JP2021177771A5 - - Google Patents
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- JP2021177771A5 JP2021177771A5 JP2021118254A JP2021118254A JP2021177771A5 JP 2021177771 A5 JP2021177771 A5 JP 2021177771A5 JP 2021118254 A JP2021118254 A JP 2021118254A JP 2021118254 A JP2021118254 A JP 2021118254A JP 2021177771 A5 JP2021177771 A5 JP 2021177771A5
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- JP
- Japan
- Prior art keywords
- polypeptide
- binding domain
- domain
- antigen binding
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 16
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 4
- 230000004068 intracellular signaling Effects 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000005809 anti-tumor immunity Effects 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 239000012642 immune effector Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 230000031146 intracellular signal transduction Effects 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361819141P | 2013-05-03 | 2013-05-03 | |
| US61/819,141 | 2013-05-03 | ||
| US201361876492P | 2013-09-11 | 2013-09-11 | |
| US61/876,492 | 2013-09-11 | ||
| JP2019079616A JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019079616A Division JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021177771A JP2021177771A (ja) | 2021-11-18 |
| JP2021177771A5 true JP2021177771A5 (enExample) | 2022-03-24 |
| JP7221338B2 JP7221338B2 (ja) | 2023-02-13 |
Family
ID=51844005
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512083A Active JP6856188B2 (ja) | 2013-05-03 | 2014-05-02 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2019079616A Pending JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2021118254A Active JP7221338B2 (ja) | 2013-05-03 | 2021-07-16 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512083A Active JP6856188B2 (ja) | 2013-05-03 | 2014-05-02 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2019079616A Pending JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10358494B2 (enExample) |
| EP (2) | EP2992020B1 (enExample) |
| JP (3) | JP6856188B2 (enExample) |
| KR (1) | KR102098985B1 (enExample) |
| CN (2) | CN105377897A (enExample) |
| AU (2) | AU2014259675B2 (enExample) |
| BR (1) | BR112015027567B1 (enExample) |
| DK (1) | DK2992020T3 (enExample) |
| ES (1) | ES2777940T3 (enExample) |
| HU (1) | HUE048312T2 (enExample) |
| IL (1) | IL242315B (enExample) |
| MX (1) | MX370173B (enExample) |
| PL (1) | PL2992020T3 (enExample) |
| PT (1) | PT2992020T (enExample) |
| WO (1) | WO2014179759A1 (enExample) |
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| DK2992020T3 (da) * | 2013-05-03 | 2020-02-10 | Ohio State Innovation Foundation | Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller |
| US10189908B2 (en) | 2014-02-05 | 2019-01-29 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants |
| CN107429253B (zh) * | 2014-12-05 | 2021-11-05 | 希望之城公司 | Cs1靶向性嵌合抗原受体修饰的t细胞 |
| HK1246180A1 (zh) * | 2014-12-31 | 2018-09-07 | Celgene Corporation | 使用自然杀伤细胞治疗血液病症、实体瘤或感染性疾病的方法 |
| EP3250611B1 (en) | 2015-01-26 | 2021-04-21 | The University of Chicago | Car t-cells recognizing cancer-specific il 13r-alpha2 |
| EP3250609A4 (en) | 2015-01-26 | 2018-07-11 | The University of Chicago | Il13ra alpha 2 binding agents and use thereof in cancer treatment |
| CN113862292B (zh) * | 2015-01-29 | 2024-12-27 | 明尼苏达大学董事会 | 嵌合抗原受体、组合物以及方法 |
| CN107530424A (zh) | 2015-02-20 | 2018-01-02 | 俄亥俄州国家创新基金会 | 针对nkg2d和肿瘤相关抗原的二价抗体 |
