JP2018508219A5 - - Google Patents
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- JP2018508219A5 JP2018508219A5 JP2017546715A JP2017546715A JP2018508219A5 JP 2018508219 A5 JP2018508219 A5 JP 2018508219A5 JP 2017546715 A JP2017546715 A JP 2017546715A JP 2017546715 A JP2017546715 A JP 2017546715A JP 2018508219 A5 JP2018508219 A5 JP 2018508219A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- item
- extracellular
- seq
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562128979P | 2015-03-05 | 2015-03-05 | |
| US62/128,979 | 2015-03-05 | ||
| PCT/US2016/021064 WO2016141357A1 (en) | 2015-03-05 | 2016-03-04 | Immunomodulatory fusion proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081118A Division JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508219A JP2018508219A (ja) | 2018-03-29 |
| JP2018508219A5 true JP2018508219A5 (enExample) | 2019-04-11 |
| JP6917896B2 JP6917896B2 (ja) | 2021-08-18 |
Family
ID=55587371
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546715A Expired - Fee Related JP6917896B2 (ja) | 2015-03-05 | 2016-03-04 | 免疫調節性融合タンパク質およびその使用 |
| JP2020081118A Expired - Fee Related JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
| JP2021150184A Active JP7441201B2 (ja) | 2015-03-05 | 2021-09-15 | 免疫調節性融合タンパク質およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081118A Expired - Fee Related JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
| JP2021150184A Active JP7441201B2 (ja) | 2015-03-05 | 2021-09-15 | 免疫調節性融合タンパク質およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20180044404A1 (enExample) |
| EP (2) | EP4406604A3 (enExample) |
| JP (3) | JP6917896B2 (enExample) |
| KR (1) | KR20170120701A (enExample) |
| CN (1) | CN107531805A (enExample) |
| AU (3) | AU2016226022B2 (enExample) |
| BR (1) | BR112017018919A8 (enExample) |
| CA (2) | CA2978186A1 (enExample) |
| ES (1) | ES2979088T3 (enExample) |
| HK (1) | HK1246317A1 (enExample) |
| IL (1) | IL254165B (enExample) |
| MX (4) | MX2017011201A (enExample) |
| MY (2) | MY196588A (enExample) |
| RU (1) | RU2755227C2 (enExample) |
| SA (1) | SA517382216B1 (enExample) |
| SG (2) | SG11201707182WA (enExample) |
| WO (1) | WO2016141357A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| KR102546296B1 (ko) | 2014-10-31 | 2023-06-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도 |
| SG11201707182WA (en) | 2015-03-05 | 2017-10-30 | Hutchinson Fred Cancer Res | Immunomodulatory fusion proteins and uses thereof |
| EP3770168A1 (en) | 2015-05-18 | 2021-01-27 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| PT3310805T (pt) | 2015-06-19 | 2021-05-19 | Kobold Sebastian | Proteínas de fusão pd-1-cd28 e a sua utilização em medicina |
| WO2017112944A1 (en) | 2015-12-23 | 2017-06-29 | Fred Hutchinson Cancer Research Center | High affinity t cell receptors and uses thereof |
| US11365237B2 (en) | 2016-03-23 | 2022-06-21 | Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) | Fusion proteins of PD-1 and 4-1BB |
| SG11201808552XA (en) | 2016-05-18 | 2018-10-30 | Cue Biopharma Inc | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2018009972A1 (en) * | 2016-07-14 | 2018-01-18 | Peter Maccallum Cancer Institute | Chimeric antigen receptor modified t cells |
