subunit alpha Proteins 0.000 claims 1
- 101000933673 Homo sapiens Complement C1q tumor necrosis factor-related protein 3 Proteins 0.000 claims 1
- 101000710883 Homo sapiens Complement C4-B Proteins 0.000 claims 1
- 101000909111 Homo sapiens Cytochrome P450 4F11 Proteins 0.000 claims 1
- 101000909108 Homo sapiens Cytochrome P450 4F12 Proteins 0.000 claims 1
- 101000909122 Homo sapiens Cytochrome P450 4F2 Proteins 0.000 claims 1
- 101000909121 Homo sapiens Cytochrome P450 4F3 Proteins 0.000 claims 1
- 101000909112 Homo sapiens Cytochrome P450 4F8 Proteins 0.000 claims 1
- 101000959030 Homo sapiens Cytosolic 10-formyltetrahydrofolate dehydrogenase Proteins 0.000 claims 1
- 101000832316 Homo sapiens DDB1- and CUL4-associated factor 8 Proteins 0.000 claims 1
- 101000722005 Homo sapiens DENN domain-containing protein 5B Proteins 0.000 claims 1
- 101000817629 Homo sapiens Dymeclin Proteins 0.000 claims 1
- 101000869175 Homo sapiens Dynein axonemal assembly factor 5 Proteins 0.000 claims 1
- 101000830231 Homo sapiens E3 ubiquitin-protein ligase TRIM63 Proteins 0.000 claims 1
- 101001056896 Homo sapiens ERI1 exoribonuclease 3 Proteins 0.000 claims 1
- 101000895665 Homo sapiens Enhancer of mRNA-decapping protein 4 Proteins 0.000 claims 1
- 101000878586 Homo sapiens F-box only protein 22 Proteins 0.000 claims 1
- 101001062402 Homo sapiens Fanconi anemia core complex-associated protein 100 Proteins 0.000 claims 1
- 101000913670 Homo sapiens Fibronectin type-III domain-containing protein 3A Proteins 0.000 claims 1
- 101001024874 Homo sapiens Galactokinase Proteins 0.000 claims 1
- 101000888841 Homo sapiens Glutamine synthetase Proteins 0.000 claims 1
- 101000904268 Homo sapiens Glycerol-3-phosphate acyltransferase 1, mitochondrial Proteins 0.000 claims 1
- 101000857856 Homo sapiens Glycogenin-2 Proteins 0.000 claims 1
- 101001081105 Homo sapiens Helicase-like transcription factor Proteins 0.000 claims 1
- 101001044626 Homo sapiens Histidine ammonia-lyase Proteins 0.000 claims 1
- 101000599453 Homo sapiens Importin-9 Proteins 0.000 claims 1
- 101001010731 Homo sapiens Intraflagellar transport protein 81 homolog Proteins 0.000 claims 1
- 101000764239 Homo sapiens Mitochondrial import receptor subunit TOM5 homolog Proteins 0.000 claims 1
- 101000987144 Homo sapiens Molybdenum cofactor sulfurase Proteins 0.000 claims 1
- 101000590830 Homo sapiens Monocarboxylate transporter 1 Proteins 0.000 claims 1
- 101001125327 Homo sapiens Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Proteins 0.000 claims 1
- 101000597417 Homo sapiens Nuclear RNA export factor 1 Proteins 0.000 claims 1
- 101000578361 Homo sapiens Nucleolar complex protein 4 homolog Proteins 0.000 claims 1
- 101001112313 Homo sapiens Nucleoside diphosphate kinase, mitochondrial Proteins 0.000 claims 1
- 101000981502 Homo sapiens Pantothenate kinase 2, mitochondrial Proteins 0.000 claims 1
- 101001134728 Homo sapiens Pecanex-like protein 3 Proteins 0.000 claims 1
- 101001041673 Homo sapiens Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] Proteins 0.000 claims 1
- 101001099381 Homo sapiens Peroxisomal biogenesis factor 19 Proteins 0.000 claims 1
- 101001070474 Homo sapiens Protein GPR107 Proteins 0.000 claims 1
- 101000654448 Homo sapiens Protein transport protein Sec16A Proteins 0.000 claims 1
- 101001062751 Homo sapiens Pseudokinase FAM20A Proteins 0.000 claims 1
- 101001125901 Homo sapiens Pterin-4-alpha-carbinolamine dehydratase Proteins 0.000 claims 1
- 101000722214 Homo sapiens Putative ATP-dependent RNA helicase DDX12 Proteins 0.000 claims 1
- 101000595869 Homo sapiens Putative PIP5K1A and PSMD4-like protein Proteins 0.000 claims 1
- 101000635838 Homo sapiens RUS family member 1 Proteins 0.000 claims 1
- 101000889795 Homo sapiens Rabankyrin-5 Proteins 0.000 claims 1
- 101000864990 Homo sapiens Serine incorporator 5 Proteins 0.000 claims 1
- 101000713879 Homo sapiens T-complex protein 1 subunit eta Proteins 0.000 claims 1
- 101000838236 Homo sapiens T-complex protein 11-like protein 2 Proteins 0.000 claims 1
