MA44999A - Nouveaux peptides et combinaison de peptides destinés à être utilisés en immunothérapie contre diverses tumeurs - Google Patents

Nouveaux peptides et combinaison de peptides destinés à être utilisés en immunothérapie contre diverses tumeurs

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Publication number
MA44999A
MA44999A MA044999A MA44999A MA44999A MA 44999 A MA44999 A MA 44999A MA 044999 A MA044999 A MA 044999A MA 44999 A MA44999 A MA 44999A MA 44999 A MA44999 A MA 44999A
Authority
MA
Morocco
Prior art keywords
peptides
combination
against various
various tumors
immunotherapy against
Prior art date
Application number
MA044999A
Other languages
English (en)
Inventor
Jens Fritsche
Andrea Mahr
Oliver Schoor
Harpreet Singh
Lea Stevermann
Toni Weinschenk
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MA44999A publication Critical patent/MA44999A/fr

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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MA044999A 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides destinés à être utilisés en immunothérapie contre diverses tumeurs MA44999A (fr)

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MA043437A MA43437A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre diverses tumeurs (seq id 245 - magea4-003)
MA044999A MA44999A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides destinés à être utilisés en immunothérapie contre diverses tumeurs
MA043439A MA43439A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides destinés à être utilisés en immunothérapie contre diverses tumeurs (seq id 253 - rad54b)
MA43435A MA43435B1 (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre diverses tumeurs (seq id 25 - mrax5-003)
MA043440A MA43440A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre diverses tumeurs (seq id 243 - spc25-001)
MA043436A MA43436A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre diverses tumeurs (seq id 274 - igf-004)
MA043438A MA43438A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides destinés à être utilisés en immunothérapie contre diverses tumeurs (seq id 23 - mmp-002)
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MA43435A MA43435B1 (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre diverses tumeurs (seq id 25 - mrax5-003)
MA043440A MA43440A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre diverses tumeurs (seq id 243 - spc25-001)
MA043436A MA43436A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre diverses tumeurs (seq id 274 - igf-004)
MA043438A MA43438A (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides destinés à être utilisés en immunothérapie contre diverses tumeurs (seq id 23 - mmp-002)
MA40813A MA40813A1 (fr) 2015-03-27 2016-03-24 Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre diverses tumeurs

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Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3388075T (pt) 2015-03-27 2023-08-18 Immatics Biotechnologies Gmbh Novos péptidos e combinações de péptidos para uso em imunoterapia contra vários tumores
GB201505305D0 (en) * 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
GB201507719D0 (en) * 2015-05-06 2015-06-17 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers
MY189596A (en) 2015-07-15 2022-02-18 Immatics Biotechnologies Gmbh A novel peptides for use in immunotherapy against epithelial ovarian cancer and other cancers
GB201520545D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
GB201520542D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520558D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520562D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520603D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520583D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
