JP2018508219A5 - - Google Patents
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- JP2018508219A5 JP2018508219A5 JP2017546715A JP2017546715A JP2018508219A5 JP 2018508219 A5 JP2018508219 A5 JP 2018508219A5 JP 2017546715 A JP2017546715 A JP 2017546715A JP 2017546715 A JP2017546715 A JP 2017546715A JP 2018508219 A5 JP2018508219 A5 JP 2018508219A5
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- Prior art keywords
- fusion protein
- item
- extracellular
- seq
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000037865 fusion proteins Human genes 0.000 claims description 175
- 108020001507 fusion proteins Proteins 0.000 claims description 175
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 121
- 108020004707 nucleic acids Proteins 0.000 claims description 79
- 102000039446 nucleic acids Human genes 0.000 claims description 79
- 150000007523 nucleic acids Chemical class 0.000 claims description 79
- 230000003834 intracellular effect Effects 0.000 claims description 62
- 230000002209 hydrophobic effect Effects 0.000 claims description 55
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 52
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 52
- 230000004068 intracellular signaling Effects 0.000 claims description 39
- 230000027455 binding Effects 0.000 claims description 38
- 101000969553 Homo sapiens Cell surface glycoprotein CD200 receptor 1 Proteins 0.000 claims description 37
- 102100021396 Cell surface glycoprotein CD200 receptor 1 Human genes 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 34
- 235000001014 amino acid Nutrition 0.000 claims description 27
- 150000001413 amino acids Chemical class 0.000 claims description 27
- 239000013598 vector Substances 0.000 claims description 25
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 23
- 102000017578 LAG3 Human genes 0.000 claims description 23
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims description 22
- 108091008874 T cell receptors Proteins 0.000 claims description 22
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 22
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 claims description 22
- 239000000427 antigen Substances 0.000 claims description 22
- 108091007433 antigens Proteins 0.000 claims description 22
- 102000036639 antigens Human genes 0.000 claims description 22
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims description 19
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims description 19
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 16
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims description 16
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 16
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 16
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 16
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 16
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 12
- 230000000139 costimulatory effect Effects 0.000 claims description 11
- -1 CD300 Proteins 0.000 claims description 10
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 10
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 10
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 8
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 8
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 8
- 101001038037 Homo sapiens Lysophosphatidic acid receptor 5 Proteins 0.000 claims description 8
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 8
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 8
- 102100040404 Lysophosphatidic acid receptor 5 Human genes 0.000 claims description 8
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims description 8
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 8
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 8
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 7
- 230000009149 molecular binding Effects 0.000 claims description 7
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 6
- 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 claims description 6
- 102100037589 OX-2 membrane glycoprotein Human genes 0.000 claims description 6
- 230000004083 survival effect Effects 0.000 claims description 6
- 102100027207 CD27 antigen Human genes 0.000 claims description 5
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 5
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims description 5
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 5
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims description 4
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims description 4
- 101150013553 CD40 gene Proteins 0.000 claims description 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 4
- 102000015212 Fas Ligand Protein Human genes 0.000 claims description 4
- 108010039471 Fas Ligand Protein Proteins 0.000 claims description 4
- 102100031351 Galectin-9 Human genes 0.000 claims description 4
- 101100229077 Gallus gallus GAL9 gene Proteins 0.000 claims description 4
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 4
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims description 4
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims description 4
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims description 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 4
- 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 claims description 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 4
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 4
- 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 claims description 4
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 4
