RU2016109150A - Мукозальная вакцинная композиция - Google Patents
Мукозальная вакцинная композиция Download PDFInfo
- Publication number
- RU2016109150A RU2016109150A RU2016109150A RU2016109150A RU2016109150A RU 2016109150 A RU2016109150 A RU 2016109150A RU 2016109150 A RU2016109150 A RU 2016109150A RU 2016109150 A RU2016109150 A RU 2016109150A RU 2016109150 A RU2016109150 A RU 2016109150A
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- Prior art keywords
- mucous membrane
- vaccine composition
- antigen
- mucosal vaccine
- solid preparation
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 6
- 229960005486 vaccine Drugs 0.000 title claims 6
- 210000004400 mucous membrane Anatomy 0.000 claims 12
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 5
- 239000002671 adjuvant Substances 0.000 claims 3
- SKCKOFZKJLZSFA-UHFFFAOYSA-N L-Gulomethylit Natural products CC(O)C(O)C(O)C(O)CO SKCKOFZKJLZSFA-UHFFFAOYSA-N 0.000 claims 2
- 241000572738 Roseomonas Species 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 230000036760 body temperature Effects 0.000 claims 2
- 241000589220 Acetobacter Species 0.000 claims 1
- 241000590020 Achromobacter Species 0.000 claims 1
- 241001502776 Acidicaldus Species 0.000 claims 1
- 241000588853 Acidiphilium Species 0.000 claims 1
- 241000501787 Acidisphaera Species 0.000 claims 1
- 241000501828 Acidocella Species 0.000 claims 1
- 241001478307 Acidomonas Species 0.000 claims 1
- 241000308413 Asaia Species 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241001459699 Belnapia Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 241000589565 Flavobacterium Species 0.000 claims 1
- 241001647840 Leclercia Species 0.000 claims 1
- 241000193751 Methanoculleus Species 0.000 claims 1
- 241000205276 Methanosarcina Species 0.000 claims 1
- 241000192041 Micrococcus Species 0.000 claims 1
- 241001604462 Neoasaia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241001610718 Oleomonas Species 0.000 claims 1
- 241000520272 Pantoea Species 0.000 claims 1
- 241001302159 Paracraurococcus Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241001478280 Rahnella Species 0.000 claims 1
- 241000190937 Rhodopila Species 0.000 claims 1
- 241001495145 Roseococcus Species 0.000 claims 1
- 241001063175 Rubritepida Species 0.000 claims 1
- 241000602127 Saccharibacter Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 241000862969 Stella Species 0.000 claims 1
- 241001248469 Swaminathania Species 0.000 claims 1
- 241000589634 Xanthomonas Species 0.000 claims 1
- 241001185312 Zavarzinia Species 0.000 claims 1
- 241000588901 Zymomonas Species 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 230000004727 humoral immunity Effects 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
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- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A61K39/15—Reoviridae, e.g. calf diarrhea virus
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
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- A61K2039/525—Virus
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
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- C12N2770/32011—Picornaviridae
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
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- Biomedical Technology (AREA)
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- General Engineering & Computer Science (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
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Claims (9)
1. Мукозальная вакцинная композиция для введения через по меньшей мере одну слизистую оболочку, выбранную из группы, состоящей из слизистой оболочки ротовой полости, слизистой оболочки глаза, слизистой оболочки уха, слизистой оболочки гениталий, слизистой оболочки глотки, слизистой оболочки дыхательных путей, слизистой оболочки бронхов, слизистой оболочки легких, слизистой оболочки желудка, слизистой оболочки кишечника и слизистой оболочки прямой кишки человека или животного, содержащая:
по меньшей мере один антиген; и
в качестве адъюванта липополисахарид, полученный из по меньшей мере одной грамотрицательной бактерии, выбранной из группы, состоящей из Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas и Enterobacter, или его соль,
при этом соотношение масс указанного адъюванта и указанного антигена (общая масса адъюванта/общая масса антигена) составляет от 0,002 до 500.