TWI765875B (zh) 2015-12-16 2022-06-01 美商磨石生物公司 新抗原辨識、製造及用途
GB201604490D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
JP7075125B2 (ja) 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ
GB201609193D0 (en) 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
ZA201900664B (en) 2016-08-17 2021-09-29 Paul Ehrlich Strasse 15 Tuebingen 72076 Germany T cell receptors and immune therapy using the same
EP4317432A3 (fr) 2016-12-08 2024-04-17 Immatics Biotechnologies GmbH Récepteurs de lymphocytes t à appariement amélioré
DE102016123859B3 (de) * 2016-12-08 2018-03-01 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
WO2018126002A1 (fr) * 2016-12-29 2018-07-05 Board Of Regents, The University Of Texas System Peptides vcx/y restreints par hla et récepteurs de lymphocytes t et leur utilisation
WO2018140525A1 (fr) * 2017-01-24 2018-08-02 Abexxa Biologics, Inc. Méthodes et compositions destinées à cibler un complexe comprenant un hla-i non classique et un néo-antigène dans le traitement du cancer
MA47367B1 (fr) * 2017-01-27 2023-06-28 Immatics Biotechnologies Gmbh Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers
US11771749B2 (en) 2017-02-03 2023-10-03 The Medical College Of Wisconsin, Inc. KRAS peptide vaccine compositions and method of use
US11649288B2 (en) 2017-02-07 2023-05-16 Seattle Children's Hospital Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
EP3366704A1 (fr) 2017-02-28 2018-08-29 Affimed GmbH Anticorps spécifiques pour le complexe mmp1/hla-a2
JP7115758B2 (ja) 2017-02-28 2022-08-09 アッフィメッド・ゲー・エム・ベー・ハー Ｃｄ１６ａ指向性ｎｋ細胞エンゲージメント用タンデムダイアボディ
WO2018160622A1 (fr) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions et méthodes de thérapie par lymphocytes t car
GB201704128D0 (en) * 2017-03-15 2017-04-26 Univ Swansea Method and apparatus for use in diagnosis and monitoring of colorectal cancer
MA49122A (fr) * 2017-04-10 2021-03-24 Immatics Biotechnologies Gmbh Peptides et combinaisons de peptides destinés à être utilisés en immunothérapie anticancéreuse
US11427614B2 (en) 2017-04-10 2022-08-30 Immatics Biotechnologies Gmbh Peptides and combination thereof for use in the immunotherapy against cancers
DE102017115966A1 (de) 2017-07-14 2019-01-17 Immatics Biotechnologies Gmbh Polypeptidmolekül mit verbesserter zweifacher Spezifität
PL3428194T3 (pl) 2017-07-14 2022-01-17 Immatics Biotechnologies Gmbh Ulepszona cząsteczka polipeptydu o podwójnej specyficzności
WO2019067887A1 (fr) * 2017-09-29 2019-04-04 Spyryx Biosciences, Inc. Peptides inhibiteurs d'enac et leurs utilisations
EP3694532A4 (fr) 2017-10-10 2021-07-14 Gritstone Oncology, Inc. Identification de néo-antigènes au moyen de points chauds
EP4219543A1 (fr) * 2017-11-06 2023-08-02 Immatics Biotechnologies GmbH Nouveaux récepteurs de lymphocytes t modifiés et thérapie immunitaire les utilisant
DE102017125888A1 (de) * 2017-11-06 2019-05-23 Immatics Biotechnologies Gmbh Neue konstruierte T-Zell-Rezeptoren und deren Verwendung in Immuntherapie
JP2021503897A (ja) 2017-11-22 2021-02-15 グリットストーン オンコロジー インコーポレイテッド 新生抗原のためのジャンクションエピトープ提示の低減
DE102017127984B4 (de) 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
CN112292138A (zh) 2018-01-22 2021-01-29 西雅图儿童医院（Dba西雅图儿童研究所） Car t细胞的使用方法
BR112020016176A2 (pt) 2018-02-09 2022-02-22 Immatics Us Inc Métodos de transdução de uma célula t, célula t transduzida geneticamente, composição farmacêutica, métodos de preparação de uma população de células t e uso da célula t
MY182816A (en) * 2018-02-15 2021-02-05 National Univ Corporation Asahikawa Medical Univ Cancer antigen peptide
DE102018107224A1 (de) * 2018-02-21 2019-08-22 Immatics Biotechnologies Gmbh Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten
