JP2019512251A5 - - Google Patents
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- Publication number
- JP2019512251A5 JP2019512251A5 JP2018549452A JP2018549452A JP2019512251A5 JP 2019512251 A5 JP2019512251 A5 JP 2019512251A5 JP 2018549452 A JP2018549452 A JP 2018549452A JP 2018549452 A JP2018549452 A JP 2018549452A JP 2019512251 A5 JP2019512251 A5 JP 2019512251A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- host cell
- amino acid
- nucleic acid
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023045262A JP7746323B2 (ja) | 2016-03-23 | 2023-03-22 | Ｐｄ－１及び４－１ｂｂの融合タンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU93006 | 2016-03-23 | ||
| LULU93006 | 2016-03-23 | ||
| PCT/EP2017/056931 WO2017162797A1 (en) | 2016-03-23 | 2017-03-23 | Fusion proteins of pd-1 and 4-1bb |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023045262A Division JP7746323B2 (ja) | 2016-03-23 | 2023-03-22 | Ｐｄ－１及び４－１ｂｂの融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512251A JP2019512251A (ja) | 2019-05-16 |
| JP2019512251A5 true JP2019512251A5 (enExample) | 2019-09-19 |
| JP7250519B2 JP7250519B2 (ja) | 2023-04-03 |
Family
ID=55702054
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018549452A Active JP7250519B2 (ja) | 2016-03-23 | 2017-03-23 | Ｐｄ－１及び４－１ｂｂの融合タンパク質 |
| JP2023045262A Active JP7746323B2 (ja) | 2016-03-23 | 2023-03-22 | Ｐｄ－１及び４－１ｂｂの融合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023045262A Active JP7746323B2 (ja) | 2016-03-23 | 2023-03-22 | Ｐｄ－１及び４－１ｂｂの融合タンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11365237B2 (enExample) |
| EP (2) | EP4286522A3 (enExample) |
| JP (2) | JP7250519B2 (enExample) |
| CN (1) | CN109195985B (enExample) |
| AU (1) | AU2017236069B2 (enExample) |
| CA (1) | CA3017036A1 (enExample) |
| ES (1) | ES2962588T3 (enExample) |
| WO (1) | WO2017162797A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3770168A1 (en) | 2015-05-18 | 2021-01-27 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| PT3310805T (pt) | 2015-06-19 | 2021-05-19 | Kobold Sebastian | Proteínas de fusão pd-1-cd28 e a sua utilização em medicina |
| US11365237B2 (en) * | 2016-03-23 | 2022-06-21 | Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) | Fusion proteins of PD-1 and 4-1BB |
| CN110177803A (zh) | 2016-11-22 | 2019-08-27 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重新编程的组合物和方法 |
| WO2018119198A1 (en) * | 2016-12-22 | 2018-06-28 | Windmil Therapeutics, Inc. | Compositions and methods for modulating the immune system |
| WO2018181390A1 (ja) * | 2017-03-31 | 2018-10-04 | 東亞合成株式会社 | Ｐｄ－１シグナル配列を有する抗腫瘍ペプチドおよびその利用 |
| IL280102B1 (en) * | 2018-07-11 | 2026-07-01 | Kahr Medical Ltd | Fusion protein containing PD1-4-1BBL and methods of using the same |
| KR102351041B1 (ko) * | 2018-12-19 | 2022-01-13 | 한국화학연구원 | 인간 lrrc24 단백질 유래 세포막 투과 도메인 |
| CN113518823B (zh) * | 2019-01-07 | 2025-05-02 | 托马斯杰斐逊大学 | 多功能的融合蛋白及其用途 |
| EP3999079A4 (en) * | 2019-07-19 | 2024-04-03 | Memorial Sloan Kettering Cancer Center | Fusion polypeptide for immunotherapy |
| EP4146701A4 (en) * | 2020-05-06 | 2024-05-15 | Navicure Biopharmaceuticals Limited | Fusion proteins for immunotherapy against cancer and infectious diseases |
| WO2022036495A1 (en) * | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| US20230374104A1 (en) * | 2020-10-09 | 2023-11-23 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods and compositions comprising pd1 chimeric polypeptides |
| CN117321079A (zh) * | 2021-01-11 | 2023-12-29 | 优特力克斯有限公司 | 包含抗4-1bb抗体及pd-1蛋白或其片段的双特异性表位结合蛋白及其用途 |
| CA3228669A1 (en) * | 2021-08-10 | 2023-02-16 | Ganesh Ramachandran | Purification of liraglutide |
| WO2023025779A1 (en) * | 2021-08-25 | 2023-03-02 | Medigene Immunotherapies Gmbh | Combination of antigen specific t cell receptors and chimeric co-stimulatory receptors |
