JP2018511321A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018511321A5 JP2018511321A5 JP2017550874A JP2017550874A JP2018511321A5 JP 2018511321 A5 JP2018511321 A5 JP 2018511321A5 JP 2017550874 A JP2017550874 A JP 2017550874A JP 2017550874 A JP2017550874 A JP 2017550874A JP 2018511321 A5 JP2018511321 A5 JP 2018511321A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- cell
- mhc
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 57
- 210000004027 cell Anatomy 0.000 claims description 19
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
- 238000000338 in vitro Methods 0.000 claims description 8
- 239000000427 antigen Substances 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 230000005847 immunogenicity Effects 0.000 claims description 6
- 238000010186 staining Methods 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 210000001519 tissue Anatomy 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 239000013604 expression vector Substances 0.000 claims 12
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 11
- 108091008874 T cell receptors Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 238000010195 expression analysis Methods 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000003053 toxin Substances 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000012636 effector Substances 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000002659 cell therapy Methods 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 108010028930 invariant chain Proteins 0.000 claims 2
- 239000012931 lyophilized formulation Substances 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 238000011510 Elispot assay Methods 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000005934 immune activation Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229940038309 personalized vaccine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000012070 whole genome sequencing analysis Methods 0.000 claims 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 239000011324 bead Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- SEBPXHSZHLFWRL-UHFFFAOYSA-N 3,4-dihydro-2,2,5,7,8-pentamethyl-2h-1-benzopyran-6-ol Chemical compound O1C(C)(C)CCC2=C1C(C)=C(C)C(O)=C2C SEBPXHSZHLFWRL-UHFFFAOYSA-N 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562140767P | 2015-03-31 | 2015-03-31 | |
| US62/140,767 | 2015-03-31 | ||
| GBGB1505585.8A GB201505585D0 (en) | 2015-03-31 | 2015-03-31 | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| GB1505585.8 | 2015-03-31 | ||
| PCT/EP2016/056601 WO2016156230A1 (en) | 2015-03-31 | 2016-03-24 | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carcinoma (rcc) and other cancers |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020192310A Division JP7272667B2 (ja) | 2015-03-31 | 2020-11-19 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
| JP2020192307A Division JP2021048852A (ja) | 2015-03-31 | 2020-11-19 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
| JP2020192308A Division JP2021048853A (ja) | 2015-03-31 | 2020-11-19 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
| JP2020192309A Division JP2021048854A (ja) | 2015-03-31 | 2020-11-19 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018511321A JP2018511321A (ja) | 2018-04-26 |
| JP2018511321A5 true JP2018511321A5 (enExample) | 2019-03-28 |
| JP7146399B2 JP7146399B2 (ja) | 2022-10-04 |
Family
ID=53178474
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550874A Active JP7146399B2 (ja) | 2015-03-31 | 2016-03-24 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