EP4197552A1 (fr) * 2018-03-12 2023-06-21 The Children's Hospital of Philadelphia Procédés et compositions pour l'utilisation d'auto-antigènes tumoraux en immunothérapie adoptive
EP3545967A1 (fr) * 2018-03-28 2019-10-02 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Plate-forme d'immunisation contre le cancer
TW202016131A (zh) * 2018-05-16 2020-05-01 德商英麥提克生物技術股份有限公司 用於抗癌免疫治療的肽
KR20210022680A (ko) * 2018-06-22 2021-03-03 메르크 파텐트 게엠베하 담도암의 치료에 사용하기 위한 표적화된 TGF-β 억제를 위한 투약 레지멘
US10925947B2 (en) 2018-06-29 2021-02-23 Immatics Biotechnologies Gmbh A*03 restricted peptides for use in immunotherapy against cancers and related methods
TW202019955A (zh) 2018-07-31 2020-06-01 德商英麥提克生物技術股份有限公司 B*07 限制肽和肽組合的抗癌免疫治療和相關方法
US11945850B2 (en) * 2018-09-17 2024-04-02 Immatics Biotechnologies Gmbh B*44 restricted peptides for use in immunotherapy against cancers and related methods
TW202024121A (zh) 2018-09-18 2020-07-01 德商英麥提克生物技術股份有限公司 A*01 限制肽和肽組合物在抗癌免疫治療中的用途和相關方法
WO2020191172A1 (fr) 2019-03-19 2020-09-24 Immatics US, Inc. Cultures de cellules t cd28, leurs compositions et leurs méthodes d'utilisation
US20220211832A1 (en) * 2019-05-15 2022-07-07 Genocea Biosciences, Inc. Treatment methods
JP2022534716A (ja) 2019-05-27 2022-08-03 イマティクス ユーエス，アイエヌシー． ウイルスベクターおよびその養子細胞療法における使用
US20200384028A1 (en) 2019-06-06 2020-12-10 Immatics Biotechnologies Gmbh Sorting with counter selection using sequence similar peptides
DE102019121007A1 (de) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Antigenbindende Proteine, die spezifisch an MAGE-A binden
US20210032370A1 (en) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Recruiting agent further binding an mhc molecule
CN110567861B (zh) * 2019-09-09 2021-12-21 浙江普罗亭健康科技有限公司 基于质谱流式检测技术筛查具有免疫原性抗原肽的试剂盒及检测方法
CN110804643B (zh) * 2019-10-29 2022-06-21 同济大学 一种体外评价卡介苗对中性粒细胞活性影响的方法
JP2023504659A (ja) 2019-12-03 2023-02-06 ニューボーゲン，インコーポレイティド 腫瘍細胞ワクチン
JP2023515131A (ja) 2020-02-24 2023-04-12 イマティクス ユーエス，アイエヌシー． がんおよび関連する悪性腫瘍の治療のためにｔ細胞を増殖させる方法
DE102020106710A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
TW202227616A (zh) 2020-08-21 2022-07-16 美商英麥提克斯股份有限公司 分離ｃｄ８＋選擇ｔ細胞的方法
WO2022047325A1 (fr) * 2020-08-31 2022-03-03 The Trustees Of Columbia University In The City Of New York Ciblage de tmg4 pour le traitement du cancer de la prostate
DE102020125457A1 (de) 2020-09-29 2022-03-31 Immatics Biotechnologies Gmbh Amidierte Peptide und ihre deamidierten Gegenstücke, die durch HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten
US11891427B2 (en) 2020-09-29 2024-02-06 Immatics Biotechnologies Gmbh Amidated peptides and their deamidated counterparts displayed by non-HLA-a*02 for use in immunotherapy against different types of cancers
WO2022125874A2 (fr) * 2020-12-11 2022-06-16 Berkeley Lights, Inc. Procédés d'identification de peptides de liaison au cmh échangeables et leurs procédés d'utilisation
EP4271481A2 (fr) 2020-12-31 2023-11-08 Immatics US, Inc. Polypeptides cd8, compositions et leurs méthodes d'utilisation
DE102021100038A1 (de) 2020-12-31 2022-06-30 Immatics US, Inc. Modifizierte cd8-polypeptide, zusammensetzungen und verfahren zu deren verwendung
KR20230169944A (ko) 2021-03-09 2023-12-18 씨디알-라이프 아게 Mage-a4 펩티드-mhc 항원 결합 단백질
CA3211645A1 (fr) * 2021-03-12 2022-09-15 Erika VON EUW Methodes d'amelioration de la diversite d'expression d'haplotype de hla dans des tumeurs pour elargir la sensibilite de cellules tumorales a une therapie tcr-t
CA3217739A1 (fr) 2021-05-05 2022-11-10 Sebastian Bunk Polypeptides de liaison a l'antigene bma031
WO2022256700A1 (fr) * 2021-06-04 2022-12-08 Second Genome, Inc. Peptides pour l'immunothérapie
EP4113120A1 (fr) 2021-06-28 2023-01-04 Immatics Biotechnologies GmbH Procédé de caractérisation des caractéristiques de liaison entre un peptide d'intérêt et des molécules du cmh