| CN108367057B (zh) | 2015-04-06 | 2022-11-22 | 赛通免疫股份有限公司 | 用于胶质母细胞瘤的egfr导向的car疗法 |
| TW201706300A (zh) * | 2015-05-20 | 2017-02-16 | 瑟勒提斯公司 | 用於癌症免疫療法之抗－ｇｄ３專一性嵌合抗原受體 |
| ES2958720T3 (es) * | 2015-06-10 | 2024-02-13 | Immunitybio Inc | Células NK-92 modificadas para tratar el cáncer |
| KR102157701B1 (ko) | 2015-08-17 | 2020-09-21 | 서울대학교산학협력단 | 항-코티닌 항체가 연결된 키메라 항체 수용체 및 이의 용도 |
| EP4289944A3 (en) * | 2015-10-08 | 2024-03-13 | National University Corporation Tokai National Higher Education and Research System | Method for preparing genetically-modified t cells which express chimeric antigen receptor |
| KR20180101540A (ko) * | 2016-01-15 | 2018-09-12 | 이투빅스 코포레이션 | T 세포 면역요법을 위한 방법 및 조성물 |
| US11090334B2 (en) | 2016-01-29 | 2021-08-17 | Med Manor Organics (P) Ltd. | Chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof |
| US11365237B2 (en) | 2016-03-23 | 2022-06-21 | Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) | Fusion proteins of PD-1 and 4-1BB |
| CN109414512A (zh) | 2016-04-22 | 2019-03-01 | 科济生物医药（上海）有限公司 | 用于细胞免疫疗法的组合物和方法 |
| US12516292B2 (en) | 2016-07-25 | 2026-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing modified natural killer cells and methods of use |
| EP3487991B1 (en) | 2016-07-25 | 2022-09-07 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods of producing modified natural killer cells and methods of use |
| CN106279432B (zh) * | 2016-08-10 | 2019-09-20 | 深圳市再生之城生物医药技术有限公司 | 一种vc-car分子及在清除hiv-1感染细胞中的应用 |
| WO2018058432A1 (zh) * | 2016-09-28 | 2018-04-05 | 李华顺 | 一种多基因重组嵌合抗原受体分子及其应用 |
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| CN110475857B (zh) | 2017-01-05 | 2023-07-18 | 韩国生命工学研究院 | 表达抗-可替宁嵌合抗原受体的天然杀伤细胞 |
| WO2018175453A1 (en) * | 2017-03-20 | 2018-09-27 | City Of Hope | Cs1 targeted chimeric antigen receptor-modified t cells for treatment of al amyloidosis |
| CN110636855B (zh) * | 2017-03-28 | 2024-08-09 | 俄亥俄州创新基金会 | 人pd1肽疫苗及其用途 |
| WO2018189360A1 (en) | 2017-04-13 | 2018-10-18 | Cellectis | New sequence specific reagents targeting ccr5 in primary hematopoietic cells |
| CN111212663A (zh) * | 2017-07-07 | 2020-05-29 | H·李·莫菲特癌症中心研究所公司 | 具有突变的cd28共刺激性结构域的嵌合抗原受体 |
| EP3652203B1 (en) * | 2017-07-14 | 2025-07-02 | The Johns Hopkins University | Engineered tsc2 |
| TWI676483B (zh) * | 2017-08-06 | 2019-11-11 | 強普生技股份有限公司 | 醫藥套組及其用途 |
| WO2019069125A1 (en) * | 2017-10-06 | 2019-04-11 | Oslo Universitetssykehus Hf | CHIMERIC ANTIGEN RECEPTORS |
| US20200283501A1 (en) | 2017-10-26 | 2020-09-10 | Regents Of The University Of Minnesota | Recombinant immune cells, methods of making, and methods of use |
| US12077598B2 (en) | 2018-03-16 | 2024-09-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Chimeric antigen receptors with mutated CD28 phosphorylation sites |
| CA3103610A1 (en) | 2018-06-12 | 2019-12-19 | The Regents Of The University Of California | Single-chain bispecific chimeric antigen receptors for the treatment of cancer |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| WO2020009868A1 (en) * | 2018-07-03 | 2020-01-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-slamf7 chimeric antigen receptors |
| WO2020010341A1 (en) * | 2018-07-05 | 2020-01-09 | Emory University | Transduction of innate immunocompetent cells using aav6 |
| CN112469734A (zh) * | 2018-08-03 | 2021-03-09 | 南京驯鹿医疗技术有限公司 | 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 |
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| BR112021017744A2 (pt) | 2019-03-08 | 2021-11-16 | Obsidian Therapeutics Inc | Composições e métodos de cd40l para regulação ajustável |
