JP2021177771A5 - - Google Patents
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- JP2021177771A5 JP2021177771A5 JP2021118254A JP2021118254A JP2021177771A5 JP 2021177771 A5 JP2021177771 A5 JP 2021177771A5 JP 2021118254 A JP2021118254 A JP 2021118254A JP 2021118254 A JP2021118254 A JP 2021118254A JP 2021177771 A5 JP2021177771 A5 JP 2021177771A5
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- Prior art keywords
- polypeptide
- binding domain
- domain
- antigen binding
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 16
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 4
- 230000004068 intracellular signaling Effects 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000005809 anti-tumor immunity Effects 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 239000012642 immune effector Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 230000031146 intracellular signal transduction Effects 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361819141P | 2013-05-03 | 2013-05-03 | |
| US61/819,141 | 2013-05-03 | ||
| US201361876492P | 2013-09-11 | 2013-09-11 | |
| US61/876,492 | 2013-09-11 | ||
| JP2019079616A JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019079616A Division JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021177771A JP2021177771A (ja) | 2021-11-18 |
| JP2021177771A5 true JP2021177771A5 (enExample) | 2022-03-24 |
| JP7221338B2 JP7221338B2 (ja) | 2023-02-13 |
Family
ID=51844005
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512083A Active JP6856188B2 (ja) | 2013-05-03 | 2014-05-02 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2019079616A Pending JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2021118254A Active JP7221338B2 (ja) | 2013-05-03 | 2021-07-16 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512083A Active JP6856188B2 (ja) | 2013-05-03 | 2014-05-02 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
| JP2019079616A Pending JP2019146579A (ja) | 2013-05-03 | 2019-04-18 | Ｃｓ１特異的キメラ抗原受容体を遺伝子操作した免疫エフェクター細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10358494B2 (enExample) |
| EP (2) | EP2992020B1 (enExample) |
| JP (3) | JP6856188B2 (enExample) |
| KR (1) | KR102098985B1 (enExample) |
| CN (2) | CN115028735A (enExample) |
| AU (2) | AU2014259675B2 (enExample) |
| BR (1) | BR112015027567B1 (enExample) |
| CA (1) | CA2910666A1 (enExample) |
| DK (1) | DK2992020T3 (enExample) |
| ES (1) | ES2777940T3 (enExample) |
| HU (1) | HUE048312T2 (enExample) |
| IL (1) | IL242315B (enExample) |
| MX (1) | MX370173B (enExample) |
| PL (1) | PL2992020T3 (enExample) |
| PT (1) | PT2992020T (enExample) |
| WO (1) | WO2014179759A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| BR112015027567B1 (pt) * | 2013-05-03 | 2024-02-20 | Ohio State Innovation Foundation | Polipeptídeo, sequência de ácido nucleico isolada, vetor, método de obtenção de célula, uso de uma célula |
| US10189908B2 (en) | 2014-02-05 | 2019-01-29 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants |
| KR102558502B1 (ko) * | 2014-12-05 | 2023-07-20 | 시티 오브 호프 | Ｃｓ1 표적화된 키메라 항원 수용체-변형된 ｔ 세포 |
| CN107249604A (zh) * | 2014-12-31 | 2017-10-13 | 人类起源公司 | 使用自然杀伤细胞治疗血液病症、实体瘤或感染性疾病的方法 |
| JP6912386B2 (ja) * | 2015-01-26 | 2021-08-04 | ザ ユニバーシティー オブ シカゴ | 癌特異的なＩＬ１３Ｒα２を認識するＣＡＲ Ｔ細胞 |
| CN107683289B (zh) | 2015-01-26 | 2021-08-06 | 芝加哥大学 | IL13Rα2结合剂和其在癌症治疗中的用途 |
| CN113862292B (zh) * | 2015-01-29 | 2024-12-27 | 明尼苏达大学董事会 | 嵌合抗原受体、组合物以及方法 |
| AU2016219785B2 (en) | 2015-02-20 | 2021-10-28 | Ohio State Innovation Foundation | Bivalent antibody directed against NKG2D and tumor associated antigens |
| WO2016164370A1 (en) * | 2015-04-06 | 2016-10-13 | Ohio State Innovation Foundation | Egfr-directed car therapy for glioblastoma |
| EP3298046B1 (en) * | 2015-05-20 | 2025-02-12 | Cellectis | Anti-gd3 specific chimeric antigen receptors for cancer immunotherapy |
| KR20240013282A (ko) * | 2015-06-10 | 2024-01-30 | 이뮤너티바이오, 인크. | 암을 치료하기 위한 변형된 nk-92 세포 |
| JP7010487B2 (ja) | 2015-08-17 | 2022-03-03 | ソウル大学校産学協力団 | 抗コチニン抗体が連結したキメラ抗原受容体およびその使用 |
| WO2017061615A1 (ja) * | 2015-10-08 | 2017-04-13 | 国立大学法人名古屋大学 | キメラ抗原受容体を発現する遺伝子改変ｔ細胞の調製方法 |