| US20190248893A1 (en) | 2016-07-14 | 2019-08-15 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| CN110177803A (zh) | 2016-11-22 | 2019-08-27 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重新编程的组合物和方法 |
| WO2018102761A1 (en) * | 2016-12-02 | 2018-06-07 | City Of Hope | Methods for manufacturing and expanding t cells expressing chimeric antigen receptors and other receptors |
| WO2018119198A1 (en) * | 2016-12-22 | 2018-06-28 | Windmil Therapeutics, Inc. | Compositions and methods for modulating the immune system |
| CN110325205B (zh) | 2016-12-22 | 2023-08-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| KR20240005989A (ko) | 2017-03-15 | 2024-01-12 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| US11725210B2 (en) * | 2017-03-17 | 2023-08-15 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| MX2020001309A (es) | 2017-08-02 | 2020-08-20 | Phanes Therapeutics Inc | Anticuerpos anti-cd47 y sus usos. |
| US10960071B2 (en) | 2017-08-07 | 2021-03-30 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
| WO2019032628A1 (en) | 2017-08-07 | 2019-02-14 | The Regents Of The University Of California | GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS |
| EP3678677A4 (en) * | 2017-09-07 | 2021-06-16 | Cue Biopharma, Inc. | ANTIGEN-PRESENTING POLYPEPTIDES AND METHOD FOR THEIR USE |
| WO2019055862A1 (en) | 2017-09-14 | 2019-03-21 | Fred Hutchinson Cancer Research Center | HIGH AFFINITY T CELL RECEPTORS AND USES THEREOF |
| WO2019090355A1 (en) * | 2017-11-06 | 2019-05-09 | Children's National Medical Center | Cells expressing antibodies and methods of treatment using the same |
| US11866731B2 (en) | 2017-11-10 | 2024-01-09 | Chineo Medical Technology Co., Ltd | Modified immune cells and uses thereof |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| CN112566650A (zh) * | 2018-06-21 | 2021-03-26 | 沙塔克实验室有限公司 | 异二聚体蛋白及其用途 |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| KR102261407B1 (ko) * | 2018-10-10 | 2021-06-08 | 한국화학연구원 | Hvem을 표적으로 하는 키메라 항원 수용체 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20210393692A1 (en) * | 2018-11-13 | 2021-12-23 | Memorial Sloan Kettering Cancer Center | Compositions and methods for adoptive cell therapy for cancer |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| TWI856047B (zh) | 2018-12-19 | 2024-09-21 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| GB201900858D0 (en) * | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| BR112021017703A8 (pt) | 2019-03-11 | 2023-04-18 | Hutchinson Fred Cancer Res | Receptores de células t wt1 de alta avidez e usos dos mesmos |
| CN113710697A (zh) * | 2019-03-15 | 2021-11-26 | 美国政府(由卫生和人类服务部的部长所代表) | 嵌合衔接子和激酶信号传导蛋白及其在免疫疗法中的用途 |
| JP2022526504A (ja) * | 2019-03-21 | 2022-05-25 | オーエヌケー セラピューティクス リミテッド | 細胞死に対する耐性が増大した改変免疫エフェクター細胞 |
| JP7711945B2 (ja) | 2019-04-30 | 2025-07-23 | センティ バイオサイエンシズ インコーポレイテッド | キメラ受容体及びその使用方法 |
| EP3999079A4 (en) * | 2019-07-19 | 2024-04-03 | Memorial Sloan Kettering Cancer Center | Fusion polypeptide for immunotherapy |
| KR20220050176A (ko) | 2019-08-20 | 2022-04-22 | 프레드 헛친슨 켄서 리서치 센터 | Wt-1에 특이적인 t-세포 면역요법 |
| WO2021057823A1 (en) * | 2019-09-27 | 2021-04-01 | Immuther Pharmtech (Shanghai) Co., Ltd. | Ror1 specific chimeric antigen receptors and their therapeutic applications |