- 101000800113 Homo sapiens THO complex subunit 2 Proteins 0.000 claims 1
- 101000670226 Homo sapiens Threonine synthase-like 2 Proteins 0.000 claims 1
- 101000648279 Homo sapiens Trafficking protein particle complex subunit 6B Proteins 0.000 claims 1
- 101000798689 Homo sapiens Transmembrane protein 33 Proteins 0.000 claims 1
- 101000795328 Homo sapiens Tripartite motif-containing protein 54 Proteins 0.000 claims 1
- 101000795353 Homo sapiens Tripartite motif-containing protein 55 Proteins 0.000 claims 1
- 101000672037 Homo sapiens UDP-glucose:glycoprotein glucosyltransferase 2 Proteins 0.000 claims 1
- 101000723913 Homo sapiens Zinc finger protein 318 Proteins 0.000 claims 1
- 102100037961 Importin-9 Human genes 0.000 claims 1
- 102100030001 Intraflagellar transport protein 81 homolog Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 108010093662 Member 11 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 102000001479 Member 11 Subfamily B ATP Binding Cassette Transporter Human genes 0.000 claims 1
- 102100026902 Mitochondrial import receptor subunit TOM5 homolog Human genes 0.000 claims 1
- 102100027983 Molybdenum cofactor sulfurase Human genes 0.000 claims 1
- 102100034068 Monocarboxylate transporter 1 Human genes 0.000 claims 1
- 102100021445 Monocarboxylate transporter 11 Human genes 0.000 claims 1
- 102100029447 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Human genes 0.000 claims 1
- 102100035402 Nuclear RNA export factor 1 Human genes 0.000 claims 1
- 102100027986 Nucleolar complex protein 4 homolog Human genes 0.000 claims 1
- 102100023609 Nucleoside diphosphate kinase, mitochondrial Human genes 0.000 claims 1
- 101100538743 Oryctolagus cuniculus TNFAIP6 gene Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100024127 Pantothenate kinase 2, mitochondrial Human genes 0.000 claims 1
- 102100033317 Pecanex-like protein 3 Human genes 0.000 claims 1
- 108010067163 Perilipin-2 Proteins 0.000 claims 1
- 102000017794 Perilipin-2 Human genes 0.000 claims 1
- 102100021404 Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] Human genes 0.000 claims 1
- 102100038883 Peroxisomal biogenesis factor 19 Human genes 0.000 claims 1
- 102100034143 Protein GPR107 Human genes 0.000 claims 1
- 102100031479 Protein transport protein Sec16A Human genes 0.000 claims 1
- 102100030553 Pseudokinase FAM20A Human genes 0.000 claims 1
- 102100029333 Pterin-4-alpha-carbinolamine dehydratase Human genes 0.000 claims 1
- 102100025313 Putative ATP-dependent RNA helicase DDX12 Human genes 0.000 claims 1
- 102100036064 Putative PIP5K1A and PSMD4-like protein Human genes 0.000 claims 1
- 102100030858 RUS family member 1 Human genes 0.000 claims 1
- 102100040160 Rabankyrin-5 Human genes 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 108091006615 SLC10A5 Proteins 0.000 claims 1
- 108091006609 SLC16A11 Proteins 0.000 claims 1
- 108091006948 SLC35B1 Proteins 0.000 claims 1
- 102100029726 Serine incorporator 5 Human genes 0.000 claims 1
- 102100021731 Sodium/bile acid cotransporter 5 Human genes 0.000 claims 1
- 102100025664 Solute carrier family 35 member B1 Human genes 0.000 claims 1
- 102100036476 T-complex protein 1 subunit eta Human genes 0.000 claims 1
- 102100028608 T-complex protein 11-like protein 2 Human genes 0.000 claims 1
- 102100033491 THO complex subunit 2 Human genes 0.000 claims 1
- 102100039276 Threonine synthase-like 2 Human genes 0.000 claims 1
- 102100028828 Trafficking protein particle complex subunit 6B Human genes 0.000 claims 1
- 102100032461 Transmembrane protein 33 Human genes 0.000 claims 1
- 102100029709 Tripartite motif-containing protein 54 Human genes 0.000 claims 1
- 102100029720 Tripartite motif-containing protein 55 Human genes 0.000 claims 1
- 102100040361 UDP-glucose:glycoprotein glucosyltransferase 2 Human genes 0.000 claims 1