| JP2023010823A Pending JP2023061974A (ja) | 2015-03-31 | 2023-01-27 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
| JP2023197848A Pending JP2024028730A (ja) | 2015-03-31 | 2023-11-22 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023010823A Pending JP2023061974A (ja) | 2015-03-31 | 2023-01-27 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
| JP2023197848A Pending JP2024028730A (ja) | 2015-03-31 | 2023-11-22 | 腎細胞がん（ｒｃｃ）およびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドとスキャフォールドの組み合わせ |
Country Status (25)
| Country | Link |
|---|---|
| US (17) | US9993536B2 (enExample) |
| EP (4) | EP3517128A1 (enExample) |
| JP (3) | JP7146399B2 (enExample) |
| KR (2) | KR102451645B1 (enExample) |
| CN (2) | CN113912702A (enExample) |
| AR (3) | AR104114A1 (enExample) |
| AU (5) | AU2016240341B2 (enExample) |
| BR (1) | BR112017019804A2 (enExample) |
| CA (1) | CA2980814A1 (enExample) |
| CL (5) | CL2017002448A1 (enExample) |
| CO (1) | CO2017009616A2 (enExample) |
| CR (3) | CR20220164A (enExample) |
| EA (1) | EA037050B1 (enExample) |
| GB (1) | GB201505585D0 (enExample) |
| HK (1) | HK1247085A1 (enExample) |
| IL (3) | IL289444B (enExample) |
| MA (5) | MA41844A (enExample) |
| MX (2) | MX2017012504A (enExample) |
| MY (2) | MY199184A (enExample) |
| PE (2) | PE20231650A1 (enExample) |
| PH (2) | PH12022553212A1 (enExample) |
| SG (2) | SG11201707043WA (enExample) |
| TW (5) | TWI756874B (enExample) |
| UA (1) | UA124519C2 (enExample) |
| WO (1) | WO2016156230A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6494233B2 (ja) | 2013-10-03 | 2019-04-03 | 日東電工株式会社 | 粘膜ワクチン組成物 |
| MX2016003321A (es) | 2013-10-03 | 2016-08-12 | Nitto Denko Corp | Composicion de vacuna para mucosa. |
| CA2980109A1 (en) | 2015-03-31 | 2016-10-06 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| HK1258386A1 (zh) | 2015-10-05 | 2019-11-08 | Immatics Biotechnologies Gmbh | 用於小细胞肺癌和其他癌症免疫治疗的肽和肽组合物 |
| US20170199961A1 (en) | 2015-12-16 | 2017-07-13 | Gritstone Oncology, Inc. | Neoantigen Identification, Manufacture, and Use |
| GB201604490D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides combination of peptides for use in immunotherapy against cancers |
| JP7075125B2 (ja) | 2016-05-25 | 2022-05-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ |
| GB201609193D0 (en) | 2016-05-25 | 2016-07-06 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| KR102379955B1 (ko) | 2016-12-08 | 2022-03-29 | 이매틱스 바이오테크놀로지스 게엠베하 | 짝짓기가 향상된 t 세포 수용체 |
| ES2946584T3 (es) * | 2017-01-27 | 2023-07-21 | Immatics Biotechnologies Gmbh | Nuevos péptidos y nuevas combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncer |
| US20190016802A1 (en) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Dual specificity polypeptide molecule |
| DE102017115966A1 (de) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
| US20200347455A1 (en) | 2017-09-05 | 2020-11-05 | Agency For Science, Technology And Research | Clear Cell Renal Cell Carcinoma Biomarkers |
| ES3029080T3 (en) | 2017-10-10 | 2025-06-23 | Seattle Project Corp | Neoantigen identification using hotspots |
| US11885815B2 (en) | 2017-11-22 | 2024-01-30 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
| DE102017127984B4 (de) | 2017-11-27 | 2019-12-05 | Immatics US, Inc. | Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen |
| US11464800B2 (en) | 2018-02-09 | 2022-10-11 | Immatics US, Inc. | Methods for manufacturing T cells |
