JP2018519243A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018519243A5 JP2018519243A5 JP2017549616A JP2017549616A JP2018519243A5 JP 2018519243 A5 JP2018519243 A5 JP 2018519243A5 JP 2017549616 A JP2017549616 A JP 2017549616A JP 2017549616 A JP2017549616 A JP 2017549616A JP 2018519243 A5 JP2018519243 A5 JP 2018519243A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- cell
- cancer
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 50
- 210000004027 cell Anatomy 0.000 claims description 19
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 15
- 238000000338 in vitro Methods 0.000 claims description 8
- 230000005847 immunogenicity Effects 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 5
- 108091007433 antigens Proteins 0.000 claims description 5
- 102000036639 antigens Human genes 0.000 claims description 5
- 238000010186 staining Methods 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 238000000034 method Methods 0.000 claims 14
- 210000001519 tissue Anatomy 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 11
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 11
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 10
- 239000013604 expression vector Substances 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 238000010195 expression analysis Methods 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 238000012163 sequencing technique Methods 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 102000043129 MHC class I family Human genes 0.000 claims 2
- 108091054437 MHC class I family Proteins 0.000 claims 2
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 2
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 239000012931 lyophilized formulation Substances 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 238000011510 Elispot assay Methods 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 201000007487 gallbladder carcinoma Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 229940038309 personalized vaccine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000012070 whole genome sequencing analysis Methods 0.000 claims 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 239000011324 bead Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 239000008364 bulk solution Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562139189P | 2015-03-27 | 2015-03-27 | |
| US62/139,189 | 2015-03-27 | ||
| GB1505305.1 | 2015-03-27 | ||
| GBGB1505305.1A GB201505305D0 (en) | 2015-03-27 | 2015-03-27 | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| PCT/EP2016/056557 WO2016156202A1 (en) | 2015-03-27 | 2016-03-24 | Novel peptides and combination of peptides for use in immunotherapy against various tumors |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018140996A Division JP6742369B2 (ja) | 2015-03-27 | 2018-07-27 | 様々な腫瘍に対する免疫療法で使用される新規ペプチドおよびペプチドの組み合わせ |
| JP2020087423A Division JP7217981B2 (ja) | 2015-03-27 | 2020-05-19 | 様々な腫瘍に対する免疫療法で使用される新規ペプチドおよびペプチドの組み合わせ |
| JP2020091899A Division JP2020188769A (ja) | 2015-03-27 | 2020-05-27 | 様々な腫瘍に対する免疫療法で使用される新規ペプチドおよびペプチドの組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519243A JP2018519243A (ja) | 2018-07-19 |
| JP2018519243A5 true JP2018519243A5 (enExample) | 2019-04-11 |
| JP6882985B2 JP6882985B2 (ja) | 2021-06-02 |
Family
ID=53178247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549616A Active JP6882985B2 (ja) | 2015-03-27 | 2016-03-24 | 様々な腫瘍に対する免疫療法で使用される新規ペプチドおよびペプチドの組み合わせ |
Country Status (19)
| Country | Link |
|---|---|
| US (52) | US10000547B2 (enExample) |
| EP (8) | EP3388080B1 (enExample) |
| JP (1) | JP6882985B2 (enExample) |
| KR (3) | KR20170129787A (enExample) |
| CN (2) | CN113480635A (enExample) |
| AR (4) | AR127118A2 (enExample) |
| AU (13) | AU2016239920B2 (enExample) |
| BR (1) | BR112017017289A2 (enExample) |
| CA (26) | CA3109693A1 (enExample) |
| CR (3) | CR20200471A (enExample) |
| EA (3) | EA202191027A3 (enExample) |
| GB (1) | GB201505305D0 (enExample) |
| MA (9) | MA41805A (enExample) |
| MX (1) | MX2017012427A (enExample) |
| PE (1) | PE20171442A1 (enExample) |
| SG (3) | SG11201706681VA (enExample) |
| TW (3) | TW202043258A (enExample) |
| UA (2) | UA123953C2 (enExample) |
| WO (1) | WO2016156202A1 (enExample) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| PT3388075T (pt) | 2015-03-27 | 2023-08-18 | Immatics Biotechnologies Gmbh | Novos péptidos e combinações de péptidos para uso em imunoterapia contra vários tumores |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| PH12021550910A1 (en) | 2015-05-06 | 2022-03-07 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (crc) and other cancers |
| GB201507719D0 (en) | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
| GB201512369D0 (en) | 2015-07-15 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
| GB201520603D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520545D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520558D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520583D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520542D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520562D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
| CN108601731A (zh) | 2015-12-16 | 2018-09-28 | 磨石肿瘤生物技术公司 | 新抗原的鉴别、制造及使用 |
| GB201604490D0 (en) * | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides combination of peptides for use in immunotherapy against cancers |