- 102100028453 Zinc finger protein 318 Human genes 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 108091006374 cAMP receptor proteins Proteins 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000009260 cross reactivity Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 230000005934 immune activation Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 108091031034 miR-1279 stem-loop Proteins 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229940038309 personalized vaccine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000012070 whole genome sequencing analysis Methods 0.000 claims 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020102005A JP7358299B2 (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102993A JP7448423B2 (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102992A JP7346361B2 (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2021052978A JP7713309B2 (ja) | 2014-12-23 | 2021-03-26 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462096165P | 2014-12-23 | 2014-12-23 | |
| GB201423016 | 2014-12-23 | ||
| US62/096,165 | 2014-12-23 | ||
| GB1423016.3 | 2014-12-23 | ||
| GB1501017.6 | 2015-01-21 | ||
| GBGB1501017.6A GB201501017D0 (en) | 2014-12-23 | 2015-01-21 | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| PCT/EP2015/080018 WO2016102272A1 (en) | 2014-12-23 | 2015-12-16 | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (hcc) and other cancers |
Related Child Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020102006A Division JP2020191866A (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102004A Division JP7109801B2 (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102005A Division JP7358299B2 (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102992A Division JP7346361B2 (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102991A Division JP2020191867A (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102993A Division JP7448423B2 (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020106475A Division JP7026411B2 (ja) | 2014-12-23 | 2020-06-19 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2021052978A Division JP7713309B2 (ja) | 2014-12-23 | 2021-03-26 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509135A JP2018509135A (ja) | 2018-04-05 |
| JP2018509135A5 true JP2018509135A5 (enExample) | 2018-09-27 |
| JP6906156B2 JP6906156B2 (ja) | 2021-07-21 |
Family
ID=52630910
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518096A Active JP6906156B2 (ja) | 2014-12-23 | 2015-12-16 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2021052978A Active JP7713309B2 (ja) | 2014-12-23 | 2021-03-26 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021052978A Active JP7713309B2 (ja) | 2014-12-23 | 2021-03-26 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US10064926B2 (enExample) |
| EP (8) | EP3715357B1 (enExample) |
| JP (2) | JP6906156B2 (enExample) |
| KR (1) | KR102284493B1 (enExample) |
| CN (4) | CN112538109A (enExample) |
| AR (2) | AR103220A1 (enExample) |
| AU (3) | AU2015371490B2 (enExample) |
| BR (1) | BR112017008972A2 (enExample) |
| CA (1) | CA2972126A1 (enExample) |
| CL (1) | CL2017001391A1 (enExample) |
| CR (1) | CR20170282A (enExample) |
| DK (4) | DK3626731T3 (enExample) |
| EA (2) | EA202190587A3 (enExample) |
| GB (1) | GB201501017D0 (enExample) |
| IL (1) | IL250989B (enExample) |
| MA (3) | MA41237B1 (enExample) |
| MX (1) | MX377144B (enExample) |
| PE (1) | PE20170940A1 (enExample) |
| PH (1) | PH12017500484B1 (enExample) |
| PL (1) | PL3236985T5 (enExample) |
| RS (4) | RS62448B1 (enExample) |
| SG (1) | SG11201703322UA (enExample) |
| SI (3) | SI3236985T2 (enExample) |
| TW (1) | TWI687436B (enExample) |
| WO (1) | WO2016102272A1 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
| US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
| US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| EP3134114A4 (en) * | 2014-04-24 | 2018-03-14 | Rhode Island Hospital | Aspartate-beta -hydroxylase induces epitope-specific t cell responses in tumors |