| DE102018108612A1 (de) | 2018-03-21 | 2019-09-26 | Immatics US, Inc. | Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen |
| US20200297768A1 (en) | 2019-03-19 | 2020-09-24 | Immatics US, Inc. | Cd28 t cell cultures, compositions, and methods of using thereof |
| PH12021552979A1 (en) | 2019-05-27 | 2023-10-09 | Immatics Us Inc | Viral vectors and their use in adoptive cellular therapy |
| CN114303060A (zh) | 2019-06-06 | 2022-04-08 | 伊玛提克斯生物技术有限公司 | 使用序列相似肽进行反向选择分选 |
| US20210032370A1 (en) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Recruiting agent further binding an mhc molecule |
| IL295891A (en) | 2020-02-24 | 2022-10-01 | Immatics Us Inc | Methods for propagating t cells for the treatment of cancer and related malignancies |
| DE102020106710A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| CN111413498B (zh) * | 2020-04-08 | 2023-08-04 | 复旦大学附属中山医院 | 一种肝细胞肝癌的自身抗体7-AAb检测panel及其应用 |
| CN116333999A (zh) * | 2020-07-14 | 2023-06-27 | 广州泛恩生物科技有限公司 | 基于cxcl13阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用 |
| US20220056411A1 (en) | 2020-08-21 | 2022-02-24 | Immatics US, Inc. | Methods for isolating cd8+ selected t cells |
| WO2022147029A2 (en) | 2020-12-31 | 2022-07-07 | Immatics US, Inc. | Cd8 polypeptides, compositions, and methods of using thereof |
| IL308258A (en) | 2021-05-05 | 2024-01-01 | Immatics Biotechnologies Gmbh | Bma031 antigen binding polypeptides |
| JP2024534825A (ja) | 2021-08-24 | 2024-09-26 | イマティクス ユーエス，アイエヌシー． | 条件付きリガンド交換により産生されたペプチドｍｈｃ複合体を使用する免疫細胞の選択 |
| TW202332765A (zh) | 2021-09-20 | 2023-08-16 | 美商英麥提克斯股份有限公司 | 用於ｔ細胞療法之ｔ細胞群體的單核球耗盡 |
| CN118541392A (zh) | 2021-09-28 | 2024-08-23 | 准星生物医药有限公司 | 多种形式的分子复合物 |
| US20230192886A1 (en) | 2021-11-08 | 2023-06-22 | Immatics Biotechnologies Gmbh | Adoptive cell therapy combination treatment and compositions thereof |
| WO2023153763A1 (ko) * | 2022-02-08 | 2023-08-17 | 고려대학교 산학협력단 | C-met의 에피토프 및 hif1alpha의 에피토프를 포함하는 암 백신 및 이의 용도 |
| EP4514834A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof |
| EP4514821A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
| AU2023262596A1 (en) | 2022-04-28 | 2024-12-05 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| WO2023215825A1 (en) | 2022-05-05 | 2023-11-09 | Immatics US, Inc. | Methods for improving t cell efficacy |
| CN117126283B (zh) * | 2022-05-19 | 2025-05-27 | 深圳市新产业生物医学工程股份有限公司 | 抗pic的抗体、试剂盒及检测pic的方法 |
| CN115074445B (zh) * | 2022-08-09 | 2023-08-08 | 河北医科大学第二医院 | Eno3在肾癌诊断及治疗中的应用 |
| NL2034657B1 (en) * | 2023-04-21 | 2024-10-28 | Academisch Ziekenhuis Leiden | RCN1-derived TEIPP neoantigens and uses thereof |
| WO2025096649A1 (en) | 2023-11-01 | 2025-05-08 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| IE53176B1 (en) | 1978-12-22 | 1988-08-17 | Biogen Nv | Recombinant dna molecules and their method of production |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
| US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
| ATE183513T1 (de) | 1993-06-03 | 1999-09-15 | Therapeutic Antibodies Inc | Herstellung von antikörperfragmenten |
| AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
| ES2203782T3 (es) | 1996-01-17 | 2004-04-16 | Imperial College Innovations Limited | Inmunoterapia que utiliza linfocitos t citotoxicos (ctl). |
| US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