2. Мукозальная вакцинная композиция по п. 1, представляющая собой жидкий препарат, аэрозоль, полутвердый препарат или твердый препарат,
при этом указанный полутвердый препарат и указанный твердый препарат растворяется за счет жидкостей организма и/или температуры тела.
3. Мукозальная вакцинная композиция по п. 2, представляющая собой твердый препарат, который растворяется за счет жидкостей организма и/или температуры тела.
4. Мукозальная вакцинная композиция по п. 1, 2 или 3, используемая для индукции гуморального иммунитета.
5. Мукозальная вакцинная композиция по п. 1, 2, 3 или 4, отличающаяся тем, что антиген представляет собой антиген, полученный из возбудителя инфекционного заболевания, или раковый антиген.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013208664 | 2013-10-03 | ||
| JP2013-208664 | 2013-10-03 | ||
| PCT/JP2014/076347 WO2015050179A1 (ja) | 2013-10-03 | 2014-10-02 | 粘膜ワクチン組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016109150A true RU2016109150A (ru) | 2017-11-10 |
| RU2016109150A3 RU2016109150A3 (ru) | 2018-07-12 |
Family
ID=52778766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016109150A RU2016109150A (ru) | 2013-10-03 | 2014-10-02 | Мукозальная вакцинная композиция |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10391167B2 (ru) |
| EP (1) | EP3053596B1 (ru) |
| JP (1) | JP6494233B2 (ru) |
| KR (1) | KR20160058772A (ru) |
| CN (1) | CN105555308A (ru) |
| AU (1) | AU2014330336A1 (ru) |
| CA (1) | CA2923028A1 (ru) |
| HK (1) | HK1218877A1 (ru) |
| MX (1) | MX2016003325A (ru) |
| RU (1) | RU2016109150A (ru) |
| TW (1) | TW201601752A (ru) |
| WO (1) | WO2015050179A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10092642B2 (en) | 2013-10-03 | 2018-10-09 | Nitto Denko Corporation | Mucosal vaccine composition |
| JP6494233B2 (ja) * | 2013-10-03 | 2019-04-03 | 日東電工株式会社 | 粘膜ワクチン組成物 |
| EP3202417A4 (en) * | 2014-10-02 | 2018-04-25 | Nitto Denko Corporation | Vaccine pharmaceutical composition for transdermal administration |
| US10857228B2 (en) * | 2015-06-10 | 2020-12-08 | The University Of Tokyo | Adjuvant for vaccines, vaccine, and immunity induction method |
| CN109125264B (zh) | 2017-06-19 | 2020-10-30 | 林海祥 | 一种抗感染抗肿瘤的粘膜免疫制剂 |
| JP6512614B1 (ja) * | 2017-10-12 | 2019-05-15 | 自然免疫応用技研株式会社 | 口腔ケア剤 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6367364A (ja) | 1986-09-05 | 1988-03-26 | ナショナル住宅産業株式会社 | 換気装置 |
| JP4043533B2 (ja) | 1995-01-27 | 2008-02-06 | 水野 傳一 | 低分子量リポポリサッカライド |
| JPH08245702A (ja) | 1995-03-13 | 1996-09-24 | Denichi Mizuno | 高分子量リポポリサッカライド |
| US6010719A (en) | 1997-09-16 | 2000-01-04 | Universiteit Gent | Freeze-dried disintegrating tablets |
| WO2005027964A1 (en) | 2003-09-15 | 2005-03-31 | Id Biomedical Corporation Of Quebec | Measles subunit vaccine |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| WO2009065415A1 (en) | 2007-11-21 | 2009-05-28 | Roskilde Universitet | Polypeptides comprising an ice-binding activity |
| JP5190628B2 (ja) * | 2008-03-31 | 2013-04-24 | 一般財団法人阪大微生物病研究会 | 混合免疫賦活剤を含む新規ワクチン |
| RU2732574C2 (ru) | 2009-06-05 | 2020-09-21 | Инфекшес Дизиз Рисерч Инститьют | Синтетические глюкопиранозиллипидные адъюванты |