| US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| MA49157A (fr) * | 2014-12-23 | 2021-06-02 | Immatics Biotechnologies Gmbh | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
| US10220036B2 (en) | 2014-12-23 | 2019-03-05 | Novartis Ag | Triazolopyrimidine compounds and uses thereof |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| PH12022551111A1 (en) | 2015-10-05 | 2023-08-23 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
| WO2017079703A1 (en) | 2015-11-05 | 2017-05-11 | Juno Therapeutics, Inc. | Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy |
| CA3008641A1 (en) | 2015-12-16 | 2017-06-22 | Gritstone Oncology, Inc. | Neoantigen identification, manufacture, and use |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| GB201609193D0 (en) | 2016-05-25 | 2016-07-06 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
| JP7075125B2 (ja) | 2016-05-25 | 2022-05-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ |
| CA3027246A1 (en) | 2016-06-20 | 2017-12-28 | Novartis Ag | Crystalline forms of triazolopyrimidine compound |
| JP2019522049A (ja) | 2016-06-20 | 2019-08-08 | ノバルティス アーゲー | トリアゾロピリジン化合物及びその使用 |
| JP2019524872A (ja) | 2016-06-20 | 2019-09-05 | ノバルティス アーゲー | 癌の治療に有用なイミダゾピリミジン化合物 |
| KR102674521B1 (ko) * | 2016-10-07 | 2024-06-11 | 아이오 바이오테크 에이피에스 | 면역원성 아르기나제 펩타이드 |
| JP2020513248A (ja) | 2016-10-19 | 2020-05-14 | フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． | 音響による親和性細胞抽出 |
| KR102379955B1 (ko) | 2016-12-08 | 2022-03-29 | 이매틱스 바이오테크놀로지스 게엠베하 | 짝짓기가 향상된 t 세포 수용체 |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| CR20210130A (es) * | 2017-01-27 | 2021-03-31 | Immatics Biotechnologies Gmbh | Nuevos péptidos y nuevas combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de càncer (divisional exp. 2019-388) |
| JP2020523022A (ja) | 2017-06-14 | 2020-08-06 | アイカーン スクール オブ メディシン アット マウント サイナイ | 免疫療法に反応する肝細胞癌のクラスの検出および治療方法 |
| DE102017115966A1 (de) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
| LT3652215T (lt) | 2017-07-14 | 2021-05-25 | Immatics Biotechnologies Gmbh | Pagerinta dvejopo savitumo polipeptido molekulė |
| US11802315B2 (en) * | 2017-08-09 | 2023-10-31 | Pamgene B.V. | Method for predicting the response of non-small-cell lung carcinoma patients to a medicament |
| GB201713700D0 (en) * | 2017-08-25 | 2017-10-11 | Anastasis Biotec Ltd | Peptide conjugates |
| WO2019075112A1 (en) | 2017-10-10 | 2019-04-18 | Gritstone Oncology, Inc. | IDENTIFICATION OF NEO-ANTIGENS USING HOT POINTS |
| EP3714275A4 (en) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS |
| US10785574B2 (en) | 2017-12-14 | 2020-09-22 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
| JP2021517810A (ja) * | 2018-03-12 | 2021-07-29 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ | 養子免疫療法における腫瘍自己抗原の使用のための方法および組成物 |
| JP7606209B2 (ja) | 2018-06-08 | 2024-12-25 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ オクラホマ | アルツハイマー病および関連状態を処置するためのペプチド治療薬 |
| DE102018122546B3 (de) * | 2018-09-14 | 2019-12-05 | Immatics Biotechnologies Gmbh | Verfahren zum Hochdurchsatz-Peptid-MHC-Affinitätsscreening für TCR-Liganden |
| GB201815549D0 (en) | 2018-09-24 | 2018-11-07 | Io Biotech Aps | Arginase1 polypeptides |
| AU2019367647A1 (en) * | 2018-10-26 | 2021-06-03 | Ethadox Ltd. | Compositions and methods for biodegrading alcohol |
| CN109663128A (zh) * | 2018-11-21 | 2019-04-23 | 中国农业大学 | 一种肺动脉高压标志物及其作为治疗靶点的应用 |
| EP3893925A4 (en) * | 2018-12-13 | 2023-01-18 | Rhode Island Hospital | INHIBITING THE GROWTH AND DEVELOPMENT OF ASPH-EXPRESSING TUMORS |
| EP3721899A1 (en) | 2019-04-08 | 2020-10-14 | China Medical University | Combination therapies comprising dendritic cells-based vaccine and immune checkpoint inhibitor |
| CN110850086B (zh) * | 2019-11-18 | 2023-05-02 | 西安交通大学 | 一种肝移植术后缺血性胆道病变血清诊断标志物acly的应用 |
| CN114249806B (zh) * | 2020-03-18 | 2023-06-13 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原组合、输卵管癌靶标抗原刺激培养的ctl细胞及其应用 |
| JP7503864B2 (ja) * | 2020-03-30 | 2024-06-21 | ロペルバイオ カンパニー リミテッド | 免疫抗がん療法に対するバイオマーカーおよびその用途 |
