BR112014032091A8 - Composição imunogênica multivalente, e composição farmacêutica para induzir uma resposta imune a um conjugado de polissacarídeo capsular de streptococcus pneumoniae - Google Patents

Composição imunogênica multivalente, e composição farmacêutica para induzir uma resposta imune a um conjugado de polissacarídeo capsular de streptococcus pneumoniae

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Publication number
BR112014032091A8
BR112014032091A8 BR112014032091A BR112014032091A BR112014032091A8 BR 112014032091 A8 BR112014032091 A8 BR 112014032091A8 BR 112014032091 A BR112014032091 A BR 112014032091A BR 112014032091 A BR112014032091 A BR 112014032091A BR 112014032091 A8 BR112014032091 A8 BR 112014032091A8
Authority
BR
Brazil
Prior art keywords
streptococcus pneumoniae
immunogenic composition
capsular polysaccharide
inducing
immune response
Prior art date
Application number
BR112014032091A
Other languages
English (en)
Other versions
BR112014032091A2 (pt
BR112014032091B1 (pt
Inventor
Shin Jin-Hwan
Yang Ji-Hye
Ham Dong-Soo
Park Mahn-Hoon
Kim Hun
Noh Myeong-Ju
Park Su-Jin
Yang Seon-Young
Original Assignee
Sk Chemicals Co Ltd
Sk Discovery Co Ltd
Sk Bioscience Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49768999&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014032091(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sk Chemicals Co Ltd, Sk Discovery Co Ltd, Sk Bioscience Co Ltd filed Critical Sk Chemicals Co Ltd
Publication of BR112014032091A2 publication Critical patent/BR112014032091A2/pt
Publication of BR112014032091A8 publication Critical patent/BR112014032091A8/pt
Publication of BR112014032091B1 publication Critical patent/BR112014032091B1/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Abstract

COMPOSIÇÃO IMUNOGÊNICA MULTIVALENTE, E COMPOSIÇÃO FARMACÊUTICA PARA INDUZIR UMA RESPOSTA IMUNE A UM CONJUGADO DE POLISSACARÍDEO CAPSULAR DE STREPTOCOCCUS PNEUMONIAE É fornecida uma composição imunogênica que compreende 15 diferentes conjugados de polissacarídeo-proteína. Cada um dos conjugados compreende um polissacarídeo capsular preparado a partir de diferentes sorotipos de Streptococcus pneumoniae conjugados a uma proteína portadora, isto é, sorotipos 1, 2, 3, 4, 5, 6A, 6B, 7F, 9N, 9V, 14, 18C, 19A, 19F e 23F. Uma composição imunogênica formulada na forma de uma vacina compreendendo um adjuvante à base de alumínio aumenta a faixa de aplicação com respeito a doenças pneumocócicas em bebês e crianças.
BR112014032091-8A 2012-06-20 2013-06-19 Composição imunogênica multivalente, e composição farmacêutica para induzir uma resposta imune a um conjugado de polissacarídeo capsular de streptococcus pneumoniae BR112014032091B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020120065893A KR102057217B1 (ko) 2012-06-20 2012-06-20 다가 폐렴구균 다당류-단백질 접합체 조성물
KR10-2012-0065893 2012-06-20
PCT/KR2013/005392 WO2013191459A1 (ko) 2012-06-20 2013-06-19 다가 폐렴구균 다당류-단백질 접합체 조성물

Publications (3)

Publication Number Publication Date
BR112014032091A2 BR112014032091A2 (pt) 2017-10-10
BR112014032091A8 true BR112014032091A8 (pt) 2018-07-31
BR112014032091B1 BR112014032091B1 (pt) 2022-07-26

Family

ID=49768999

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014032091-8A BR112014032091B1 (pt) 2012-06-20 2013-06-19 Composição imunogênica multivalente, e composição farmacêutica para induzir uma resposta imune a um conjugado de polissacarídeo capsular de streptococcus pneumoniae

Country Status (14)

Country Link
US (2) US10034949B2 (pt)
EP (1) EP2865392B2 (pt)
JP (1) JP2015520227A (pt)
KR (1) KR102057217B1 (pt)
CN (1) CN104755102B (pt)
AU (1) AU2013278145B2 (pt)
BR (1) BR112014032091B1 (pt)
CA (1) CA2877648C (pt)
CO (1) CO7240387A2 (pt)
ES (1) ES2613720T5 (pt)
MX (1) MX358977B (pt)
PH (1) PH12014502843B1 (pt)
RU (1) RU2605834C2 (pt)
WO (1) WO2013191459A1 (pt)

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Also Published As

Publication number Publication date
EP2865392B2 (en) 2020-02-12
RU2015100140A (ru) 2016-08-10
KR102057217B1 (ko) 2020-01-22
EP2865392A4 (en) 2016-01-20
CN104755102A (zh) 2015-07-01
EP2865392A1 (en) 2015-04-29
CO7240387A2 (es) 2015-04-17
CN104755102B (zh) 2018-01-23
MX358977B (es) 2018-09-11
EP2865392B1 (en) 2016-11-16
MX2014016065A (es) 2015-10-09
RU2605834C2 (ru) 2016-12-27
US20170232101A1 (en) 2017-08-17
KR20130142574A (ko) 2013-12-30
JP2015520227A (ja) 2015-07-16
US10034949B2 (en) 2018-07-31
ES2613720T5 (es) 2020-07-09
US20150190520A1 (en) 2015-07-09
CA2877648C (en) 2016-08-23
AU2013278145B2 (en) 2016-04-21
AU2013278145A1 (en) 2015-02-05
ES2613720T3 (es) 2017-05-25
US10058607B2 (en) 2018-08-28
BR112014032091A2 (pt) 2017-10-10
BR112014032091B1 (pt) 2022-07-26
CA2877648A1 (en) 2013-12-27
PH12014502843A1 (en) 2015-02-09
PH12014502843B1 (en) 2015-02-09
WO2013191459A1 (ko) 2013-12-27

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