US20230024554A1 (en) 2021-06-28 2023-01-26 Immatics Biotechnologies Gmbh Method of characterizing the binding characteristics between a peptide of interest and mhc molecules
WO2023025851A1 (fr) 2021-08-24 2023-03-02 Immatics US, Inc. Sélection de cellules immunitaires à l'aide de complexes peptide-cmh générés par échange de ligands conditionnel
WO2023044488A1 (fr) 2021-09-20 2023-03-23 Immatics US, Inc. Déplétion monocytaire des populations de lymphocytes t pour une thérapie par lymphocytes t
US20230192886A1 (en) 2021-11-08 2023-06-22 Immatics Biotechnologies Gmbh Adoptive cell therapy combination treatment and compositions thereof
US20240066127A1 (en) 2022-04-28 2024-02-29 Immatics US, Inc. Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof
WO2023212697A1 (fr) 2022-04-28 2023-11-02 Immatics US, Inc. Il-15 liée à une membrane, polypeptides de cd8, cellules, compositions et leurs procédés d'utilisation
WO2023212691A1 (fr) 2022-04-28 2023-11-02 Immatics US, Inc. Polypeptides récepteurs de tgfβ négatifs dominants, polypeptides cd8, cellules, compositions et leurs méthodes d'utilisation
WO2023215825A1 (fr) 2022-05-05 2023-11-09 Immatics US, Inc. Procédés d'amélioration de l'efficacité d'un lymphocyte t
CN115785204B (zh) * 2022-06-10 2024-02-13 河北博海生物工程开发有限公司 肺癌特异性分子靶标08及其用途

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211999B2 (en) * 1970-02-11 2012-07-03 Immatics Biotechnologies Gmbh Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
US4493795A (en) * 1983-10-17 1985-01-15 Syntex (U.S.A.) Inc. Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture
JPH07108224B2 (ja) 1985-11-07 1995-11-22 重三 鵜高 バチルス・ブレビスを用いる遺伝子の発現方法
US4772557A (en) * 1985-11-12 1988-09-20 Washington University DNA clone of human skin fibroblast collagenase enzyme
US9340577B2 (en) 1992-08-07 2016-05-17 Epimmune Inc. HLA binding motifs and peptides and their uses
WO1997000449A1 (fr) 1995-06-14 1997-01-03 Aberdeen University Systeme pronostique et therapeutique du cancer
US6143509A (en) 1996-02-06 2000-11-07 Abbott Laboratories Prostate specific antigen peptides and uses thereof
NZ333203A (en) * 1996-06-07 2000-07-28 Kyogo Itoh Tumour antigen proteins, genes thereof, and tumour antigen peptides
AU4086397A (en) 1996-09-06 1998-03-26 Centocor Inc. Monoclonal antibodies specific for prostate specific antigen and methods of detecting prostate specific antigen
US6291430B1 (en) * 1997-09-12 2001-09-18 Ludwig Institute For Cancer Research Mage-3 peptides presented by HLA class II molecules
US7105488B1 (en) * 1998-02-27 2006-09-12 The United States Of America As Represented By The Department Of Health And Human Services G protein-coupled receptor antagonists
ES2299242T3 (es) 1998-02-27 2008-05-16 The Government Of The Usa As Represented By The Secretary Of Department Of Health And Human Services Antagonistas de los receptores copulados a proteina g.
US6255055B1 (en) 1998-03-09 2001-07-03 Wisconsin Alumni Research Foundation c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence
US7579160B2 (en) 1998-03-18 2009-08-25 Corixa Corporation Methods for the detection of cervical cancer
US7258860B2 (en) 1998-03-18 2007-08-21 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US20030236209A1 (en) * 1998-03-18 2003-12-25 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
AU2001213184A1 (en) 1998-09-28 2002-05-06 Bio Polymer Products Of Sweden Ab A process of producing polyphenolic adhesive proteins and proteins produced in accordance with the process
US20070020327A1 (en) 1998-11-10 2007-01-25 John Fikes Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions
US7259253B2 (en) 1999-05-14 2007-08-21 Quark Biotech, Inc. Genes associated with mechanical stress, expression products therefrom, and uses thereof
US6869951B1 (en) 1999-07-16 2005-03-22 Pharmacia Corporation Method of changing conformation of a matrix metalloproteinase