| CA3163258A1 (en) * | 2019-11-27 | 2021-06-03 | Board Of Regents, The University Of Texas System | Large-scale combined car transduction and crispr gene editing of nk cells |
| US20230000918A1 (en) * | 2019-11-29 | 2023-01-05 | Suzhou Nova Therapeutics Co. Ltd | Chimeric antigen receptors, compositions and applications thereof |
| MX2022007107A (es) * | 2019-12-11 | 2022-11-14 | Myeloid Therapeutics Inc | Composiciones celulares terapeuticas y metodos de preparacion y usos de las mismas. |
| WO2021142835A1 (zh) * | 2020-01-19 | 2021-07-22 | 北京卡替医疗技术有限公司 | 一种提升免疫细胞功能的增强受体 |
| CN115298209A (zh) * | 2020-02-20 | 2022-11-04 | 森迪生物科学公司 | 抑制性嵌合受体构造体 |
| EP4132962A1 (en) * | 2020-04-09 | 2023-02-15 | Autolus Limited | Molecule |
| GB202101491D0 (en) * | 2021-02-03 | 2021-03-17 | Autolus Ltd | Molecule |
| CN115315439A (zh) * | 2020-04-09 | 2022-11-08 | 奥托路斯有限公司 | 细胞 |
| IL296209A (en) | 2020-05-12 | 2022-11-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of using them |
| CN117843812A (zh) * | 2020-05-22 | 2024-04-09 | 重庆精准生物技术有限公司 | 逆转肿瘤微环境的融合蛋白及其应用 |
| CN116348485A (zh) | 2020-07-17 | 2023-06-27 | 英研生物(英国)有限公司 | 提供用于过继性细胞疗法的靶向共刺激的受体 |
| WO2022020745A1 (en) * | 2020-07-23 | 2022-01-27 | Emory University | Galectin-9 specific binding agents for use in treating cancer |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ， インコーポレイテッド | １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| CN116600820A (zh) * | 2020-12-16 | 2023-08-15 | 奥赖恩公司 | 嵌合抗原受体(car)间隔子修饰增强car t细胞功能 |
| EP4305174A4 (en) * | 2021-03-10 | 2025-04-30 | B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University | REPORTER CELLS EXPRESSING CHIMERIC POLYPEPTIDES TO DETERMINE THE PRESENCE AND/OR ACTIVITY OF IMMUNE CHECKPOINT MOLECULES |
| JP2024519945A (ja) * | 2021-05-20 | 2024-05-21 | アチェロイス バイオファーマ，インク． | 免疫チェックポイント多価粒子の組成物、および使用方法 |
| WO2022246041A2 (en) * | 2021-05-20 | 2022-11-24 | Achelois Biopharma, Inc. | Compositions and methods for multivalent surface display on enveloped particles |
| TW202306997A (zh) | 2021-06-16 | 2023-02-16 | 英商英斯特生物科技有限公司 | 用於在過繼細胞療法中提供標靶共刺激之受體 |
| EP4370213A4 (en) | 2021-07-16 | 2025-06-04 | Instil Bio (Uk) Limited | Chimeric molecules for targeted costimulation for adoptive cell therapy |
| CN113621077B (zh) * | 2021-09-02 | 2023-01-31 | 山东大学 | 一种tim-3/cd28融合蛋白及所述融合蛋白修饰的car-t细胞 |
| EP4476246A4 (en) * | 2022-02-07 | 2026-05-13 | Seattle Childrens Hospital D/B/A Seattle Childrens Res Institute | Recombinant proteins that stimulate an immune response in the presence of a naturally inhibitory ligand bond |
| JP2025541309A (ja) * | 2022-12-15 | 2025-12-18 | カリヴィル イムノセラピューティクス， インコーポレイテッド | Ｃｄ４７／ｓｉｒｐ－アルファ免疫チェックポイント阻害剤の組成物およびその使用 |
| WO2025081123A1 (en) | 2023-10-12 | 2025-04-17 | Fred Hutchinson Cancer Center | Methods and compositions for improving t cell immunotherapy |
| EP4599843A1 (en) | 2024-02-09 | 2025-08-13 | Fundació Institut de recerca de l'Hospital de la Santa Creu i Sant Pau | Car and modified cd200r combination |
| TW202604968A (zh) * | 2024-04-17 | 2026-02-01 | 大陸商上海藥明巨諾生物醫藥研發有限公司 | 多肽系統 |