| CA3010869A1 (en) * | 2016-01-15 | 2017-07-20 | Etubics Corporation | Methods and compositions for t-cell immunotherapy |
| EP3408297A2 (en) | 2016-01-29 | 2018-12-05 | Med Manor Organics, (P) Ltd | A chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof |
| EP4286522A3 (en) | 2016-03-23 | 2024-02-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| WO2018018958A1 (en) * | 2016-04-22 | 2018-02-01 | Carsgen Therapeutics Co., Ltd. | Compositions and methods of cellular immunotherapy |
| SG11201810871WA (en) | 2016-07-25 | 2019-01-30 | Us Health | Methods of producing modified natural killer cells and methods of use |
| CN106279432B (zh) * | 2016-08-10 | 2019-09-20 | 深圳市再生之城生物医药技术有限公司 | 一种vc-car分子及在清除hiv-1感染细胞中的应用 |
| CN108699163B (zh) * | 2016-09-28 | 2021-11-19 | 阿思科力(苏州)生物科技有限公司 | 一种多基因重组嵌合抗原受体分子及其应用 |
| EP4653464A2 (en) | 2016-12-23 | 2025-11-26 | MacroGenics, Inc. | Adam9-binding molecules, and methods of use thereof |
| CN110475857B (zh) * | 2017-01-05 | 2023-07-18 | 韩国生命工学研究院 | 表达抗-可替宁嵌合抗原受体的天然杀伤细胞 |
| WO2018175453A1 (en) * | 2017-03-20 | 2018-09-27 | City Of Hope | Cs1 targeted chimeric antigen receptor-modified t cells for treatment of al amyloidosis |
| BR112019020386A2 (pt) * | 2017-03-28 | 2020-06-09 | Mayo Found Medical Education & Res | vacinas de peptídeos de pd-1 humana e usos das mesmas |
| CA3059643A1 (en) | 2017-04-13 | 2018-10-18 | Cellectis | New sequence specific reagents targeting ccr5 in primary hematopoietic cells |
| MX2019015484A (es) * | 2017-07-07 | 2020-07-28 | H Lee Moffitt Cancer Ct & Res | Receptores quiméricos de antígeno con dominios coestimuladores cd28 mutados. |
| EP4640832A2 (en) * | 2017-07-14 | 2025-10-29 | The Johns Hopkins University | Engineered tsc2 |
| TWI676483B (zh) * | 2017-08-06 | 2019-11-11 | 強普生技股份有限公司 | 醫藥套組及其用途 |
| EP3692058A1 (en) * | 2017-10-06 | 2020-08-12 | Oslo Universitetssykehus HF | Chimeric antigen receptors |
| WO2019178463A1 (en) * | 2018-03-16 | 2019-09-19 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Chimeric antigen receptors with mutated cd28 phosphorylation sites |
| CN112566643A (zh) | 2018-06-12 | 2021-03-26 | 加利福尼亚大学董事会 | 用于治疗癌症的单链双特异性嵌合抗原受体 |
| WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| US11951131B2 (en) | 2018-07-03 | 2024-04-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-SLAMF7 chimeric antigen receptors |
| US20210163989A1 (en) * | 2018-07-05 | 2021-06-03 | Emory University | Transduction of innate immunocompetent cells using aav6 |
| WO2020025039A1 (zh) * | 2018-08-03 | 2020-02-06 | 南京驯鹿医疗技术有限公司 | 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 |
| WO2020123716A1 (en) | 2018-12-11 | 2020-06-18 | Obsidian Therapeutics, Inc. | Membrane bound il12 compositions and methods for tunable regulation |
| KR20210149251A (ko) | 2019-03-08 | 2021-12-08 | 옵시디안 테라퓨틱스, 인크. | 조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법 |
| CN116200342A (zh) | 2019-04-03 | 2023-06-02 | 精密生物科学公司 | 包含microRNA适应的shRNA（shRNAmiR）的遗传修饰的免疫细胞 |
| EP3983538A1 (en) | 2019-06-12 | 2022-04-20 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2020252404A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| US20220257796A1 (en) | 2019-07-02 | 2022-08-18 | Fred Hutchinson Cancer Research Center | Recombinant ad35 vectors and related gene therapy improvements |
| CN112442126B (zh) * | 2019-09-04 | 2022-07-29 | 杭州济元基因科技有限公司 | 一种抗人cs1抗原的单克隆抗体及其car-t细胞 |
| EP4054602A4 (en) * | 2019-11-08 | 2023-12-06 | Mayo Foundation for Medical Education and Research | EPHA3 TARGETED CAR-T CELLS FOR TREATING TUMORS |
| US20230242641A1 (en) * | 2020-06-29 | 2023-08-03 | Julius-Maximilians-Universität Würzburg | Slamf7 cars |
| CN114286691B (zh) * | 2020-08-06 | 2024-08-06 | 武汉思安医疗技术有限公司 | Cs1-抗体和抗cs1-car-t细胞 |
| WO2022063302A1 (zh) * | 2020-09-25 | 2022-03-31 | 克莱格医学有限公司 | 免疫细胞活性调节 |
| EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| CN116410331B (zh) * | 2021-12-31 | 2024-01-30 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
| WO2024114691A1 (en) * | 2022-12-02 | 2024-06-06 | Guangzhou Litai Biotechnology Co., Ltd. | Human cs1 car-t cells |