| GB201604458D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| JP7075125B2 (ja) | 2016-05-25 | 2022-05-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ |
| GB201609193D0 (en) | 2016-05-25 | 2016-07-06 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
| ZA201900664B (en) | 2016-08-17 | 2021-09-29 | Paul Ehrlich Strasse 15 Tuebingen 72076 Germany | T cell receptors and immune therapy using the same |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| DE102016123859B3 (de) | 2016-12-08 | 2018-03-01 | Immatics Biotechnologies Gmbh | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie |
| EP4317432A3 (en) | 2016-12-08 | 2024-04-17 | Immatics Biotechnologies GmbH | T cell receptors with improved pairing |
| CN110637028B (zh) * | 2016-12-29 | 2024-10-22 | 得克萨斯州大学系统董事会 | Hla限制性vcx/y肽和t细胞受体及其用途 |
| JP7303750B2 (ja) * | 2017-01-24 | 2023-07-05 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物 |
| WO2018138257A1 (en) * | 2017-01-27 | 2018-08-02 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
| SI3573647T1 (sl) * | 2017-01-27 | 2023-07-31 | Immatics Biotechnologies Gmbh | Peptidi in kombinacija peptidov za uporabo v imunoterapiji proti raku jajčnikov in drugim oblikam raka |
| CN110709094A (zh) | 2017-02-03 | 2020-01-17 | 威斯康星州医药大学股份有限公司 | Kras肽疫苗组合物及其使用方法 |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| EP3366704A1 (en) | 2017-02-28 | 2018-08-29 | Affimed GmbH | Antibodies specific for mmp1/hla-a2 complex |
| JP7115758B2 (ja) | 2017-02-28 | 2022-08-09 | アッフィメッド・ゲー・エム・ベー・ハー | Ｃｄ１６ａ指向性ｎｋ細胞エンゲージメント用タンデムダイアボディ |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| GB201704128D0 (en) * | 2017-03-15 | 2017-04-26 | Univ Swansea | Method and apparatus for use in diagnosis and monitoring of colorectal cancer |
| TW201841934A (zh) | 2017-04-10 | 2018-12-01 | 德商英麥提克生物技術股份有限公司 | 用於治療癌症免疫治療的新穎肽及其肽組合物 |
| CN111533796A (zh) * | 2017-04-10 | 2020-08-14 | 伊玛提克斯生物技术有限公司 | 用于癌症免疫治疗的肽及其肽组合物 |
| CN119080881A (zh) | 2017-07-07 | 2024-12-06 | 伊玛提克斯生物技术有限公司 | 用于肺癌(包括nsclc、sclc和其他癌症)免疫治疗的新型肽和肽组合物 |
| DE102017115966A1 (de) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
| ES2871146T3 (es) | 2017-07-14 | 2021-10-28 | Immatics Biotechnologies Gmbh | Molécula de polipéptido con especificidad dual mejorada |
| WO2019067887A1 (en) * | 2017-09-29 | 2019-04-04 | Spyryx Biosciences, Inc. | ENAC INHIBITOR PEPTIDES AND USES THEREOF |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| IL308007A (en) * | 2017-11-06 | 2023-12-01 | Immatics Biotechnologies Gmbh | Transgenic T-cell receptors and immunotherapy using them |
| DE102017125888A1 (de) * | 2017-11-06 | 2019-05-23 | Immatics Biotechnologies Gmbh | Neue konstruierte T-Zell-Rezeptoren und deren Verwendung in Immuntherapie |
| EP3714275A4 (en) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS |
| DE102017127984B4 (de) | 2017-11-27 | 2019-12-05 | Immatics US, Inc. | Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen |
| AU2019209432A1 (en) | 2018-01-22 | 2020-08-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| CN111936518A (zh) | 2018-02-06 | 2020-11-13 | 西雅图儿童医院（Dba西雅图儿童研究所） | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| JP7470640B2 (ja) | 2018-02-09 | 2024-04-18 | イマティクス ユーエス，アイエヌシー． | Ｔ細胞を製造する方法 |
| CN112812153B (zh) * | 2018-02-15 | 2022-06-14 | 国立大学法人旭川医科大学 | 癌症抗原肽 |
| DE102018107224A1 (de) * | 2018-02-21 | 2019-08-22 | Immatics Biotechnologies Gmbh | Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
| WO2019165237A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| US12357694B2 (en) | 2018-03-12 | 2025-07-15 | The Children's Hospital Of Philadelphia | Methods and compositions for use of tumor self-antigens in adoptive immunotherapy |
| DE102018108612A1 (de) | 2018-03-21 | 2019-09-26 | Immatics US, Inc. | Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen |
| EP3545967A1 (en) * | 2018-03-28 | 2019-10-02 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Cancer immunization platform |
| TW202016131A (zh) * | 2018-05-16 | 2020-05-01 | 德商英麥提克生物技術股份有限公司 | 用於抗癌免疫治療的肽 |
| MX2020014191A (es) | 2018-06-19 | 2021-03-09 | Dsm Ip Assets Bv | Variantes de enzimas lipoliticas. |
| BR112020026159A2 (pt) * | 2018-06-22 | 2021-04-06 | Merck Patent Gmbh | Regimes de dosagem para inibição de tgf-beta alvos para uso no tratamento de câncer do trato biliar |
| US10925947B2 (en) | 2018-06-29 | 2021-02-23 | Immatics Biotechnologies Gmbh | A*03 restricted peptides for use in immunotherapy against cancers and related methods |
| TW202019955A (zh) | 2018-07-31 | 2020-06-01 | 德商英麥提克生物技術股份有限公司 | B*07 限制肽和肽組合的抗癌免疫治療和相關方法 |
| US11945850B2 (en) | 2018-09-17 | 2024-04-02 | Immatics Biotechnologies Gmbh | B*44 restricted peptides for use in immunotherapy against cancers and related methods |
| TW202024121A (zh) * | 2018-09-18 | 2020-07-01 | 德商英麥提克生物技術股份有限公司 | A*01 限制肽和肽組合物在抗癌免疫治療中的用途和相關方法 |
| CN113301913A (zh) | 2019-01-06 | 2021-08-24 | 第二基因组股份有限公司 | 用于免疫疗法的源自微生物的肽和蛋白质 |
| US20200297768A1 (en) | 2019-03-19 | 2020-09-24 | Immatics US, Inc. | Cd28 t cell cultures, compositions, and methods of using thereof |
| WO2020232408A1 (en) * | 2019-05-15 | 2020-11-19 | Genocea Biosciences, Inc. | Treatment methods |
| PH12021552979A1 (en) | 2019-05-27 | 2023-10-09 | Immatics Us Inc | Viral vectors and their use in adoptive cellular therapy |
| US20200384028A1 (en) | 2019-06-06 | 2020-12-10 | Immatics Biotechnologies Gmbh | Sorting with counter selection using sequence similar peptides |
| DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