- 102000007497 Patched-2 Receptor Human genes 0.000 claims description 4
- 108010071083 Patched-2 Receptor Proteins 0.000 claims description 4
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims description 4
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 4
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 239000013603 viral vector Substances 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 102000004127 Cytokines Human genes 0.000 claims description 3
- 108090000695 Cytokines Proteins 0.000 claims description 3
- 102100024965 Caspase recruitment domain-containing protein 11 Human genes 0.000 claims description 2
- 108090000288 Glycoproteins Proteins 0.000 claims description 2
- 102000003886 Glycoproteins Human genes 0.000 claims description 2
- 101000761179 Homo sapiens Caspase recruitment domain-containing protein 11 Proteins 0.000 claims description 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 2
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims description 2
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 claims description 2
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims description 2
- 101100268066 Mus musculus Zap70 gene Proteins 0.000 claims description 2
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 2
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims description 2
- 102000011408 Tripartite Motif Proteins Human genes 0.000 claims description 2
- 108010023649 Tripartite Motif Proteins Proteins 0.000 claims description 2
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 claims description 2
- 210000000170 cell membrane Anatomy 0.000 claims description 2
- 230000003013 cytotoxicity Effects 0.000 claims description 2
- 231100000135 cytotoxicity Toxicity 0.000 claims description 2
- 210000000428 immunological synapse Anatomy 0.000 claims description 2
- 230000006872 improvement Effects 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 230000001177 retroviral effect Effects 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 125000006850 spacer group Chemical group 0.000 claims description 2
- 230000009870 specific binding Effects 0.000 claims description 2
- 230000000638 stimulation Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 239000003446 ligand Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 230000011664 signaling Effects 0.000 description 3
- 102000006306 Antigen Receptors Human genes 0.000 description 2
- 108010083359 Antigen Receptors Proteins 0.000 description 2
- 102000008160 Cyclin A1 Human genes 0.000 description 2
- 108010060267 Cyclin A1 Proteins 0.000 description 2
- 101000621309 Homo sapiens Wilms tumor protein Proteins 0.000 description 2
- 102000003735 Mesothelin Human genes 0.000 description 2
- 108090000015 Mesothelin Proteins 0.000 description 2
- 108020004459 Small interfering RNA Proteins 0.000 description 2
- 102100022748 Wilms tumor protein Human genes 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 102000057542 human CD200R1 Human genes 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562128979P | 2015-03-05 | 2015-03-05 | |
| US62/128,979 | 2015-03-05 | ||
| PCT/US2016/021064 WO2016141357A1 (en) | 2015-03-05 | 2016-03-04 | Immunomodulatory fusion proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081118A Division JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508219A JP2018508219A (ja) | 2018-03-29 |
| JP2018508219A5 true JP2018508219A5 (enExample) | 2019-04-11 |
| JP6917896B2 JP6917896B2 (ja) | 2021-08-18 |
Family
ID=55587371
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546715A Active JP6917896B2 (ja) | 2015-03-05 | 2016-03-04 | 免疫調節性融合タンパク質およびその使用 |
| JP2020081118A Expired - Fee Related JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
| JP2021150184A Active JP7441201B2 (ja) | 2015-03-05 | 2021-09-15 | 免疫調節性融合タンパク質およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081118A Expired - Fee Related JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
| JP2021150184A Active JP7441201B2 (ja) | 2015-03-05 | 2021-09-15 | 免疫調節性融合タンパク質およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20180044404A1 (enExample) |
| EP (2) | EP4406604A3 (enExample) |
| JP (3) | JP6917896B2 (enExample) |
| KR (1) | KR20170120701A (enExample) |
| CN (1) | CN107531805A (enExample) |
| AU (3) | AU2016226022B2 (enExample) |
| BR (1) | BR112017018919A8 (enExample) |
| CA (2) | CA2978186A1 (enExample) |
| ES (1) | ES2979088T3 (enExample) |
| HK (1) | HK1246317A1 (enExample) |
| IL (1) | IL254165B (enExample) |
| MX (4) | MX2017011201A (enExample) |
| MY (2) | MY196588A (enExample) |
| RU (1) | RU2755227C2 (enExample) |
| SA (1) | SA517382216B1 (enExample) |
| SG (2) | SG10201908203SA (enExample) |
| WO (1) | WO2016141357A1 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| SG11201609118RA (en) | 2014-05-15 | 2016-11-29 | Univ Singapore | Modified natural killer cells and uses thereof |
| BR112017008693A2 (pt) | 2014-10-31 | 2018-02-27 | The Trustees Of The University Of Pennsylvania | célula t modificada, métodos para gerar uma célula t modificada, para tratar uma doença ou condição, para estimular uma resposta imune mediada por célula t e para terapia de transferência de célula adotiva, uso de uma célula t modificada, e, composição. |
| HK1246317A1 (zh) | 2015-03-05 | 2018-09-07 | Fred Hutchinson Cancer Center | 免疫调节融合蛋白及其用途 |
| PT3298033T (pt) | 2015-05-18 | 2020-09-22 | Tcr2 Therapeutics Inc | Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão |
