HUE048312T2 - CS-1 specifikus kiméra antigén receptor módosított immuneffektor sejtek - Google Patents

CS-1 specifikus kiméra antigén receptor módosított immuneffektor sejtek

Info

Publication number
HUE048312T2
HUE048312T2 HUE14791494A HUE14791494A HUE048312T2 HU E048312 T2 HUE048312 T2 HU E048312T2 HU E14791494 A HUE14791494 A HU E14791494A HU E14791494 A HUE14791494 A HU E14791494A HU E048312 T2 HUE048312 T2 HU E048312T2
Authority
HU
Hungary
Prior art keywords
effector cells
antigen receptor
chimeric antigen
immune effector
engineered immune
Prior art date
Application number
HUE14791494A
Other languages
English (en)
Hungarian (hu)
Inventor
Jianhua Yu
Craig Hofmeister
Jianhong Chu
Original Assignee
Ohio State Innovation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State Innovation Foundation filed Critical Ohio State Innovation Foundation
Publication of HUE048312T2 publication Critical patent/HUE048312T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
HUE14791494A 2013-05-03 2014-05-02 CS-1 specifikus kiméra antigén receptor módosított immuneffektor sejtek HUE048312T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361819141P 2013-05-03 2013-05-03
US201361876492P 2013-09-11 2013-09-11

Publications (1)

Publication Number Publication Date
HUE048312T2 true HUE048312T2 (hu) 2020-07-28

Family

ID=51844005

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14791494A HUE048312T2 (hu) 2013-05-03 2014-05-02 CS-1 specifikus kiméra antigén receptor módosított immuneffektor sejtek

Country Status (15)

Country Link
US (3) US10358494B2 (enExample)
EP (2) EP2992020B1 (enExample)
JP (3) JP6856188B2 (enExample)
KR (1) KR102098985B1 (enExample)
CN (2) CN105377897A (enExample)
AU (2) AU2014259675B2 (enExample)
BR (1) BR112015027567B1 (enExample)
DK (1) DK2992020T3 (enExample)
ES (1) ES2777940T3 (enExample)
HU (1) HUE048312T2 (enExample)
IL (1) IL242315B (enExample)
MX (1) MX370173B (enExample)
PL (1) PL2992020T3 (enExample)
PT (1) PT2992020T (enExample)
WO (1) WO2014179759A1 (enExample)

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Also Published As

Publication number Publication date
JP2016524598A (ja) 2016-08-18
EP3663320A1 (en) 2020-06-10
US20200002418A1 (en) 2020-01-02
JP7221338B2 (ja) 2023-02-13
CN115028735A (zh) 2022-09-09
CN105377897A (zh) 2016-03-02
EP2992020A1 (en) 2016-03-09
WO2014179759A1 (en) 2014-11-06
EP2992020A4 (en) 2016-12-28
DK2992020T3 (da) 2020-02-10
US10358494B2 (en) 2019-07-23
BR112015027567B1 (pt) 2024-02-20
BR112015027567A2 (pt) 2017-12-05
KR102098985B1 (ko) 2020-04-09
AU2019203823A1 (en) 2019-06-20
HK1218925A1 (en) 2017-03-17
US20160075784A1 (en) 2016-03-17
AU2014259675A1 (en) 2015-11-12
JP2019146579A (ja) 2019-09-05
US11845794B2 (en) 2023-12-19
AU2014259675B2 (en) 2019-05-02
JP2021177771A (ja) 2021-11-18
US10227409B2 (en) 2019-03-12
PT2992020T (pt) 2020-02-28
AU2019203823B2 (en) 2021-05-13
MX2015015182A (es) 2016-05-05
PL2992020T3 (pl) 2020-06-01
US20170320941A1 (en) 2017-11-09
ES2777940T3 (es) 2020-08-06
MX370173B (es) 2019-12-04
IL242315B (en) 2020-07-30
JP6856188B2 (ja) 2021-04-07
KR20160003071A (ko) 2016-01-08
CA2910666A1 (en) 2014-11-06
EP2992020B1 (en) 2020-01-15

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