US20020123095A1 (en) 1999-10-20 2002-09-05 Pe Corporation (Ny) Estrogen receptor alpha variants and methods of detection thereof
US20040142361A1 (en) 1999-11-30 2004-07-22 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
EP1235841A4 (fr) 1999-12-10 2006-04-12 Epimmune Inc Declenchement de reponses immunitaires cellulaires a mage2/3 au moyen de compositions de peptides et d'acides nucleiques
AU2001236589A1 (en) 2000-02-04 2001-08-14 Aeomica, Inc. Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
US20030050456A1 (en) 2000-02-24 2003-03-13 Gabriel Vogeli Novel G protein-coupled receptors
US6934639B1 (en) 2000-02-25 2005-08-23 Wyeth Methods for designing agents that interact with MMP-13
US7094890B1 (en) 2000-03-10 2006-08-22 Novartis Ag Arthritis-associated protein
WO2001070979A2 (fr) 2000-03-21 2001-09-27 Millennium Pharmaceuticals, Inc. Nouveaux genes, compositions, trousses et methodes d'identification, de verification, de prevention et de traitement du cancer des ovaires
US6861234B1 (en) 2000-04-28 2005-03-01 Mannkind Corporation Method of epitope discovery
US20030073622A1 (en) 2000-06-07 2003-04-17 Kumud Majumder Novel proteins and nucleic acids encoding same
AU2001268361A1 (en) 2000-07-07 2002-01-21 Saint Louis University Method of modulating expression of ldl-receptor-related protein and uses thereof
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
US20070014801A1 (en) 2001-01-24 2007-01-18 Gish Kurt C Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer
EP1911461B1 (fr) 2000-10-19 2011-12-07 Epimmune Inc. Peptides de liaisons HLA de classe I et II et leurs utilisations
JP2004531228A (ja) 2000-10-20 2004-10-14 アプレラ コーポレーション エストロゲン受容体アルファ変異体及びその検出方法
US7919467B2 (en) 2000-12-04 2011-04-05 Immunotope, Inc. Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
US20040053822A1 (en) 2000-12-11 2004-03-18 John Fikes Inducing cellular immune responses to mage2/3 using peptide and nucleic acid compositions
US20030170630A1 (en) 2000-12-21 2003-09-11 Alsobrook John P. Proteins and nucleic acids encoding same
WO2002068649A2 (fr) 2001-01-31 2002-09-06 Curagen Corporation Proteines et acides nucleiques les codant
US20050069976A1 (en) 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
CA2440747A1 (fr) * 2001-03-15 2002-09-26 Hyseq, Inc. Nouveaux acides nucleiques et nouveaux polypeptides
US20030077664A1 (en) 2001-04-18 2003-04-24 Yi Zhao Methods of screening for compounds that modulate hormone receptor activity
JP2005527180A (ja) * 2001-04-18 2005-09-15 プロテイン デザイン ラブス， インコーポレイテッド 肺がんの診断方法、肺がんの修飾因子の組成及びスクリーニングの方法
US6867283B2 (en) 2001-05-16 2005-03-15 Technion Research & Development Foundation Ltd. Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells
US20050053918A1 (en) 2001-05-16 2005-03-10 Technion Research & Development Foundation Ltd. Method of identifying peptides capable of binding to MHC molecules, peptides identified thereby and their uses
US7049413B2 (en) * 2001-05-18 2006-05-23 Ludwig Institute For Cancer Research MAGE-A3 peptides presented by HLA class II molecules
CA2449042A1 (fr) 2001-05-30 2002-12-27 Biomedical Center Criblage in silico de sequences exprimees associees a un phenotype
US7705120B2 (en) 2001-06-21 2010-04-27 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
US20030068636A1 (en) 2001-06-21 2003-04-10 Millennium Pharmaceuticals, Inc. Compositions, kits and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer
CA2489420A1 (fr) 2001-06-25 2003-01-03 Buadbo Aps Innovation en matiere de therapie anti-cancereuse
US20030108963A1 (en) 2001-07-25 2003-06-12 Millennium Pharmaceuticals, Inc. Novel genes, compositions, kit, and methods for identification, assessment, prevention and therapy of prostate cancer