| EP0960114B1 (en) * | 1996-10-01 | 2007-09-19 | Bio-Rad Laboratories, Inc. | Polymorphisms and new genes in the region of the human hemochromatosis gene |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6670328B1 (en) * | 1997-06-24 | 2003-12-30 | Institut Pasteur De Lille | Proteins and peptides derived from protein ESM-1 and their uses in the treatment and diagnosis of diseases linked to leukocyte migration |
| US6934639B1 (en) | 2000-02-25 | 2005-08-23 | Wyeth | Methods for designing agents that interact with MMP-13 |
| US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
| CA2404489A1 (en) | 2000-03-27 | 2001-10-04 | Technion Research And Development Foundation Ltd. | Single chain class i major histo-compatibility complexes, constructs encoding same and methods of generating same |
| US20030144474A1 (en) | 2000-06-05 | 2003-07-31 | Sunol Molecular Corporation | T cell receptor fusions and conjugates and methods of use thereof |
| US20070037165A1 (en) * | 2000-09-08 | 2007-02-15 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| FR2816214B1 (fr) * | 2000-11-09 | 2005-10-21 | Pasteur Institut | Utilisation d'un compose antagoniste de la proteine esm-1 pour la fabrication d'un medicament pour la prevention et/ou le traitement d'un cancer |
| FR2816410B1 (fr) * | 2000-11-09 | 2003-04-18 | Pasteur Institut | Necessaire de detection de la proteine esm-1 et procede de detection mettant en oeuvre ledit necessaire |
| US20030191073A1 (en) | 2001-11-07 | 2003-10-09 | Challita-Eid Pia M. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
| US7803915B2 (en) * | 2001-06-20 | 2010-09-28 | Genentech, Inc. | Antibody compositions for the diagnosis and treatment of tumor |
| AU2002322280A1 (en) | 2001-06-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| WO2003000012A2 (en) | 2001-06-21 | 2003-01-03 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer |
| IL161268A0 (en) | 2001-11-07 | 2004-09-27 | Agensys Inc | Nucleic acid and corresponding protein entitled 161p2f10b and pharmaceutical and diagnostic compositions containing the same |
| US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| US20030223994A1 (en) | 2002-02-20 | 2003-12-04 | Hoogenboom Henricus Renerus Jacobus Mattheus | MHC-peptide complex binding ligands |
| US20040167067A1 (en) * | 2002-07-01 | 2004-08-26 | David Griggs | ESM-1 gene differentially expressed in angiogenesis, antagonists thereof, and methods of using the same |
| NZ539225A (en) | 2002-10-09 | 2006-09-29 | Avidex Ltd | Single chain recombinant T cell receptors |
| AU2003263607A1 (en) * | 2002-10-25 | 2004-05-13 | Japan As Represented By The President Of The University Of Tokyo | Method for diagnosing diffuse-type gastric cancer |
| ES2327229T3 (es) | 2002-11-09 | 2009-10-27 | Immunocore Ltd. | Presentacion del receptor de linfocitos t. |
| AU2003294510A1 (en) * | 2002-11-22 | 2004-06-18 | Incyte Corporation | Transporters and ion channels |
| GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| DE10313819A1 (de) | 2003-03-24 | 2004-10-07 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| EP2003196A3 (en) | 2003-06-09 | 2009-01-07 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing cancer |
| CN107213469A (zh) * | 2003-11-06 | 2017-09-29 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| US7569662B2 (en) | 2004-01-27 | 2009-08-04 | Compugen Ltd | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
| US7667001B1 (en) | 2004-01-27 | 2010-02-23 | Compugen Ltd. | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
| WO2005084116A2 (en) | 2004-01-27 | 2005-09-15 | Compugen Usa, Inc. | Calcium channel variants |
