JP2017524337A5 - - Google Patents
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- JP2017524337A5 JP2017524337A5 JP2016567242A JP2016567242A JP2017524337A5 JP 2017524337 A5 JP2017524337 A5 JP 2017524337A5 JP 2016567242 A JP2016567242 A JP 2016567242A JP 2016567242 A JP2016567242 A JP 2016567242A JP 2017524337 A5 JP2017524337 A5 JP 2017524337A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 38
- 238000000034 method Methods 0.000 claims 22
- 206010028980 Neoplasm Diseases 0.000 claims 19
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 11
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 9
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108020001507 fusion proteins Proteins 0.000 claims 9
- 102000037865 fusion proteins Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- -1 MYCH2 Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 230000005847 immunogenicity Effects 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 229940023041 peptide vaccine Drugs 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
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- 229940079593 drug Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 102100021283 1-aminocyclopropane-1-carboxylate synthase-like protein 1 Human genes 0.000 claims 1
- 102100023779 40S ribosomal protein S5 Human genes 0.000 claims 1
- 102100027787 ATP synthase subunit g, mitochondrial Human genes 0.000 claims 1
- 102100022423 ATP-dependent RNA helicase DHX33 Human genes 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 102100033568 Acyl-CoA-binding domain-containing protein 6 Human genes 0.000 claims 1
- 102100029457 Adenine phosphoribosyltransferase Human genes 0.000 claims 1
- 108010024223 Adenine phosphoribosyltransferase Proteins 0.000 claims 1
- 102100033326 Alpha-1B-glycoprotein Human genes 0.000 claims 1
- 102100033658 Alpha-globin transcription factor CP2 Human genes 0.000 claims 1
- 102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 claims 1
- 102100027139 Ankyrin repeat and SAM domain-containing protein 1A Human genes 0.000 claims 1
- 102100026444 Arrestin domain-containing protein 1 Human genes 0.000 claims 1
- 102100030009 Azurocidin Human genes 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 claims 1
- 102100026349 Beta-1,4-galactosyltransferase 1 Human genes 0.000 claims 1
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- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
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- 102100028796 Chromosome transmission fidelity protein 18 homolog Human genes 0.000 claims 1
- 102100023661 Coiled-coil domain-containing protein 115 Human genes 0.000 claims 1
- 102100033601 Collagen alpha-1(I) chain Human genes 0.000 claims 1
- 102100033855 Complex I assembly factor TMEM126B, mitochondrial Human genes 0.000 claims 1
- 102100032903 Copper chaperone for superoxide dismutase Human genes 0.000 claims 1
- 102100028233 Coronin-1A Human genes 0.000 claims 1
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- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
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- 102100040792 DNA primase small subunit Human genes 0.000 claims 1
- 102100031230 DNA topoisomerase I, mitochondrial Human genes 0.000 claims 1
- 102100036727 Deformed epidermal autoregulatory factor 1 homolog Human genes 0.000 claims 1
- 102100023526 Deubiquitinating protein VCPIP1 Human genes 0.000 claims 1
- 102100030220 Diacylglycerol kinase zeta Human genes 0.000 claims 1
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- 102100027414 E3 ubiquitin-protein ligase RNF19B Human genes 0.000 claims 1
- 102100032064 EMILIN-2 Human genes 0.000 claims 1
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- 238000011510 Elispot assay Methods 0.000 claims 1
- 102100035074 Elongator complex protein 3 Human genes 0.000 claims 1
- 102100031862 Endoplasmic reticulum-Golgi intermediate compartment protein 1 Human genes 0.000 claims 1
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- 102100036089 Fascin Human genes 0.000 claims 1
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- 102100039622 Granulocyte colony-stimulating factor receptor Human genes 0.000 claims 1
- 102100027490 H2.0-like homeobox protein Human genes 0.000 claims 1
- 102100033079 HLA class II histocompatibility antigen, DM alpha chain Human genes 0.000 claims 1
- 108010050568 HLA-DM antigens Proteins 0.000 claims 1