JP2003088388A (ja) 2001-09-14 2003-03-25 Herikkusu Kenkyusho:Kk 新規な全長ｃＤＮＡ
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
CA2461280A1 (fr) 2001-09-24 2003-04-10 Nuvelo, Inc. Nouveaux acides nucleiques et polypeptides
JP2003135075A (ja) 2001-11-05 2003-05-13 Research Association For Biotechnology 新規な全長ｃＤＮＡ
AU2002357747A1 (en) 2001-12-10 2003-06-23 Millennium Pharmaceuticals Inc. Novel genes encoding colon cancer antigens
US6689431B2 (en) 2001-12-12 2004-02-10 Eastman Kodak Company Ink jet recording element
US20050084841A1 (en) 2002-01-29 2005-04-21 Orit Segev Isle gene and its association with osteoarthritis and other bone and cartilage disorders expression products derived therefrom and uses thereof
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
DE10225144A1 (de) 2002-05-29 2003-12-18 Immatics Biotechnologies Gmbh An MHC-Moleküle bindende Tumor-assoziierte Peptide
SE0201863D0 (en) 2002-06-18 2002-06-18 Cepep Ab Cell penetrating peptides
US7311914B2 (en) 2002-08-13 2007-12-25 Ludwig Institute For Cancer Research MAGE-A4 antigenic peptides and uses thereof
WO2004014867A2 (fr) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Inhibiteurs de metalloproteinases matricielles et procedes d'identification de tetes de serie
US20070224201A1 (en) 2002-10-02 2007-09-27 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2004058052A2 (fr) 2002-12-20 2004-07-15 Applera Corporation Polymorphismes genetiques associes a l'infarctus du myocarde, techniques de detection et utilisations de ceux-ci
US20050181375A1 (en) * 2003-01-10 2005-08-18 Natasha Aziz Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer
JP2009523404A (ja) 2003-01-30 2009-06-25 アプレラ コーポレイション 慢性関節リウマチに関連する遺伝的多型、その検出方法および使用
DE10309729A1 (de) 2003-02-26 2004-09-16 Hinzmann, Bernd, Dr. Humane Nukleinsäuresequenzen aus Harnblasenkarzinomen
WO2004081186A2 (fr) 2003-03-10 2004-09-23 Applera Corporation Polymorphismes genetiques associes a la stenose, procedes de detection et utilisations associees
CN1331885C (zh) * 2003-05-15 2007-08-15 北京大学 肿瘤抗原蛋白及抗原肽在作为肿瘤－睾丸抗原、制备治疗肝癌/肺癌药物中的应用
CA2529659A1 (fr) 2003-06-18 2004-12-29 Ulrich Haupts Enzymes proteolytiques genetiquement modifiees au moyen de zones de determination de la specificite alterees
US20050002897A1 (en) 2003-06-18 2005-01-06 Ulrich Haupts Biological entities and the pharmaceutical or diagnostic use thereof
US7807392B1 (en) 2003-09-15 2010-10-05 Celera Corporation Lung disease targets and uses thereof
EP1892306A3 (fr) 2003-10-06 2008-06-11 Bayer HealthCare AG Méthode et trousses pour évaluer un cancer
US7667001B1 (en) 2004-01-27 2010-02-23 Compugen Ltd. Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer
US7569662B2 (en) 2004-01-27 2009-08-04 Compugen Ltd Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer
EP1749025A2 (fr) 2004-01-27 2007-02-07 Compugen Ltd. Nouveaux nucleotides et sequences d'acides amines, et leurs dosages et procedes d'utilisation pour le diagnostic du cancer du colon
WO2005084116A2 (fr) 2004-01-27 2005-09-15 Compugen Usa, Inc. Nouveaux variants du canal calcique et leurs procedes d'utilisation
ES2533002T3 (es) * 2004-03-10 2015-04-06 Creighton University Receptores estrogénicos y métodos de uso
EP1766412B1 (fr) * 2004-05-21 2009-04-01 The Institute for Systems Biology Compositions et methodes de quantification de glycoproteines du serum
WO2006088483A2 (fr) * 2004-06-16 2006-08-24 Trustees Of Dartmouth College Compositions et methodes permettant d'inhiber la synthese ou l'expression de mmp-1
WO2006037993A2 (fr) 2004-10-02 2006-04-13 Auvation Limited Marqueurs cancereux
DE102005059937A1 (de) 2004-12-21 2006-07-13 Continental Teves Ag & Co. Ohg Verfahren zum Betrieb einer hydraulischen Bremsanlage für Kraftfahrzeuge