| US20210032370A1 (en) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Recruiting agent further binding an mhc molecule |
| CN110567861B (zh) * | 2019-09-09 | 2021-12-21 | 浙江普罗亭健康科技有限公司 | 基于质谱流式检测技术筛查具有免疫原性抗原肽的试剂盒及检测方法 |
| CN110804643B (zh) * | 2019-10-29 | 2022-06-21 | 同济大学 | 一种体外评价卡介苗对中性粒细胞活性影响的方法 |
| JP2023504659A (ja) | 2019-12-03 | 2023-02-06 | ニューボーゲン，インコーポレイティド | 腫瘍細胞ワクチン |
| MX2022010461A (es) | 2020-02-24 | 2022-12-13 | Immatics Us Inc | Metodos para expandir linfocitos t para el tratamiento de cancer y neoplasias malignas asociadas. |
| DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| DE102020106710A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| US20220056411A1 (en) | 2020-08-21 | 2022-02-24 | Immatics US, Inc. | Methods for isolating cd8+ selected t cells |
| WO2022047325A1 (en) * | 2020-08-31 | 2022-03-03 | The Trustees Of Columbia University In The City Of New York | Targeting of tgm4 to treat prostate cancer |
| US11891427B2 (en) | 2020-09-29 | 2024-02-06 | Immatics Biotechnologies Gmbh | Amidated peptides and their deamidated counterparts displayed by non-HLA-a*02 for use in immunotherapy against different types of cancers |
| DE102020125465A1 (de) | 2020-09-29 | 2022-03-31 | Immatics Biotechnologies Gmbh | Amidierte Peptide und ihre deamidierten Gegenstücke, die durch nicht-HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
| DE102020125457A1 (de) | 2020-09-29 | 2022-03-31 | Immatics Biotechnologies Gmbh | Amidierte Peptide und ihre deamidierten Gegenstücke, die durch HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
| WO2022125874A2 (en) * | 2020-12-11 | 2022-06-16 | Berkeley Lights, Inc. | Methods for identification of exchangeable mhc binding peptides and methods of use thereof |
| EP4259206A4 (en) * | 2020-12-14 | 2025-07-09 | Biontech Us Inc | TISSUE-SPECIFIC ANTIGENS FOR CANCER IMMUNOTHERAPY |
| DE102021100038A1 (de) | 2020-12-31 | 2022-06-30 | Immatics US, Inc. | Modifizierte cd8-polypeptide, zusammensetzungen und verfahren zu deren verwendung |
| WO2022147029A2 (en) | 2020-12-31 | 2022-07-07 | Immatics US, Inc. | Cd8 polypeptides, compositions, and methods of using thereof |
| JP2024509910A (ja) | 2021-03-09 | 2024-03-05 | シーディアール－ライフ・アクチェンゲゼルシャフト | Ｍａｇｅ－ａ４ペプチド－ｍｈｃ抗原結合タンパク質 |
| EP4304725A1 (en) | 2021-03-09 | 2024-01-17 | CDR-Life AG | Rabbit-derived antigen binding protein nucleic acid libraries |
| CA3211645A1 (en) * | 2021-03-12 | 2022-09-15 | Erika VON EUW | Methods of enhancing diversity of hla haplotype expression in tumors to broaden tumor cell susceptibility to tcr-t therapy |
| US12162940B2 (en) | 2021-05-05 | 2024-12-10 | Immatics Biotechnologies Gmbh | BMA031 antigen binding polypeptides |
| US20240317816A1 (en) * | 2021-06-04 | 2024-09-26 | Genevive, Inc. | Peptides for immunotherapy |
| US20230024554A1 (en) | 2021-06-28 | 2023-01-26 | Immatics Biotechnologies Gmbh | Method of characterizing the binding characteristics between a peptide of interest and mhc molecules |
| EP4113120A1 (en) | 2021-06-28 | 2023-01-04 | Immatics Biotechnologies GmbH | Method of characterizing the binding characteristics between a peptide of interest and mhc molecules |
| WO2023025851A1 (en) | 2021-08-24 | 2023-03-02 | Immatics US, Inc. | Selection of immune cells using peptide mhc complexes generated by conditional ligand exchange |
| WO2023044488A1 (en) | 2021-09-20 | 2023-03-23 | Immatics US, Inc. | Monocyte depletion of t cells populations for t-cell therapy |
| EP4448108A1 (en) | 2021-11-08 | 2024-10-23 | Immatics Biotechnologies GmbH | Adoptive cell therapy combination treatment and compositions thereof |
| EP4514834A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof |
| JP2025516189A (ja) | 2022-04-28 | 2025-05-27 | イマティクス ユーエス，アイエヌシー． | 膜結合型ｉｌ－１５、ｃｄ８ポリペプチド、細胞、組成物、およびそれらの使用方法 |
| US20240066127A1 (en) | 2022-04-28 | 2024-02-29 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
| EP4519418A1 (en) | 2022-05-05 | 2025-03-12 | Immatics US, Inc. | Methods for improving t cell efficacy |
| CN115785204B (zh) * | 2022-06-10 | 2024-02-13 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标08及其用途 |
| KR20250067130A (ko) | 2022-09-14 | 2025-05-14 | 씨디알-라이프 아게 | Mage-a4 펩티드 이중 t 세포 연결체 |
| CN115747307A (zh) * | 2022-11-03 | 2023-03-07 | 郑州大学 | 一种用于富集检测复发肿瘤细胞的dna水凝胶的制备方法及其应用 |
| US20250134931A1 (en) | 2023-11-01 | 2025-05-01 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| WO2025124536A1 (zh) * | 2023-12-15 | 2025-06-19 | 江苏康缘药业股份有限公司 | 趋化因子受体8拮抗多肽化合物、组合物、试剂盒及用途 |
| CN118166098B (zh) * | 2024-02-05 | 2024-09-10 | 北京大学深圳医院 | 检测magea4-as1的试剂在制备诊断口腔鳞状细胞癌的试剂盒中的应用 |
| CN120718855A (zh) * | 2025-09-03 | 2025-09-30 | 天津医科大学总医院 | 一种具有高淋巴结转移潜力的中国人肺大细胞神经内分泌癌细胞系及应用 |
Family Cites Families (146)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8211999B2 (en) * | 1970-02-11 | 2012-07-03 | Immatics Biotechnologies Gmbh | Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules |
| US4493795A (en) * | 1983-10-17 | 1985-01-15 | Syntex (U.S.A.) Inc. | Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture |
| JPH07108224B2 (ja) | 1985-11-07 | 1995-11-22 | 重三 鵜高 | バチルス・ブレビスを用いる遺伝子の発現方法 |
| US4772557A (en) * | 1985-11-12 | 1988-09-20 | Washington University | DNA clone of human skin fibroblast collagenase enzyme |
| US9340577B2 (en) | 1992-08-07 | 2016-05-17 | Epimmune Inc. | HLA binding motifs and peptides and their uses |
| AU6012696A (en) | 1995-06-14 | 1997-01-15 | Aberdeen University | Prognostic and therapeutic system for cancer |