| DE102004026135A1 (de) * | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| US20070026424A1 (en) | 2005-04-15 | 2007-02-01 | Powell Charles A | Gene profiles correlating with histology and prognosis |
| EP1760089B1 (en) * | 2005-09-05 | 2009-08-19 | Immatics Biotechnologies GmbH | Tumor-associated peptides binding to human leukocyte antigen (HLA) class I or II molecules and related anti-cancer vaccine |
| ATE461215T1 (de) | 2005-09-05 | 2010-04-15 | Immatics Biotechnologies Gmbh | Tumor-assoziierte peptide, welche an unterschiedliche menschliche leukozytenantigene der klasse ii binden |
| JPWO2007119515A1 (ja) * | 2006-03-28 | 2009-08-27 | 昇志 佐藤 | 新規腫瘍抗原ペプチド |
| US20070264651A1 (en) | 2006-04-05 | 2007-11-15 | Corixa Corporation | Methods, compositions, and kits for the detection and monitoring of kidney cancer |
| WO2008021290A2 (en) | 2006-08-09 | 2008-02-21 | Homestead Clinical Corporation | Organ-specific proteins and methods of their use |
| WO2008053573A1 (fr) | 2006-10-30 | 2008-05-08 | National University Corporation Hokkaido University | Remède pour néoplasme malin |
| KR101351195B1 (ko) | 2007-07-27 | 2014-01-14 | 이매틱스 바이오테크놀로지스 게엠베하 | 면역 치료를 위한 새로운 면역원성 에피톱 |
| HUE032379T2 (en) * | 2007-07-27 | 2017-09-28 | Immatics Biotechnologies Gmbh | Composition of tumour-associated peptides and related anti-cancer vaccine |
| US20090263574A1 (en) | 2008-04-21 | 2009-10-22 | Quinn Daniel E | Method of restoring an article |
| FR2933304A1 (fr) * | 2008-07-07 | 2010-01-08 | Adocia | Composition synergique osteogenique |
| PL2172211T3 (pl) | 2008-10-01 | 2015-05-29 | Immatics Biotechnologies Gmbh | Kompozycja związanych z guzem peptydów i związana z tym szczepionka przeciwrakowa do leczenia glejaka (GBM) i innych rodzajów raka |
| KR101192297B1 (ko) | 2008-12-10 | 2012-10-17 | 한국생명공학연구원 | 간암에 대한 신규 바이오마커 및 그의 용도 |
| EP2403523A1 (en) | 2009-03-06 | 2012-01-11 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloprotease 1 und uses thereof |
| EP2464744A1 (en) | 2009-08-14 | 2012-06-20 | F. Hoffmann-La Roche AG | Biological markers for monitoring patient response to vegf antagonists |
| US20120315283A1 (en) * | 2010-02-02 | 2012-12-13 | Dana-Farber Cancer Institute, Inc. | Methods of promoting tissue growth and tissue regeneration |
| WO2011119484A1 (en) * | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
| JP2011211970A (ja) | 2010-03-31 | 2011-10-27 | Toray Ind Inc | インターフェロンに対する感受性又は応答性を予測する方法、キット及びマーカー遺伝子 |
| GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
| EP2632955A1 (en) | 2010-10-26 | 2013-09-04 | Technion Research & Development Foundation Ltd. | Antibodies which bind soluble t-cell receptor ligands |
| GB201021289D0 (en) * | 2010-12-15 | 2011-01-26 | Immatics Biotechnologies Gmbh | Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer |
| US20120207743A1 (en) * | 2011-02-14 | 2012-08-16 | Allergan, Inc. | Inhibiting Aberrant Blood Vessel Formation Using Retargeted Endopeptidases |
| WO2012162468A1 (en) | 2011-05-25 | 2012-11-29 | Janssen Pharmaceutica Nv | Thiazol derivatives as pro -matrix metalloproteinase inhibitors |
| TW201302800A (zh) * | 2011-06-10 | 2013-01-16 | 腫瘤療法 科學股份有限公司 | Ｓｅｍａ５ｂ胜肽及含其之疫苗 |
| WO2013057586A1 (en) | 2011-10-19 | 2013-04-25 | Oslo Universitetssykehus Hf | Compositions and methods for producing soluble t - cell receptors |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| US9540657B2 (en) * | 2012-05-25 | 2017-01-10 | California Institute Of Technology | Expression of secreted and cell-surface polypeptides |