| WO2025245169A1 (en) | 2024-05-21 | 2025-11-27 | Fred Hutchinson Cancer Center | Immunotherapy cells equipped with a collagen-targeting payload |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1999A (en) | 1841-03-12 | Improvement in seed-planters | ||
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| EP0737207B1 (en) | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibitors of human plasmin derived from the kunitz domains |
| AU685693B2 (en) | 1994-11-01 | 1998-01-22 | Targeted Genetics Corporation | Chimeric receptors for the generation of selectively-activatable TH-independent cytotoxic T cells |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| EP1791865B1 (en) | 2004-06-29 | 2010-07-28 | Immunocore Ltd. | Cells expressing a modified t cell receptor |
| ATE423140T1 (de) | 2005-01-05 | 2009-03-15 | F Star Biotech Forsch & Entw | Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| WO2008042814A2 (en) | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| WO2012012695A2 (en) * | 2010-07-23 | 2012-01-26 | Fred Hutchinson Cancer Research Center | A method for the treatment of obesity |
| EP2621514B1 (en) | 2010-09-28 | 2016-09-21 | KAHR Medical (2005) Ltd | Compositions and methods for treatment of hematological malignancies |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012129514A1 (en) * | 2011-03-23 | 2012-09-27 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| EP2694640B1 (en) | 2011-04-08 | 2017-10-18 | Baylor College Of Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
| MX2014001222A (es) | 2011-07-29 | 2014-09-15 | Univ Pennsylvania | Receptores coestimuladores de cambio. |
| JP6074435B2 (ja) | 2011-10-26 | 2017-02-01 | ナショナル キャンサー センター | 変異ｃｔｌａ４遺伝子移入ｔ細胞及びこれを含む抗がん免疫治療用組成物 |
| EP2814846B1 (en) * | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| EP2941438A1 (en) | 2013-01-01 | 2015-11-11 | Kahr Medical Ltd. | Stable form of signal converting protein fusion proteins, and methods of use and preparation thereof |
| WO2014110591A1 (en) * | 2013-01-14 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
| CN103965361B (zh) | 2013-02-06 | 2018-10-30 | 上海细胞治疗工程技术研究中心集团有限公司 | 一种t细胞信号的嵌合分子转换器及其用途 |
| WO2014172584A1 (en) | 2013-04-17 | 2014-10-23 | Baylor College Of Medicine | IMMUNOSUPPRESSIVE TGF-β SIGNAL CONVERTER |
| JP6831777B2 (ja) | 2014-07-21 | 2021-02-17 | ノバルティス アーゲー | Ｃｄ３３キメラ抗原受容体を使用する癌の処置 |
| AU2015292744C1 (en) | 2014-07-21 | 2021-01-21 | Novartis Ag | Treatment of cancer using humanized anti-BCMA chimeric antigen receptor |
| BR112017000939A2 (pt) | 2014-07-21 | 2017-11-14 | Novartis Ag | tratamento de câncer usando um receptor antigênico quimérico de cll-1 |
| EP3177314B1 (en) * | 2014-08-04 | 2020-10-07 | Fred Hutchinson Cancer Research Center | T cell immunotherapy specific for wt-1 |
| ES2751915T5 (es) * | 2014-08-15 | 2022-12-23 | Merck Patent Gmbh | Proteínas de fusión de inmunoglobulina con SIRP alfa |
| HRP20240357T1 (hr) | 2014-12-24 | 2024-06-07 | Autolus Limited | Stanica |
| US10350245B2 (en) * | 2015-01-21 | 2019-07-16 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
| SG11201707182WA (en) | 2015-03-05 | 2017-10-30 | Hutchinson Fred Cancer Res | Immunomodulatory fusion proteins and uses thereof |