| MX2022014636A (es) | 2020-05-19 | 2023-02-23 | Amgen Inc | Construcciones de unión a mageb2. |
| CN116333984A (zh) * | 2020-07-14 | 2023-06-27 | 广州泛恩生物科技有限公司 | 基于galnt2阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用 |
| CN112063718A (zh) * | 2020-09-18 | 2020-12-11 | 中国医科大学 | Usp14在肝细胞肝癌诊断、预后判断以及治疗中的应用 |
| CN112043722B (zh) * | 2020-09-25 | 2022-02-15 | 中国医科大学 | Prpf6在前列腺癌及去势抵抗前列腺癌治疗中的应用 |
| CN114574486B (zh) * | 2020-12-01 | 2024-04-16 | 中国科学院大连化学物理研究所 | 作用于OPLAH的siRNA、DNA及构建物和应用 |
| CN114163510B (zh) * | 2021-03-24 | 2024-12-06 | 深圳市新靶向生物科技有限公司 | 一种与肝癌驱动基因突变相关的抗原肽组合及其应用 |
| CA3215594A1 (en) | 2021-04-02 | 2022-10-06 | Agnieszka KIELCZEWSKA | Mageb2 binding constructs |
| US20250084159A1 (en) * | 2021-07-19 | 2025-03-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Mct11 antibodies to treat t cell functional exhaustion and enhance cancer immunotherapy |
| CN115634281B (zh) * | 2021-07-20 | 2025-12-02 | 肖伯端 | Ctrp3蛋白的抗瘤作用及编码其的重组溶瘤病毒及制备方法和应用 |
| CN113502300B (zh) * | 2021-07-21 | 2024-02-06 | 徐州医科大学 | 一种含有hdac10基因启动子序列和报告基因的重组质粒、制备方法及应用 |
| WO2023069933A2 (en) * | 2021-10-18 | 2023-04-27 | Board Of Regents, The University Of Texas System | Peptides and engineered t cell receptors targeting ndc80 antigen and methods of use |
| CN115572764B (zh) * | 2022-03-30 | 2024-06-21 | 江苏鹍远生物技术有限公司 | 一组肿瘤检测标志物及其用途 |
| CN116334031A (zh) * | 2022-07-21 | 2023-06-27 | 中国人民解放军陆军军医大学 | 三个多肽及其在制备ⅰ型糖尿病免疫防治疫苗或药物中的应用 |
| CN116042825B (zh) * | 2022-09-28 | 2025-07-01 | 南方医科大学 | 一种评估5-fu治疗胃癌癌敏感性的探针引物组及其试剂盒 |
| WO2024235848A1 (en) * | 2023-05-12 | 2024-11-21 | Fundación Para La Investigación Médica Aplicada | Novel t cell receptors |
| WO2025021968A1 (en) | 2023-07-27 | 2025-01-30 | Immatics Biotechnologies Gmbh | Antigen binding proteins against mageb2 |
| WO2025021979A1 (en) | 2023-07-27 | 2025-01-30 | Immatics Biotechnologies Gmbh | Novel t cell receptors targeting melanoma-associated antigen (mage) b2 and immune therapy using the same |
| CN119524137A (zh) * | 2024-12-11 | 2025-02-28 | 徐州医科大学 | Fbxo22在诊断、治疗非酒精性脂肪性肝病中的应用 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| NZ192465A (en) | 1978-12-22 | 1983-09-30 | Biogen Nv | Recombinant dna molecule comprising gene coding for polypeptide displaying hbv (hepatitis b virus) antigenicity usesthereof |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
| US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
| CA2163032C (en) | 1993-06-03 | 2001-02-06 | John Landon | Antibody fragments in therapy |
| AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
| ATE244300T1 (de) | 1996-01-17 | 2003-07-15 | Imp College Innovations Ltd | Immunotherapie mit verwendung von zytotoxischen t lymphozyten (ctl) |
| US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| WO2001044279A2 (en) * | 1999-12-17 | 2001-06-21 | Chiron Corporation | Mammalian dishevelled-associated proteins |
| AU2001232204A1 (en) | 2000-02-22 | 2001-09-03 | Ahuva Nissim | Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof |
| EP2316950A1 (en) | 2000-03-27 | 2011-05-04 | Technion Research and Development Foundation, Ltd. | Single chain class I major histo-compatibility complexes, constructs encoding same and methods of generating same |
| US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
| AU2001275246B2 (en) | 2000-06-05 | 2006-06-29 | Altor Bioscience Corporation | T cell receptor fusions and conjugates and methods of use thereof |
| AU2001276018A1 (en) | 2000-07-20 | 2002-02-05 | Regents Of The University Of Minnesota | Radiolabeled immunotoxins |
| US6867283B2 (en) | 2001-05-16 | 2005-03-15 | Technion Research & Development Foundation Ltd. | Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells |
| US20050053918A1 (en) | 2001-05-16 | 2005-03-10 | Technion Research & Development Foundation Ltd. | Method of identifying peptides capable of binding to MHC molecules, peptides identified thereby and their uses |
| US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| CA2476625A1 (en) | 2002-02-20 | 2003-08-28 | Dyax Corp. | Mhc-peptide complex binding ligands |
