BR112020004396A8 - Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora - Google Patents
Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadoraInfo
- Publication number
- BR112020004396A8 BR112020004396A8 BR112020004396A BR112020004396A BR112020004396A8 BR 112020004396 A8 BR112020004396 A8 BR 112020004396A8 BR 112020004396 A BR112020004396 A BR 112020004396A BR 112020004396 A BR112020004396 A BR 112020004396A BR 112020004396 A8 BR112020004396 A8 BR 112020004396A8
- Authority
- BR
- Brazil
- Prior art keywords
- protein conjugates
- carrier protein
- serotypes
- polysaccharide
- pneumococcal polysaccharides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Sustainable Development (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
A presente invenção fornece polissacarídeos capsulares de sorotipos de Streptococcus pneumoniae identificados com o uso de RMN. A presente invenção fornece, adicionalmente, conjugados de polissacarídeo-proteína em que polissacarídeos capsulares de um ou mais dentre esses sorotipos são conjugados a uma proteína carreadora, tal como CRM197. Os conjugados de polissacarídeo-proteína de um ou mais dentre esses sorotipos podem ser incluídos em vacinas pneumocócicas conjugadas multivalentes que têm polissacarídeos de múltiplos sorotipos adicionais de Steptococcus pneumoniae.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762555455P | 2017-09-07 | 2017-09-07 | |
US62/555,455 | 2017-09-07 | ||
PCT/US2018/049306 WO2019050814A1 (en) | 2017-09-07 | 2018-09-04 | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112020004396A2 BR112020004396A2 (pt) | 2020-09-08 |
BR112020004396A8 true BR112020004396A8 (pt) | 2023-01-31 |
Family
ID=65635315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112020004396A BR112020004396A8 (pt) | 2017-09-07 | 2018-09-04 | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
Country Status (10)
Country | Link |
---|---|
US (6) | US11491216B2 (pt) |
EP (1) | EP3678655A4 (pt) |
JP (2) | JP2020533437A (pt) |
KR (1) | KR20200051003A (pt) |
CN (2) | CN111065388A (pt) |
AU (2) | AU2018328036B2 (pt) |
BR (1) | BR112020004396A8 (pt) |
CA (1) | CA3074706A1 (pt) |
MX (2) | MX2020002559A (pt) |
WO (1) | WO2019050814A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6612260B2 (ja) * | 2014-01-21 | 2019-11-27 | ファイザー・インク | 肺炎連鎖球菌(Streptococcus pneumoniae)莢膜多糖およびそのコンジュゲート |
US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
CA3048981A1 (en) | 2016-12-30 | 2018-07-05 | Sutrovax, Inc. | Polypeptide-antigen conjugates with non-natural amino acids |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
CN110225757A (zh) * | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
CN110337307A (zh) | 2017-02-24 | 2019-10-15 | 默沙东公司 | 增强肺炎链球菌多糖-蛋白缀合物的免疫原性 |
US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
CN118063638A (zh) * | 2017-09-07 | 2024-05-24 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
JP7218358B2 (ja) | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体-キャリアタンパク質コンジュゲートでのその使用 |
US11491216B2 (en) | 2017-09-07 | 2022-11-08 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
WO2019070994A1 (en) * | 2017-10-04 | 2019-04-11 | Liffey Biotech Limited | SACCHARIDE-POLYPEPTIDE CONJUGATE COMPOSITIONS AND METHODS OF USE |
JP7369123B2 (ja) | 2017-12-06 | 2023-10-25 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖類-タンパク質コンジュゲートを含む組成物およびその使用方法 |
KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
KR20210002641A (ko) | 2018-04-30 | 2021-01-08 | 머크 샤프 앤드 돔 코포레이션 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
MA54533A (fr) | 2018-12-19 | 2022-03-30 | Merck Sharp & Dohme | Compositions comprenant des conjugués polysaccharide-protéine de streptococcus pneumoniae et leurs méthodes d'utilisation |
JP2021132644A (ja) * | 2020-02-21 | 2021-09-13 | ファイザー・インク | 糖の精製 |
EP4288106A1 (en) * | 2021-02-04 | 2023-12-13 | Merck Sharp & Dohme LLC | Lipid nanoparticle adjuvant composition for pneumococcal conjugate vaccines |
WO2024110839A2 (en) | 2022-11-22 | 2024-05-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
CN102716480B (zh) * | 2005-04-08 | 2023-03-21 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
AU2006336520B2 (en) * | 2005-12-28 | 2011-09-15 | The Uab Research Foundation | Pneumococcal serotypes |
GB0703369D0 (en) * | 2007-02-21 | 2007-03-28 | Health Prot Agency | Compositions Comprising Capsular Polysaccharides and Their Use as Vaccines |