| WO2014071978A1 (en) | 2012-11-08 | 2014-05-15 | Roche Diagnostics Gmbh | Nucleic acids encoding chimeric polypeptides for library screening |
| SG11201503918XA (en) * | 2012-12-04 | 2015-06-29 | Oncotherapy Science Inc | Sema5b peptides and vaccines containing the same |
| EP2808392A1 (en) | 2013-05-28 | 2014-12-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamers and use of the aptamers in the diagnosis and treatment of cancer |
| TWI714869B (zh) | 2013-08-05 | 2021-01-01 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物 |
| CN107074910B (zh) * | 2014-08-17 | 2022-02-18 | 塞里维瑞疗法公司 | 高级大分子转导域序列、编码其的多核苷酸及其用途 |
| DK3388075T5 (da) | 2015-03-27 | 2024-09-23 | Immatics Biotechnologies Gmbh | Hidtil ukendte peptider og kombination af peptider til anvendelse ved immunterapi mod forskellige tumorer |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
-
2015
- 2015-03-31 GB GBGB1505585.8A patent/GB201505585D0/en not_active Ceased
-
2016
- 2016-03-23 MA MA041844A patent/MA41844A/fr unknown
- 2016-03-24 KR KR1020177027590A patent/KR102451645B1/ko active Active
- 2016-03-24 KR KR1020227015914A patent/KR20220070328A/ko not_active Ceased
- 2016-03-24 CN CN202111198057.3A patent/CN113912702A/zh active Pending
- 2016-03-24 UA UAA201708037A patent/UA124519C2/uk unknown
- 2016-03-24 MY MYPI2022003398A patent/MY199184A/en unknown
- 2016-03-24 SG SG11201707043WA patent/SG11201707043WA/en unknown
- 2016-03-24 EP EP19160336.4A patent/EP3517128A1/en not_active Withdrawn
- 2016-03-24 PE PE2022002819A patent/PE20231650A1/es unknown
- 2016-03-24 EP EP19160322.4A patent/EP3517127A1/en active Pending
- 2016-03-24 MA MA046304A patent/MA46304A/fr unknown
- 2016-03-24 CA CA2980814A patent/CA2980814A1/en active Pending
- 2016-03-24 SG SG10202001834UA patent/SG10202001834UA/en unknown
- 2016-03-24 CN CN201680020165.2A patent/CN107438619B/zh not_active Expired - Fee Related
- 2016-03-24 BR BR112017019804-5A patent/BR112017019804A2/pt not_active Application Discontinuation
- 2016-03-24 PH PH1/2022/553212A patent/PH12022553212A1/en unknown
- 2016-03-24 AU AU2016240341A patent/AU2016240341B2/en not_active Ceased
- 2016-03-24 MA MA40794A patent/MA40794A1/fr unknown
- 2016-03-24 CR CR20220164A patent/CR20220164A/es unknown
- 2016-03-24 EP EP16715808.8A patent/EP3277310A1/en not_active Withdrawn
- 2016-03-24 IL IL289444A patent/IL289444B/en unknown
- 2016-03-24 MY MYPI2017703153A patent/MY181449A/en unknown
- 2016-03-24 EP EP19160307.5A patent/EP3517126A1/en active Pending
- 2016-03-24 PE PE2017001627A patent/PE20180505A1/es unknown
- 2016-03-24 MX MX2017012504A patent/MX2017012504A/es unknown
- 2016-03-24 CR CR20170440A patent/CR20170440A/es unknown
- 2016-03-24 HK HK18106394.9A patent/HK1247085A1/zh unknown
- 2016-03-24 JP JP2017550874A patent/JP7146399B2/ja active Active
- 2016-03-24 WO PCT/EP2016/056601 patent/WO2016156230A1/en not_active Ceased
- 2016-03-24 EA EA201791950A patent/EA037050B1/ru unknown
- 2016-03-24 MA MA046305A patent/MA46305A/fr unknown
- 2016-03-24 PH PH1/2017/501651A patent/PH12017501651B1/en unknown
- 2016-03-24 CR CR20220163A patent/CR20220163A/es unknown
- 2016-03-24 MA MA046303A patent/MA46303A/fr unknown
- 2016-03-28 TW TW109136263A patent/TWI756874B/zh not_active IP Right Cessation
- 2016-03-28 TW TW109136260A patent/TWI758912B/zh not_active IP Right Cessation
- 2016-03-28 US US15/082,876 patent/US9993536B2/en active Active
- 2016-03-28 AR ARP160100819A patent/AR104114A1/es not_active Application Discontinuation