| US6143509A (en) | 1996-02-06 | 2000-11-07 | Abbott Laboratories | Prostate specific antigen peptides and uses thereof |
| CN1203177C (zh) * | 1996-06-07 | 2005-05-25 | 伊东恭悟 | 肿瘤抗原蛋白质及其基因和肿瘤抗原肽 |
| WO1998010292A1 (en) | 1996-09-06 | 1998-03-12 | Centocor, Inc. | Monoclonal antibodies specific for prostate specific antigen and methods of detecting prostate specific antigen |
| US6291430B1 (en) * | 1997-09-12 | 2001-09-18 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
| WO1999043711A1 (en) | 1998-02-27 | 1999-09-02 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | G protein-coupled receptor antagonists |
| US7105488B1 (en) * | 1998-02-27 | 2006-09-12 | The United States Of America As Represented By The Department Of Health And Human Services | G protein-coupled receptor antagonists |
| US6255055B1 (en) | 1998-03-09 | 2001-07-03 | Wisconsin Alumni Research Foundation | c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence |
| US7579160B2 (en) | 1998-03-18 | 2009-08-25 | Corixa Corporation | Methods for the detection of cervical cancer |
| US20030236209A1 (en) * | 1998-03-18 | 2003-12-25 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US7258860B2 (en) | 1998-03-18 | 2007-08-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| ES2284539T3 (es) | 1998-09-28 | 2007-11-16 | Bio Polymer Products Of Sweden Ab | Un proceso de produccion de proteinas adhesivas polifenolicas. |
| US20070020327A1 (en) | 1998-11-10 | 2007-01-25 | John Fikes | Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions |
| US7259253B2 (en) * | 1999-05-14 | 2007-08-21 | Quark Biotech, Inc. | Genes associated with mechanical stress, expression products therefrom, and uses thereof |
| US6869951B1 (en) | 1999-07-16 | 2005-03-22 | Pharmacia Corporation | Method of changing conformation of a matrix metalloproteinase |
| US20020123095A1 (en) | 1999-10-20 | 2002-09-05 | Pe Corporation (Ny) | Estrogen receptor alpha variants and methods of detection thereof |
| US20040142361A1 (en) | 1999-11-30 | 2004-07-22 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| AU2085001A (en) | 1999-12-10 | 2001-06-18 | Epimmune, Inc. | Inducing cellular immune responses to mage2/3 using peptide and nucleic acid compositions |
| GB2373500B (en) | 2000-02-04 | 2004-12-15 | Aeomica Inc | Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence |
| AU2001238682A1 (en) | 2000-02-24 | 2001-09-03 | Pharmacia And Upjohn Company | Human g protein-coupled receptors |
| US6934639B1 (en) | 2000-02-25 | 2005-08-23 | Wyeth | Methods for designing agents that interact with MMP-13 |
| US7094890B1 (en) | 2000-03-10 | 2006-08-22 | Novartis Ag | Arthritis-associated protein |
| AU4592601A (en) | 2000-03-21 | 2001-10-03 | Millennium Predictive Medicine | Novel genes, compositions, kits, and method for identification, assessment, prevention, and therapy of ovarian cancer |
| US6861234B1 (en) | 2000-04-28 | 2005-03-01 | Mannkind Corporation | Method of epitope discovery |
| US20030073622A1 (en) | 2000-06-07 | 2003-04-17 | Kumud Majumder | Novel proteins and nucleic acids encoding same |
| AU2001268361A1 (en) | 2000-07-07 | 2002-01-21 | Saint Louis University | Method of modulating expression of ldl-receptor-related protein and uses thereof |
| US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| US20070014801A1 (en) | 2001-01-24 | 2007-01-18 | Gish Kurt C | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
| ATE536187T1 (de) | 2000-10-19 | 2011-12-15 | Epimmune Inc | Hla-klasse-i- und -klasse-ii-bindende peptide und ihre verwendungen |
| EP1328661A2 (en) | 2000-10-20 | 2003-07-23 | Applera Corporation | Estrogen receptor alpha variants and methods of detection thereof |
| US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| US20040053822A1 (en) | 2000-12-11 | 2004-03-18 | John Fikes | Inducing cellular immune responses to mage2/3 using peptide and nucleic acid compositions |
| WO2002050277A2 (en) | 2000-12-21 | 2002-06-27 | Curagen Corporation | Protein and nucleic acids encoding same |
| WO2002068649A2 (en) | 2001-01-31 | 2002-09-06 | Curagen Corporation | Proteins and nucleic acids encoding same |
| US20050069976A1 (en) | 2001-02-14 | 2005-03-31 | Peter Lind | Protein-coupled receptor |
| EP1368475A4 (en) * | 2001-03-15 | 2004-10-20 | Nuvelo Inc | NEW NUCLEIC ACIDS AND NEW POLYPEPTIDES |
| US20030077664A1 (en) | 2001-04-18 | 2003-04-24 | Yi Zhao | Methods of screening for compounds that modulate hormone receptor activity |
| AU2002309583A1 (en) * | 2001-04-18 | 2002-11-05 | Protein Desing Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| US6867283B2 (en) | 2001-05-16 | 2005-03-15 | Technion Research & Development Foundation Ltd. | Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells |
| US20050053918A1 (en) | 2001-05-16 | 2005-03-10 | Technion Research & Development Foundation Ltd. | Method of identifying peptides capable of binding to MHC molecules, peptides identified thereby and their uses |
| US7049413B2 (en) * | 2001-05-18 | 2006-05-23 | Ludwig Institute For Cancer Research | MAGE-A3 peptides presented by HLA class II molecules |
| CA2449042A1 (en) | 2001-05-30 | 2002-12-27 | Biomedical Center | In silico screening for phenotype-associated expressed sequences |
| US7705120B2 (en) | 2001-06-21 | 2010-04-27 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20030068636A1 (en) | 2001-06-21 | 2003-04-10 | Millennium Pharmaceuticals, Inc. | Compositions, kits and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer |
| CA2489420A1 (en) | 2001-06-25 | 2003-01-03 | Buadbo Aps | Oncology drug innovation |
| AU2002337657A1 (en) | 2001-07-25 | 2003-02-17 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of prostate cancer |
| JP2003088388A (ja) | 2001-09-14 | 2003-03-25 | Herikkusu Kenkyusho:Kk | 新規な全長ｃＤＮＡ |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| CA2461280A1 (en) | 2001-09-24 | 2003-04-10 | Nuvelo, Inc. | Novel nucleic acids and polypeptides |
| JP2003135075A (ja) | 2001-11-05 | 2003-05-13 | Research Association For Biotechnology | 新規な全長ｃＤＮＡ |
| US20030148410A1 (en) | 2001-12-10 | 2003-08-07 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer |
| US6689431B2 (en) | 2001-12-12 | 2004-02-10 | Eastman Kodak Company | Ink jet recording element |
| AU2003207738A1 (en) | 2002-01-29 | 2003-09-02 | Quark Biotech, Inc. | Islr gene and its association with osteoarthritis and other bone and cartilage disorders, expression products derived therefrom, and uses thereof |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| DE10225144A1 (de) | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| AU2002368151A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Matrix metalloproteinase inhibitors and methods for identification of lead compounds |
| US7311914B2 (en) | 2002-08-13 | 2007-12-25 | Ludwig Institute For Cancer Research | MAGE-A4 antigenic peptides and uses thereof |
| AU2003295328A1 (en) | 2002-10-02 | 2004-04-23 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| EP2474630B1 (en) | 2002-12-20 | 2016-04-27 | Celera Corporation | Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof |
| US20050181375A1 (en) * | 2003-01-10 | 2005-08-18 | Natasha Aziz | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer |
| US7833706B2 (en) | 2003-01-30 | 2010-11-16 | Celera Corporation | Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof |
| DE10309729A1 (de) | 2003-02-26 | 2004-09-16 | Hinzmann, Bernd, Dr. | Humane Nukleinsäuresequenzen aus Harnblasenkarzinomen |
| WO2004081186A2 (en) | 2003-03-10 | 2004-09-23 | Applera Corporation | Single nucleotide polymorphisms associated with stenosis, methods of detection and uses thereof |
| CN1331885C (zh) * | 2003-05-15 | 2007-08-15 | 北京大学 | 肿瘤抗原蛋白及抗原肽在作为肿瘤－睾丸抗原、制备治疗肝癌/肺癌药物中的应用 |
| JP2006527738A (ja) | 2003-06-18 | 2006-12-07 | ディレボ・ビオテク・アーゲー | 新規生物学的実体およびその薬学的または診断的使用 |
| EP1633865B1 (en) | 2003-06-18 | 2011-09-28 | Bayer Pharma Aktiengesellschaft | New biological entities and the use thereof |
| US7807392B1 (en) | 2003-09-15 | 2010-10-05 | Celera Corporation | Lung disease targets and uses thereof |
| EP1522594A3 (en) | 2003-10-06 | 2005-06-22 | Bayer HealthCare AG | Methods and kits for investigating cancer |
| US7569662B2 (en) | 2004-01-27 | 2009-08-04 | Compugen Ltd | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
| WO2005084116A2 (en) | 2004-01-27 | 2005-09-15 | Compugen Usa, Inc. | Calcium channel variants |
| WO2005072053A2 (en) | 2004-01-27 | 2005-08-11 | Compugen Ltd. | Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of colon cancer |
| US7667001B1 (en) | 2004-01-27 | 2010-02-23 | Compugen Ltd. | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
| CA2559144C (en) * | 2004-03-10 | 2014-01-21 | Creighton University | Estrogen receptor alpha splice variant er-.alpha.36 |
| WO2005114221A2 (en) * | 2004-05-21 | 2005-12-01 | The Institute For Systems Biology | Compositions and methods for quantification of serum glycoproteins |
| WO2006088483A2 (en) * | 2004-06-16 | 2006-08-24 | Trustees Of Dartmouth College | Compositions and methods for inhibiting the synthesis or expression of mmp-1 |
| WO2006037993A2 (en) | 2004-10-02 | 2006-04-13 | Auvation Limited | Cancer markers |
| DE102005059937A1 (de) | 2004-12-21 | 2006-07-13 | Continental Teves Ag & Co. Ohg | Verfahren zum Betrieb einer hydraulischen Bremsanlage für Kraftfahrzeuge |
| WO2006067198A2 (en) | 2004-12-22 | 2006-06-29 | Direvo Biotech Ag | Targeted use of engineered enzymes |
| US7883858B2 (en) | 2005-01-27 | 2011-02-08 | Institute For Systems Biology | Methods for identifying and monitoring drug side effects |
| KR20080003321A (ko) * | 2005-02-24 | 2008-01-07 | 세미네스 인코퍼레이티드 | 생물학적 샘플을 분류하는 조성물 및 방법 |
| US8404803B2 (en) | 2005-03-31 | 2013-03-26 | Chugai Seiyaku Kabushiki Kaisha | Cancer-associated antigen analogue peptides and uses thereof |
| US7842467B1 (en) | 2005-05-12 | 2010-11-30 | Celera Corporation | Breast disease targets and uses thereof |
| US7521195B1 (en) | 2005-07-21 | 2009-04-21 | Celera Corporation | Lung disease targets and uses thereof |
| PL1760088T3 (pl) * | 2005-09-05 | 2008-10-31 | Immatics Biotechnologies Gmbh | Związane z nowotworem peptydy wiążące się w sposób niedyskryminujący z cząsteczkami antygenu ludzkiego leukocytu klasy II (HLA) |
| PL1760089T3 (pl) * | 2005-09-05 | 2010-03-31 | Immatics Biotechnologies Gmbh | Peptydy towarzyszące nowotworom, wiążące się z cząsteczkami klasy I i II antygenów ludzkich leukocytów (HLA) i związana z nimi szczepionka przeciwnowotworowa |
| EP1934246B8 (en) * | 2005-10-07 | 2012-02-08 | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. | Matrix metalloproteinase 11 vaccine |
| CA2625403A1 (en) * | 2005-10-17 | 2007-04-26 | Institute For System Biology | Tissue-and serum-derived glycoproteins and methods of their use |
| US20070248628A1 (en) * | 2005-12-06 | 2007-10-25 | Keller Lorraine H | Immunogens in cancer stem cells |