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| US7083950B2 (en) * | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | High affinity fusion proteins and therapeutic and diagnostic methods for use |
| EP1266014A2 (en) * | 2000-03-24 | 2002-12-18 | Peter Kufer | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
| US20050025763A1 (en) * | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
| US7709610B2 (en) * | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| WO2008034076A2 (en) | 2006-09-15 | 2008-03-20 | The Johns Hopkins University | Cyclophosphamide in combination with immune therapeutics |
| EP2626371A1 (en) | 2007-07-31 | 2013-08-14 | MedImmune, LLC | Multispecific epitope binding proteins and uses thereof |
| WO2010017103A2 (en) | 2008-08-04 | 2010-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Fully human anti-human nkg2d monoclonal antibodies |
| KR20110096536A (ko) | 2008-10-31 | 2011-08-30 | 애보트 바이오테라퓨틱스 코포레이션 | 희귀 림프종의 치료를 위한 항ｃｓ1 항체의 용도 |
| TW201109438A (en) | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| US9073990B2 (en) | 2010-04-05 | 2015-07-07 | Bar-Llan University | Protease-activatable pore-forming polypeptides |
| US9212229B2 (en) * | 2010-09-08 | 2015-12-15 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
| US9844593B2 (en) * | 2010-11-22 | 2017-12-19 | Innate Pharma Sa | Methods for treatment of recurrent hematological malignancies |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2765193B1 (en) * | 2011-10-07 | 2017-08-09 | Mie University | Chimeric antigen receptor |
| PE20141937A1 (es) | 2011-11-16 | 2014-12-18 | Amgen Inc | Metodos para tratar trastornos relacionados con mutante viii de eliminacion de factor de crecimiento epidermico |
| JP6850528B2 (ja) * | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| CN104968788A (zh) | 2012-12-07 | 2015-10-07 | 索拉兹米公司 | 包括原始小球藻脂质途径基因的基因工程化微生物菌株 |
| CN103224561A (zh) | 2013-01-16 | 2013-07-31 | 天津大学 | 葡萄球菌肠毒素小分子抗体及制备方法及用途 |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| BR112015027567B1 (pt) * | 2013-05-03 | 2024-02-20 | Ohio State Innovation Foundation | Polipeptídeo, sequência de ácido nucleico isolada, vetor, método de obtenção de célula, uso de uma célula |
| CA2927543C (en) | 2013-10-15 | 2021-07-20 | The California Institute For Biomedical Research | Peptidic chimeric antigen receptor t cell switches and uses thereof |
| CN112118850A (zh) * | 2018-03-16 | 2020-12-22 | 赛通免疫治疗公司 | 双特异性抗体car细胞免疫疗法 |
-
2014
- 2014-05-02 BR BR112015027567-2A patent/BR112015027567B1/pt active IP Right Grant
- 2014-05-02 CN CN202210255676.XA patent/CN115028735A/zh active Pending
- 2014-05-02 PT PT147914949T patent/PT2992020T/pt unknown
- 2014-05-02 KR KR1020157033493A patent/KR102098985B1/ko active Active
- 2014-05-02 WO PCT/US2014/036684 patent/WO2014179759A1/en not_active Ceased
- 2014-05-02 US US14/888,877 patent/US10358494B2/en active Active
- 2014-05-02 DK DK14791494.9T patent/DK2992020T3/da active
- 2014-05-02 EP EP14791494.9A patent/EP2992020B1/en active Active
- 2014-05-02 ES ES14791494T patent/ES2777940T3/es active Active
- 2014-05-02 CN CN201480030178.9A patent/CN105377897A/zh active Pending
- 2014-05-02 EP EP20150396.8A patent/EP3663320A1/en not_active Withdrawn
- 2014-05-02 PL PL14791494T patent/PL2992020T3/pl unknown
- 2014-05-02 JP JP2016512083A patent/JP6856188B2/ja active Active
- 2014-05-02 CA CA2910666A patent/CA2910666A1/en active Pending
- 2014-05-02 HU HUE14791494A patent/HUE048312T2/hu unknown
- 2014-05-02 MX MX2015015182A patent/MX370173B/es active IP Right Grant
- 2014-05-02 AU AU2014259675A patent/AU2014259675B2/en active Active
-
2015
- 2015-10-28 IL IL242315A patent/IL242315B/en active IP Right Grant
-
2017
- 2017-05-17 US US15/597,436 patent/US10227409B2/en active Active
-
2019
- 2019-04-18 JP JP2019079616A patent/JP2019146579A/ja active Pending
- 2019-05-31 AU AU2019203823A patent/AU2019203823B2/en active Active
- 2019-07-09 US US16/506,327 patent/US11845794B2/en active Active
-
2021
- 2021-07-16 JP JP2021118254A patent/JP7221338B2/ja active Active
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