- 2016-03-28 US US15/082,920 patent/US9931388B2/en active Active
- 2016-03-28 TW TW105109709A patent/TWI758243B/zh not_active IP Right Cessation
- 2016-03-28 TW TW111113655A patent/TW202231656A/zh unknown
- 2016-03-28 TW TW109136262A patent/TWI745127B/zh not_active IP Right Cessation
-
2017
- 2017-08-29 IL IL254204A patent/IL254204B/en unknown
- 2017-09-22 CO CONC2017/0009616A patent/CO2017009616A2/es unknown
- 2017-09-28 MX MX2022000219A patent/MX2022000219A/es unknown
- 2017-09-28 CL CL2017002448A patent/CL2017002448A1/es unknown
- 2017-10-31 US US15/799,495 patent/US10105428B2/en active Active
-
2018
- 2018-05-14 US US15/978,700 patent/US10213498B2/en active Active
- 2018-08-03 US US16/054,561 patent/US10357552B2/en active Active
- 2018-11-23 CL CL2018003348A patent/CL2018003348A1/es unknown
- 2018-12-07 US US16/212,787 patent/US10314899B2/en active Active
- 2018-12-07 US US16/212,783 patent/US10363296B2/en active Active
-
2019
- 2019-03-13 AU AU2019201708A patent/AU2019201708B2/en not_active Ceased
- 2019-03-13 AU AU2019201714A patent/AU2019201714B2/en not_active Ceased
- 2019-03-13 AU AU2019201713A patent/AU2019201713B2/en not_active Ceased
- 2019-03-28 US US16/367,790 patent/US10548958B2/en active Active
- 2019-05-17 US US16/415,753 patent/US10478481B2/en active Active
- 2019-05-17 US US16/415,686 patent/US10449240B2/en active Active
- 2019-09-17 CL CL2019002663A patent/CL2019002663A1/es unknown
- 2019-12-16 US US16/715,846 patent/US10835586B2/en not_active Expired - Fee Related
-
2020
- 2020-06-11 AU AU2020203850A patent/AU2020203850B2/en not_active Ceased
- 2020-10-16 US US17/072,528 patent/US20210030854A1/en not_active Abandoned
-
2021
- 2021-02-19 AR ARP210100436A patent/AR121380A2/es not_active Application Discontinuation
- 2021-02-19 AR ARP210100439A patent/AR121383A2/es unknown
- 2021-05-07 US US17/314,492 patent/US11938176B2/en active Active
- 2021-07-05 CL CL2021001776A patent/CL2021001776A1/es unknown
- 2021-08-08 IL IL285434A patent/IL285434B/en unknown
- 2021-08-13 US US17/402,068 patent/US12221626B2/en active Active
- 2021-10-29 US US17/514,599 patent/US12059458B2/en active Active
- 2021-11-04 US US17/519,192 patent/US12005105B2/en active Active
-
2023
- 2023-01-27 JP JP2023010823A patent/JP2023061974A/ja active Pending
- 2023-03-21 CL CL2023000812A patent/CL2023000812A1/es unknown
- 2023-11-22 JP JP2023197848A patent/JP2024028730A/ja active Pending
-
2024
- 2024-12-27 US US19/003,495 patent/US20250154459A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018511321A5 (enExample) | ||
| JP2018518937A5 (enExample) | ||
| JP2018519243A5 (enExample) | ||
| JP2018529320A5 (enExample) | ||
| JP2019510465A5 (enExample) | ||
| JP2018510628A5 (enExample) | ||
| JP2018521641A5 (enExample) | ||
| JP2021168652A5 (enExample) | ||
| JP2018536383A5 (enExample) | ||
| JP2019502360A5 (enExample) | ||
| JP2018520653A5 (enExample) | ||
| JP7712970B2 (ja) | ホットスポットを利用した新生抗原の特定 | |
| JP2018518956A5 (enExample) | ||
| JP2018509135A5 (enExample) | ||
| JP2019506838A5 (enExample) | ||
| JP7480064B2 (ja) | パンアレルモデルによる新生抗原の特定方法 | |
| JP7668742B2 (ja) | Ｍｈｃクラスｉｉモデルによる新生抗原の特定 | |
| RU2017137142A (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака | |
| JP7763588B2 (ja) | Ｔ細胞療法用の新生抗原の特定法 | |
| JP2019511214A5 (enExample) | ||
| JP2017502076A5 (enExample) | ||
| JP2017525336A5 (enExample) | ||
| KR101391561B1 (ko) | Ｈｌａ-ａ*3303 구속성 ｗｔ1 펩티드, 및 그것을 포함하는 의약 조성물 | |
| JP2024041841A5 (enExample) | ||
| JP2024099580A5 (enExample) |