| US7311914B2 (en) | 2002-08-13 | 2007-12-25 | Ludwig Institute For Cancer Research | MAGE-A4 antigenic peptides and uses thereof |
| WO2004018667A1 (ja) * | 2002-08-26 | 2004-03-04 | Kirin Beer Kabushiki Kaisha | ペプチド及びこれを含む医薬 |
| EP1549748B1 (en) | 2002-10-09 | 2014-10-01 | Immunocore Ltd. | Single chain recombinant t cell receptors |
| ES2327229T3 (es) | 2002-11-09 | 2009-10-27 | Immunocore Ltd. | Presentacion del receptor de linfocitos t. |
| US20040096982A1 (en) | 2002-11-19 | 2004-05-20 | International Business Machines Corporation | Methods and apparatus for analysis of mass spectra |
| EP1998177A3 (en) * | 2003-01-06 | 2009-02-18 | Wyeth | Compositions and methods for diagnosing and treating colon cancers |
| GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| US20090304679A1 (en) | 2004-05-27 | 2009-12-10 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| US20090075304A1 (en) | 2004-05-27 | 2009-03-19 | Weidanz Jon A | Methods of assaying vaccine potency |
| US20090233318A1 (en) | 2004-12-28 | 2009-09-17 | Weidanz Jon A | Methods of assaying vaccine potency |
| ATE461215T1 (de) | 2005-09-05 | 2010-04-15 | Immatics Biotechnologies Gmbh | Tumor-assoziierte peptide, welche an unterschiedliche menschliche leukozytenantigene der klasse ii binden |
| ES2330013T3 (es) | 2005-09-05 | 2009-12-03 | Immatics Biotechnologies Gmbh | Peptidos asociados a tumores unidos a moleculas del antigeno de leucocito humano (hla) de clase i o ii y vacunas contra el cancer relacionadas. |
| AU2007284651B2 (en) | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
| JP5352586B2 (ja) * | 2007-07-27 | 2013-11-27 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 腫瘍関連ペプチドおよび関連抗癌ワクチンの組成物 |
| CN103911358B (zh) * | 2007-07-27 | 2017-03-01 | 伊玛提克斯生物技术有限公司 | 神经元和脑肿瘤的新型免疫疗法 |
| WO2009026547A1 (en) | 2007-08-22 | 2009-02-26 | Receptor Logi, Ltd. | Methods of assaying vaccine potency |
| ES2573458T3 (es) * | 2007-09-14 | 2016-06-08 | Vrije Universiteit Brussel | Mejoramiento de la capacidad estimulatoria de las células T de las células que presentan antígeno humano y su uso en vacunación |
| EP2262834A4 (en) | 2008-02-27 | 2011-08-17 | Receptor Logic Inc | ANTIBODIES THAT IMITATE L-CELL RECEPTORS AND METHODS OF MAKING AND USING SAME |
| ME02267B (me) * | 2008-03-27 | 2016-04-28 | Immatics Biotechnologies Gmbh | Nova imunoterapija protiv tumora nervnih ćelija i mozga |
| US20090263574A1 (en) | 2008-04-21 | 2009-10-22 | Quinn Daniel E | Method of restoring an article |
| WO2009151487A1 (en) | 2008-06-13 | 2009-12-17 | Receptor Logic, Inc. | Methods of assaying vaccine potency |
| DE102008049136B4 (de) | 2008-09-26 | 2012-10-25 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. | Neue Regulatoren des angeborenen Immunsystems |
| PL2172211T3 (pl) * | 2008-10-01 | 2015-05-29 | Immatics Biotechnologies Gmbh | Kompozycja związanych z guzem peptydów i związana z tym szczepionka przeciwrakowa do leczenia glejaka (GBM) i innych rodzajów raka |
| WO2011060329A1 (en) | 2009-11-14 | 2011-05-19 | Kuang-Yuh Chyu | Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis |
| US8506964B2 (en) | 2010-02-05 | 2013-08-13 | Cardiovax, Llc | Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis |
| GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
| CA2816225A1 (en) | 2010-10-26 | 2012-05-03 | Technion Research & Development Foundation Ltd. | Antibodies which bind soluble t-cell receptor ligands |
| CN103561760A (zh) | 2010-11-12 | 2014-02-05 | 赛达斯西奈医疗中心 | 包含apob100的免疫原性片段的免疫调节组合物、方法和系统 |
| US9205139B2 (en) | 2010-11-12 | 2015-12-08 | Cardiovax, Llc | Immunomodulatory methods and systems for treatment and/or prevention of aneurysms |
| EP2637689A2 (en) | 2010-11-12 | 2013-09-18 | Cedars-Sinai Medical Center | Immunomodulatory methods and systems for treatment and/or prevention of hypertension |
| WO2013057586A1 (en) | 2011-10-19 | 2013-04-25 | Oslo Universitetssykehus Hf | Compositions and methods for producing soluble t - cell receptors |