EP1827486A2 (fr) 2004-12-22 2007-09-05 Direvo Biotech AG Nouvelles entites biologiques et utilisation ciblee de celles-ci
US7883858B2 (en) 2005-01-27 2011-02-08 Institute For Systems Biology Methods for identifying and monitoring drug side effects
CA2598889A1 (fr) * 2005-02-24 2006-08-31 Cemines, Inc. Compositions et procedes de classification d'echantillons biologiques
WO2006106912A1 (fr) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha Peptide analogue d’antigene associe au cancer et son utilisation
US7842467B1 (en) 2005-05-12 2010-11-30 Celera Corporation Breast disease targets and uses thereof
US7521195B1 (en) 2005-07-21 2009-04-21 Celera Corporation Lung disease targets and uses thereof
ATE440107T1 (de) * 2005-09-05 2009-09-15 Immatics Biotechnologies Gmbh Tumorassoziierte peptide, die hla klasse i oder ii-moleküle binden, und anti-tumor impfstoffe
PT1806358E (pt) * 2005-09-05 2010-05-28 Immatics Biotechnologies Gmbh Peptídeos associados a tumor ligando promiscuamente às moléculas do antigénio de leucócitos humanos (hla) da classe ii
CA2623531C (fr) * 2005-10-07 2013-12-10 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Vaccin de metalloproteinase 11 matricielle
WO2007047796A2 (fr) * 2005-10-17 2007-04-26 Institute For Systems Biology Glycoproteines derivees de tissus et du serum et leurs methodes d'utilisation
US20070248628A1 (en) * 2005-12-06 2007-10-25 Keller Lorraine H Immunogens in cancer stem cells
EP1806413A1 (fr) * 2006-01-06 2007-07-11 Oligene GmbH Procédé in vitro et outiles pour la détection des differents types de tumeur et prédiction des résultats d'intervention chirurgical du cancer de l'ovaire
US20100120627A1 (en) 2006-08-02 2010-05-13 Abdelmajid Belouchi Genemap of the human genes associated with psoriasis
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
WO2008053573A1 (fr) 2006-10-30 2008-05-08 National University Corporation Hokkaido University Remède pour néoplasme malin
GEP20125659B (en) * 2006-12-29 2012-10-10 Ipsen Pharma Sas Pharmaceutical compositions containing glucagon-like peptide-1 (glp-1)
US7589662B1 (en) 2007-06-20 2009-09-15 The United States Of America As Represented By The Secretary Of The Navy Synthetic aperture radar systems and methods
CA2694805C (fr) 2007-07-27 2014-09-09 Immatics Biotechnologies Gmbh Nouveaux epitopes immunogenes destines a l'immunotherapie
CN101835892B (zh) 2007-08-20 2013-11-06 肿瘤疗法科学股份有限公司 Cdca1肽和包含cdca1肽的药剂
WO2009036246A2 (fr) * 2007-09-14 2009-03-19 Immunotope, Inc. Immunogènes qui induisent des lymphocytes t cytotoxiques et leur utilisation dans la prévention, le traitement et le diagnostic du cancer
WO2009102909A2 (fr) * 2008-02-15 2009-08-20 Board Of Regents, The University Of Texas System Vaccins anti-cancer
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
WO2009126271A1 (fr) * 2008-04-11 2009-10-15 China Synthetic Rubber Corporation Procédés, agents et trousses pour le dépistage du cancer
NO2119726T3 (fr) * 2008-05-14 2015-05-23
WO2010037395A2 (fr) * 2008-10-01 2010-04-08 Dako Denmark A/S Multimères de mhc dans des vaccins et la surveillance immunitaire contre le cancer
US20110189694A1 (en) 2008-10-22 2011-08-04 Biomarker Design Forschungs Gmbh Methods for detection and diagnosis of a bone or cartilage disorder
KR101032860B1 (ko) 2008-10-22 2011-05-06 한국식품연구원 췌장 조직 특이적 유전자 ｍｍｐ1
CN102307595A (zh) * 2009-02-10 2012-01-04 盛诺基医药科技有限公司 治疗雌激素受体相关疾病的抗体及方法
WO2010102157A1 (fr) * 2009-03-04 2010-09-10 The Regents Of The University Of California Prédicteurs moléculaires de la réponse biologique à un inhibiteur de cenpe dans un cancer
US20110229451A2 (en) 2009-03-06 2011-09-22 Halozyme, Inc. Temperature sensitive mutants of matrix metalloproteases and uses thereof
WO2010106535A1 (fr) 2009-03-15 2010-09-23 Technion Research And Development Foundation Ltd. Complexes hla solubles utiles pour diagnostiquer des maladies