- 102100022695 Histidine ammonia-lyase Human genes 0.000 claims 1
- 101000675558 Homo sapiens 1-aminocyclopropane-1-carboxylate synthase-like protein 1 Proteins 0.000 claims 1
- 101000622644 Homo sapiens 40S ribosomal protein S5 Proteins 0.000 claims 1
- 101000936950 Homo sapiens ATP synthase subunit g, mitochondrial Proteins 0.000 claims 1
- 101000901934 Homo sapiens ATP-dependent RNA helicase DHX33 Proteins 0.000 claims 1
- 101000801610 Homo sapiens Acyl-CoA-binding domain-containing protein 6 Proteins 0.000 claims 1
- 101000799853 Homo sapiens Alpha-1B-glycoprotein Proteins 0.000 claims 1
- 101000800875 Homo sapiens Alpha-globin transcription factor CP2 Proteins 0.000 claims 1
- 101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 claims 1
- 101000694621 Homo sapiens Ankyrin repeat and SAM domain-containing protein 1A Proteins 0.000 claims 1
- 101000785762 Homo sapiens Arrestin domain-containing protein 1 Proteins 0.000 claims 1
- 101000793686 Homo sapiens Azurocidin Proteins 0.000 claims 1
- 101001000001 Homo sapiens Basement membrane-specific heparan sulfate proteoglycan core protein Proteins 0.000 claims 1
- 101000766145 Homo sapiens Beta-1,4-galactosyltransferase 1 Proteins 0.000 claims 1
- 101001016707 Homo sapiens Beta-mannosidase Proteins 0.000 claims 1
- 101000912622 Homo sapiens C-type lectin domain family 12 member A Proteins 0.000 claims 1
- 101000896583 Homo sapiens C3a anaphylatoxin chemotactic receptor Proteins 0.000 claims 1
- 101000916423 Homo sapiens Calsyntenin-1 Proteins 0.000 claims 1
- 101000793825 Homo sapiens Capping protein, Arp2/3 and myosin-I linker protein 2 Proteins 0.000 claims 1
- 101000910846 Homo sapiens Carboxypeptidase Q Proteins 0.000 claims 1
- 101000797586 Homo sapiens Chromobox protein homolog 2 Proteins 0.000 claims 1
- 101000777053 Homo sapiens Chromodomain-helicase-DNA-binding protein 1-like Proteins 0.000 claims 1
- 101000916387 Homo sapiens Chromosome transmission fidelity protein 18 homolog Proteins 0.000 claims 1
- 101000978267 Homo sapiens Coiled-coil domain-containing protein 115 Proteins 0.000 claims 1
- 101000640719 Homo sapiens Complex I assembly factor TMEM126B, mitochondrial Proteins 0.000 claims 1
- 101000868241 Homo sapiens Copper chaperone for superoxide dismutase Proteins 0.000 claims 1
- 101000860852 Homo sapiens Coronin-1A Proteins 0.000 claims 1
- 101000884191 Homo sapiens Cyclin-G1 Proteins 0.000 claims 1
- 101000876529 Homo sapiens DNA excision repair protein ERCC-1 Proteins 0.000 claims 1
- 101000611567 Homo sapiens DNA primase small subunit Proteins 0.000 claims 1
- 101000929421 Homo sapiens Deformed epidermal autoregulatory factor 1 homolog Proteins 0.000 claims 1
- 101000622317 Homo sapiens Deubiquitinating protein VCPIP1 Proteins 0.000 claims 1
- 101000864576 Homo sapiens Diacylglycerol kinase zeta Proteins 0.000 claims 1
- 101001053946 Homo sapiens Dystrophin Proteins 0.000 claims 1
- 101000921278 Homo sapiens EMILIN-2 Proteins 0.000 claims 1
- 101000895713 Homo sapiens ER degradation-enhancing alpha-mannosidase-like protein 2 Proteins 0.000 claims 1
- 101000877382 Homo sapiens Elongator complex protein 3 Proteins 0.000 claims 1
- 101000920804 Homo sapiens Endoplasmic reticulum-Golgi intermediate compartment protein 1 Proteins 0.000 claims 1
- 101000812663 Homo sapiens Endoplasmin Proteins 0.000 claims 1
- 101000814010 Homo sapiens Erlin-1 Proteins 0.000 claims 1
- 101000914654 Homo sapiens FAS-associated factor 1 Proteins 0.000 claims 1
- 101001021925 Homo sapiens Fascin Proteins 0.000 claims 1
- 101000913642 Homo sapiens Fibronectin type III domain-containing protein 3B Proteins 0.000 claims 1
- 101000886596 Homo sapiens Geminin Proteins 0.000 claims 1
- 101001070504 Homo sapiens Golgin subfamily A member 7B Proteins 0.000 claims 1
- 101000746364 Homo sapiens Granulocyte colony-stimulating factor receptor Proteins 0.000 claims 1
- 101001081101 Homo sapiens H2.0-like homeobox protein Proteins 0.000 claims 1
- 101001044626 Homo sapiens Histidine ammonia-lyase Proteins 0.000 claims 1
- 101000994369 Homo sapiens Integrin alpha-5 Proteins 0.000 claims 1
- 101001027631 Homo sapiens Kinesin-like protein KIF20B Proteins 0.000 claims 1
- 101001050567 Homo sapiens Kinesin-like protein KIF2C Proteins 0.000 claims 1
- 101001139146 Homo sapiens Krueppel-like factor 2 Proteins 0.000 claims 1
- 101001090713 Homo sapiens L-lactate dehydrogenase A chain Proteins 0.000 claims 1