| WO2013070603A1 (en) * | 2011-11-11 | 2013-05-16 | Cedars-Sinai Medical Center | Compositions and methods for treatment of kidney diseases |
| GB201208293D0 (en) * | 2012-05-11 | 2012-06-20 | Circassia Ltd | Hydrochlorice salt of peptide |
| EP2892544A4 (en) * | 2012-09-05 | 2016-11-02 | Univ Virginia Patent Found | TARGET PEPTIDES FOR THERAPY AND DIAGNOSIS OF COLORECTAL CARCINOMAS |
| ES2603589T3 (es) | 2012-11-08 | 2017-02-28 | F. Hoffmann-La Roche Ag | Ácidos nucleicos que codifican polipéptidos quiméricos para la identificación sistemática de bibliotecas |
| GB201301632D0 (en) * | 2013-01-30 | 2013-03-13 | Imp Innovations | Complement System |
| WO2014160275A2 (en) * | 2013-03-14 | 2014-10-02 | Battell Memorial Institute | Biomarkers for liver fibrosis |
| EP2808392A1 (en) | 2013-05-28 | 2014-12-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamers and use of the aptamers in the diagnosis and treatment of cancer |
| CN103739667B (zh) * | 2013-09-24 | 2017-08-25 | 上海宇研生物技术有限公司 | 卵巢癌特异的肿瘤抗原肽及其制备方法 |
| CA2942433C (en) | 2014-03-14 | 2023-08-01 | Immunocore Limited | Tcr libraries |
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| GB201507719D0 (en) * | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
| US20180179283A1 (en) | 2015-06-08 | 2018-06-28 | Adicet Bio Inc. | T cell receptor like antibodies having fine specificity |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| MX2018012265A (es) | 2016-04-08 | 2019-02-07 | Adaptimmune Ltd | Receptores de celulas t. |
| PT3440106T (pt) | 2016-04-08 | 2021-09-29 | Adaptimmune Ltd | Recetores de células t |
| SG11201808750PA (en) | 2016-04-08 | 2018-11-29 | Adaptimmune Ltd | T cell receptors |
| MX395725B (es) | 2016-07-27 | 2025-03-25 | Sharp Kk | Métodos y aparatos de telecomunicaciones inalámbricas que usan etiqueta de valor de información del sistema. |
| JP7303750B2 (ja) | 2017-01-24 | 2023-07-05 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物 |
| US20200325244A1 (en) | 2020-05-18 | 2020-10-15 | Abexxa Biologics, Inc. | Antibodies and methods of use thereof |
| WO2018225732A1 (ja) | 2017-06-05 | 2018-12-13 | 国立大学法人三重大学 | Ｍａｇｅ－ａ４由来ペプチドを認識する抗原結合性タンパク質 |
| AU2018298422B2 (en) | 2017-07-04 | 2023-04-06 | CureVac SE | Novel nucleic acid molecules |
| US20210147550A1 (en) | 2017-08-18 | 2021-05-20 | Joshua Michael Francis | Antigen-binding proteins targeting shared antigens |
| CN111315769A (zh) | 2017-09-06 | 2020-06-19 | 加州理工学院 | 信号传导和抗原呈递双功能受体(sabr) |
| WO2019133853A1 (en) | 2017-12-28 | 2019-07-04 | Gritstone Oncology, Inc. | Antigen-binding proteins targeting shared antigens |
| CN112236447B (zh) | 2018-04-19 | 2023-10-20 | 得克萨斯州大学系统董事会 | 具有mage-b2特异性的t细胞受体及其用途 |
| AU2019275072A1 (en) | 2018-05-23 | 2021-01-21 | Seattle Project Corp. | Shared antigens |
| US20200291128A1 (en) | 2020-05-18 | 2020-09-17 | Abexxa Biologics, Inc. | Antibodies and methods of use thereof |
| US20200291116A1 (en) | 2020-05-18 | 2020-09-17 | Abexxa Biologics, Inc. | Antibodies and methods of use thereof |
| US20200291127A1 (en) | 2020-05-18 | 2020-09-17 | Abexxa Biologics, Inc. | Antibodies and methods of use thereof |
-
2015
- 2015-01-21 GB GBGB1501017.6A patent/GB201501017D0/en not_active Ceased
- 2015-12-16 EP EP20172206.3A patent/EP3715357B1/en active Active
- 2015-12-16 JP JP2017518096A patent/JP6906156B2/ja active Active
- 2015-12-16 EP EP19199098.5A patent/EP3616706B1/en active Active
- 2015-12-16 MA MA41237A patent/MA41237B1/fr unknown
- 2015-12-16 EP EP19170191.1A patent/EP3545965B1/en active Active
- 2015-12-16 DK DK19199125.6T patent/DK3626731T3/da active
- 2015-12-16 WO PCT/EP2015/080018 patent/WO2016102272A1/en not_active Ceased
- 2015-12-16 EP EP15813809.9A patent/EP3236985B2/en active Active
- 2015-12-16 RS RS20211276A patent/RS62448B1/sr unknown
- 2015-12-16 KR KR1020177017192A patent/KR102284493B1/ko active Active
- 2015-12-16 BR BR112017008972-6A patent/BR112017008972A2/pt not_active Application Discontinuation