WO2010014888A2 (en) * | 2008-07-31 | 2010-02-04 | The Gov't Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods of enhancing opsonophagocytosis in response to a pathogen |
TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
SI3170508T1 (sl) | 2010-06-04 | 2020-01-31 | Wyeth Llc | Formulacije cepiva |
RU2013131795A (ru) * | 2010-12-10 | 2015-01-20 | Мерк Шарп Энд Домэ Корп. | Новые композиции, которые уменьшают вызываемую встряхиванием агрегацию иммуногенных композиций |
JP2015510872A (ja) * | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Streptococcuspneumoniae抗原の増強された製剤 |
MX363511B (es) | 2012-08-16 | 2019-03-26 | Pfizer | Proceso de glucoconjugación y composiciones. |
CN103623401A (zh) * | 2012-08-23 | 2014-03-12 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 |
EP3616716A3 (en) * | 2014-01-21 | 2020-05-06 | Pfizer Inc | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
US10668164B2 (en) * | 2014-02-14 | 2020-06-02 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
US10307474B2 (en) * | 2014-08-08 | 2019-06-04 | Glaxosmithkline Biologicals S.A. | Modified host cells and hybrid oligosaccharides for use in bioconjugate production |
US10729780B2 (en) * | 2015-06-08 | 2020-08-04 | Serum Institute Of India Private Ltd. | Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof |
PE20240927A1 (es) * | 2015-07-21 | 2024-04-30 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados, kits que las comprenden y sus usos |
US11058757B2 (en) | 2016-03-31 | 2021-07-13 | Pogona, LLC | Saccharide-polypeptide conjugate compositions and methods of use thereof |
CN109311924B (zh) * | 2016-04-14 | 2020-04-17 | 马克斯·普朗克科学促进学会 | 针对肺炎链球菌3型的疫苗的改善的制备 |
GB201610599D0 (en) * | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
CN109415104A (zh) * | 2016-06-30 | 2019-03-01 | 福特全球技术公司 | 用于框架安装式踏板节奏传感器的系统、方法和装置 |
WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
CN110225757A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
US11400162B2 (en) * | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
WO2018156465A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Polysaccharide-protein conjugates utilizing diphtheria toxin fragment b as a carrier |
CA3049985A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharide-protein vaccine formulations comprising improved surfactant systems |
US20200061542A1 (en) | 2017-02-24 | 2020-02-27 | Merck Sharp & Dohme Corp. | Methods for improving filterability of polysaccharide-protein conjugate reactions |
CN110337307A (zh) * | 2017-02-24 | 2019-10-15 | 默沙东公司 | 增强肺炎链球菌多糖-蛋白缀合物的免疫原性 |
BR112019022868A2 (pt) * | 2017-05-05 | 2020-05-19 | Serum Institute Of India Private Limited | método para remoção de impurezas de preparações à base de polissacarídeo capsular bacteriano |
GB201711635D0 (en) * | 2017-07-19 | 2017-08-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
GB201711637D0 (en) * | 2017-07-19 | 2017-08-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
JP2020531421A (ja) | 2017-08-16 | 2020-11-05 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 肺炎球菌コンジュゲートワクチン製剤 |
JP7218358B2 (ja) | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体-キャリアタンパク質コンジュゲートでのその使用 |
CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
US11491216B2 (en) | 2017-09-07 | 2022-11-08 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
US11524076B2 (en) * | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
JP2020533299A (ja) | 2017-09-07 | 2020-11-19 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | キャリアタンパク質へのコンジュゲーションのための肺炎球菌多糖の製剤方法 |
CN118063638A (zh) | 2017-09-07 | 2024-05-24 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
EP3700565A4 (en) | 2017-10-25 | 2021-09-29 | Merck Sharp & Dohme Corp. | ADJUVED VACCINES |
JP7369123B2 (ja) * | 2017-12-06 | 2023-10-25 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖類-タンパク質コンジュゲートを含む組成物およびその使用方法 |
US20210236646A1 (en) * | 2018-04-30 | 2021-08-05 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
MA54533A (fr) * | 2018-12-19 | 2022-03-30 | Merck Sharp & Dohme | Compositions comprenant des conjugués polysaccharide-protéine de streptococcus pneumoniae et leurs méthodes d'utilisation |
TW202116352A (zh) * | 2019-07-18 | 2021-05-01 | 南韓商賽特瑞恩股份有限公司 | 包含多價肺炎球菌多醣-蛋白共軛物的免疫組成物、醫藥組成物及其用途 |
CA3191005A1 (en) * | 2020-08-10 | 2022-02-17 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
-
2018
- 2018-09-04 US US16/645,048 patent/US11491216B2/en active Active
- 2018-09-04 JP JP2020513530A patent/JP2020533437A/ja active Pending