| EP1806413A1 (en) * | 2006-01-06 | 2007-07-11 | Oligene GmbH | An in-vitro-method and means for determination of different tumor types and predicting success of surgical procedures in ovarian cancer |
| US20100120627A1 (en) | 2006-08-02 | 2010-05-13 | Abdelmajid Belouchi | Genemap of the human genes associated with psoriasis |
| JP5244103B2 (ja) | 2006-08-09 | 2013-07-24 | ホームステッド クリニカル コーポレイション | 器官特異的蛋白質およびその使用方法 |
| WO2008053573A1 (fr) | 2006-10-30 | 2008-05-08 | National University Corporation Hokkaido University | Remède pour néoplasme malin |
| NZ578126A (en) * | 2006-12-29 | 2012-05-25 | Ipsen Pharma Sas | Phamaceutical compostions comprising Glucagon-like peptide-1 (GLP-1) analog |
| US7589662B1 (en) | 2007-06-20 | 2009-09-15 | The United States Of America As Represented By The Secretary Of The Navy | Synthetic aperture radar systems and methods |
| CN105566450A (zh) | 2007-07-27 | 2016-05-11 | 伊玛提克斯生物技术有限公司 | 免疫疗法的新型免疫抗原表位 |
| MX2010002001A (es) | 2007-08-20 | 2010-03-11 | Oncotherapy Science Inc | Peptido cdca1 y agente farmaceutico que comprende elmismo. |
| WO2009036246A2 (en) * | 2007-09-14 | 2009-03-19 | Immunotope, Inc. | Immunogens that induce cytotoxic t-lymphocytes and their use in prevention, treatment, and diagnosis of cancer |
| US20110097312A1 (en) * | 2008-02-15 | 2011-04-28 | Board Of Regents, The University Of Texas System | Anti-cancer vaccines |
| TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
| WO2009126271A1 (en) * | 2008-04-11 | 2009-10-15 | China Synthetic Rubber Corporation | Methods, agents and kits for the detection of cancer |
| PT2119726E (pt) * | 2008-05-14 | 2015-03-30 | Immatics Biotechnologies Gmbh | Novos e poderosos peptídeos para mhc classe ii derivados de survinina e neurocano |
| US20110318380A1 (en) | 2008-10-01 | 2011-12-29 | Dako Denmark A/S | MHC Multimers in Cancer Vaccines and Immune Monitoring |
| KR101032860B1 (ko) | 2008-10-22 | 2011-05-06 | 한국식품연구원 | 췌장 조직 특이적 유전자 ｍｍｐ1 |
| CN102203617A (zh) | 2008-10-22 | 2011-09-28 | 生物标记设计研究有限责任公司 | 用于检测和诊断骨或软骨障碍的方法 |
| CN102307595A (zh) * | 2009-02-10 | 2012-01-04 | 盛诺基医药科技有限公司 | 治疗雌激素受体相关疾病的抗体及方法 |
| WO2010102157A1 (en) * | 2009-03-04 | 2010-09-10 | The Regents Of The University Of California | Molecular predictors of biological response to a cenpe inhibitor in cancer |
| WO2010102262A1 (en) | 2009-03-06 | 2010-09-10 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloprotease 1 und uses thereof |
| US20120077696A1 (en) | 2009-03-15 | 2012-03-29 | Technion Research And Development Foundation Ltd. | Soluble hla complexes for use in disease diagnosis |
| WO2010125566A2 (en) * | 2009-04-27 | 2010-11-04 | Technion Research And Development Foundation Ltd. | Markers for cancer detection |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| US20130011496A1 (en) | 2009-11-25 | 2013-01-10 | Ludwig Institute For Cancer Research Ltd. | Cancer testis antigens as biomarkers in non-small cell lung cancer |
| RU2015108348A (ru) * | 2010-02-04 | 2015-07-20 | Джилид Байолоджикс, Инк. | Антитела, связывающиеся с лизилоксидазоподобным ферментом-2 (loxl2), и способы их применения |
| KR101963460B1 (ko) * | 2010-08-17 | 2019-03-28 | 암브룩스, 인코포레이티드 | 변형된 릴랙신 폴리펩타이드 및 그것의 용도 |
| JP6021021B2 (ja) | 2010-11-05 | 2016-11-02 | 国立大学法人京都大学 | 多発性嚢胞腎の検査方法および治療剤のスクリーニング方法 |
| WO2012068210A1 (en) | 2010-11-18 | 2012-05-24 | Janssen Pharmaceutica Nv | Pyridyl-thiazolyl inhibitors of pro-matrix metalloproteinase activation |
| US20130303826A1 (en) | 2011-01-11 | 2013-11-14 | University Health Network | Prognostic signature for oral squamous cell carcinoma |
| US20130064901A1 (en) * | 2011-04-18 | 2013-03-14 | Agency For Science, Technology And Research | Gene expression profiling for classifying and treating gastric cancer |
| WO2012162468A1 (en) | 2011-05-25 | 2012-11-29 | Janssen Pharmaceutica Nv | Thiazol derivatives as pro -matrix metalloproteinase inhibitors |
| US20120302569A1 (en) | 2011-05-25 | 2012-11-29 | Paul Francis Jackson | Phenyl-thiazolyl inhibitors of pro-matrix metalloproteinase activation |
| KR20140057354A (ko) | 2011-08-31 | 2014-05-12 | 온코사이트 코포레이션 | 결장직장암의 치료 및 진단을 위한 방법 및 조성물 |
| WO2013036754A2 (en) * | 2011-09-09 | 2013-03-14 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for diagnosis of ovarian cancer |
| US9091651B2 (en) | 2011-12-21 | 2015-07-28 | Integrated Diagnostics, Inc. | Selected reaction monitoring assays |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| TWI582424B (zh) | 2012-03-30 | 2017-05-11 | Junichiro Futami | A method for producing a reagent for detecting an antibody, and a use thereof |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| GB201208293D0 (en) * | 2012-05-11 | 2012-06-20 | Circassia Ltd | Hydrochlorice salt of peptide |
| EP2669378A1 (en) | 2012-05-31 | 2013-12-04 | Helmut Hanenberg | Cytochrome P450 suicide gene system |
| US9879065B2 (en) * | 2012-09-14 | 2018-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing MHC class II-restricted MAGE-A3 |
| AU2013359001A1 (en) | 2012-12-13 | 2015-07-23 | The Board Of Regents Of The University Of Oklahoma | Target peptides for ovarian cancer therapy and diagnostics |
| WO2015014375A1 (en) | 2013-07-30 | 2015-02-05 | Biontech Ag | Tumor antigens for determining cancer therapy |
| TWI819228B (zh) | 2013-08-05 | 2023-10-21 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（八） |