| PT3310805T (pt) | 2015-06-19 | 2021-05-19 | Kobold Sebastian | Proteínas de fusão pd-1-cd28 e a sua utilização em medicina |
| JP6976960B2 (ja) | 2015-11-27 | 2021-12-08 | カーサリクス プロプライエタリー リミテッド | 遺伝子改変された細胞およびその使用 |
| WO2017112944A1 (en) * | 2015-12-23 | 2017-06-29 | Fred Hutchinson Cancer Research Center | High affinity t cell receptors and uses thereof |
| EP4166161B1 (en) * | 2016-04-14 | 2026-03-04 | Fred Hutchinson Cancer Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| JP7198670B2 (ja) * | 2016-04-20 | 2023-01-04 | フレッド ハッチンソン キャンサー センター | 免疫調整性ｉｌ２ｒ融合タンパク質およびその使用 |
| US11725210B2 (en) | 2017-03-17 | 2023-08-15 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
| WO2019061012A1 (zh) | 2017-09-26 | 2019-04-04 | 南京凯地生物科技有限公司 | 靶向cd47的特异性嵌合抗原受体t细胞的制备及其应用 |
| CN110330567B (zh) | 2019-07-02 | 2020-11-06 | 南京凯地生物科技有限公司 | 双特异性嵌合抗原受体t细胞，其制备方法和应用 |
-
2016
- 2016-03-04 SG SG11201707182WA patent/SG11201707182WA/en unknown
- 2016-03-04 WO PCT/US2016/021064 patent/WO2016141357A1/en not_active Ceased
- 2016-03-04 HK HK18105732.2A patent/HK1246317A1/zh unknown
- 2016-03-04 US US15/555,951 patent/US20180044404A1/en not_active Abandoned
- 2016-03-04 ES ES16711081T patent/ES2979088T3/es active Active
- 2016-03-04 EP EP24169396.9A patent/EP4406604A3/en not_active Withdrawn
- 2016-03-04 CA CA2978186A patent/CA2978186A1/en active Pending
- 2016-03-04 AU AU2016226022A patent/AU2016226022B2/en not_active Ceased
- 2016-03-04 MY MYPI2021007596A patent/MY196588A/en unknown
- 2016-03-04 RU RU2017133637A patent/RU2755227C2/ru active
- 2016-03-04 MX MX2017011201A patent/MX2017011201A/es unknown
- 2016-03-04 JP JP2017546715A patent/JP6917896B2/ja not_active Expired - Fee Related
- 2016-03-04 SG SG10201908203S patent/SG10201908203SA/en unknown
- 2016-03-04 BR BR112017018919A patent/BR112017018919A8/pt not_active Application Discontinuation
- 2016-03-04 CN CN201680023758.4A patent/CN107531805A/zh active Pending
- 2016-03-04 KR KR1020177027794A patent/KR20170120701A/ko active Pending
- 2016-03-04 MY MYPI2017001281A patent/MY189195A/en unknown
- 2016-03-04 EP EP16711081.6A patent/EP3265481B1/en active Active
- 2016-03-04 CA CA3177938A patent/CA3177938A1/en active Pending
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2017
- 2017-08-27 IL IL254165A patent/IL254165B/en unknown
- 2017-08-30 SA SA517382216A patent/SA517382216B1/ar unknown
- 2017-08-31 MX MX2022006006A patent/MX2022006006A/es unknown
- 2017-08-31 MX MX2022006004A patent/MX2022006004A/es unknown
- 2017-08-31 MX MX2022006002A patent/MX2022006002A/es unknown
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2020
- 2020-05-01 JP JP2020081118A patent/JP7026161B2/ja not_active Expired - Fee Related
- 2020-09-30 AU AU2020244495A patent/AU2020244495B2/en not_active Ceased
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2021
- 2021-02-03 US US17/166,903 patent/US12012443B2/en active Active
- 2021-09-15 JP JP2021150184A patent/JP7441201B2/ja active Active
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2022
- 2022-11-16 AU AU2022271411A patent/AU2022271411A1/en not_active Abandoned
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2024
- 2024-05-07 US US18/657,687 patent/US20250109180A1/en active Pending
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