- 2018-09-04 CN CN201880058250.7A patent/CN111065388A/zh active Pending
- 2018-09-04 KR KR1020207009613A patent/KR20200051003A/ko not_active Application Discontinuation
- 2018-09-04 AU AU2018328036A patent/AU2018328036B2/en active Active
- 2018-09-04 CA CA3074706A patent/CA3074706A1/en active Pending
- 2018-09-04 MX MX2020002559A patent/MX2020002559A/es unknown
- 2018-09-04 BR BR112020004396A patent/BR112020004396A8/pt unknown
- 2018-09-04 WO PCT/US2018/049306 patent/WO2019050814A1/en active Application Filing
- 2018-09-04 EP EP18854598.2A patent/EP3678655A4/en active Pending
- 2018-09-04 CN CN202311711412.1A patent/CN117736348A/zh active Pending
-
2020
- 2020-03-05 MX MX2022014850A patent/MX2022014850A/es unknown
-
2022
- 2022-09-22 US US17/934,379 patent/US20230075760A1/en active Pending
- 2022-09-22 US US17/934,396 patent/US20230107713A1/en active Pending
- 2022-09-27 US US17/935,856 patent/US20230094548A1/en active Pending
- 2022-09-27 US US17/935,864 patent/US20230041441A1/en active Pending
- 2022-09-27 US US17/935,871 patent/US20230029424A1/en active Pending
-
2023
- 2023-06-12 JP JP2023096312A patent/JP2023113922A/ja active Pending
-
2024
- 2024-03-06 AU AU2024201479A patent/AU2024201479A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN117736348A (zh) | 2024-03-22 |
JP2020533437A (ja) | 2020-11-19 |
EP3678655A4 (en) | 2021-05-05 |
BR112020004396A2 (pt) | 2020-09-08 |
JP2023113922A (ja) | 2023-08-16 |
RU2020112312A3 (pt) | 2022-03-23 |
US11491216B2 (en) | 2022-11-08 |
AU2018328036A1 (en) | 2020-03-19 |
KR20200051003A (ko) | 2020-05-12 |
CN111065388A (zh) | 2020-04-24 |
US20230107713A1 (en) | 2023-04-06 |
AU2018328036B2 (en) | 2024-03-07 |
WO2019050814A1 (en) | 2019-03-14 |
US20200330578A1 (en) | 2020-10-22 |
US20230041441A1 (en) | 2023-02-09 |
US20230029424A1 (en) | 2023-01-26 |
RU2020112312A (ru) | 2021-10-07 |
US20230075760A1 (en) | 2023-03-09 |
MX2022014850A (es) | 2022-12-15 |
EP3678655A1 (en) | 2020-07-15 |
AU2024201479A1 (en) | 2024-03-28 |
CA3074706A1 (en) | 2019-03-14 |
US20230094548A1 (en) | 2023-03-30 |
MX2020002559A (es) | 2020-07-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112020004396A8 (pt) | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora | |
BR112020004509A8 (pt) | Conjugado polissacarídeo-proteína carreadora, composição imunogênica compreendendo o mesmo e uso do referido conjugado | |
BR112020004502A8 (pt) | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora | |
BR112020004471A8 (pt) | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora | |
CU24660B1 (es) | Composiciones de vacunas multivalentes que comprenden conjugados de polisacárido-proteína de streptococcus pneumoniae utilizando proteínas portadoras psaa y crm197 | |
GEP20227420B (en) | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof | |
BR112019001995A2 (pt) | composição de conjugado de polissacarídeo pneumocócico multivalente ? proteína | |
PH12017501898A1 (en) | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof | |
BR112019001971A2 (pt) | composição conjugada de polissacarídeo-proteína pneumocócica multivalente | |
PE20161095A1 (es) | Composiciones inmunogenicas que comprenden antigenos de sacaridos capsulares conjugados y uso de los mismos | |
MX2018004939A (es) | Vacuna. | |
CO7240387A2 (es) | Composición conjugada de polisacáridos-proteínas neumocócica polivalente | |
BR112013012626A2 (pt) | formulação, composição imunogênica, e, seringa pré-carregada | |
BR112015013560A2 (pt) | composição imunogênica multivalente; e composição farmacêutica para induzir uma resposta imunológica aos conjugados de polissacarídeo capsular de streptococcus pneumoniae | |
AR092897A1 (es) | Composiciones inmunogenicas | |
CO2021007863A2 (es) | Vacuna conjugada polisacárido-proteína neumocócica multivalente | |
BR112019004303A2 (pt) | composição de conjugados multivalentes de polissacarídeo capsular pneumocócico-proteína portadora e uso da mesma | |
PH12018501205A1 (en) | Synthetic vaccines against streptococcus pneumoniae serotype 2 | |
AR109377A1 (es) | Composición conjugada neumocócica multivalente de polisacárido y proteína | |
AR117713A1 (es) | Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso | |
AR104514A1 (es) | Conjugados proteína-polisacárido de estreptococo grupo b, métodos para producir conjugados, composiciones inmunógenas que comprenden conjugados y sus usos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: MERCK SHARP AND DOHME LLC (US) |