JP2019515672A5 - - Google Patents
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- JP2019515672A5 JP2019515672A5 JP2018554677A JP2018554677A JP2019515672A5 JP 2019515672 A5 JP2019515672 A5 JP 2019515672A5 JP 2018554677 A JP2018554677 A JP 2018554677A JP 2018554677 A JP2018554677 A JP 2018554677A JP 2019515672 A5 JP2019515672 A5 JP 2019515672A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- amino acid
- acid sequence
- seq
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022139098A JP2022164858A (ja) | 2016-04-20 | 2022-09-01 | 免疫調整性ｉｌ２ｒ融合タンパク質およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662325428P | 2016-04-20 | 2016-04-20 | |
| US62/325,428 | 2016-04-20 | ||
| PCT/US2017/028693 WO2017184901A1 (en) | 2016-04-20 | 2017-04-20 | Immunomodulatory il2r fusion proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022139098A Division JP2022164858A (ja) | 2016-04-20 | 2022-09-01 | 免疫調整性ｉｌ２ｒ融合タンパク質およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019515672A JP2019515672A (ja) | 2019-06-13 |
| JP2019515672A5 true JP2019515672A5 (enExample) | 2020-05-28 |
| JP7198670B2 JP7198670B2 (ja) | 2023-01-04 |
Family
ID=58710057
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554677A Active JP7198670B2 (ja) | 2016-04-20 | 2017-04-20 | 免疫調整性ｉｌ２ｒ融合タンパク質およびその使用 |
| JP2022139098A Ceased JP2022164858A (ja) | 2016-04-20 | 2022-09-01 | 免疫調整性ｉｌ２ｒ融合タンパク質およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022139098A Ceased JP2022164858A (ja) | 2016-04-20 | 2022-09-01 | 免疫調整性ｉｌ２ｒ融合タンパク質およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190127435A1 (enExample) |
| EP (1) | EP3445847B1 (enExample) |
| JP (2) | JP7198670B2 (enExample) |
| CN (1) | CN109312304A (enExample) |
| CA (1) | CA3021455A1 (enExample) |
| ES (1) | ES2981274T3 (enExample) |
| WO (1) | WO2017184901A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107531805A (zh) | 2015-03-05 | 2018-01-02 | 弗雷德哈钦森癌症研究中心 | 免疫调节融合蛋白及其用途 |
| EP3458485B1 (en) * | 2016-05-19 | 2021-12-29 | The General Hospital Corporation | Tethered interleukin-2 to its receptor il-2rbeta, a platform to enhance natural killer and regulatory t cell activity |
| MX2019010812A (es) | 2017-03-17 | 2019-12-11 | Hutchinson Fred Cancer Res | Proteinas de fusion inmunomoduladoras y sus usos. |
| CN109503715B (zh) * | 2017-09-15 | 2023-12-15 | 科济生物医药（上海）有限公司 | Il-4r的融合蛋白及其应用 |
| CN108504685A (zh) * | 2018-03-27 | 2018-09-07 | 宜明细胞生物科技有限公司 | 一种利用CRISPR/Cas9系统同源重组修复IL-2RG缺陷基因的方法 |
| CN110615843B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
| CA3097443A1 (en) * | 2018-11-12 | 2020-05-22 | I-Mab Biopharma Us Limited | Fusion proteins containing cd47 antibodies and cytokines |
| EP3992204A4 (en) * | 2019-06-28 | 2023-09-27 | CRAGE medical Co., Limited | CELL FOR RESISTANCE TO TRANSPLANT REACTION AND METHOD |
| JP2022548069A (ja) * | 2019-09-11 | 2022-11-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | キメラ直交受容体タンパク質および使用方法 |
| EP4031583A4 (en) * | 2019-09-16 | 2023-11-15 | Fred Hutchinson Cancer Center | CHIMERIC RECEPTOR PROTEINS AND THEIR USES |
| GB201913697D0 (en) * | 2019-09-23 | 2019-11-06 | King S College London | DAP10/DAP12 fusion polypeptides |
| US20240122979A1 (en) * | 2019-10-08 | 2024-04-18 | Provincial Health Services Authority | Chimeric Cytokine Receptors |
| WO2021141986A1 (en) * | 2020-01-07 | 2021-07-15 | St. Jude Children's Research Hospital, Inc. | Chimeric gmcsf-il18 receptor |
| CN113249330A (zh) * | 2021-05-20 | 2021-08-13 | 深圳市先康达生命科学有限公司 | 免疫细胞及其应用 |
| JP2024542027A (ja) * | 2021-11-02 | 2024-11-13 | フレッド ハッチンソン キャンサー センター | 細胞標的療法を利用したがんの治療及び関連する研究プロトコル |
| JP2026507228A (ja) | 2023-03-03 | 2026-02-27 | アーセナル バイオサイエンシズ インコーポレイテッド | Ｐｓｍａ及びｃａ９を標的とするシステム |
| WO2025039159A1 (en) * | 2023-08-21 | 2025-02-27 | Hangzhou Hervor Therapeutics Co., Ltd | Synthetic cytokine signaling system, preparation method, and uses thereof |
| WO2025081123A1 (en) | 2023-10-12 | 2025-04-17 | Fred Hutchinson Cancer Center | Methods and compositions for improving t cell immunotherapy |
| AU2024364809A1 (en) * | 2023-10-16 | 2026-05-07 | Lankenau Institute For Medical Research | Biologic conjugates that inhibit production of inflammatory cells and methods of use |
| CN117511885B (zh) * | 2024-01-08 | 2024-06-11 | 青岛华赛伯曼医学细胞生物有限公司 | 提高识别和杀伤肿瘤能力的工程化til细胞及其应用 |
| WO2025245169A1 (en) | 2024-05-21 | 2025-11-27 | Fred Hutchinson Cancer Center | Immunotherapy cells equipped with a collagen-targeting payload |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| WO1994022914A1 (en) * | 1993-04-06 | 1994-10-13 | Fred Hutchinson Cancer Research Center | Chimeric cytokine receptors in lymphocytes |
| CN101684158A (zh) * | 2001-01-17 | 2010-03-31 | 特鲁比昂药品公司 | 结合域-免疫球蛋白融合蛋白 |
| US8119772B2 (en) | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
| US9272002B2 (en) * | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
| EP3594245A1 (en) * | 2012-02-13 | 2020-01-15 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| EP2986636B1 (en) * | 2013-04-17 | 2018-11-14 | Baylor College Of Medicine | Immunosuppressive tgf-beta signal converter |
-
2017
- 2017-04-20 US US16/094,420 patent/US20190127435A1/en not_active Abandoned
- 2017-04-20 CN CN201780037786.6A patent/CN109312304A/zh active Pending
- 2017-04-20 CA CA3021455A patent/CA3021455A1/en active Pending
- 2017-04-20 ES ES17724147T patent/ES2981274T3/es active Active
- 2017-04-20 JP JP2018554677A patent/JP7198670B2/ja active Active
- 2017-04-20 WO PCT/US2017/028693 patent/WO2017184901A1/en not_active Ceased
- 2017-04-20 EP EP17724147.8A patent/EP3445847B1/en active Active
-
2022
- 2022-09-01 JP JP2022139098A patent/JP2022164858A/ja not_active Ceased
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