| GB201009273D0 (en) | 2010-06-03 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel vaccine |
| JP2012082156A (ja) | 2010-10-09 | 2012-04-26 | Bio Medical Research Group:Kk | 免疫活性化剤及び免疫活性化剤配合物 |
| CA2843854A1 (en) | 2011-07-01 | 2013-01-10 | The Regents Of The University Of California | Herpes virus vaccine and methods of use |
| JP5650780B2 (ja) * | 2012-04-04 | 2015-01-07 | 日東電工株式会社 | ワクチン組成物 |
| EP2762160A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Wt1 peptide cancer vaccine composition for mucosal administration |
| CN103961697A (zh) * | 2013-02-05 | 2014-08-06 | 日东电工株式会社 | 粘膜给予用疫苗组合物 |
| CA2840978A1 (en) | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Vaccine composition for mucosal administration |
| CN103961701B (zh) | 2013-02-05 | 2018-09-14 | 日东电工株式会社 | 疫苗组合物 |
| KR20140100420A (ko) * | 2013-02-05 | 2014-08-14 | 닛토덴코 가부시키가이샤 | 경피 또는 점막 투여용 백신 조성물 |
| RU2016109363A (ru) | 2013-10-03 | 2017-11-10 | Нитто Денко Корпорейшн | Инъекционная вакцинная композиция |
| JP6494233B2 (ja) * | 2013-10-03 | 2019-04-03 | 日東電工株式会社 | 粘膜ワクチン組成物 |
| US20160206728A1 (en) * | 2013-10-03 | 2016-07-21 | Nitto Denko Corporation | Dried influenza vaccine preparation and method of producing the same |
| US10092642B2 (en) * | 2013-10-03 | 2018-10-09 | Nitto Denko Corporation | Mucosal vaccine composition |
| WO2015050178A1 (ja) * | 2013-10-03 | 2015-04-09 | 日東電工株式会社 | 鼻粘膜ワクチン組成物 |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| MX2018012719A (es) * | 2016-04-19 | 2019-05-30 | Us Health | Ram negativas para tratar la dermatitis atopica. |
-
2014
- 2014-10-02 JP JP2014204023A patent/JP6494233B2/ja active Active
- 2014-10-02 CA CA2923028A patent/CA2923028A1/en not_active Abandoned
- 2014-10-02 WO PCT/JP2014/076347 patent/WO2015050179A1/ja active Application Filing
- 2014-10-02 CN CN201480050378.0A patent/CN105555308A/zh active Pending
- 2014-10-02 US US14/917,077 patent/US10391167B2/en not_active Expired - Fee Related
- 2014-10-02 MX MX2016003325A patent/MX2016003325A/es unknown
- 2014-10-02 TW TW103134466A patent/TW201601752A/zh unknown
- 2014-10-02 KR KR1020167006133A patent/KR20160058772A/ko not_active Application Discontinuation
- 2014-10-02 EP EP14851195.9A patent/EP3053596B1/en active Active
- 2014-10-02 AU AU2014330336A patent/AU2014330336A1/en not_active Abandoned
- 2014-10-02 RU RU2016109150A patent/RU2016109150A/ru not_active Application Discontinuation
-
2016
- 2016-06-16 HK HK16106939.3A patent/HK1218877A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6494233B2 (ja) | 2019-04-03 |
| MX2016003325A (es) | 2016-07-06 |
| CN105555308A (zh) | 2016-05-04 |
| RU2016109150A3 (ru) | 2018-07-12 |
| EP3053596A1 (en) | 2016-08-10 |
| WO2015050179A1 (ja) | 2015-04-09 |
| JP2015091793A (ja) | 2015-05-14 |
| US10391167B2 (en) | 2019-08-27 |
| US20160213773A1 (en) | 2016-07-28 |
| CA2923028A1 (en) | 2015-04-09 |
| KR20160058772A (ko) | 2016-05-25 |
| AU2014330336A1 (en) | 2016-03-17 |
| EP3053596B1 (en) | 2020-05-06 |
| EP3053596A4 (en) | 2017-04-26 |
| TW201601752A (zh) | 2016-01-16 |
| HK1218877A1 (zh) | 2017-03-17 |
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| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20181106 |