WO2010125566A2 (fr) * 2009-04-27 2010-11-04 Technion Research And Development Foundation Ltd. Marqueurs pour la détection d'un cancer
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US20130011496A1 (en) 2009-11-25 2013-01-10 Ludwig Institute For Cancer Research Ltd. Cancer testis antigens as biomarkers in non-small cell lung cancer
SG183174A1 (en) * 2010-02-04 2012-09-27 Gilead Biologics Inc Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor
MA34521B1 (fr) * 2010-08-17 2013-09-02 Ambrx Inc Polypeptides de relaxine modifiés et leurs utilisations
US20130225443A1 (en) 2010-11-05 2013-08-29 Kyoto University Method of examining polycystic kidney disease and method of screening for therapeutic agent of the disease
WO2012068210A1 (fr) 2010-11-18 2012-05-24 Janssen Pharmaceutica Nv Inhibiteurs pyridyl-thiazolyle d'activation de métalloprotéinases promatricielles
EP2663672A1 (fr) 2011-01-11 2013-11-20 University Health Network Signature prognostique d'un carcinome épidermoïde de la cavité buccale
US20130064901A1 (en) * 2011-04-18 2013-03-14 Agency For Science, Technology And Research Gene expression profiling for classifying and treating gastric cancer
WO2012162461A1 (fr) 2011-05-25 2012-11-29 Janssen Pharmaceutica Nv Inhibiteurs phényle-thiazolylés de l'activation de pro-métalloprotéinase de matrice
US20120302573A1 (en) 2011-05-25 2012-11-29 Paul Francis Jackson Methods of inhibiting pro matrix metalloproteinase activation
KR20140057354A (ko) 2011-08-31 2014-05-12 온코사이트 코포레이션 결장직장암의 치료 및 진단을 위한 방법 및 조성물
US20140274794A1 (en) * 2011-09-09 2014-09-18 The Wistar Institute Of Anatomy And Biology Methods and Compositions for Diagnosis of Ovarian Cancer
CA2860307A1 (fr) 2011-12-21 2013-06-27 Integrated Diagnostics, Inc. Dosages de surveillance de reaction selectionnee
WO2013126726A1 (fr) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Lymphocytes t doubles transgéniques comportant un car et un tcr, et leurs procédés d'utilisation
WO2013147233A1 (fr) 2012-03-30 2013-10-03 国立大学法人岡山大学 Procédé pour produire un réactif destiné à la détection d'anticorps et ses utilisations
AU2013243953A1 (en) 2012-04-02 2014-10-30 Modernatx, Inc. Modified polynucleotides for the production of nuclear proteins
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
GB201208293D0 (en) * 2012-05-11 2012-06-20 Circassia Ltd Hydrochlorice salt of peptide
EP2669378A1 (fr) 2012-05-31 2013-12-04 Helmut Hanenberg Système de gène suicide du cytochrome P450
HUE048014T2 (hu) * 2012-09-14 2020-05-28 Us Health MHC Class II-korlátozott MAGE-A3-at felismerõ T-sejt receptorok
EP2931312A4 (fr) 2012-12-13 2016-10-19 Univ Virginia Patent Found Peptides cibles pour une thérapie et le diagnostic du cancer de l'ovaire
WO2015014375A1 (fr) 2013-07-30 2015-02-05 Biontech Ag Antigènes de tumeur pour déterminer une thérapie anticancéreuse
TWI777194B (zh) 2013-08-05 2022-09-11 德商伊瑪提克斯生物科技有限公司 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（一）
GB201505305D0 (en) * 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
PT3388075T (pt) * 2015-03-27 2023-08-18 Immatics Biotechnologies Gmbh Novos péptidos e combinações de péptidos para uso em imunoterapia contra vários tumores
GB201520583D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
DE102017006829B3 (de) 2017-07-19 2018-09-06 Daimler Ag Regalsystem
EP3731876A4 (fr) 2017-12-28 2022-04-06 Gritstone bio, Inc. Protéines se liant à l'antigène ciblant des antigènes partagés
EP3796927A4 (fr) 2018-05-23 2022-04-20 Gritstone bio, Inc. Antigènes partagés
EP3946439A4 (fr) 2019-03-30 2023-08-02 BioNTech US Inc. Compositions et procédés de préparation de compositions de lymphocytes t et leurs utilisations

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