| US11026969B2 (en) | 2015-12-23 | 2021-06-08 | Fred Hutchinson Cancer Research Center | High affinity T cell receptors and uses thereof |
| US11365237B2 (en) | 2016-03-23 | 2022-06-21 | Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) | Fusion proteins of PD-1 and 4-1BB |
| CA3019005A1 (en) | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2018009972A1 (en) * | 2016-07-14 | 2018-01-18 | Peter Maccallum Cancer Institute | Chimeric antigen receptor modified t cells |
| TW202244061A (zh) | 2016-07-14 | 2022-11-16 | 美商必治妥美雅史谷比公司 | 針對tim3之抗體及其用途 |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| WO2018102761A1 (en) * | 2016-12-02 | 2018-06-07 | City Of Hope | Methods for manufacturing and expanding t cells expressing chimeric antigen receptors and other receptors |
| KR20190096969A (ko) * | 2016-12-22 | 2019-08-20 | 윈드밀 테라퓨틱스, 인크. | 면역계를 조절하기 위한 조성물 및 방법 |
| MX2019007611A (es) | 2016-12-22 | 2020-07-29 | Cue Biopharma Inc | Polipéptidos multiméricos moduladores de linfocitos t y métodos para su uso. |
| EP3565829A4 (en) | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | T-CELL-MODULATING MULTIMERIC POLYPEPTIDES AND METHOD OF USING THEREOF |
| AU2018234628B2 (en) | 2017-03-15 | 2023-07-20 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| JP2020511136A (ja) * | 2017-03-17 | 2020-04-16 | フレッド ハッチンソン キャンサー リサーチ センター | 免疫調節性融合タンパク質およびその使用 |
| RU2019128544A (ru) | 2017-03-27 | 2021-04-28 | Нэшнл Юниверсити Оф Сингапур | Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров |
| CN110636851B (zh) | 2017-03-27 | 2023-11-03 | 新加坡国立大学 | 截短的nkg2d嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| CA3071860A1 (en) | 2017-08-02 | 2019-02-07 | Phanes Therapeutics, Inc. | Anti-cd47 antibodies and uses thereof |
| US10960071B2 (en) | 2017-08-07 | 2021-03-30 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
| EP3664830A4 (en) | 2017-08-07 | 2020-07-01 | The Regents of the University of California | RISK-FREE CELL THERAPEUTIC GENERATION PLATFORM |
| CA3071881A1 (en) * | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | Antigen-presenting polypeptides and methods of use thereof |
| WO2019055862A1 (en) | 2017-09-14 | 2019-03-21 | Fred Hutchinson Cancer Research Center | HIGH AFFINITY T CELL RECEPTORS AND USES THEREOF |
| WO2019090355A1 (en) * | 2017-11-06 | 2019-05-09 | Children's National Medical Center | Cells expressing antibodies and methods of treatment using the same |
| WO2019091478A1 (en) | 2017-11-10 | 2019-05-16 | Chineo Medical Technology Co., Ltd. | Modified immune cells and uses thereof |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| CA3089170A1 (en) | 2018-02-09 | 2019-08-15 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| CA3103975A1 (en) * | 2018-06-21 | 2019-12-26 | Shattuck Labs, Inc. | Heterodimeric proteins and uses thereof |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| KR102261407B1 (ko) * | 2018-10-10 | 2021-06-08 | 한국화학연구원 | Hvem을 표적으로 하는 키메라 항원 수용체 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20210393692A1 (en) * | 2018-11-13 | 2021-12-23 | Memorial Sloan Kettering Cancer Center | Compositions and methods for adoptive cell therapy for cancer |
| TWI856047B (zh) | 2018-12-19 | 2024-09-21 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| GB201900858D0 (en) * | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
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| US12448430B2 (en) | 2019-03-11 | 2025-10-21 | Fred Hutchinson Cancer Center | High avidity WT1 T cell receptors and uses thereof |
| EP3938387A1 (en) * | 2019-03-15 | 2022-01-19 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Chimeric adaptor and kinase signaling proteins and their use in immunotherapy |
| KR20210142665A (ko) * | 2019-03-21 | 2021-11-25 | 오엔케이 테라퓨틱스 리미티드 | 세포 사멸에 대한 증가된 내성을 갖는 변형된 면역 효과기 세포 |
| KR20220016083A (ko) | 2019-04-30 | 2022-02-08 | 센티 바이오사이언시스, 인코포레이티드 | 키메라 수용체 및 이의 사용 방법 |
| CA3148072A1 (en) * | 2019-07-19 | 2021-01-28 | Memorial Sloan-Kettering Cancer Center | Fusion polypeptide for immunotherapy |
| KR20220106803A (ko) * | 2019-11-27 | 2022-07-29 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Nk 세포에 대한 대규모 조합형 car 형질도입 및 crispr 유전자 편집 |
| CN115666594A (zh) * | 2019-11-29 | 2023-01-31 | 苏州诺沃泰医药科技有限公司 | Cart细胞在制备治疗癌症的药物中的应用 |
| MX2022007107A (es) * | 2019-12-11 | 2022-11-14 | Myeloid Therapeutics Inc | Composiciones celulares terapeuticas y metodos de preparacion y usos de las mismas. |
| CN115003701A (zh) * | 2020-01-19 | 2022-09-02 | 北京卡替医疗技术有限公司 | 一种提升免疫细胞功能的增强受体 |
| GB202101491D0 (en) * | 2021-02-03 | 2021-03-17 | Autolus Ltd | Molecule |
| EP4132962A1 (en) * | 2020-04-09 | 2023-02-15 | Autolus Limited | Molecule |
| CN115315439A (zh) * | 2020-04-09 | 2022-11-08 | 奥托路斯有限公司 | 细胞 |
| MX2022013208A (es) | 2020-05-12 | 2022-11-14 | Cue Biopharma Inc | Polipeptidos multimericos moduladores de linfocitos t y metodos de uso de estos. |
| CN113698490B (zh) * | 2020-05-22 | 2024-04-30 | 重庆精准生物技术有限公司 | 靶向cea的缺氧诱导启动的car结构及免疫细胞和应用 |
| EP4182338A1 (en) | 2020-07-17 | 2023-05-24 | Instil Bio (Uk) Limited | Receptors providing targeted costimulation for adoptive cell therapy |
| US20230295564A1 (en) * | 2020-07-23 | 2023-09-21 | Emory University | Galectin-9 Specific Binding Agents for Use in Treating Cancer |
| WO2022056014A1 (en) | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
| IL305795A (en) * | 2021-03-10 | 2023-11-01 | B G Negev Technologies & Applications Ltd At Ben Gurion Univ | Reporter cells expressing chimeric proteins for use in determining the presence and or activity of immune barrier molecules |
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