| US20260055159A1 (en) * | 2022-08-23 | 2026-02-26 | Medigene Immunotherapies Gmbh | Combination of ny-eso-1 specific t cell receptors and chimeric co-stimulatory receptors |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2014001222A (es) | 2011-07-29 | 2014-09-15 | Univ Pennsylvania | Receptores coestimuladores de cambio. |
| JP6074435B2 (ja) * | 2011-10-26 | 2017-02-01 | ナショナル キャンサー センター | 変異ｃｔｌａ４遺伝子移入ｔ細胞及びこれを含む抗がん免疫治療用組成物 |
| AU2013204922B2 (en) * | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| EP2970372B1 (en) * | 2013-03-15 | 2020-09-30 | Celgene Corporation | Modified t lymphocytes |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| DK2992020T3 (da) | 2013-05-03 | 2020-02-10 | Ohio State Innovation Foundation | Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller |
| CN122399016A (zh) * | 2014-03-15 | 2026-07-17 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| EP3172231B1 (en) * | 2014-07-24 | 2021-05-05 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| WO2016019300A1 (en) * | 2014-07-31 | 2016-02-04 | Novartis Ag | Subset-optimized chimeric antigen receptor-containing t-cells |
| EP3250602A1 (en) * | 2015-01-26 | 2017-12-06 | Cellectis | T cell receptor knock out engineered immune cells, endowed with chimeric antigen receptors binding to cd123 for the treatment of relapsed/refractory acute myeloid lymphoma or blastic plasmacytoid dendritic cell neoplasm |
| AU2015380397B2 (en) * | 2015-01-31 | 2021-10-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| BR112017018770A2 (pt) * | 2015-03-02 | 2018-04-17 | Innovative Cellular Therapeutics CO., LTD. | redução da tolerância imunológica induzida por pd-l1 |
| SG11201707182WA (en) * | 2015-03-05 | 2017-10-30 | Hutchinson Fred Cancer Res | Immunomodulatory fusion proteins and uses thereof |
| EP3770168A1 (en) * | 2015-05-18 | 2021-01-27 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN104829733B (zh) * | 2015-05-25 | 2018-06-05 | 广州百暨基因科技有限公司 | 抗原结合单元稳定的嵌合抗原受体及制备方法与应用 |
| PT3310805T (pt) * | 2015-06-19 | 2021-05-19 | Kobold Sebastian | Proteínas de fusão pd-1-cd28 e a sua utilização em medicina |
| MX2018000278A (es) * | 2015-06-29 | 2018-03-08 | Univ Johns Hopkins | Terapia de receptores quimericos de puntos de control inmunitarios. |
| US11242375B2 (en) * | 2015-09-04 | 2022-02-08 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
| US20190241910A1 (en) * | 2016-03-11 | 2019-08-08 | Bluebird Bio, Inc. | Genome edited immune effector cells |
| US11365237B2 (en) * | 2016-03-23 | 2022-06-21 | Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) | Fusion proteins of PD-1 and 4-1BB |
| AU2019227979B2 (en) * | 2018-03-02 | 2024-09-05 | Allogene Therapeutics, Inc. | Inducible chimeric cytokine receptors |
| US12291557B2 (en) * | 2018-03-28 | 2025-05-06 | Cero Therapeutics Holdings, Inc. | Chimeric TIM4 receptors and uses thereof |
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2017
- 2017-03-23 US US16/087,262 patent/US11365237B2/en active Active
- 2017-03-23 CA CA3017036A patent/CA3017036A1/en active Pending
- 2017-03-23 JP JP2018549452A patent/JP7250519B2/ja active Active
- 2017-03-23 EP EP23193951.3A patent/EP4286522A3/en active Pending
- 2017-03-23 EP EP17713250.3A patent/EP3433269B1/en active Active
- 2017-03-23 AU AU2017236069A patent/AU2017236069B2/en active Active
- 2017-03-23 CN CN201780031958.9A patent/CN109195985B/zh active Active
- 2017-03-23 WO PCT/EP2017/056931 patent/WO2017162797A1/en not_active Ceased
- 2017-03-23 ES ES17713250T patent/ES2962588T3/es active Active
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2022
- 2022-06-08 US US17/835,936 patent/US12516101B2/en active Active
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2023
- 2023-03-22 JP JP2023045262A patent/JP7746323B2/ja active Active
- 2023-11-16 US US18/510,940 patent/US20240247046A1/en active Pending