HRP20231504T1 - Polisaharidi kapsule iz bakterije streptococcus pneumoniae i njihovi konjugati - Google Patents
Polisaharidi kapsule iz bakterije streptococcus pneumoniae i njihovi konjugati Download PDFInfo
- Publication number
- HRP20231504T1 HRP20231504T1 HRP20231504TT HRP20231504T HRP20231504T1 HR P20231504 T1 HRP20231504 T1 HR P20231504T1 HR P20231504T T HRP20231504T T HR P20231504TT HR P20231504 T HRP20231504 T HR P20231504T HR P20231504 T1 HRP20231504 T1 HR P20231504T1
- Authority
- HR
- Croatia
- Prior art keywords
- accordance
- immunogenic
- immunogenic preparation
- serotype
- polysaccharide
- Prior art date
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- 150000004676 glycans Chemical class 0.000 title claims 8
- 229920001282 polysaccharide Polymers 0.000 title claims 8
- 239000005017 polysaccharide Substances 0.000 title claims 8
- 241000193998 Streptococcus pneumoniae Species 0.000 title claims 3
- 229940031000 streptococcus pneumoniae Drugs 0.000 title 1
- 230000002163 immunogen Effects 0.000 claims 16
- 239000002775 capsule Substances 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Claims (11)
1. Imunogeni pripravak, koji sadrži imunogeni konjugat, koji sadrži izolirani polisaharid kapsule iz bakterije Streptococcus pneumoniae serotipa 15B, kovalentno vezan na proteinski nosač, gdje navedeni konjugat sadrži najmanje 0,6 mM acetata po mM navedenog polisaharida kapsule iz serotipa 15B, namijenjen upotrebi u postupku sprječavanja infekcije bakterijom Streptococcus pneumoniae serotipa 15C, naznačen time što se postupak sastoji u primjeni na subjektu imunogene količine navedenog imunogenog pripravka.
2. Imunogeni pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što navedeni polisaharid kapsule iz serotipa 15B ima molekulsku težinu između 100 kDa i 350 kDa.
3. Imunogeni pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-2, naznačen time što navedeni konjugat sadrži najmanje 0,6 mM glicerola po mM navedenog polisaharida kapsule iz serotipa 15B.
4. Imunogeni pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-3, naznačen time što je navedeni proteinski nosač CRM197.
5. Imunogeni pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-4, naznačen time što imunogeni konjugat sadrži manje od 40, 35, 30, 25, 20 ili 15% slobodnog polisaharida kapsule iz serotipa 15B u usporedbi s ukupnom količinom polisaharida kapsule iz serotipa 15B.
6. Imunogeni pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačen time što imunogeni konjugat ima molekulsku težinu između 10000 i 16000 kDa.
7. Imunogeni pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što je omjer (težinski) između polisaharida kapsule iz serotipa 15B i proteinskog nosača u konjugatu između 0,7 i 0,9.
8. Imunogeni pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačen time što je stupanj konjugiranja između: 2 i 15; 2 i 13; 2 i 10; 2 i 8; 2 i 6; 2 i 5; 2 i 4; 3 i 15; 3 i 13; 3 i 10; 3 i 8; 3 i 6; 3 i 5; 3 i 4; 5 i 15; 5 i 10; 8 i 15; 8 i 12; 10 i 15; ili 10 i 12.
9. Imunogeni pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-8, naznačen time što dodatno sadrži najmanje jedan dodatni antigen.
10. Imunogeni pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 9, naznačen time što dodatno sadrži adjuvans.
11. Imunogeni pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 10, naznačen time što je adjuvans aluminijev fosfat.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461929561P | 2014-01-21 | 2014-01-21 | |
EP19179577.2A EP3583947B1 (en) | 2014-01-21 | 2015-01-15 | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20231504T1 true HRP20231504T1 (hr) | 2024-03-01 |
Family
ID=52630421
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20231504TT HRP20231504T1 (hr) | 2014-01-21 | 2015-01-15 | Polisaharidi kapsule iz bakterije streptococcus pneumoniae i njihovi konjugati |
HRP20211288TT HRP20211288T1 (hr) | 2014-01-21 | 2021-08-11 | Kapsularni polisaharidi bakterije streptococcus pneumoniae i njihovi konjugati |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20211288TT HRP20211288T1 (hr) | 2014-01-21 | 2021-08-11 | Kapsularni polisaharidi bakterije streptococcus pneumoniae i njihovi konjugati |
Country Status (22)
Country | Link |
---|---|
US (3) | US20160324949A1 (hr) |
EP (3) | EP3096786B1 (hr) |
JP (3) | JP6585624B2 (hr) |
KR (4) | KR102229568B1 (hr) |
CN (2) | CN106413747A (hr) |
AU (3) | AU2015208822B2 (hr) |
BR (2) | BR122023022294A2 (hr) |
CA (1) | CA2937190A1 (hr) |
DK (2) | DK3096786T3 (hr) |
ES (2) | ES2965616T3 (hr) |
FI (1) | FI3583947T3 (hr) |
FR (1) | FR22C1041I2 (hr) |
HK (1) | HK1232133A1 (hr) |
HR (2) | HRP20231504T1 (hr) |
HU (1) | HUE055553T2 (hr) |
IL (1) | IL246738B1 (hr) |
MX (2) | MX2020001138A (hr) |
PL (2) | PL3096786T3 (hr) |
PT (2) | PT3096786T (hr) |
RU (2) | RU2743793C1 (hr) |
SI (2) | SI3096786T1 (hr) |
WO (1) | WO2015110942A2 (hr) |
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MY182282A (en) | 2015-05-04 | 2021-01-18 | Pfizer | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
KR102225282B1 (ko) | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
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CN109862908B (zh) | 2016-08-05 | 2023-05-02 | 圣诺菲·帕斯图尔公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
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