JP2018519825A5 - - Google Patents
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- JP2018519825A5 JP2018519825A5 JP2017567663A JP2017567663A JP2018519825A5 JP 2018519825 A5 JP2018519825 A5 JP 2018519825A5 JP 2017567663 A JP2017567663 A JP 2017567663A JP 2017567663 A JP2017567663 A JP 2017567663A JP 2018519825 A5 JP2018519825 A5 JP 2018519825A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 69
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 12
- 108091008874 T cell receptors Proteins 0.000 claims description 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 9
- 238000000338 in vitro Methods 0.000 claims description 8
- 239000000427 antigen Substances 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 230000027455 binding Effects 0.000 claims description 7
- 230000005847 immunogenicity Effects 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 4
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- 206010028980 Neoplasm Diseases 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 13
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- 210000001519 tissue Anatomy 0.000 claims 13
- 239000013604 expression vector Substances 0.000 claims 11
- 239000003446 ligand Substances 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
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- 150000001413 amino acids Chemical class 0.000 claims 3
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- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 102000043129 MHC class I family Human genes 0.000 claims 2
- 108091054437 MHC class I family Proteins 0.000 claims 2
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- 239000003814 drug Substances 0.000 claims 2
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- 239000003053 toxin Substances 0.000 claims 2
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- 206010004593 Bile duct cancer Diseases 0.000 claims 1
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- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
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- 206010009944 Colon cancer Diseases 0.000 claims 1
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- 102000004127 Cytokines Human genes 0.000 claims 1
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- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
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- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
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- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
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- 239000004480 active ingredient Substances 0.000 claims 1
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- 210000004443 dendritic cell Anatomy 0.000 claims 1
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- 210000000232 gallbladder Anatomy 0.000 claims 1
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- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 238000011502 immune monitoring Methods 0.000 claims 1
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- 229940038309 personalized vaccine Drugs 0.000 claims 1
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- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
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- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
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- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102000011786 HLA-A Antigens Human genes 0.000 description 1
- 108010075704 HLA-A Antigens Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 229910018119 Li 3 PO 4 Inorganic materials 0.000 description 1
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- 108010090804 Streptavidin Proteins 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