- 101001065536 Homo sapiens LYR motif-containing protein 1 Proteins 0.000 claims 1
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- 101000958390 Homo sapiens Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA Proteins 0.000 claims 1
- 101000578830 Homo sapiens Methionine aminopeptidase 1 Proteins 0.000 claims 1
- 101000575376 Homo sapiens Microfibrillar-associated protein 1 Proteins 0.000 claims 1
- 101000869796 Homo sapiens Microprocessor complex subunit DGCR8 Proteins 0.000 claims 1
- 101001030591 Homo sapiens Mitochondrial ubiquitin ligase activator of NFKB 1 Proteins 0.000 claims 1
- 101001128431 Homo sapiens Myeloid-derived growth factor Proteins 0.000 claims 1
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- 101000973439 Homo sapiens NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Proteins 0.000 claims 1
- 101001072765 Homo sapiens Neutral alpha-glucosidase AB Proteins 0.000 claims 1
- 101001007862 Homo sapiens Nuclear pore complex protein Nup85 Proteins 0.000 claims 1
- 101000578361 Homo sapiens Nucleolar complex protein 4 homolog Proteins 0.000 claims 1
- 101000981502 Homo sapiens Pantothenate kinase 2, mitochondrial Proteins 0.000 claims 1
- 101000603761 Homo sapiens Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Proteins 0.000 claims 1
- 101000728117 Homo sapiens Plasma membrane calcium-transporting ATPase 4 Proteins 0.000 claims 1
- 101001094868 Homo sapiens Plexin-D1 Proteins 0.000 claims 1
- 101000829538 Homo sapiens Polypeptide N-acetylgalactosaminyltransferase 15 Proteins 0.000 claims 1
- 101000610110 Homo sapiens Pre-B-cell leukemia transcription factor 2 Proteins 0.000 claims 1
- 101000874142 Homo sapiens Probable ATP-dependent RNA helicase DDX46 Proteins 0.000 claims 1
- 101000788412 Homo sapiens Probable methyltransferase TARBP1 Proteins 0.000 claims 1
- 101000859935 Homo sapiens Protein CREG1 Proteins 0.000 claims 1
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- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
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- 102100034977 N-acylglucosamine 2-epimerase Human genes 0.000 claims 1
- 102100022195 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Human genes 0.000 claims 1
- 102100036592 Neutral alpha-glucosidase AB Human genes 0.000 claims 1
- 102100027582 Nuclear pore complex protein Nup85 Human genes 0.000 claims 1
- 102100027986 Nucleolar complex protein 4 homolog Human genes 0.000 claims 1
- 102100024127 Pantothenate kinase 2, mitochondrial Human genes 0.000 claims 1
- 102100038551 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Human genes 0.000 claims 1
- 108010068633 Perilipin-3 Proteins 0.000 claims 1
- 102000001486 Perilipin-3 Human genes 0.000 claims 1
- 102100029743 Plasma membrane calcium-transporting ATPase 4 Human genes 0.000 claims 1
- 102100035380 Plexin-D1 Human genes 0.000 claims 1
- 102100023229 Polypeptide N-acetylgalactosaminyltransferase 15 Human genes 0.000 claims 1
- 102100040168 Pre-B-cell leukemia transcription factor 2 Human genes 0.000 claims 1
- 102100035725 Probable ATP-dependent RNA helicase DDX46 Human genes 0.000 claims 1
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- 102100034758 Putative methyltransferase-like protein 7A Human genes 0.000 claims 1
- 102100039899 Queuine tRNA-ribosyltransferase accessory subunit 2 Human genes 0.000 claims 1
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- 102100027669 RNA polymerase II subunit A C-terminal domain phosphatase Human genes 0.000 claims 1
- 102100024939 RNA-binding motif protein, X chromosome Human genes 0.000 claims 1
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- 102100030681 SH3 and multiple ankyrin repeat domains protein 3 Human genes 0.000 claims 1
- 101710101741 SH3 and multiple ankyrin repeat domains protein 3 Proteins 0.000 claims 1
- 108091006567 SLC31A2 Proteins 0.000 claims 1
- 101001053942 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) Diphosphomevalonate decarboxylase Proteins 0.000 claims 1
- 101100329714 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CTR3 gene Proteins 0.000 claims 1
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- 102100034371 Sulfhydryl oxidase 1 Human genes 0.000 claims 1
- 102100031446 Suppressor of IKBKE 1 Human genes 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 102100031291 THO complex subunit 7 homolog Human genes 0.000 claims 1