| EP4332115A3 (en) | 2019-04-03 | 2024-05-29 | Precision Biosciences, Inc. | Genetically-modified immune cells comprising a microrna-adapted shrna (shrnamir) |
| CA3140668A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2020252404A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| BR112021026832A2 (pt) | 2019-07-02 | 2022-05-10 | Hutchinson Fred Cancer Res | Vetores ad35 recombinantes e aprimoramentos da terapia gênica relacionada |
| CN112442126B (zh) * | 2019-09-04 | 2022-07-29 | 杭州济元基因科技有限公司 | 一种抗人cs1抗原的单克隆抗体及其car-t细胞 |
| EP4054602A4 (en) * | 2019-11-08 | 2023-12-06 | Mayo Foundation for Medical Education and Research | EPHA3 TARGETED CAR-T CELLS FOR TREATING TUMORS |
| US12703750B2 (en) | 2020-04-11 | 2026-08-11 | Northwestern University | Humanized antibody targeting the tumor associated antigen IL13Ra2 |
| US20230242641A1 (en) * | 2020-06-29 | 2023-08-03 | Julius-Maximilians-Universität Würzburg | Slamf7 cars |
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| TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
| CN116410331B (zh) * | 2021-12-31 | 2024-01-30 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
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| CN103224561A (zh) | 2013-01-16 | 2013-07-31 | 天津大学 | 葡萄球菌肠毒素小分子抗体及制备方法及用途 |
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| DK2992020T3 (da) * | 2013-05-03 | 2020-02-10 | Ohio State Innovation Foundation | Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller |
| AU2014337367B2 (en) | 2013-10-15 | 2020-04-30 | The Scripps Research Institute | Peptidic chimeric antigen receptor T cell switches and uses thereof |
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-
2014
- 2014-05-02 DK DK14791494.9T patent/DK2992020T3/da active
- 2014-05-02 MX MX2015015182A patent/MX370173B/es active IP Right Grant
- 2014-05-02 EP EP14791494.9A patent/EP2992020B1/en active Active
- 2014-05-02 CN CN201480030178.9A patent/CN105377897A/zh active Pending
- 2014-05-02 ES ES14791494T patent/ES2777940T3/es active Active
- 2014-05-02 KR KR1020157033493A patent/KR102098985B1/ko active Active
- 2014-05-02 PT PT147914949T patent/PT2992020T/pt unknown
- 2014-05-02 AU AU2014259675A patent/AU2014259675B2/en active Active
- 2014-05-02 US US14/888,877 patent/US10358494B2/en active Active
- 2014-05-02 JP JP2016512083A patent/JP6856188B2/ja active Active
- 2014-05-02 HU HUE14791494A patent/HUE048312T2/hu unknown
- 2014-05-02 BR BR112015027567-2A patent/BR112015027567B1/pt active IP Right Grant
- 2014-05-02 CN CN202210255676.XA patent/CN115028735A/zh active Pending
- 2014-05-02 PL PL14791494T patent/PL2992020T3/pl unknown
- 2014-05-02 EP EP20150396.8A patent/EP3663320A1/en not_active Withdrawn
- 2014-05-02 WO PCT/US2014/036684 patent/WO2014179759A1/en not_active Ceased
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2015
- 2015-10-28 IL IL242315A patent/IL242315B/en active IP Right Grant
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2017
- 2017-05-17 US US15/597,436 patent/US10227409B2/en active Active
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2019
- 2019-04-18 JP JP2019079616A patent/JP2019146579A/ja active Pending
- 2019-05-31 AU AU2019203823A patent/AU2019203823B2/en active Active
- 2019-07-09 US US16/506,327 patent/US11845794B2/en active Active
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2021
- 2021-07-16 JP JP2021118254A patent/JP7221338B2/ja active Active