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- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- -1 cations Alkali salts Chemical class 0.000 description 1
- QUPYHCHUQVNFJW-UHFFFAOYSA-M cesium;thiocyanate Chemical compound [Cs+].[S-]C#N QUPYHCHUQVNFJW-UHFFFAOYSA-M 0.000 description 1
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- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021145069A JP2022020614A (ja) | 2015-07-06 | 2021-09-06 | 食道がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
| JP2024000243A JP7803986B2 (ja) | 2015-07-06 | 2024-01-04 | 食道がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188870P | 2015-07-06 | 2015-07-06 | |
| GB1511792.2 | 2015-07-06 | ||
| GBGB1511792.2A GB201511792D0 (en) | 2015-07-06 | 2015-07-06 | Novel peptides and combination of peptides for use in immunotherapy against esopageal cancer and other cancers |
| US62/188,870 | 2015-07-06 | ||
| PCT/EP2016/065812 WO2017005733A2 (en) | 2015-07-06 | 2016-07-05 | Novel peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021145069A Division JP2022020614A (ja) | 2015-07-06 | 2021-09-06 | 食道がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519825A JP2018519825A (ja) | 2018-07-26 |
| JP2018519825A5 true JP2018519825A5 (enExample) | 2019-03-28 |
| JP6944382B2 JP6944382B2 (ja) | 2021-10-06 |
Family
ID=56368954
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567663A Active JP6944382B2 (ja) | 2015-07-06 | 2016-07-05 | 食道がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
| JP2021145069A Pending JP2022020614A (ja) | 2015-07-06 | 2021-09-06 | 食道がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
| JP2024000243A Active JP7803986B2 (ja) | 2015-07-06 | 2024-01-04 | 食道がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021145069A Pending JP2022020614A (ja) | 2015-07-06 | 2021-09-06 | 食道がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
| JP2024000243A Active JP7803986B2 (ja) | 2015-07-06 | 2024-01-04 | 食道がんおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ |
Country Status (32)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA51531A (fr) | 2015-07-06 | 2020-11-11 | Immatics Biotechnologies Gmbh | Nouveaux peptides et nouvelle combinaison de peptides à utiliser dans l'immunothérapie du cancer de l' oesophage et d'autres cancers |
| HK1258386A1 (zh) | 2015-10-05 | 2019-11-08 | Immatics Biotechnologies Gmbh | 用於小细胞肺癌和其他癌症免疫治疗的肽和肽组合物 |
| CN109628591B (zh) * | 2018-12-04 | 2022-04-15 | 南方医科大学南方医院 | 用于肺腺癌预后预测的标志物 |
| CN112007167B (zh) * | 2020-08-29 | 2023-01-24 | 南京中医药大学 | 蟾酥多肽在作为蟾蜍甾烯促渗剂中的应用 |
| CN112812197B (zh) * | 2021-01-11 | 2022-05-31 | 中国药科大学 | 一种兰州百合多糖及其制备方法和应用 |
| CN114057860B (zh) * | 2021-11-09 | 2023-10-20 | 中国科学技术大学 | 特定组氨酸甲基化修饰的s100a9蛋白免疫原、多克隆抗体及其制备方法 |
| CN114717191B (zh) * | 2022-04-26 | 2023-06-16 | 兰州大学第一医院 | 一株人肝内胆管癌细胞株icc-x3及其应用 |
| CN115322967B (zh) * | 2022-06-13 | 2023-08-08 | 浙江省人民医院 | 一种永生化人甲状腺乳头状癌成纤维细胞株及其构建方法和应用 |
| CN114957399B (zh) * | 2022-06-29 | 2023-05-09 | 湖北工业大学 | 一种多肽、多肽衍生物及其在制备抗肿瘤药物中的应用 |
| CN115261471A (zh) * | 2022-07-18 | 2022-11-01 | 武汉儿童医院 | 与胶质母细胞瘤预后显著相关的抗原及其应用 |
| CN116449015A (zh) * | 2022-08-26 | 2023-07-18 | 成都益安博生物技术有限公司 | 一种胃癌的外周血tcr标志物序列及其检测试剂盒和应用 |
| CN116183920B (zh) * | 2022-09-22 | 2023-10-20 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 用于检测鼻咽癌预后的抗体组合、系统及应用 |
| CN116144772B (zh) * | 2022-11-18 | 2023-08-25 | 昆明医科大学第一附属医院 | 一种Hsa_circ_0006117在制备治疗肺腺癌药物中的应用 |
| CN115737619A (zh) * | 2022-11-21 | 2023-03-07 | 深圳承启生物科技有限公司 | 一种用于抑制肿瘤的药物靶点、用途及口服药物 |
| CN115831228B (zh) * | 2022-12-08 | 2025-05-16 | 西北工业大学 | 一种基于线性混合模型的基因调控网络推断方法 |
| CN116676334B (zh) * | 2023-02-08 | 2025-05-27 | 深圳大学 | 抑郁症动物模型的构建方法 |
| CN117106910B (zh) * | 2023-08-10 | 2025-03-11 | 杭州师范大学 | 外周血白细胞rna联合标志物在制备检测或诊断早期原发性胆囊癌试剂盒中的应用 |
| CN117843721B (zh) * | 2024-03-07 | 2024-05-10 | 鲁东大学 | 一种扇贝源抗氧化肽及其制备方法与应用 |
| CN119307618B (zh) * | 2024-12-13 | 2025-03-14 | 浙江大学医学院附属邵逸夫医院 | 肝内胆管癌发生与发展过程中的关键分子的创新筛选方法及应用 |
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