- 2015-12-16 DK DK19170191.1T patent/DK3545965T3/da active
- 2015-12-16 SI SI201531025T patent/SI3236985T2/sl unknown
- 2015-12-16 CR CR20170282A patent/CR20170282A/es unknown
- 2015-12-16 EP EP19199106.6A patent/EP3626730A1/en not_active Withdrawn
- 2015-12-16 EP EP19199125.6A patent/EP3626731B1/en active Active
- 2015-12-16 CN CN202011429041.4A patent/CN112538109A/zh active Pending
- 2015-12-16 MA MA40136A patent/MA40136A1/fr unknown
- 2015-12-16 RS RS20211033A patent/RS62237B1/sr unknown
- 2015-12-16 CN CN201580055141.6A patent/CN107001414A/zh active Pending
- 2015-12-16 EP EP19199114.0A patent/EP3620168A1/en not_active Withdrawn
- 2015-12-16 CN CN202011429073.4A patent/CN112646025A/zh active Pending
- 2015-12-16 EP EP19199101.7A patent/EP3626729B1/en active Active
- 2015-12-16 CA CA2972126A patent/CA2972126A1/en active Pending
- 2015-12-16 SI SI201531682T patent/SI3545965T1/sl unknown
- 2015-12-16 RS RS20191606A patent/RS59836B2/sr unknown
- 2015-12-16 MX MX2017008329A patent/MX377144B/es active IP Right Grant
- 2015-12-16 EA EA202190587A patent/EA202190587A3/ru unknown
- 2015-12-16 CN CN202011432405.4A patent/CN112646021A/zh active Pending
- 2015-12-16 EA EA201791150A patent/EA201791150A1/ru unknown
- 2015-12-16 DK DK19199098.5T patent/DK3616706T3/da active
- 2015-12-16 AU AU2015371490A patent/AU2015371490B2/en not_active Ceased
- 2015-12-16 SG SG11201703322UA patent/SG11201703322UA/en unknown
- 2015-12-16 SI SI201531721T patent/SI3626729T1/sl unknown
- 2015-12-16 PE PE2017000542A patent/PE20170940A1/es unknown
- 2015-12-16 MA MA49158A patent/MA49158B1/fr unknown
- 2015-12-16 PL PL15813809.9T patent/PL3236985T5/pl unknown
- 2015-12-16 PH PH1/2017/500484A patent/PH12017500484B1/en unknown
- 2015-12-16 RS RS20211341A patent/RS62508B1/sr unknown
- 2015-12-16 DK DK19199101.7T patent/DK3626729T3/da active
- 2015-12-21 US US14/975,952 patent/US10064926B2/en active Active
- 2015-12-21 AR ARP150104228A patent/AR103220A1/es not_active Application Discontinuation
- 2015-12-21 TW TW104142988A patent/TWI687436B/zh not_active IP Right Cessation
-
2016
- 2016-11-21 US US15/357,757 patent/US20170080070A1/en not_active Abandoned
-
2017
- 2017-03-07 IL IL250989A patent/IL250989B/en active IP Right Grant
- 2017-05-31 CL CL2017001391A patent/CL2017001391A1/es unknown
-
2018
- 2018-03-09 US US15/917,098 patent/US20180207252A1/en not_active Abandoned
- 2018-03-12 US US15/918,788 patent/US11406693B2/en active Active
- 2018-09-18 US US16/134,422 patent/US20190000947A1/en not_active Abandoned
-
2020
- 2020-06-29 US US16/915,308 patent/US20200376103A1/en not_active Abandoned
- 2020-08-04 AU AU2020213294A patent/AU2020213294B2/en not_active Ceased
- 2020-08-04 AU AU2020213295A patent/AU2020213295B2/en not_active Ceased
- 2020-09-11 US US17/018,915 patent/US20200405831A1/en not_active Abandoned
-
2021
- 2021-03-26 JP JP2021052978A patent/JP7713309B2/ja active Active
- 2021-04-30 US US17/245,918 patent/US11786583B2/en active Active
- 2021-07-14 AR ARP210101973A patent/AR122964A2/es not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018509135A5 (enExample) | ||
| JP2018510628A5 (enExample) | ||
| JP2019510465A5 (enExample) | ||
| JP2018529320A5 (enExample) | ||
| JP2019506838A5 (enExample) | ||
| JP2019502360A5 (enExample) | ||
| JP2018536383A5 (enExample) | ||
| JP2021168652A5 (enExample) | ||
| JP2018519243A5 (enExample) | ||
| JP2018511321A5 (enExample) | ||
| JP2018520653A5 (enExample) | ||
| JP2017525336A5 (enExample) | ||
| JP2018518937A5 (enExample) | ||
| JP2019511214A5 (enExample) | ||
| RU2017137142A (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака | |
| JP2017502076A5 (enExample) | ||
| JP2018521641A5 (enExample) | ||
| JP2024099580A5 (enExample) | ||
| JP2018518956A5 (enExample) | ||
| JP2024041841A5 (enExample) | ||
| JP2017524337A5 (enExample) | ||
| Lu et al. | Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression | |
| JP2020530759A5 (enExample) | ||
| JP2018530579A (ja) | ウイルス性癌ネオエピトープのための組成物および方法 | |
| JP2013521789A5 (enExample) |