| PT3388075T (pt) * | 2015-03-27 | 2023-08-18 | Immatics Biotechnologies Gmbh | Novos péptidos e combinações de péptidos para uso em imunoterapia contra vários tumores |
| GB201505305D0 (en) * | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| GB201520583D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| DE102017006829B3 (de) | 2017-07-19 | 2018-09-06 | Daimler Ag | Regalsystem |
| KR20250097989A (ko) | 2017-12-28 | 2025-06-30 | 그릿스톤 바이오, 인코포레이티드 | 공통 항원을 표적화하는 항원-결합 단백질 |
| CA3099644A1 (en) | 2018-05-23 | 2019-11-28 | Gritstone Oncology, Inc. | Shared antigens |
| JP7668226B2 (ja) | 2019-03-30 | 2025-04-24 | ビオンテック ユーエス インコーポレイテッド | Ｔ細胞組成物を調製するための組成物および方法、ならびにそれらの使用 |
-
2015
- 2015-03-27 GB GBGB1505305.1A patent/GB201505305D0/en not_active Ceased
-
2016
- 2016-03-23 MA MA041805A patent/MA41805A/fr unknown
- 2016-03-24 CA CA3109693A patent/CA3109693A1/en active Pending
- 2016-03-24 CA CA3111203A patent/CA3111203A1/en active Pending
- 2016-03-24 EP EP18174354.3A patent/EP3388080B1/en active Active
- 2016-03-24 CA CA3111881A patent/CA3111881A1/en active Pending
- 2016-03-24 CA CA3111648A patent/CA3111648A1/en active Pending
- 2016-03-24 CA CA2980805A patent/CA2980805A1/en active Pending
- 2016-03-24 MA MA043438A patent/MA43438A/fr unknown
- 2016-03-24 CA CA3111899A patent/CA3111899A1/en active Pending
- 2016-03-24 UA UAA201808809A patent/UA123953C2/uk unknown
- 2016-03-24 CA CA3109690A patent/CA3109690A1/en active Pending
- 2016-03-24 MA MA043440A patent/MA43440A/fr unknown
- 2016-03-24 EP EP16711659.9A patent/EP3273986B1/en active Active
- 2016-03-24 AU AU2016239920A patent/AU2016239920B2/en not_active Ceased
- 2016-03-24 CA CA3108776A patent/CA3108776A1/en active Pending
- 2016-03-24 CA CA3110245A patent/CA3110245A1/en not_active Abandoned
- 2016-03-24 EP EP18174337.8A patent/EP3388079B1/en active Active
- 2016-03-24 EP EP18174251.1A patent/EP3388075B1/en active Active
- 2016-03-24 EP EP18174323.8A patent/EP3388078B1/en active Active
- 2016-03-24 MA MA043437A patent/MA43437A/fr unknown
- 2016-03-24 CA CA3111621A patent/CA3111621A1/en active Pending
- 2016-03-24 CR CR20200471A patent/CR20200471A/es unknown
- 2016-03-24 EP EP18201235.1A patent/EP3456347B1/en active Active
- 2016-03-24 CA CA3111891A patent/CA3111891A1/en active Pending
- 2016-03-24 CR CR20200478A patent/CR20200478A/es unknown
- 2016-03-24 KR KR1020177027189A patent/KR20170129787A/ko not_active Ceased
- 2016-03-24 CA CA3110160A patent/CA3110160A1/en active Pending
- 2016-03-24 CA CA3110180A patent/CA3110180A1/en active Pending
- 2016-03-24 EA EA202191027A patent/EA202191027A3/ru unknown
- 2016-03-24 EA EA201891699A patent/EA201891699A3/ru unknown
- 2016-03-24 PE PE2017001462A patent/PE20171442A1/es unknown
- 2016-03-24 SG SG11201706681VA patent/SG11201706681VA/en unknown
- 2016-03-24 EA EA201791925A patent/EA039163B1/ru unknown
- 2016-03-24 CA CA3112084A patent/CA3112084A1/en active Pending
- 2016-03-24 SG SG10201806839PA patent/SG10201806839PA/en unknown
- 2016-03-24 CN CN202110716733.5A patent/CN113480635A/zh active Pending
- 2016-03-24 CA CA3111741A patent/CA3111741A1/en active Pending
- 2016-03-24 WO PCT/EP2016/056557 patent/WO2016156202A1/en not_active Ceased
- 2016-03-24 EP EP18174292.5A patent/EP3388076B1/en active Active
- 2016-03-24 CA CA3111744A patent/CA3111744A1/en active Pending
- 2016-03-24 CA CA3111037A patent/CA3111037A1/en active Pending
- 2016-03-24 CA CA3111077A patent/CA3111077A1/en active Pending
- 2016-03-24 CA CA3111096A patent/CA3111096A1/en active Pending
- 2016-03-24 CN CN201680018847.XA patent/CN107531754B/zh active Active
- 2016-03-24 MA MA043439A patent/MA43439A/fr unknown
- 2016-03-24 CA CA3110241A patent/CA3110241A1/en active Pending
- 2016-03-24 MA MA43435A patent/MA43435B1/fr unknown
- 2016-03-24 CA CA3111059A patent/CA3111059A1/en active Pending
- 2016-03-24 CA CA3111739A patent/CA3111739A1/en active Pending
- 2016-03-24 MX MX2017012427A patent/MX2017012427A/es unknown
- 2016-03-24 MA MA40813A patent/MA40813A1/fr unknown
- 2016-03-24 KR KR1020217011039A patent/KR20210043752A/ko not_active Ceased
- 2016-03-24 CA CA3111194A patent/CA3111194A1/en active Pending
- 2016-03-24 EP EP18174312.1A patent/EP3388077A1/en not_active Withdrawn
- 2016-03-24 KR KR1020187023154A patent/KR102251606B1/ko active Active
- 2016-03-24 BR BR112017017289A patent/BR112017017289A2/pt not_active Application Discontinuation
- 2016-03-24 CA CA3111633A patent/CA3111633A1/en active Pending
- 2016-03-24 CR CR20180422A patent/CR20180422A/es unknown
- 2016-03-24 MA MA044999A patent/MA44999A/fr unknown
- 2016-03-24 CA CA3112078A patent/CA3112078A1/en active Pending
- 2016-03-24 MA MA043436A patent/MA43436A/fr unknown
- 2016-03-24 JP JP2017549616A patent/JP6882985B2/ja active Active
- 2016-03-24 UA UAA201708272A patent/UA124139C2/uk unknown
- 2016-03-24 CA CA3111740A patent/CA3111740A1/en active Pending
- 2016-03-24 SG SG10202001485UA patent/SG10202001485UA/en unknown
- 2016-03-28 US US15/083,075 patent/US10000547B2/en active Active
- 2016-03-28 TW TW109124266A patent/TW202043258A/zh unknown
- 2016-03-28 US US15/082,978 patent/US20160279216A1/en not_active Abandoned
- 2016-03-28 TW TW105109711A patent/TWI721971B/zh not_active IP Right Cessation
- 2016-03-28 TW TW107128267A patent/TWI722311B/zh active
- 2016-03-28 US US15/082,933 patent/US9932384B2/en active Active
- 2016-03-28 US US15/082,962 patent/US20160279215A1/en not_active Abandoned
- 2016-03-28 US US15/082,948 patent/US10081664B2/en active Active
- 2016-03-28 US US15/082,986 patent/US9988432B2/en active Active