- 101150106297 Top1mt gene Proteins 0.000 claims 1
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- 102100025765 Transmembrane protein 164 Human genes 0.000 claims 1
- 102100034298 Tyrosine-tRNA ligase, cytoplasmic Human genes 0.000 claims 1
- 102100038833 Ubiquitin recognition factor in ER-associated degradation protein 1 Human genes 0.000 claims 1
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- 101710160987 Uracil-DNA glycosylase Proteins 0.000 claims 1
- 102100029150 Uridine-cytidine kinase 2 Human genes 0.000 claims 1
- 102100020777 VPS35 endosomal protein-sorting factor-like Human genes 0.000 claims 1
- 102100040987 Volume-regulated anion channel subunit LRRC8D Human genes 0.000 claims 1
- 102100021367 Zinc finger protein 264 Human genes 0.000 claims 1
- 102100034658 Zinc finger protein 543 Human genes 0.000 claims 1
- 102100035806 Zinc finger protein 638 Human genes 0.000 claims 1
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- 102100037793 Zinc finger protein Eos Human genes 0.000 claims 1
- 102100028346 Zinc finger protein with KRAB and SCAN domains 8 Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
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- 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 claims 1
- 239000003139 biocide Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000005880 cancer cell killing Effects 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 239000013256 coordination polymer Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
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- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000010195 expression analysis Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000011502 immune monitoring Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 229920002477 rna polymer Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 102100022110 tRNA (adenine(37)-N6)-methyltransferase Human genes 0.000 claims 1
- 238000012070 whole genome sequencing analysis Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461990980P | 2014-05-09 | 2014-05-09 | |
| US61/990,980 | 2014-05-09 | ||
| GB1408255.6 | 2014-05-09 | ||
| GBGB1408255.6A GB201408255D0 (en) | 2014-05-09 | 2014-05-09 | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
| PCT/EP2015/060168 WO2015169945A2 (en) | 2014-05-09 | 2015-05-08 | Novel immunotherapy against several tumors of the blood, such as acute myeloid leukemia (aml) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524337A JP2017524337A (ja) | 2017-08-31 |
| JP2017524337A5 true JP2017524337A5 (enExample) | 2019-10-03 |
| JP6659582B2 JP6659582B2 (ja) | 2020-03-04 |
Family
ID=51032516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567242A Expired - Fee Related JP6659582B2 (ja) | 2014-05-09 | 2015-05-08 | 急性骨髄性白血病（ａｍｌ）などの血液のいくつかの腫瘍に対する新規免疫療法 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10064924B2 (enExample) |
| EP (3) | EP3449937A1 (enExample) |
| JP (1) | JP6659582B2 (enExample) |
| KR (1) | KR20170003976A (enExample) |
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2014
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2015
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- 2015-05-08 CN CN201580022755.4A patent/CN106459167A/zh active Pending
- 2015-05-08 JP JP2016567242A patent/JP6659582B2/ja not_active Expired - Fee Related
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- 2015-05-08 MA MA049280A patent/MA49280A/fr unknown
- 2015-05-08 DK DK15732544.0T patent/DK3140319T3/da active
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- 2015-05-08 WO PCT/EP2015/060168 patent/WO2015169945A2/en not_active Ceased
- 2015-05-08 EP EP18193811.9A patent/EP3449937A1/en not_active Withdrawn
- 2015-05-08 RS RS20191183A patent/RS59471B1/sr unknown
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- 2015-05-08 CA CA2946349A patent/CA2946349A1/en not_active Abandoned
- 2015-05-08 SI SI201530901T patent/SI3140319T1/sl unknown
- 2015-05-08 KR KR1020167034386A patent/KR20170003976A/ko not_active Withdrawn
- 2015-05-08 ES ES15732544T patent/ES2747734T3/es active Active
- 2015-05-08 EP EP19185183.1A patent/EP3604327A1/en not_active Withdrawn
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- 2015-05-08 PL PL15732544T patent/PL3140319T3/pl unknown
- 2015-05-08 BR BR112016025035A patent/BR112016025035A2/pt not_active Application Discontinuation
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