- 2016-03-28 US US15/082,967 patent/US10072063B2/en active Active
- 2016-03-28 US US15/083,139 patent/US10336809B2/en active Active
- 2016-03-28 US US15/082,999 patent/US10081665B2/en active Active
- 2016-03-28 US US15/083,035 patent/US20160279218A1/en not_active Abandoned
- 2016-03-28 US US15/083,106 patent/US9802997B2/en active Active
- 2016-11-28 US US15/362,294 patent/US9982030B2/en active Active
- 2016-11-28 US US15/362,281 patent/US9862756B2/en active Active
- 2016-11-28 US US15/362,274 patent/US9840548B2/en active Active
-
2017
- 2017-06-30 US US15/638,667 patent/US9994628B2/en active Active
- 2017-06-30 US US15/638,678 patent/US20170305992A1/en not_active Abandoned
- 2017-06-30 US US15/638,687 patent/US9951119B2/en active Active
- 2017-10-20 US US15/789,589 patent/US9982031B2/en active Active
- 2017-10-20 US US15/789,683 patent/US10766944B2/en active Active
- 2017-10-20 US US15/789,771 patent/US10370429B2/en active Active
- 2017-10-20 US US15/789,731 patent/US10059755B2/en active Active
- 2017-10-20 US US15/789,750 patent/US20180037628A1/en not_active Abandoned
- 2017-10-20 US US15/789,567 patent/US10138288B2/en active Active
- 2017-12-14 US US15/842,381 patent/US10005828B2/en active Active
- 2017-12-19 US US15/847,825 patent/US10501522B2/en active Active
-
2018
- 2018-03-09 US US15/917,159 patent/US10202436B2/en active Active
- 2018-03-13 US US15/919,984 patent/US10131703B2/en active Active
- 2018-04-12 US US15/951,789 patent/US10183982B2/en active Active
- 2018-04-13 US US15/953,128 patent/US10066003B1/en active Active
- 2018-04-18 US US15/956,641 patent/US10106593B2/en active Active
- 2018-04-18 US US15/956,638 patent/US10093715B2/en active Active
- 2018-05-03 US US15/970,194 patent/US20180251517A1/en not_active Abandoned
- 2018-05-04 US US15/971,799 patent/US10106594B2/en active Active
- 2018-05-10 US US15/976,621 patent/US10519215B2/en not_active Expired - Fee Related
- 2018-07-24 US US16/044,289 patent/US10155801B1/en active Active
- 2018-07-24 US US16/044,266 patent/US20180327475A1/en not_active Abandoned
- 2018-08-06 US US16/055,796 patent/US10934338B2/en not_active Expired - Fee Related
- 2018-09-10 US US16/126,663 patent/US10487131B2/en active Active
- 2018-09-19 AU AU2018232952A patent/AU2018232952C1/en not_active Ceased
- 2018-10-04 US US16/152,122 patent/US10479823B2/en active Active
- 2018-12-20 US US16/227,257 patent/US20190119352A1/en not_active Abandoned
- 2018-12-20 US US16/227,228 patent/US10450362B2/en active Active
-
2019
- 2019-03-06 US US16/293,749 patent/US20190185540A1/en not_active Abandoned
- 2019-04-12 AU AU2019202561A patent/AU2019202561B2/en not_active Ceased
- 2019-09-02 AU AU2019222976A patent/AU2019222976B2/en not_active Ceased
- 2019-10-02 US US16/590,933 patent/US10723781B2/en active Active
- 2019-10-02 US US16/591,177 patent/US11702460B2/en active Active
- 2019-10-02 US US16/591,083 patent/US11466072B2/en active Active
- 2019-11-12 US US16/681,363 patent/US11155597B2/en active Active
-
2020
- 2020-06-12 US US16/900,542 patent/US10947293B2/en not_active Expired - Fee Related
- 2020-06-24 US US16/911,066 patent/US10947294B2/en not_active Expired - Fee Related
- 2020-10-12 AU AU2020256298A patent/AU2020256298B2/en not_active Ceased
-
2021
- 2021-02-10 US US17/172,621 patent/US11897934B2/en active Active
- 2021-02-10 US US17/172,577 patent/US11873329B2/en active Active
- 2021-02-18 US US17/179,074 patent/US12060406B2/en active Active
- 2021-06-18 AU AU2021204081A patent/AU2021204081B2/en not_active Ceased
- 2021-06-18 AU AU2021204077A patent/AU2021204077B2/en not_active Ceased
- 2021-06-18 AU AU2021204075A patent/AU2021204075B2/en not_active Ceased
- 2021-06-18 AU AU2021204079A patent/AU2021204079B2/en not_active Ceased
- 2021-06-18 AU AU2021204080A patent/AU2021204080B2/en not_active Ceased
- 2021-06-18 AU AU2021204076A patent/AU2021204076B2/en not_active Ceased
- 2021-06-18 AU AU2021204078A patent/AU2021204078B2/en not_active Ceased
- 2021-06-18 AU AU2021204074A patent/AU2021204074B2/en not_active Ceased
- 2021-07-23 US US17/384,330 patent/US11407807B2/en active Active
-
2022
- 2022-09-21 AR ARP220102549A patent/AR127118A2/es not_active Application Discontinuation
- 2022-09-21 AR ARP220102548A patent/AR127117A2/es not_active Application Discontinuation
- 2022-09-21 AR ARP220102547A patent/AR127116A2/es not_active Application Discontinuation
- 2022-09-21 AR ARP220102550A patent/AR127119A2/es not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018519243A5 (enExample) | ||
| JP2018518937A5 (enExample) | ||
| JP2018511321A5 (enExample) | ||
| JP2018529320A5 (enExample) | ||
| JP2019510465A5 (enExample) | ||
| JP2019506838A5 (enExample) | ||
| JP2019502360A5 (enExample) | ||
| JP2021168652A5 (enExample) | ||
| JP2018510628A5 (enExample) | ||
| JP2018536383A5 (enExample) | ||
| JP2018509135A5 (enExample) | ||
| JP2018521641A5 (enExample) | ||
| JP2018520653A5 (enExample) | ||
| JP2019511214A5 (enExample) | ||
| JP2018518956A5 (enExample) | ||
| RU2017137142A (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака | |
| JP2017525336A5 (enExample) | ||
| JP2024041841A5 (enExample) | ||
| JP2024099580A5 (enExample) | ||
| JP2017502076A5 (enExample) | ||
| JP2022105069A5 (enExample) | ||
| JP2018519825A5 (enExample) | ||
| Tang et al. | Personalized neoantigen-pulsed DC vaccines: advances in clinical applications | |
| JP2017524337A5 (enExample) | ||
| JP2020530759A5 (enExample) |